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Rare Metals 2023年第3期42卷 1043-1049页

作者： Yan-Wei Sui ren sun Ji-Qiu Qi Ye-Zeng He Fu-Xiang Wei Qing-Kun Meng Zhi sun School of Material Science and Engineering China University of Mining and TechnologyXuzhou 221116China

This study investigated the morphologies of the intermetallic compounds(IMC)formed during soldering reaction between Sn_(1.0)Ag_(0.7)Cu-1.0SnO_(2) composite solder and Cu substrate at various temperatures.The prismtype Cu_(6)Sn_(5) forms when the soldering temperature is 260or 2800C,while those grains transform from prism type to scallop type at the temperatures of 300 and 320℃.It can be found that the morphologies of Cu6Sn5 grains affect adsorption of Ag_(3)Sn nanoparticles during soldering reaction.The scallop-type grains with a higher growth rate need to adsorb large amounts of Ag_(3)Sn particles.In terms of mechanical behavior,the shear strength of solder joint is improved from 40 to 46 MPa at soldering temperature of 300℃.In addition,the thickness of IMC increases with the extension of aging time.During aging,the morphology of Cu6Sn5 grains remains scallop type,but the number of Ag_(3)Sn nanoparticles is reduced largely.The scallop-type Cu^(6)Sn_(5) can increase in size and flatten in morphology with the aging time increasing.

关键词： Composite solder CugSns Ag_(3)Sn Adsorption

Role of interstitial flow in tumor migration through 3D ECM

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Acta Mechanica Sinica 2020年第3期36卷 768-774页

作者： Ang Li ren sun MOE Key Laboratory of Hydrodynamics School of Naval ArchitectureOcean&Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Cancer invasion in tissue is simultaneously regulated by chemical and mechanical cues.Evidences suggest that interstitial flow plays a critical role in tumor metastasis.On one hand,the distribution of chemokines around cell is influenced by flow.On the other hand,interstitial flow may reconfigure the alignment of fiber matrix,which greatly changes the contact force between cell and extracellular matrix.In this study,we have upgraded a model by which we can quantitatively investigate the influence of flow on tumor cell migration.A hydrodynamic analysis of shear stress on a slender body is introduced to simulate the fiber realignment.Factors such as subtle flow and cell-matrix interaction which dominate tumor migration are integrated in this novel model.Simulation results show interstitial flow facilitates tumor cell migration in the flow direction.Moreover,the flow-related chemical and mechanical cues have a synergistic effect on the migration.This model provides better understanding on cancer metastasis and helps design vitro experiment precisely.

关键词： Interstitial flow Tumor cell migration Extracellular matrix

电化学合成2,5-二甲氧基-2,5-二氢呋喃甲醇工艺研究

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应用化工 2024年第1期53卷 118-121页

作者：孙任伟马养民陕西科技大学化学与化工学院、中国轻工业轻化助剂重点实验室陕西西安710021

以糠醇为原料,NaBr为电解质,甲醇为溶剂,利用电化学法合成焦袂康酸中间体2,5-二甲氧基-2,5-二氢呋喃甲醇,考察反应时间、NaBr添加量、反应温度对产率的影响。结果表明,反应时间与反应温度对产率有显著影响,NaBr添加量对产率影响不显著... 详细信息

以糠醇为原料,NaBr为电解质,甲醇为溶剂,利用电化学法合成焦袂康酸中间体2,5-二甲氧基-2,5-二氢呋喃甲醇,考察反应时间、NaBr添加量、反应温度对产率的影响。结果表明,反应时间与反应温度对产率有显著影响,NaBr添加量对产率影响不显著。当加入糠醇3 g(24 mmol),恒压15 V,最优条件为反应时间2.4 h,NaBr添加量为1.76 g,反应温度-10℃时,平均电流0.93 A,2,5-二甲氧基-2,5-二氢呋喃甲醇产率为67.9%。

关键词：糠醇 2,5-二甲氧基-2,5-二氢呋喃甲醇焦袂康酸 Box-Behnken

邻苯二甲酸二(2-乙基己基)酯对睾丸的毒性作用及机制

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生物化学与生物物理进展 2024年第3期51卷 555-563页

作者：冯安妮孙任任肖玉波曾昭明莫中成谢远杰桂林医学院基础医学院组织学与胚胎学教研室桂林541199 湖南医药学院公共卫生与检验医学院怀化418000 桂林医学院-明舜制药慢性病防治研究联合实验室邵东422800

邻苯二甲酸二(2-乙基己基)酯(DEHP)是目前使用最广泛的增塑剂之一,DEHP具有毒性,长期暴露会对机体的多个系统产生损害,特别是对雄性生殖系统的毒性作用更为明显。DEHP通过诱导氧化应激、调控细胞自噬,促进生精细胞和睾丸间质细胞凋亡、... 详细信息

邻苯二甲酸二(2-乙基己基)酯(DEHP)是目前使用最广泛的增塑剂之一,DEHP具有毒性,长期暴露会对机体的多个系统产生损害,特别是对雄性生殖系统的毒性作用更为明显。DEHP通过诱导氧化应激、调控细胞自噬,促进生精细胞和睾丸间质细胞凋亡、抑制睾酮合成、破坏血-睾屏障、诱导睾丸支持细胞铁死亡以及影响子代雄性的表观遗传等,造成生殖器官的病理损伤。本文就DEHP对睾丸的毒性作用及机制进行综述,拟为男性生殖障碍的防治研究提供新思路。

关键词：邻苯二甲酸二(2-乙基己基) 酯睾丸生殖毒性氧化应激铁死亡

Spontaneous and continuous anti-virus disinfection from nonstoichiometric perovskite-type lanthanum manganese oxide

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Progress in Natural Science:Materials International 2015年第3期25卷 191-196页

作者： Ding Weng Chao Lei Ting-Ting Wu ren sun Meiqing Shen Yunfeng Lu Department of Chemical and Biomolecular Engineering University of California Department of Orthopedic Surgery Brigham and Women's HospitalHarvard Medical School Key Laboratory for Green Chemical Technology of State Education Ministry School of Chemical Engineering and Technology and State Key Laboratory of EnginesTianjin University Department of Molecular and Medical Pharmacology University of California

Viral pathogens have threatened human being’s health for a long time, from periodically breakout flu epidemics to recent rising Ebola virus disease. Herein, we report a new application of nonstoichiometric Perovskite-type LaxMn O3(x ? 1, 0.95, and 0.9) compounds in spontaneous and continuous disinfection of viruses. Perovskite-type LaxMn O3(x ? 1, 0.95, and 0.9) is well-known for their catalytic properties involving oxidization reactions, which are usually utilized as electrodes in fuel cells. By utilizing superb oxidative ability of LaxMn O3(x ? 1, 0.95, and 0.9),amino acid residues in viral envelope proteins are oxidized, thus envelope proteins are denatured and infectivity of the virus is neutralized. It is of great importance that this process does not require external energy sources like light or heat. The A/PR/8/34H1N1 influenza A virus(PR8) was employed as the sample virus in our demonstration, and high-throughput disinfections were observed. The efficiency of disinfection was correlated to oxidative ability of LaxMn O3(x ? 1, 0.95, and 0.9) by EPR and H2-TPR results that La0.9Mn O3 had the highest oxidative ability and correspondingly gave out the best disinfecting results within three nonstoichiometric compounds. Moreover, denaturation of hemagglutinin and neuraminidase, the two key envelope proteins of influenza A viruses, was demonstrated by HA unit assay with chicken red blood cells and NA fluorescence assay, respectively. This unique disinfecting application of La0.9Mn O3 is considered as a great make up to current sterilizing methods especially to photocatalyst based disinfectants and can be widely applied to cut-off spread routes of viruses, either viral aerosol or contaminated fluid, and help in controlling the possibly upcoming epidemics like flus and hemorrhagic fever.

关键词： Disinfect Influenza A virus LaxMnO3 Nonstoichiometric Perovskite

基于自我效能感理论的职校学生手机依赖分析及管理对策

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江苏经贸职业技术学院学报 2024年第1期 38-40页

作者：孙仁喆南京金陵高等职业技术学校现代商贸系江苏南京210007

职业学校学生手机依赖问题已对学生的身心健康与学习产生了负面影响。传统的管控方式往往只治标而不治本,难以形成有效的管理。以班杜拉提出的自我效能感理论为指导,针对职业学校学生的特性,对手机依赖的原因进行深入分析。根据分析结果... 详细信息

职业学校学生手机依赖问题已对学生的身心健康与学习产生了负面影响。传统的管控方式往往只治标而不治本,难以形成有效的管理。以班杜拉提出的自我效能感理论为指导,针对职业学校学生的特性,对手机依赖的原因进行深入分析。根据分析结果,提出“管”与“教”相结合的理念,旨在降低学生过度使用手机的自我效能感,同时提高他们对于学习活动的自我效能感。

关键词：职校学生手机依赖自我效能感

3D numerical study of tumor blood perfusion and oxygen transport during vascular normalization

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Applied Mathematics and Mechanics(English Edition) 2015年第2期36卷 153-162页

作者： Jie WU Yan CAI Yi FU Zhujun TAN ren sun Shixiong XU Zurong DING Cheng DONG Ministry of Education of China(MOE)Key Laboratory of Hydrodynamics Shanghai Jiao Tong University School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong University School of Biological Science and Medical Engineering Southeast University Institute of Biliary Tract Disease Xinhua Hospital Department of Mechanics and Engineering Science Fudan University Department of Biomedical Engineering The Pennsylvania State University

The changes of blood perfusion and oxygen transport in tumors during tumor vascular normalization are studied with 3-dimensional mathematical modeling and numerical simulation. The models of tumor angiogenesis and vascular-disrupting are used to simulate ＂un-normalized＂ and ＂normalized＂ vasculatures. A new model combining tumor hemodynamics and oxygen transport is developed. In this model, the intravasculartransvascular-interstitial flow with red blood cell（RBC） delivery is tightly coupled, and the oxygen resource is produced by heterogeneous distribution of hematocrit from the flow simulation. The results show that both tumor blood perfusion and hematocrit in the vessels increase, and the hypoxia microenvironment in the tumor center is greatly improved during vascular normalization. The total oxygen content inside the tumor tissue increases by about 67%, 51%, and 95% for the three approaches of vascular normalization,respectively. The elevation of oxygen concentration in tumors can improve its metabolic environment, and consequently reduce malignancy of tumor cells. It can also enhance radiation and chemotherapeutics to tumors.

关键词： tumor hypoxia environment oxygen transport red blood cell（RBC） delivery vascular normalization numerical simulation

Krüppel样转录因子8与乳腺癌他莫昔芬耐药的相关性

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吉林医学 2024年第5期45卷 1017-1022页

作者：孙任成于渊潍坊市中医院肿瘤外科山东潍坊261041 潍坊市人民医院肿瘤内科

目的:探讨Krüppel样转录因子8(KLF8)与乳腺癌他莫昔芬(TAM)耐药及预后的相关性。方法:利用公共数据库分析KLF8 mRNA在TAM敏感与耐药细胞中的表达差异及KLF8 mRNA对接受TAM治疗乳腺癌患者预后的影响。运用RT-PCR及Western印迹方法检测MC... 详细信息

目的:探讨Krüppel样转录因子8(KLF8)与乳腺癌他莫昔芬(TAM)耐药及预后的相关性。方法:利用公共数据库分析KLF8 mRNA在TAM敏感与耐药细胞中的表达差异及KLF8 mRNA对接受TAM治疗乳腺癌患者预后的影响。运用RT-PCR及Western印迹方法检测MCF-7与LCC2细胞中KLF8 mRNA及蛋白表达差异,免疫组化检测97例Luminal A/B亚型接受TAM治疗乳腺癌中KLF8表达情况并分析其与预后的关系,运用CCK-8试剂盒检测沉默及过表达KLF8后在不同浓度TAM作用下细胞增殖变化。结果:TAM耐药细胞中KLF8表达水平高于TAM敏感细胞,接受TAM治疗Luminal A/B亚型乳腺癌患者中,KLF8高表达者预后差,过表达KLF8后细胞对TAM耐药性增强,而沉默KLF8后细胞对TAM耐药性减弱。结论:KLF8高表达与乳腺癌TAM耐药正相关,在Luminal A/B亚型的乳腺癌中,KLF8高表达TAM治疗效果差,KLF8或可成为TAM疗效判断及逆转耐药的新靶点。

关键词：乳腺癌他莫昔芬耐药 Krüppel样转录因子8

单次注射亚麻醉剂量氯胺酮对腹腔镜结直肠癌根治术患者术后疲劳综合征的影响

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徐州医科大学学报 2024年第4期44卷 291-295页

作者：郭文静孙韧苏州大学附属张家港医院麻醉科江苏张家港215600

目的探讨单次注射亚麻醉剂量氯胺酮对腹腔镜结直肠癌根治术患者术后疲劳综合征的影响。方法选取2020年1月—2022年9月就诊于苏州大学附属张家港医院行腹腔镜结直肠癌根治术的老年患者共计90例。纳入标准:年龄60~75岁,ASAⅡ—Ⅲ级,体... 详细信息

目的探讨单次注射亚麻醉剂量氯胺酮对腹腔镜结直肠癌根治术患者术后疲劳综合征的影响。方法选取2020年1月—2022年9月就诊于苏州大学附属张家港医院行腹腔镜结直肠癌根治术的老年患者共计90例。纳入标准:年龄60~75岁,ASAⅡ—Ⅲ级,体重指数(BMI)18.5~27.9 kg/m2,术前1dChristensen疲劳评分≤4分,预期手术时间小于6 h,预期失血量低于800 mL。患者随机纳入氯胺酮组(K组)或安慰剂组(P组),每组各纳入45例患者。于术前1 d、术后3 d、术后5 d、术后7 d评估患者Christensen疲劳评分和简明围术期疲劳检测量表(ICFS-10)评分。于麻醉诱导前10 min(T0)、手术结束即刻(T1)、术后6 h(T2)、术后12 h(T3)、术后24 h(T4)抽取外周静脉血,检测白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平。记录拔管时间、PACU停留时间以及苏醒延迟、躁动、恶心呕吐、复视发生情况。结果 2组患者拔管时间、麻醉后监测治疗室(PACU)停留时间的比较差异无统计学意义(P>0.05)。2组患者苏醒延迟、躁动、恶心呕吐、复视发生率的比较差异无统计学意义(P>0.05)。K组患者术后3 d、术后5 d、术后7 d的Christensen疲劳评分和ICFS-10评分明显低于P组患者,差异有统计学意义(P<0.05)。2组患者术后3 d Christensen疲劳评分和ICFS-10评分明显高于同组其他时点,差异有统计学意义(P<0.05)。K组患者术后T1至T4时点的IL-6和TNF-α水平明显低于P组患者,差异有统计学意义(P<0.05)。2组患者T1时点IL-6和TNF-α水平明显高于同组其他时点,差异有统计学意义(P<0.05)。结论单次注射亚麻醉剂量氯胺酮能够改善腹腔镜结直肠癌根治术患者术后疲劳综合征,且对苏醒质量无明显不良影响。

关键词：氯胺酮术后疲劳综合征腹腔镜结直肠癌根治术老年

Targeting papain-like protease for broad-spectrum coronavirus inhibition

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Protein & Cell 2022年第12期13卷 940-953页

作者： Shuofeng Yuan Xiaopan Gao Kaiming Tang Jian-Piao Cai Menglong Hu Peng Luo Lei Wen Zi-Wei Ye Cuiting Luo Jessica Oi-Ling Tsang Chris Chun-Yiu Chan Yaoqiang Huang Jianli Cao Ronghui Liang Zhenzhi Qin Bo Qin Feifei Yin Hin Chu Dong-Yan Jin ren sun Jasper Fuk-Woo Chan Sheng Cui Kwok-Yung Yuen State Key Laboratory of Emerging Infectious Diseases Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong SARChina Department of Microbiology Li Ka ShingFaculty of MedicineThe University of Hong KongPokfulamHong Kong SARChina NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong SARChina Department of Molecular and Medical Pharmacology David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCAUSA Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Medical UniversityHaikou 571199China Academician Workstation of Hainan Province Hainan Medical UniversityHaikou 571199China Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases The University of Hong KongPokfulamHong Kong Special Administrative RegionChina Guangzhou Laboratory Guangzhou 510320China Department of Clinical Microbiology and Infection Control The University of Hong Kong-Shenzhen HospitalShenzhen 518053China

The emergence of SARS-CoV-2 variants of concern and repeated outbreaks of coronavirus epidemics in the past two decades emphasize the need for next-generation pan-coronaviral therapeutics.Drugging the multi-functional papain-like protease(PLpro)domain of the viral nsp3 holds promise.However,none of the known coronavirus PLpro inhibitors has been shown to be in vivo active.Herein,we screened a structurally diverse library of 50,080 compounds for potential coronavirus PLpro inhibitors and identified a noncovalent lead inhibitor F0213 that has broad-spectrum anti-coronaviral activity,including against the Sarbecoviruses(SARSCoV-1 and SARS-CoV-2),Merbecovirus(MERS-CoV),as well as the Alphacoronavirus(hCoV-229E and hCoVOC43).Importantly,F0213 confers protection in both SARS-CoV-2-infected hamsters and MERS-CoV-infected human DPP4-knockin mice.F0213 possesses a dual therapeutic functionality that suppresses coronavirus replication via blocking viral polyprotein cleavage,as well as promoting antiviral immunity by antagonizing the PLpro deubiquitinase activity.Despite the significant difference of substrate recognition,mode of inhibition studies suggest that F0213 is a competitive inhibitor against SARS2-PLpro via binding with the 157K amino acid residue,whereas an allosteric inhibitor of MERSPLpro interacting with its 271E position.Our proof-ofconcept findings demonstrated that PLpro is a valid target for the development of broad-spectrum anticoronavirus agents.The orally administered F0213 may serve as a promising lead compound for combating the ongoing COVID-19 pandemic and future coronavirus outbreaks.

关键词： protease inhibitor coronavirus Nsp3 antiviral