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Protective Effects of Different Hypothermal Preservation Solutions on Structure and Function of Isolated Rat Arteries

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当代医学科学(英文) 2023年第4期43卷 768-778页

作者： Zhang-yong ren Shao-cheng LYU Han-xuan WANG Jing WANG Lin ZHOU Qiang HE ren lang Department of Hepatobiliary and Pancreaticosplenic Surgery Beijing Organ Transplant CenterBeijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China

Objective:With the increasing application of vascular reconstruction in surgical procedures,allogeneic vessels are becoming more popular in clinical practice due to their abundant sources,precise diameter matching,improved histocompatibility,and higher long-term patency rate.This study aimed to investigate the protective effect of various preservation solutions on the function and structure of the isolated rat abdominal aorta preserved under hypothermal conditions.Methods:The study utilized a total of 150 Sprague-Dawley(SD)rats,with 144 rats allocated to the experimental groups and 6 rats allocated to the control groups.The abdominal aorta of the rats was chosen as the subject of our research.The aorta in the experimental groups were randomly assigned to 4 groups:University of Wisconsin(UW)solution group,histidine-tryptophan-ketoglutarate(HTK)solution group,normal saline(NS)group,and sodium lactate Ringer's solution(RS)group.Samples were subjected to examination after preservation periods of 1 day,3 days,5 days,7 days,14 days,30 days,and 90 days.Evaluation of vascular physiological function involved detecting and assessing vasoconstriction ability and measuring cell viability through the MTT test.Evaluation of the vascular wall structure involved tension tolerance tests and pathological staining.Results:The pathogen-positive rate in the HTK group and NS group at 1 month was 16.7%.Regarding the vascular skeleton structure,both the UW group and HTK group exhibited intact structures after 2 weeks of preservation,with slightly edematous collagen and elastic fibers,which was significantly better than that of the NS group and RS group.In terms of cell activity and contractile function,all preservation groups showed similar effects within 2 weeks.However,after 2 weeks,the UW group showed the most favorable preservation effect(Prent groups exhibited similar effects within 1 week.However,after 2 weeks,the UW group showed the best preservation effect(P<0.05).Conclusion:All 4 types o

关键词： rat model allogeneic artery preservation solution vascular preservation technique vascular reconstruction

Clinical value of extended lymphadenectomy in radical surgery for pancreatic head carcinoma at different T stages

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World Journal of Gastrointestinal Surgery 2022年第11期14卷 1204-1218页

作者： Shao-Cheng Lyu Han-Xuan Wang Ze-Ping Liu Jing Wang Jin-Can Huang Qiang He ren lang Department of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China School of Biomedicine Bejing City UniversityBeijing 100084China

BACKGROUND As the lymph-node metastasis rate and sites vary among pancreatic head carcinomas(PHCs)of different T stages,selective extended lymphadenectomy(ELD)performance may improve the prognosis of patients with PHC.AIM To investigate the effect of ELD on the long-term prognosis of patients with PHC of different T stages.METHODS We analyzed data from 216 patients with PHC who underwent surgery at our hospital between January 2011 and December 2021.The patients were divided into extended and standard lymphadenectomy(SLD)groups according to extent of lymphadenectomy and into T1,T2,and T3 groups according to the 8 th edition of the American Joint Committee on Cancer’s staging system.Perioperative data and prognoses were compared among groups.Risk factors associated with prognoses were identified through univariate and multivariate analyses.RESULTS The 1-,2-and 3-year overall survival(OS)rates in the extended and SLD groups were 69.0%,39.5%,and 26.8%and 55.1%,32.6%,and 22.1%,respectively(P=0.073).The 1-,2-and 3-year disease-free survival rates in the extended and SLD groups of patients with stage-T3 PHC were 50.3%,25.1%,and 15.1%and 22.1%,1.7%,and 0%,respectively(P=0.025);the corresponding OS rates were 65.3%,38.1%,and 21.8%and 36.1%,7.5%,and 0%,respectively(P=0.073).Multivariate analysis indicated that portal vein invasion and lymphadenectomy extent were risk factors for prognosis in patients with stage-T3 PHC.CONCLUSION ELD may improve the prognosis of patients with stage-T3 PHC and may be of benefit if performed selectively.

关键词： Pancreatic head carcinoma Extended lymphadenectomy T stage Surgical treatment Risk factor Long-term prognosis

TNFR2 is a potent prognostic biomarker for post-transplant lung metastasis in patients with hepatocellular carcinoma

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Chinese Journal of Cancer Research 2023年第1期35卷 66-80页

作者： Huigang Li Zuyuan Lin Jianyong Zhuo Modan Yang Wei Shen Zhihang Hu Yichen Ding Hao Chen Chiyu He Xinyu Yang Siyi Dong Xuyong Wei Beicheng Sun Shusen Zheng ren lang Di Lu Xiao Xu Zhejiang University School of Medicine Hangzhou 310058China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryAffiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou 310006China The Institute for Organ Repair and Regenerative Medicine of Hangzhou Hangzhou 310006China Institute of Organ Transplantation Zhejiang UniversityHangzhou 310003China National Center for Healthcare Quality Management in Liver Transplant Hangzhou 310003China Department of Hepatobiliary Surgery the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalHangzhou 311112China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 31003China Department of Hepatobiliary Surgery Beijing Chaoyang Hospital Affiliated to Capital Medical UniversityBeijing 100020China

Objective:Lung metastasis is a common and fatal complication of liver transplantation for hepatocellular carcinoma(HCC).The precise prediction of post-transplant lung metastasis in the early phase is of great value.Methods:The mRNA profiles of primary and paired lung metastatic lesions were analyzed to determine key signaling pathways.We enrolled 241 HCC patients who underwent liver transplantation from three centers.Tissue microarrays were used to evaluate the prognostic capacity of tumor necrosis factor(TNF),tumor necrosis factor receptor 1(TNFR1),and TNFR2,particularly for post-transplant lung metastasis.Results:Comparison of primary and lung metastatic lesions revealed that the TNF-dependent signaling pathway was related to lung metastasis of HCC.The expression of TNF was degraded in comparison to that in para-tumor tissues(Prence risk(5-year OS rate:31.9%vs.62.5%,P<0.001).Notably,elevated TNFR2 levels were also associated with an increased risk of post-transplant lung metastasis(hazard ratio:1.146;P<0.001).Cox regression analysis revealed that TNFR2,Hangzhou criteria,age,and hepatitis B surface antigen were independent risk factors for post-transplant lung metastasis,and a novel nomogram was established accordingly.The nomogram achieved excellent prognostic efficiency(area under time-dependent receiver operating characteristic=0.755,concordance-index=0.779)and was superior to conventional models,such as the Milan criteria.Conclusions:TNFR2 is a potent prognostic biomarker for predicting post-transplant lung metastasis in patients with HCC.A nomogram incorporating TNFR2 deserves to be a helpful prognostic tool in liver transplantation for HCC.

关键词： Lung metastasis hepatocellular carcinoma liver transplantation nomogram

与鲨鱼共游:合法性视角下边缘互补者竞合感知对价值创造的影响研究

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研究与发展管理 2024年第1期36卷 80-93页

作者：郭元源陈意锒池仁勇浙江工业大学管理学院杭州310023 浙江工业大学中国中小企业研究院杭州310023

竞合是平台市场的关系基础,但平台主参与竞争会打破原有的市场配置,处于弱势地位的边缘互补者可能会加剧陷入生存泥沼。如何在与平台主竞合中寻找生存突破口,成为边缘互补者亟待解决的核心问题。基于306家用户基数排名在后50%的中小型... 详细信息

竞合是平台市场的关系基础,但平台主参与竞争会打破原有的市场配置,处于弱势地位的边缘互补者可能会加剧陷入生存泥沼。如何在与平台主竞合中寻找生存突破口,成为边缘互补者亟待解决的核心问题。基于306家用户基数排名在后50%的中小型边缘互补者的调查数据,从合法性视角分析在与平台主竞合的关系中边缘互补者如何实现价值创造的可持续发展。研究表明:在认知合法性的介质传递下,边缘互补者对竞合关系的主观感知对个体价值与生态价值的创造均存在正向作用;进一步,在社会政治合法性的边界影响下,边缘互补者的竞合关系感知会促成更多生态价值的产生,但抑制个体价值的产生。研究发现在补充了平台竞合关系文献的同时,对边缘互补者推进战略决策、实现生态共生发展具有启示作用。

关键词：平台生态系统互补者合法性竞合

Carbohydrate antigen 19-9 as a novel prognostic biomarker in distal cholangiocarcinoma

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World Journal of Gastrointestinal Surgery 2021年第9期13卷 1025-1038页

作者： Tao Jiang Shao-Cheng Lyu Lin Zhou Jing Wang Han Li Qiang He ren lang Department of Hepatobiliary Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China

BACKGROUND Distal cholangiocarcinoma(DCC)presents as one of the relatively rare malignant tumors in the digestive system and has a poor long-term prognosis.Curative resection is currently the most appropriate therapy for patients with DCC because of the lack of effective adjuvant therapies.Therefore,it is important to accurately predict the prognosis for formulating a reasonable treatment plan and avoiding unnecessary surgical trauma.AIM To minimize the interference of obstructive jaundice on carbohydrate antigen 19-9(CA19-9)level by adapting CA19-9 toγ-glutamyltransferase(GGT)as an indicator,to determine the strong associations between CA19-9/GGT and postoperative neoplasm recurrence and long-term outcome of DCC.METHODS We enrolled 186 patients who were diagnosed with DCC between January 2010 and December 2019 and performed radical excision with strict criteria as follows in our hospital.Receiver operating characteristic curves were drawn according to preoperative CA19-9/GGT and 1-year survival.Based on this,patients were divided into two groups(group 1,low-ratio,n=81;group 2,high-ratio,n=105).Afterwards,by the way of univariate and multivariate analysis,the risk factors influencing postoperative tumor recrudesce and long-term prognosis of patients with DCC were screened out.RESULTS Optimum cut-off value of CA19-9/GGT was 0.12.Patients in group 2 represented higher CA19-9 and lymphatic metastasis rate accompanied by lower GGT,when compared with group 1(Prentiation were independent risk factors for tumor recurrence and long-term prognosis of DCC.CONCLUSION Elevation of CA19-9/GGT performed better as a biomarker of aggressive carcinoma and predictor of poor clinical outcomes by reducing the effect of obstruction of biliary tract on CA19-9 concentration in patients with DCC.

关键词： Distal cholangiocarcinoma Pancreaticoduodenectomy Carbohydrate antigen 19-9 γ-Glutamyltransferase Relapse Prognosis

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密闭空间环境空气监测技术研究进展

科技资讯 2024年第4期22卷 174-178页

作者：郎悦任向红火箭军工程大学陕西西安710025

密闭空间是一个独特大气环境,人员在其中长期工作生活存在着缺氧、二氧化碳和有害气体超标的风险,密闭空间环境监测对作业人员的生命安全和身体健康起着至关重要的作用。旨在针对密闭空间的特点,分析了密闭空间空气污染物来源及危害,对... 详细信息

密闭空间是一个独特大气环境,人员在其中长期工作生活存在着缺氧、二氧化碳和有害气体超标的风险,密闭空间环境监测对作业人员的生命安全和身体健康起着至关重要的作用。旨在针对密闭空间的特点,分析了密闭空间空气污染物来源及危害,对密闭空间光谱监测技术、色谱-质谱联用监测技术、色谱-离子迁移谱监测技术、半导体监测技术、电化学监测技术、光离子化监测技术的特点、应用及发展趋势进行了分析,为不同类型的环境监测技术在密闭空间中的应用提供借鉴和参考。

关键词：密闭空间有害气体监测技术环境监测

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基于疲劳强度的双层底船体典型节点优化设计

舰船科学技术 2024年第10期46卷 59-64页

作者：乔浪豪严仁军邱屿刘瑞武汉理工大学船海与能源动力工程学院湖北武汉430063 武汉理工大学高性能舰船技术教育部重点实验室湖北武汉430063

结构疲劳破坏是造成船舶与海洋结构物的主要破坏模式之一,对于双层底船体某些结构形式,其疲劳强度问题尤为突出。选取某大型散货船为研究对象,依据整船有限计算结果以及大量文献调查,确定疲劳损伤部位,对船体双层底过渡区典型节点及优... 详细信息

结构疲劳破坏是造成船舶与海洋结构物的主要破坏模式之一,对于双层底船体某些结构形式,其疲劳强度问题尤为突出。选取某大型散货船为研究对象,依据整船有限计算结果以及大量文献调查,确定疲劳损伤部位,对船体双层底过渡区典型节点及优化后节点分别设计和开展缩比模型试验,综合试验与有限元计算结果验证了疲劳试验以及优化方式的可靠性,并采用D曲线与CCS《船体结构疲劳强度指南》对节点模型进行疲劳强度评估,结合疲劳试验结果进一步说明,该优化方案对双层底船体类似节点的结构设计具有一定借鉴意义。

关键词：双层底船体典型节点疲劳强度疲劳试验

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氮磷钾配合施用提高白芷种子产量和质量

植物营养与肥料学报 2024年第4期30卷 812-823页

作者：刘仁浪刘思琴张宇柔冯冬菊侯凯吴卫四川农业大学农学院四川成都611100

[目的]白芷留种繁育生产中缺乏施肥技术,造成白芷种子产量低,质量不稳定。为此,研究了用于白芷良种繁育及种子高效生产的施肥技术体系。[方法]以白芷品种‘川芷2号’为试验材料,于2021-2022年采用“3414”不完全正交回归设计,在四川省... 详细信息

[目的]白芷留种繁育生产中缺乏施肥技术,造成白芷种子产量低,质量不稳定。为此,研究了用于白芷良种繁育及种子高效生产的施肥技术体系。[方法]以白芷品种‘川芷2号’为试验材料,于2021-2022年采用“3414”不完全正交回归设计,在四川省成都市进行了田间试验。试验三因素为氮(N)、磷(P_(2)O_(5))和钾(K_(2)O)肥,分别设4个施肥水平,共14个处理。于白芷收获期,测定种子产量、千粒重、长度、宽度、发芽率、发芽势、发芽指数和生活力;利用灰色关联度分析法,对各施肥处理下的白芷种子产量和质量进行综合评价;通过肥效模型拟合得出氮、磷和钾肥的推荐施肥量。[结果]当N、P_(2)O_(5)和K_(2)O用量分别为180.6、306.5和149.8 kg/hm^(2)(N_(2)P_2K_(2))时,白芷种子产量、千粒重、长度、宽度、生活力、发芽率、发芽势和发芽指数最高,与不施肥(N_0P_0K_0)相比分别提高了83.3%、27.3%、16.4%、18.9%、23.3个百分点、16.7个百分点、24.0个百分点和28.2%。灰色关联度分析表明,白芷种子产量对种子生活力的影响最大,其次是发芽率、发芽势、千粒重。N_(2)P_2K_(2)处理的加权关联度和等权关联度系数均最高,分别为0.825和0.824;其次是N_1P_2K_1处理(N 90.3、P_(2)O_(5) 306.5、K_(2)0 74.9 kg/hm^(2)),分别为0.745和0.751。在施肥区间内,白芷种子产量均随氮、磷和钾肥任一单种肥料施用量的增大呈先上升后下降的趋势,均在N_(2)P_(2)K_(2)处理下达到最大值;氮、磷和钾肥对白芷种子产量存在明显的互作效应,N_(2)P_(2)K_(2)处理下的施肥水平有利于提升氮、磷、钾的肥效。由拟合白芷种子产量的三元二次肥料效应方程可得出,当N、P_(2)O_(5)和K_(2)O养分用量分别为177.0、274.6和133.7 kg/hm^(2)时,白芷种子产量最高,为1766.6 kg/hm^(2)。[结论]适宜的氮、磷、钾肥配施显著提高白芷种子产量和质量,氮肥(N)、磷肥(P_(2)O_(5))和钾肥(K_(2)O)最优推荐施肥量分别为177.0、274.6和133.7 kg/hm^(2),适宜的氮、磷、钾施肥比例为1:1.55:0.75。

关键词：白芷氮磷钾肥种子产量种子质量最优施肥量

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辽宁某海水淡化系统反渗透膜污染成因分析

膜科学与技术 2024年第3期44卷 89-96页

作者：刘思雨明红霞任恺佳郎咸龙樊景凤上海海洋大学海洋生态与环境学院上海200000 国家海洋环境监测中心大连116000 大连海洋大学大连116000

膜污染已成为阻碍海水淡化反渗透系统正常运行的主要问题,辽宁某核电站海水淡化系统一级反渗透产水量下降,初步确定一级反渗透膜发生了污堵,且化学清洗效果不佳.为解析其污染的主要成因,本研究选取该核电站一级反渗透系统产水端的一支R... 详细信息

膜污染已成为阻碍海水淡化反渗透系统正常运行的主要问题,辽宁某核电站海水淡化系统一级反渗透产水量下降,初步确定一级反渗透膜发生了污堵,且化学清洗效果不佳.为解析其污染的主要成因,本研究选取该核电站一级反渗透系统产水端的一支RO膜组件进行剖解,从物理化学和生物角度进行综合分析.通过FESEM分析揭示了非晶体基质污染层中嵌入了颗粒,表面可见微生物及生物膜结构.EDS检测到污染层中主要元素为C、N、O,此外,还含有少量的Al、Na、Ca,分析其污染以生物和有机污染为主,铝盐可与阻垢剂发生反应,形成胶状沉淀物,与SEM观察到的胶状污染物结果相吻合.FTIR光谱进一步确认污染层主要是多糖、蛋白质等生物代谢物,与SEM观察到的生物污染结果相吻合.结合可培养技术对生物污染进行进一步鉴定,确定其优势菌群为芽孢杆菌属和假单胞菌属,这两类菌均与反渗透膜污堵有关.建议有针对性地开展芽孢杆菌和假单胞菌等细菌的消杀,调整工艺中杀菌剂、絮凝剂及还原剂的种类和用量,研究可为海水淡化系统生物污染控制提供参考依据.

关键词：海水淡化反渗透膜污染细菌膜剖检