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Insights into the history and tendency of glycosylation and digestive system tumor:A bibliometric-based visual analysis

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1059-1075页

作者： Jie Jiang Zai Luo ren-chao zhang Yue-Ling Wang Jun zhang Ming-Yu Duan Zheng-Jun Qiu Chen Huang Department of Gastrointestinal Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Jiangnan University Wuxi School of Medicine Wuxi 214122Jiangsu ProvinceChina Department of Education Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

BACKGROUND Glycosylation,a commonly occurring post-translational modification,is highly expressed in several tumors,specifically in those of the digestive system,and plays a role in various cellular pathophysiological mechanisms.Although the importance and detection methods of glycosylation in digestive system tumors have garnered increasing attention in recent years,bibliometric analysis of this field remains scarce.The present study aims to identify the developmental trends and research hotspots of glycosylation in digestive system tumors.AIM To find and identify the developmental trends and research hotspots of glycosylation in digestive system tumors.METHODS We obtained relevant literature from the Web of Science Core Collection and employed VOSviewer 1.6.19 and CiteSpace(version 6.1.R6)to perform bibliometric analysis.RESULTS A total of 2042 documents spanning from 1978 to the present were analyzed,with the research process divided into three phases:the period of obscurity(1978-1990),continuous development period(1991-2006),and the rapid outbreak period(2007-2023).These documents were authored by researchers from 66 countries or regions,with the United States and China leading in terms of publication output.Reis Celso A had the highest number of publications,while Pinho SS was the most cited author.Co-occurrence analysis revealed the most popular keywords in this field are glycosylation,expression,cancer,colorectal cancer,and pancreatic cancer.Furthermore,the Journal of Proteome Research was the most prolific journal in terms of publications,while the Journal of Biological Chemistry had the most citations.CONCLUSION The bibliometric analysis shows current research focus is primarily on basic research in this field.However,future research should aim to utilize glycosylation as a target for treating tumor patients.

关键词： Glycosylation Cancer Digestive system Bibliometric analysis CiteSpace VOS viewer

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Systematic review and meta-analysis of laparoscopy-assisted and open total gastrectomy for gastric cancer

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World Journal of Gastroenterology 2013年第32期19卷 5365-5376页

作者： Ke Chen Xiao-Wu Xu ren-chao zhang Yu Pan Di Wu Yi-Ping Mou Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang University

AIM:To evaluate the safety and efficacy of laparoscopy-assisted total gastrectomy(LATG)and open total gastrectomy(OTG)for gastric cancer.METHODS:A comprehensive search of PubMed,Cochrane Library,Web of Science and BIOSIS Previews was performed to identify studies that compared LATG and OTG.The following factors were checked:operating time,blood loss,harvested lymph nodes,flatus time,hospital stay,mortality and morbidity.Data synthesis and statistical analysis were carried out using RevMan 5.1 software.RESULTS:Nine studies with 1221 participants were included(436 LATG and 785 OTG).Compared to OTG,LATG involved a longer operating time[weighted mean difference(WMD)=57.68 min,95%CI:30.48-84.88;Prence(SMD)=-1.71;95%CI:-2.48--0.49;Prence rate and long-term survival rate of patients undergoing LATG were similar to those in patients undergoing OTG.CONCLUSION:Despite a longer operation,LATG can be performed safely in experienced surgical centers with a shorter hospital stay and fewer complications than open surgery.

关键词： Laparoscopy Total gastrectomy Gastric cancer Complications Meta-analysis

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Laparoscopic vs open distal pancreatectomy for solid pseudopapillary tumor of the pancreas

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World Journal of Gastroenterology 2013年第37期19卷 6272-6277页

作者： ren-chao zhang Jia-Fei Yan Xiao-Wu Xu Ke Chen Harsha Ajoodhea Yi-Ping Mou Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang University

AIM:To compare short-and long-term outcomes of laparoscopic vs open distal pancreatectomy for solid pseudopapillary tumor(SPT)of the pancreas.METHODS:This retrospective study included 28 patients who underwent distal pancreatectomy for SPT of the pancreas between 1998 and 2012.The patients were divided into two groups based on the surgical approach:the laparoscopic surgery group and the open surgery group.The patients’demographic data,operative results,pathological reports,hospital courses,morbidity and mortality,and follow-up data were compared between the two groups.RESULTS:Fifteen patients with SPT of the pancreas underwent laparoscopic distal pancreatectomy(LDP),and 13 underwent open distal pancreatectomy(ODP).Baseline characteristics were similar between the two groups except for a female predominance in the LDP group(100.0%vs 69.2%,P=0.035).Mortality,morbidity(33.3%vs 38.5%,P=1.000),pancreatic fistula rates(26.7%vs 30.8%,P=0.728),and reoperation rates(0.0%vs 7.7%,P=0.464)were similar in the two groups.There were no significant differences in the operating time(171 min vs 178 min,P=0.755)between the two groups.The intraoperative blood loss(149 mL vs 580 mL,P=0.002),transfusion requirement(6.7%vs 46.2%,P=0.029),first flatus time(1.9d vs 3.5 d,P=0.000),diet start time(2.3 d vs 4.9 d,P=0.000),and postoperative hospital stay(8.1 d vs 12.8d,P=0.029)were significantly less in the LDP group than in the ODP group.All patients had negative surgical margins at final pathology.There were no significant differences in number of lymph nodes harvested(4.6 vs6.4,P=0.549)between the two groups.The median follow-up was 33(3-100)mo for the LDP group and 45(17-127)mo for the ODP group.All patients were alive with one recurrence.CONCLUSION:LDP for SPT has short-term benefits compared with ODP.Long-term outcomes of LDP are similar to those of ODP.

关键词： Solid pseudopapillary tumor Pancreatic tumor Laparoscopic surgery Distal pancreatectomy

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Laparoscopic spleen-preserving distal pancreatectomy for pancreatic neoplasms:A retrospective study

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World Journal of Gastroenterology 2014年第38期20卷 13966-13972页

作者： Jia-Fei Yan Xiao-Wu Xu Wei-Wei Jin chao-Jie Huang Ke Chen ren-chao zhang Ajoodhea Harsha Yi-Ping Mou Department of General Surgery Sir Run Run Shaw HospitalInstitute of Micro-invasive SurgeryZhejiang University School of Medicine

AIM:To describe the clinical characteristics,technical procedures,and outcomes of patients undergoing laparoscopic spleen-preserving distal pancreatectomy(LSPDP)for benign and malignant pancreatic neoplasms.METHODS:The clinical data of 38 patients who underwent LSPDP in the Sir Run Run Shaw Hospital between January 2003 and August 2013 were analyzed retrospectively.Surgical techniques for LSPDP included preservation of the splenic artery and vein(Kimura’s technique)and ligation of the splenic pedicle with preservation of the short gastric vessels(Warshaw’s technique).RESULTS:There were no conversions to open surgery in the 38 patients.Splenic vessels were conserved during spleen-preserving pancreatectomy,except in two patients who underwent resection of the splenic vessels and preservation only of the short gastric vessels.The mean operation time was 123.2±52.4 min,the mean intraoperative blood loss was 78.2±39.5 mL,and the mean postoperative hospital stay was 7.6±2.9 d.The overall rate of postoperative complications was 18.4%(7/38),and the rate of clinical pancreatic fistula was13.2%(5/38).All postoperative complications were treated conservatively.The postoperative pathological diagnoses were 22 cases of benign pancreatic disease and 16 cases of borderline or low-grade malignant lesions.During a median follow-up of 38 mo(range:5-133mo),no recurrence was observed.CONCLUSION:LSPDP is a safe,feasible and effective procedure for the treatment of benign and low-grade malignant tumors of the distal pancreas.

关键词： Laparoscopic surgery Splenic preservation Distal p

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Laparoscopic ligation of proximal splenic artery aneurysm with splenic function preservation

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World Journal of Gastroenterology 2014年第16期20卷 4835-4838页

作者： Yun-Hai Wei Jie-Wei Xu Hua-Ping Shen Guo-Lei zhang Harsha Ajoodhea ren-chao zhang Yi-Ping Mou Department of General Surgery the Central Hospital of Huzhou Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang University

Splenic artery aneurysm is one of the most common visceral aneurysms,and patients with this type of aneurysm often present without symptoms.However,when rupture occurs,it can be a catastrophic event.Although most of these aneurysms can be treated with percutaneous embolization,some located in uncommon parts of the splenic artery may make this approach impossible.We present a patient with an aneurysm in the proximal splenic artery,close to the celiac trunk,which was treated by laparoscopic ligation only,without resection of the aneurysm,and with long-term preservation of splenic function.

关键词： Laparoscopy Splenic artery AneurysmLaparoscopic li

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Laparoscopic transduodenal local resection of periampullary neuroendocrine tumor: A case report

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World Journal of Gastroenterology 2013年第39期19卷 6693-6698页

作者： ren-chao zhang Xiao-Wu Xu Di Wu Yu-Cheng Zhou Harsha Ajoodhea Ke Chen Yi-Ping Mou Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang University

Studies on laparoscopic transduodenal local resection have not been readily available.Only three cases have been reported in the English-language literature.We describe herein a case of 25-year-old woman with periampullary neuroendocrine tumor(NET).Endoscopic ultrasonography revealed a duodenal papilla mass originated from the submucosa and close to the ampulla.The periampullary tumor was successfully managed with laparoscopic transduodenal local resection without any procedure-related complications.Pathological examination showed a NET(Grade 2)with negative margin.The patient was followed up for six months without signs of recurrence.This case suggests that laparoscopic transduodenal local resection is a feasible procedure in selected patients with periampullary tumor.

关键词： Laparoscopic surgery Transduodenal local resection Neuroendocrine tumor Periampullary tumor

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Wireless semantic communication based on semantic matching multiple access and intent bias multiplexing

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The Journal of China Universities of Posts and Telecommunications 2024年第1期31卷 26-36页

作者： ren chao He Zongrui Sun Chen Li Haojin zhang Haijun University of Science and Technology Beijing Beijing 100083China Research and Development Center Sony(China)LimitedBeijing 100027China

This paper proposes a multi-access and multi-user semantic communication scheme based on semantic matching and intent deviation to address the increasing demand for wireless users and data.The scheme enables flexible management of long frames,allowing each unit of bandwidth to support a higher number of users.By leveraging semantic classification,different users can independently access the network through the transmission of long concatenated sequences without modifying the existing wireless communication architecture.To overcome the potential disadvantage of incomplete semantic database matching leading to semantic intent misunderstanding,the scheme proposes using intent deviation as an advantage.This allows different receivers to interpret the same semantic information differently,enabling multiplexing where one piece of information can serve multiple users with distinct purposes.Simulation results show that at a bit error rate(BER)of 0.1,it is possible to reduce the transmission by approximately 20 semantic basic units.

关键词： semantic communication multiple access multiplexing multimodal communication

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Fever as a first manifestation of advanced gastric adenosquamous carcinoma:A case report

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World Journal of Gastroenterology 2014年第29期20卷 10193-10201页

作者： Harsha Ajoodhea ren-chao zhang Xiao-Wu Xu Wei-Wei Jin Ke Chen Yong-Tao He Yi-Ping Mou Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang University Department of Pathology Sir Run Run Shaw HospitalSchool of MedicineZhejiang University

Gastric adenosquamous carcinoma(ASC)is a rare type of gastric cancer.It is a mixed neoplasm,consisting of glandular cells and squamous cells.It is often diagnosed at an advanced stage,thus carrying a poor prognosis.We describe a case of a 73-year-old male,who presented with refractory fever and an intra-abdominal mass on imaging.He underwent a laparoscopic exploration followed by a successful totally laparoscopic total gastrectomy with D2 lymphadenectomy for gastric cancer.Postoperative pathology revealed primary gastric ASC(T4aN0M0).The patient received adjuvant radiotherapy and chemotherapy with S1 and is alive 20mo after surgery without recurrence.This is the first case of advanced gastric ASC with fever as the initial presentation treated with totally laparoscopic total gastrectomy reported in the English literature.

关键词： Gastric adenosquamous carcinoma Advanced gastric c

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腹腔镜与开腹胰体尾切除术双中心对照研究（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第7期16卷 573-579页

作者： Jia-fei YAN Tian-tao KUANG Da-yong JI Xiao-wu XU Dan-song WANG ren-chao zhang Wei-wei JIN Yi-ping MOU Wen-hui LOU Department of General Surgery Institute of Micro-Invasive Surgery Sir Run Run Shaw HospitalSchool of Medicine Zhejiang University Department of General Surgery Zhongshan Hospital Shanghai Medical College Fudan University

目的:评估腹腔镜胰体尾切除术安全有效性,对比腹腔镜胰体尾切除术与开腹胰体尾切除术治疗胰腺体尾部良性或低度恶性病变临床疗效。创新点:本研究为回顾性对照研究,相较于过往腹腔镜胰体尾切除术与开腹胰体尾切除术的对照研究,其创新点... 详细信息

目的:评估腹腔镜胰体尾切除术安全有效性,对比腹腔镜胰体尾切除术与开腹胰体尾切除术治疗胰腺体尾部良性或低度恶性病变临床疗效。创新点:本研究为回顾性对照研究,相较于过往腹腔镜胰体尾切除术与开腹胰体尾切除术的对照研究,其创新点一为本组91例病例均为良性或低度恶性病例,剔除了恶性病变病例;二为本研究中腹腔镜胰体尾切除术组及开腹胰体尾切除术组分别由两家大型综合医院胰腺疾病诊治中心的两组医生分别施行手术,这样避免了病人及手术方式选择等造成的影响,结果更为客观。方法:回顾分析自2010年1月至2012年12月浙江大学医学院附属邵逸夫医院45例施行腹腔镜胰体尾切除术治疗胰腺体尾部良性或低度恶性病变病例(LDP组),以及同期上海复旦大学附属中山医院46例施行开腹胰体尾切除术胰腺体尾部良性或低度恶性病变病例(ODP组)的相关临床资料,进行对照研究。结论:本研究包括胰腺体尾部良性或低度恶性病例91例,其中LDP组45例(无中转开腹)和ODP组46例。手术时间分别为(158.7±38.3)min(LDP组)和(92.2±24.1)min(ODP组);术中出血LDP组明显少于ODP组((122.6±61.1)ml vs.(203.1±84.8)ml,P<0.001)。两组保脾率相似(53.3%vs.47.8%,P=0.35),其中LDP组中保脾病例均保留脾血管。在术后恢复指标方面,LDP组优于ODP组,恢复进食流质时间((1.6±0.5)d vs.(3.2±0.7)d,P<0.01)及恢复活动时间((1.8±0.4)d vs.(2.1±0.6)d,P=0.02)较短,且LDP组术后住院时间也少于ODP组((7.9±3.8)d vs.(11.9±5.8)d,P=0.006)。术后胰瘘率两组无明显差异(15.6%vs.19.6%,P=0.62),但术中总并发症率LDP组低于ODP组(26.7%vs.47.8%,P=0.04)。研究结果显示腹腔镜胰体尾切除术治疗胰腺体尾部良性或低度恶性肿瘤安全可行,与开腹胰体尾切除术术相比术中出血更少、术后恢复更快,具有明显微创优势。

关键词：胰腺肿瘤腹腔镜胰体尾切除术

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Identifying coronary artery bypass grafting patients at high risk for adverse long-term prognosis using serial health-related quality of life assessments

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中华医学杂志(英文版) 2024年第9期137卷 1069-1077页

作者： Wang Juncheng Liu Hanning Yue chao Yang Limeng Yang Kai Zhao Yan ren Huan zhang Ying Zheng Zhe National Clinical Research Center for Cardiovascular Diseases State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Cardiovascular Surgery Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Vascular Surgery Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Cardiac Surgery Wuhan Asia Heart Hospital Wuhan Hubei China

Background: Patients who undergo coronary artery bypass grafting (CABG) are known to be at a significant risk of experiencing long-term adverse events, emphasizing the importance of regular assessments. Evaluating health-related quality of life (HRQoL) serves as a direct method to gauge prognosis. Our objective is to ascertain the prognostic significance of consecutive HRQoL assessments using the Physical Component Summary (PCS) and Mental Component Summary (MCS) derived from the Short-Form 36 (SF-36) health survey in CABG patients.Methods: The study population consisted of 433 patients who underwent isolated elective CABG at Fuwai Hospital between 2012 and 2013. SF-36 assessments were conducted during both the hospitalization period and follow-up. The primary endpoint of the study was all-cause mortality, while the secondary outcome was a composite measure including death, myocardial infarction, stroke, and repeat revascularization. We assessed the relationships between the PCS and MCS at baseline, as well as their changes during the first 6 months after the surgery (referred to as ΔPCS and ΔMCS, respectively), and the observed outcomes.Results: The patients were followed for an average of 6.28 years, during which 35 individuals (35/433, 8.1%) died. After adjusting for clinical variables, it was observed that baseline MCS scores (hazard ratio [HR] for a 1-standard deviation [SD] decrease, 1.57; 95% confidence interval [CI], 1.07–2.30) and ΔMCS (HR for a 1-SD decrease, 1.67; 95% CI, 1.09–2.56) were associated with all-cause mortality. However, baseline PCS scores and ΔPCS did not exhibit a significant relationship with all-cause mortality. Notably, there was a dose-response relationship observed between ΔMCS and the likelihood of all-cause mortality (HRs for the 2nd, 3rd and 4th quartiles compared to the 1st quartile, 0.33, 0.45 and 0.11, respectively).Conclusions: Baseline MCS and changes in MCS were independent predictors for long-term mortality of CABG. Better mental health status and recovery indicated better

关键词： Coronary artery bypass grafting Coronary artery disease Prognosis Quality of life Short-Form 36 Risk factor Serial measurements

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