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Journal of Iron and Steel Research International 2015年第10期22卷 885-891页

作者： Jian-hong dong Min CHEN nan WANG School of Materials and Metallurgy Northeastern University

A novel-type delivery system consisting of a special feeding device and delivery device was developed and applied to a φ600 mm× 1 000 mm twin-roll casting system for producing the steel strip of 2 mm in thickness, and the characteristics of fluid flow and temperature field in the casting pool were investigated by mathematical simulation. The results showed that the melt from the novel-type delivery system was distributed to the casting pool along the width direction smoothly and uniformly. At the casting speed of 80 m/min, the difference of minimum residence time （groin） and actual average residence time （tave） among different ports of the delivery device was less than 0.18 s and 0.26 s respectively, and the average amplitude of level fluctuation was 0.3 mm to 0.6 mm on the free surface of casting pool. In addition, the difference of temperature on the free surface of the pool was below 20 K and the difference across the width direction of roll in different pool depths was less than 13 K, which indicates that the uniformity of temperature distribution was obtained in the casting pool to maintain the casting process and the defect-free steel strip can also be obtained.

关键词： twin-roll strip casting novel-type delivery system fluid flow temperature field mathematical simulation

Deformation Mechanism and Hot Workability of Extruded Magnesium Alloy AZ31

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Acta Metallurgica Sinica(English Letters) 2018年第1期31卷 71-81页

作者： Zhao-Yang Jin nan-nan Li Kai Yan Jian Wang Jing Bai Hongbiao dong School of Mechanical Engineering Yangzhou University School of Physics and Optoelectronic Engineering Nanjing University of Information Science and Technology School of Materials Science and Engineering Southeast University Department of Engineering University of Leicester

Using the flow stress curves obtained by Gleeble thermo-mechanical testing, the processing map of extruded magnesium alloy AZ31 was established to analyze the hot workability. Stress exponent and activation energy were calculated to characterize the deformation mechanism. Then, the effects of hot deformation parameters on deformation mechanism, microstructure evolution and hot workability of AZ31 alloy were discussed. With increasing deformation temperature, the operation of non-basal slip systems and full development of dynamic recrystallization （DRX） contribute to effective improvement in hot workability of AZ31 alloy. The influences of strain rate and strain are complex. When temperature exceeds 350 ℃, the deformation mechanism is slightly dependent of the strain rate or strain. The dominant mechanism is dislocation cross-slip, which favors DRX nucleation and grain growth and thus leads to good plasticity. At low temperature （below 350 ℃）, the deformation mechanism is sensitive to strain and strain rate. Both the dominant deformation mechanism and inadequate development of DRX deteriorate the ductility of AZ31 alloy. The flow instability mainly occurs in the vicinity of 250 ℃ and 1 s^-1.

关键词： Hot workability. Deformation mechanism Dynamic recrystallization Activation energy Magnesium alloy

Morphine-3-glucuronide upregulates PD-L1 expression via TLR4 and promotes the immune escape of non-small cell lung cancer

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Cancer Biology & Medicine 2021年第1期18卷 155-171页

作者： Kaiyuan Wang Jian Wang Ting Liu Wenwen Yu nan dong Chen Zhang Wenbin Xia Feng Wei Lili Yang Xiubao ren Department of Anesthesiology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China Department of Immunology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China Department of Cancer Biobank Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China Department of Biotherapy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China

Objective:Patients with cancer pain are highly dependent on morphine analgesia,but studies have shown a negative correlation between morphine demand and patient *** long-term use of morphine may result in abnormally elevated serum morphine-3-glucuronide(M3G)***,the effects of M3G on tumor progression are worth ***:The effects of M3G on PD-L1 expressions in human non-small cell lung cancer(NSCLC)cell lines were first *** of TLR4 downstream pathways after M3G treatment was then determined by Western *** effects of M3G on human cytotoxic T lymphocytes(CTL)cytotoxicity and INF-γrelease was also ***,the LLC murine lung adenocarcinoma cell line were used to establish a murine lung cancer model,and the effects of M3G on tumor growth and metastasis were ***:M3G promoted the expressions of PD-L1 in the A549 and H1299 cell lines in a TLR4-dependent manner(P<0.05).M3G activated the PI3 K and the NFκB signaling pathways,and this effect was antagonized by a TLR4 pathway inhibitor.A PI3 K pathway inhibitor reversed the M3G-mediated PD-L1 upregulation.M3G inhibited the cytotoxicity of CTL on A549 cells and decreased the level of INF-γ.Repeated M3G intraperitoneal injections promoted LLC tumor growth and lung metastasis through the upregulation of tumor expressed PD-L1 and the reduction of CTL in the tumor ***:M3G specifically activated TLR4 in NSCLC cells and upregulated PD-L1 expression through the PI3 K signaling pathway,thereby inhibiting CTL cytotoxicity and finally promoting tumor immune escape.

关键词： Non-small cell lung cancer TLR4 PD-L1 morphine-3-glucuronide immune escape

Menger概率度量空间压缩映象的公共不动点定理

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新疆师范大学学报（自然科学版） 2025年第2期44卷 67-76页

作者：方楠楠安徽新华学院通识教育部安徽合肥230088

在Menger概率度量空间中,研究一种新的压缩条件,在这个条件下得到一个新的弱相容映象对的耦合重合点和公共耦合不动点定理。定理的证明通过以下三步展开:第一步:构造并证明gx_(n)和gy_(n)是柯西序列;第二步:证明(x^(*),y^(*))是弱相容... 详细信息

在Menger概率度量空间中,研究一种新的压缩条件,在这个条件下得到一个新的弱相容映象对的耦合重合点和公共耦合不动点定理。定理的证明通过以下三步展开:第一步:构造并证明gx_(n)和gy_(n)是柯西序列;第二步:证明(x^(*),y^(*))是弱相容映象对g和T的公共耦合重合点;第三步:证明此重合点的唯一性,进而得到了g和T的公共耦合不动点也是唯一的。该定理在一定程度上推广和发展了原有结果。

关键词： Menger概率度量空间耦合重合点公共耦合不动点

Effects of different alloying elements M(M=Fe,Ni,Mn,Si,Mo,Cu,Y)on Cr_(2)0_(3)with Cl:a first-principles study

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Journal of Iron and Steel Research International 2021年第5期28卷 613-620页

作者： Ya-nan Niu nan dong Si Liu Jing Yang Pei-de Han Yu-cheng Wu College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024ShanxiChina Shanxi Engineering Technology Research Center for Energy Materials and Analysis and Testing Taiyuan University of TechnologyTaiyuan 030024ShanxiChina

Using the first-principles methods,the effects of different alloying elements M(M=Fe,Ni,Mn,Si,Mo,Cu,Y)on Cr_(2)0_(3)with Cl adsorption are *** results show that the layer distance of all doped models has been widened to different degrees with Cl *** Mo or Y is doped into the passive film,the difference of layer distance is reduced to a certain *** interaction between alloying elements and Cl is studied by calculating the adsorption height,bond population and electron density *** results show that Mo and Y can inhibit Cl erosion and improve the corrosion resistance of passive ***,we investigate the CrMoFe and CrMoY co-doped system with Cl *** calculations point out that when Mo and Y are doped together in the passive film,the corrosion resistance of the system is more prominent than that of CrMo,CrY and CrMoFe co-doping systems.

关键词： Density functional theory Cr_(2)0_(3) Doping Cl Austenitic stainless steel

Experimental study of viscosity characteristics of hightemperature heat transfer molten salts

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Science China(Technological Sciences) 2011年第11期54卷 3022-3026页

作者： CHEN YongChang WU YuTing ren nan MA ChongFang Key Laboratory of Enhanced Heat Transfer and Energy Conservation Ministry of Education and Key Laboratory of HeatTransfer and Energy Conversion Beijing Education Commission Beijing University of Technology Beijing 100124 China

In this paper several kinds of high temperature molten salts were investigated experimentally on viscosity-temperature characteristics with high-temperature *** viscosities of the molten salts were measured and compared with those from references to verify the reliability of the viscometer and measuring methods,and a good agreement was observed from the ***,two new high-temperature molten salts were made from the HITEC salt by some additives and the viscosity-temperature profiles of them were obtained by *** results show that the new molten salts have much lower viscosities,thus suitable for reducing the flow resistance in transportation system of high-temperature solar thermal power generation.

关键词： high-temperature molten salts viscosity temperature

Novel Terpolymers of Poly(p-dioxanone-co-trimethylene carbonate-co-Lphenylalanine)： Synthesis, Characterization, Thermal Properties and Copolymerization Mechanism

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Chinese Journal of Polymer Science 2016年第5期34卷 594-605页

作者： Li-nan Li Cheng-dong Xiong 陈栋梁 Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China University of Chinese Academy of Sciences Beijing 100049 China

In order to exploit the biological functions of materials, a series of new random terpolymers were synthesized by the ring-opening polymerization of p-dioxanone, trimethylene carbonate, and L-phenylalanine N-carboxyanhydride（L-PheNCA） in the presence of stannous octoate. The terpolymers were characterized by 1H-NMR, 13C-NMR, FTIR, and gel permeation chromatography. The effects of the reactant ratio, catalyst dosage, reaction temperature and time on the copolymerization were investigated, and were found to regulate the composition of the terpolymer. Increases in the reaction temperature, polymerization time, L-Phe-NCA monomer amount, and catalyst content generated a product with a slightly decreased molecular weight. The crystallinity of the terpolymer was investigated by differential scanning calorimetry and polarized optical microscopy. A reasonable mechanism for the polymerization was proposed based on the obtained results.

关键词： polymerization crystallinity calorimetry permeation monomer phenylalanine carbonate slightly dosage biodegradable

激素性股骨头坏死动物模型的造模方式和评价标准

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中国组织工程研究 2025年第21期29卷 4560-4567页

作者：吴秀丽阎晓霞任之强孙楠李金菊河南中医药大学河南省郑州市450000 河南省洛阳正骨医院(河南省骨科医院) 河南省郑州市450000

背景:激素性股骨头坏死是非创伤性股骨头坏死的关键危险因素,近年来发病率逐渐上升,但其具体发病机制尚不清楚,寻找一个合理的动物模型对于疾病研究及治疗至关重要。目的:综述近年来常用的激素性股骨头坏死动物模型,分析不同造模方式和... 详细信息

背景:激素性股骨头坏死是非创伤性股骨头坏死的关键危险因素,近年来发病率逐渐上升,但其具体发病机制尚不清楚,寻找一个合理的动物模型对于疾病研究及治疗至关重要。目的:综述近年来常用的激素性股骨头坏死动物模型,分析不同造模方式和评价标准的优缺点,为后续研究提供参考。方法:以“股骨头坏死,激素性股骨头坏死,动物模型,femoral head necrosis,osteonecrosis of the femoral head,steroid-induced osteonecrosis of the femoral head,animal model”为关键词,在中国知网、万方及Pub Med等数据库中检索2013-2023年发表的文献,根据纳入标准,纳入61篇文献进行综合分析,其中英文文献38篇,中文文献23篇。结果与结论:(1)兔子、大鼠和鸡是目前在激素性股骨头坏死模型研究中应用较多的动物;(2)激素联合脂多糖或马血清建模死亡率低,模型成功率高,稳定性强;(3)组织病理学是评价模型金标准,但需要终止实验,不利于后续实验研究,所以寻找一种无创替代方法仍是未来的努力方向;(4)目前尚未探索出一种理想激素性股骨头坏死动物模型,未来研究者需继续努力早日在该领域实现突破。

关键词：激素性股骨头坏死组织病理学动物模型造模综述

Differences in Contents and Formation Methods of Clinical Questions in Chinese and Korean Clinical Practice Guidelines of Acupuncture-Moxibustion:Scoping Review

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Chinese Journal of Integrative Medicine 2023年第12期29卷 1133-1141页

作者： ZHAO nan-qi LIU Ya-li DING nan YUAN Jing-yun MOU dong-xiao dong Guo-feng WANG Xin WU Xiao-dong Institute of Acupuncture-Moxibustion China Academy of Chinese Medical SciencesBeijing(100700)China Center for Clinical Epidemiology and Evidence-based Medicine Beijing Children's HospitalCapital Medical UniversityBeijing(100045)China College of Acupuncture and Massage Beijing University of Chinese MedicineBeijing(100029)China

Objective:To analyze the differences in the needs of users and the value orientation of clinical practice guidelines(CPGs)by comparing the contents and formation methods of clinical questions in Chinese and Korean CPGs of acupuncture-moxibustion(Acup-Mox).Methods:The full text of CPGs was systematically searched from the official websites of Chinese and Korean traditional medicine societies and Acup-Mox associations,with the topic"Acup-Mox for treating diseases"and the retrieval time up to September 28,*** researchers screened the CPGs independently,and extracted the guidelines'topics,content,quantity and formation methods of clinical *** quantitative data were collected by counting the frequency,and the qualitative data were classified and described by thematic ***:A total of 29 guidelines were included in this study,including 20 Chinese guidelines(305 questions)and 9 Korean guidelines(223 questions).The differences lie in the aspects of content and diversity,and formation *** for content and diversity,Chinese guidelines focused mainly on the questions related to treatment such as the operation of specific intervention(86,28.2%),efficacy of intervention(78,25.6%),and also involving questions in diagnosis,prevention,and *** the clinical questions in Korean guidelines were concentrated to efficacy of intervention(218,97.8%).As for formation method,in Chinese guidelines,questions were usually collected directly from clinicians,and then determined and optimized by *** Korean guidelines,frequently used clinical Acup-Mox interventions would be screened *** the expert group would set up corresponding intervention control measures so as to form clinical questions related to treatment ***:The differences reflect the different needs of clinical practitioners,and the different aims or concepts in developing Acup-Mox guidelines between China and South *** guidelines emphasized promoting oper

关键词： association of acupuncture-moxibustion clinical practice guidelines clinical questions optimize

On Connected Components of Skew Group Algebras

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Acta Mathematica Sinica,English Series 2023年第5期39卷 799-813页

作者： Jian Min CHEN Qiang dong Ya nan LIN School of Mathematical Sciences Xiamen UniversityXiamen 361005P.R.China

Let A be a basic connected finite dimensional associative algebra over an algebraically closed field k and G be a cyclic *** is a quiver QGwith relationsρG such that the skew group algebras A[G]is Morita equivalent to the quotient algebra of path algebra kQGmodulo ideal(ρG).Generally,the quiver QGis not *** this paper we develop a method to determine the number of connect components of ***,we introduce the notion of weight for underlying quiver of A such that A is G-graded and determine the connect components of smash product A#kG*.

关键词： Smash product skew group algebra n-translation algebra path algebra connected component