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Andrographolide sulfonate ameliorates lipopolysaccharide-induced acute lung injury in mice by down-regulating MAPK and NF-κB pathways

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Acta Pharmaceutica Sinica B 2016年第3期6卷 205-211页

作者： Shuang Peng nan Hang Wen Liu Wenjie Guo Chunhong Jiang Xiaoling Yang Qiang Xu Yang Sun State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University Jiangxi Qingfeng Pharmaceutical Co. Ltd. State Key Laboratory of Innovative Nature Medicine and TCM Injections Jiangxi Qingfeng Pharmaceutical Co. Ltd.

Acute lung injury(ALI) or acute respiratory distress syndrome(ARDS) is a severe, lifethreatening medical condition characterized by widespread inflammation in the lungs, and is a significant source of morbidity and mortality in the patient population. New therapies for the treatment of ALI are desperately needed. In the present study, we examined the effect of andrographolide sulfonate, a water-soluble form of andrographolide(trade name: Xi-Yan-Ping Injection), on lipopolysaccharide(LPS)-induced ALI and inflammation. Andrographolide sulfonate was administered by intraperitoneal injection to mice with LPS-induced ALI. LPS-induced airway inflammatory cell recruitment and lung histological alterations were significantly ameliorated by andrographolide sulfonate. Protein levels of pro-inflammatory cytokines in bronchoalveolar lavage fluid(BALF) and serum were reduced by andrographolide sulfonate administration. m RNA levels of pro-inflammatory cytokines in lung tissue were also suppressed. Moreover, andrographolide sulfonate markedly suppressed the activation of mitogen-activated protein kinase(MAPK) as well as p65 subunit of nuclear factor-κB(NF-κB). In summary, these results suggest that andrographolide sulfonate ameliorated LPS-induced ALI in mice by inhibiting NF-κB and MAPK-mediated inflammatory responses. Our study shows that water-soluble andrographolide sulfonate may represent a new therapeutic approach for treating inflammatory lung disorders.

关键词： Andrographolide sulfonate Lipopolysaccharide Lung injury NF-κB MAPK Mouse

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发挥统一战线优势促进非公有制经济发展

中央社会主义学院学报 2007年第1期 32-34页

作者：任映红任江南温州大学民盟江西省委会

在当前,统一战线要在促进非公有制企业发展方面作出重大贡献,必须做到:发挥广泛性优势,加强与新的社会阶层的联系;发挥包容性优势,求同存异,共同发展;发挥智力性优势,为科学决策服务;发挥思想政治工作优势,创造稳定的政治社会环境;发挥... 详细信息

在当前,统一战线要在促进非公有制企业发展方面作出重大贡献,必须做到:发挥广泛性优势,加强与新的社会阶层的联系;发挥包容性优势,求同存异,共同发展;发挥智力性优势,为科学决策服务;发挥思想政治工作优势,创造稳定的政治社会环境;发挥民间性优势,加强非公企业与政府的沟通与联系。

关键词：统一战线优势非公有制经济发展

Basilar artery occlusion successfully treated with delayed intravascular intervention and mild hypothermia

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Chinese Medical Journal 2019年第6期132卷 723-725页

作者： dong-Mei Wang Zhen-Zhou Lin Sheng-nan Wang Yong-Ming Wu Yue Pan Su-Yue Pan Zhong Ji Department of Neurology Nanfang Hospital Southern Medical University Guangzhou Guangdong 510515 China

To the Editor: Acute basilar artery occlusion (BAO) is a catastrophic variant of stroke, which accounts for about 1% of all strokes.[1] Though rare, BAOs are associated with high morbidity and mortality rates.[2] Although treatable, the rate of death or disability associated with BAO is still as high as 80%.[2] Early recanalization either with thrombolysis or intravascular thrombectomy was shown to significantly improve the outcome of patients with BAO.

关键词： Basilar artery occlusion successfully treated delayed intravascular intervention mild hypothermia

Learning Local Contrast for Crisp Edge Detection

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Journal of Computer Science & Technology 2023年第3期38卷 554-566页

作者：方晓楠张松海 Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China

In recent years, the accuracy of edge detection on several benchmarks has been significantly improved by deep learning based methods. However, the prediction of deep neural networks is usually blurry and needs further post-processing including non-maximum suppression and morphological thinning. In this paper, we demonstrate that the blurry effect arises from the binary cross-entropy loss, and crisp edges could be obtained directly from deep convolutional neural networks. We propose to learn edge maps as the representation of local contrast with a novel local contrast loss. The local contrast is optimized in a stochastic way to focus on specific edge directions. Experiments show that the edge detection network trained with local contrast loss achieves a high accuracy comparable to previous methods and dramatically improves the crispness. We also present several applications of the crisp edges, including image completion, image retrieval, sketch generation, and video stylization.

关键词： edge detection image processing neural network local contrast

混合菌群降解纤维素产氢特性及群落演替规律研究

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粮食与油脂 2025年第2期38卷 120-126,132页

作者：张靖楠周涵钰王耀祖李甜甜徐清萍魏涛郑州轻工业大学食品与生物工程学院河南郑州450001

采用微晶纤维素作为限制性底物对混合菌群进行驯化,考察在中温发酵条件下混合菌群降解纤维素产氢特性,并采用变性梯度凝胶电泳(DGGE)和Illumina MiSeq高通量测序技术探究产氢菌群在富集驯化过程中的演替规律及种群互作规律。结果表明:经... 详细信息

采用微晶纤维素作为限制性底物对混合菌群进行驯化,考察在中温发酵条件下混合菌群降解纤维素产氢特性,并采用变性梯度凝胶电泳(DGGE)和Illumina MiSeq高通量测序技术探究产氢菌群在富集驯化过程中的演替规律及种群互作规律。结果表明:经过30轮驯化培养获得了具有较强纤维素降解产氢能力的菌群,在35℃下发酵78 h时,利用微晶纤维素产氢的最大累积产氢量和产氢速率分别为264.1 mL/g、10.1 mL/(g·h),纤维素降解率达到86.7%。随着驯化过程的进行,微生物的种群数量和多样性呈明显的演替规律,能够利用微晶纤维素生长的种群活性明显增强,成为优势物种,不能够利用微晶纤维素生长的种群丰度和多样性逐渐降低并趋于稳定;在门水平上,厚壁菌门(Firmicutes),变形菌门(Proteobacteria)和拟杆菌门(Bacteroidetes)为优势菌门;在属水平上,厌氧细杆菌属(Anaerofilum)的丰度逐渐下降,梭状芽孢杆菌属(Clostridium)和假单胞菌属(Pseudomonas)的丰度逐渐升高,并成为驯化末期的优势菌;纤维素降解菌、发酵产氢菌和纤维素降解产氢菌是体系中的主要功能菌群,菌群之间形成的互养关系是实现纤维素降解产氢的主要途径。

关键词：混合菌群驯化纤维素降解微生物群落

电针预处理对心肌缺血再灌注损伤大鼠“内关”穴区Toll样受体4、髓样分化因子88及核转录因子-κB基因表达的影响

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针刺研究 2018年第5期43卷 302-306,329页

作者：朱怡李毅张楠东贵荣上海中医药大学附属岳阳中西医结合医院针灸科上海200437

目的:观察电针预处理对心肌缺血再灌注损伤(MIRI)大鼠"内关"穴区Toll样受体4(TLR 4)、髓样分化因子88(MyD 88)以及核转录因子-κB(NF-κB)mRNA表达的影响,探讨"内关"抗心肌缺血再灌注的作用与TLR 4/MyD 88/NF-κB信号通路的关系。方法:W... 详细信息

目的:观察电针预处理对心肌缺血再灌注损伤(MIRI)大鼠"内关"穴区Toll样受体4(TLR 4)、髓样分化因子88(MyD 88)以及核转录因子-κB(NF-κB)mRNA表达的影响,探讨"内关"抗心肌缺血再灌注的作用与TLR 4/MyD 88/NF-κB信号通路的关系。方法:Wistar大鼠随机分成正常组、正常电针组、假手术组、模型组、电针组和假电针组,每组8只。采用左冠状动脉前降支结扎法制备MIRI大鼠模型,造模前5d开始电针预处理,电针组、正常电针组、假电针组针刺"内关"穴,并给予相应的电针干预,每次30min,每日1次,连续5d。Real-time PCR法检测大鼠"内关"穴区TLR 4、MyD 88和NF-κB mRNA表达水平。结果:与正常组比较,模型组心电图(ECG)-J点显著升高(P<0.01),电针组与模型组和假电针组相比,ECG-J点高度降低(P<0.01)。与正常组相比,模型组大鼠"内关"穴区TLR 4、MyD 88和NF-κB mRNA表达水平显著升高(P<0.01);电针组与模型组、假电针组相比,"内关"穴区TLR 4、MyD 88和NF-κB mRNA的表达水平降低(P<0.05)。结论:电针预处理能降低MIRI大鼠"内关"穴区TLR 4、MyD 88和NF-κB mRNA的表达水平,因此针刺信号的启动-传递-放大可能与TLR 4/MyD 88/NF-κB信号通路有关。

关键词：电针心肌缺血再灌注损伤 “内关”穴区 Toll样受体4/髓样分化因子88/核转录因子-κB信号通路

血清TGF-β、CCL20、IFN-γ对胃癌前病变与胃癌的联合鉴别诊断价值及与病情进展的关系

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海南医学 2025年第3期36卷 311-316页

作者：邓亚男谢媛媛李文君倪猛南阳市中心医院消化内科一病区河南南阳473000 南阳市中心医院科研科河南南阳473000

目的探讨血清转化生长因子-β(TGF-β)、CC趋化因子配体20(CCL20)、干扰素γ(IFN-γ)对胃癌前病变与胃癌的联合鉴别诊断价值及与病情进展的关系。方法选取2020年8月至2023年1月南阳市中心医院收治的103例胃癌患者作为癌变组,103例胃癌... 详细信息

目的探讨血清转化生长因子-β(TGF-β)、CC趋化因子配体20(CCL20)、干扰素γ(IFN-γ)对胃癌前病变与胃癌的联合鉴别诊断价值及与病情进展的关系。方法选取2020年8月至2023年1月南阳市中心医院收治的103例胃癌患者作为癌变组,103例胃癌前病变患者作为癌前病变组,比较两组患者的血清TGF-β、CCL20、IFN-γ水平,采用受试者工作特征(ROC)曲线分析血清TGF-β、CCL20、IFN-γ对胃癌前病变与胃癌的诊断价值,采用相对危险度分析血清TGF-β、CCL20、IFN-γ与胃癌发生风险的关系,并比较癌变组不同病理特征患者的血清TGF-β、CCL20、IFN-γ水平,采用Spearman相关系数分析血清TGF-β、CCL20、IFN-γ与胃癌病理特征的相关性。结果癌变组患者的血清TGF-β、CCL20水平分别为(40.78±6.44)pg/mL、(44.53±9.18)pg/mL,明显高于癌前病变组的(31.19±4.81)pg/mL、(33.76±6.47)pg/mL,IFN-γ水平为(31.47±10.03)μg/L,明显低于癌前病变组的(50.68±16.22)μg/L,差异均有统计学意义(P<0.05);ROC曲线分析结果显示,血清TGF-β、CCL20、IFN-γ诊断胃癌前病变与胃癌的AUC为0.796、0.806、0.810,联合诊断的AUC为0.905,敏感度为84.47%,特异度为83.50%,明显优于各指标单独诊断(P<0.05);相对危险度分析结果显示,血清TGF-β、CCL20β高表达患者的胃癌发生风险分别是低表达患者的2.758倍、3.101倍,IFN-γ低表达患者胃癌发生风险是高表达患者的2.668倍,差异均有统计学意义(P<0.05);临床分期Ⅲ~Ⅳ期患者血清TGF-β、CCL20水平明显高于Ⅰ~Ⅱ期患者,IFN-γ水平明显低于Ⅰ~Ⅱ期患者,差异均有统计学意义(P<0.05);有淋巴结转移患者血清TGF-β、CCL20水平高于无淋巴结转移患者,IFN-γ水平明显低于无淋巴结转移患者,差异均有统计学意义(P<0.05);低分化患者血清TGF-β、CCL20水平明显高于中高分化患者,IFN-γ水平明显低于中高分化患者,差异均有统计学意义(P<0.05);Spearman相关性分析结果显示,血清TGF-β、CCL20与胃癌临床分期、淋巴结转移呈正相关(P<0.05),与分化程度呈负相关(P<0.05),IFN-γ与胃癌临床分期、淋巴结转移呈负相关(P<0.05),与分化程度呈正相关(P<0.05)。结论血清TGF-β、CCL20、IFN-γ可作为胃癌前病变与胃癌的辅助诊断指标,联合诊断价值较好,且均与胃癌病理进展密切相关,能为临床诊治提供相关信息。

关键词：胃癌胃癌前病变转化生长因子-β CC趋化因子配体20 干扰素γ 诊断价值病理特征

Community Dynamics of Seed Rain in Mixed Evergreen Broad-leaved and Deciduous Forests in a Subtropical Mountain of Central China

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Journal of Integrative Plant Biology 2007年第9期49卷 1294-1303页

作者： Ze-Hao Shen Yuan-Yuan Tang nan Lü Jun Zhao Dao-Xing Li Gong-Fang Wang Department of Ecology College of Environmental Sciences the Key Laboratory for Earth Surface Processes of the Ministry of Education Peking University Beijing 100871 China National Dalaoling Forest Park Yichang 435000 China

Seed dispersal is a key process within community dynamics. The spatial and temporal variations of seed dispersal and the interspecific differences are crucial for understanding species coexistence and community dynamics. This might also hold for the mixed evergreen broadleaved and deciduous forests in the mountains of subtropical China, but until now little existing knowledge is available for this question. In 2001, we chose to monitor the seed rain process of our mixed evergreen broad-leaved and deciduous forest communities in Mount Dalaoling National Forest Park, Yichang, Hubei Province, China. The preliminary analyses show obvious variations in seed rain density, species compositions and timing of seed rain among four communities. The average seed rain densities of the four communities are 2.43 ± 5.15, 54.13 ±182.75, 10.05 ±19.30 and 24.91 ± 58.86 inds/m^2, respectively; about one tenth the values in other studies in subtropical forests of China. in each community, the seed production is dominated by a limited number of species, and the contributions from the others are generally minor. Fecundity of evergreen broadleaved tree species is weaker than deciduous species. The seed rain of four communities begins earlier than September, and stops before December, peaking from early September to late October. The beginning date, ending date and peak times of seed rain are extensively varied among the species, indicating different types of dispersal strategies. According to the existing data, the timing of seed rain is not determined by the climate conditions in the same period, while the density of seed rain may be affected by the disturbances of weather variations at a finer temporal resolution.

关键词： interspecific difference Mount Dalaoling mountain mixed evergreen broad-leaved and deciduous forests seed rain species composition weather effect.

The Spin Measurement of MAXI J0637-430:a Black Hole Candidate with High Disk Density

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Research in Astronomy and Astrophysics 2023年第7期23卷 277-287页

作者： nan Jia Ye Feng Yu-Jia Song Jun Yang Jieun Yuh Pei-Jun Huang Li-Jun Gou Key Laboratory for Computational Astrophysics National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China Shanghai American School Puxi Campus Shanghai 201107China Shenzhen Yaohua Experimental School Shenzhen 518034China

The Galactic black hole candidate MAXI J0637-430 was first discovered by MAXI/GSC on 2019 November *** study the spectral properties of MAXI J0637-430 by using the archived NuSTAR data and Swift/XRT *** fitting the eight spectra by using a disk component and a powerlaw component model with absorption,we select the spectra with relatively strong reflection components for detailed X-ray reflection *** the most state-of-art reflection model,relxillCp,the spectral fitting measures a black hole spin a_(*)>0.72 and the inclination angle of the accretion disk i=46.1_(-5.3)^(+4.0)degrees,at a 90%confidence *** addition,the fitting results show an extreme supersolar iron *** with the fitting results of reflection model reflionx_hd,we consider that this unphysical iron abundance may be caused by a very high-density accretion disk(n_(e)>2.34×10^(21)cm^(-3))or a strong Fe K_(α) emission *** soft excess is found in the soft state spectral fitting results,which may be an extra free-free heating effect caused by high density of the accretion ***,we discuss the robustness of black hole spin obtained by X-ray reflection *** result of relatively high spin is self-consistent with broadened Fe K_(α) *** abundance and disk density have no effect on the spin results.

关键词： black hole physics X-rays:binaries accretion accretion disks