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Obituary:*** Zhang(1963-2023)-A scientist focused on toxins and their underlying mechanisms to decipher human diseases

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Zoological Research 2024年第1期45卷 230-232页

作者： Wenhui Lee ren lai the Key Laboratory of Bioactive Peptides of Yunnan Province Engineering Laboratory of Peptides of Chinese Academy of SciencesKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Centre for Non-Human PrimatesKunming Primate Research CentreNational Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Sino-African Joint Research CentreNew Cornerstone Science InstituteKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China

*** Zhang was born on 9 July 1963 in Kunming,Yunnan,China,during a tumultuous period which he often *** his life,he harbored a steadfast belief in using knowledge to unravel the mysteries of human *** educational journey was marked by frequent changes in schools due to his parents’occupational ***,despite these challenges,he consistently displayed diligence and was admitted to the East China University of Science and Technology,Shanghai,after completing high school in *** remained an active and loyal member of the School of Biotechnology at the university.

关键词： admitted harbor mechanisms

DEFORMATION OF COPOLYMER MICELLES INDUCED BY AMPHIPHILIC DIMER PARTICLES

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Chinese Journal of Polymer Science 2012年第2期30卷 164-172页

作者： Xiao-chun Qin Chun-lai ren National Laboratory of Solid State Microstructures Nanjing UniversityNanjing 210093China

Combining self-consistent-field theory and density-functional theory, we systematically study the deformation of copolymer micelles induced by the presence of amphiphilic dimer particles. Due to the amphiphilic nature, dimer particles tend to accumulate onto the interface of the copolymer micelle. With increasing concentration of the symmetric dimer particles, which are made of two identical spherical particles, the micelle deforms from the initial sphere to ellipse, dumbbell, and finally separates into two micelles. Furthermore, asymmetric dimer particles, composed by two particles with different sizes, are considered to investigate the influence of geometry of dimer particles on the deformation of the micelle. It is found that the micelle inclines to deform into dumbbell due to the additional curvature originating in the gathering of asymmetric dimer particles onto the interface of the micelle. The present study on the deformation of micelles is useful to understand the possible shape variation in the course of cell division/fusion.

关键词： Dimer particle Copolymer micelle Deformation Self consistent field theory Density function theory.

Antimicrobial peptides: new hope in the war against multidrug resistance

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Zoological Research 2019年第6期40卷 488-505页

作者： James Mwangi Xue Hao ren lai Zhi-Ye Zhang Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunming Yunnan 650204China Sino-African Joint Research Center Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Institutes for Drug Discovery and Development Chinese Academy of SciencesShanghai 201203China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Center for Biosafety Mega-Science Chinese Academy of SciencesWuhan Hubei 430071China

The discovery of antibiotics marked a golden age in the revolution of human medicine. However,decades later, bacterial infections remain a global healthcare threat, and a return to the pre-antibiotic era seems inevitable if stringent measures are not adopted to curb the rapid emergence and spread of multidrug resistance and the indiscriminate use of antibiotics. In hospital settings, multidrug resistant(MDR) pathogens, including carbapenem-resistant Pseudomonas aeruginosa, vancomycin-resistant enterococci(VRE), methicillin-resistant Staphylococcus aureus(MRSA), and extendedspectrum β-lactamases(ESBL) bearing Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae are amongst the most problematic due to the paucity of treatment options,increased hospital stay, and exorbitant medical costs. Antimicrobial peptides(AMPs) provide an excellent potential strategy for combating these threats. Compared to empirical antibiotics, they show low tendency to select for resistance, rapid killing action, broad-spectrum activity, and extraordinary clinical efficacy against several MDR strains. Therefore, this review highlights multidrug resistance among nosocomial bacterial pathogens and its implications and reiterates the importance of AMPs as next-generation antibiotics for combating MDR superbugs.

关键词： Multidrug resistance Nosocomial infections Antimicrobial peptide Antibiotic alternatives

Design methods for antimicrobial peptides with improved performance

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Zoological Research 2023年第6期44卷 1095-1114页

作者： James Mwangi Peter Muiruri Kamau Rebecca Caroline Thuku ren lai Key Laboratory of Bioactive Peptides of Yunnan Province Engineering Laboratory of Peptides of Chinese Academy of SciencesKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Centre for Non-Human PrimatesKunming Primate Research CentreNational Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Sino-African Joint Research CentreNew Cornerstone Science InstituteKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China Centre for Evolution and Conservation Biology Southern Marine Science and Engineering Guangdong LaboratoryGuangzhouGuangdong 511458China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China

The recalcitrance of pathogens to traditional antibiotics has made treating and eradicating bacterial infections more *** this regard,developing new antimicrobial agents to combat antibiotic-resistant strains has become a top *** peptides(AMPs),a ubiquitous class of naturally occurring compounds with broadspectrum antipathogenic activity,hold significant promise as an effective solution to the current antimicrobial resistance(AMR)*** AMPs have been identified and evaluated for their therapeutic application,with many already in the drug development *** distinct properties,such as high target specificity,potency,and ability to bypass microbial resistance mechanisms,make AMPs a promising alternative to traditional ***,several challenges,such as high toxicity,lability to proteolytic degradation,low stability,poor pharmacokinetics,and high production costs,continue to hamper their clinical ***,recent research has focused on optimizing the properties of AMPs to improve their *** understanding the physicochemical properties of AMPs that correspond to their activity,such as amphipathicity,hydrophobicity,structural conformation,amino acid distribution,and composition,researchers can design AMPs with desired and improved *** this review,we highlight some of the key strategies used to optimize the performance of AMPs,including rational design and de novo *** also discuss the growing role of predictive computational tools,utilizing artificial intelligence and machine learning,in the design and synthesis of highly efficacious lead drug candidates.

关键词： Antimicrobial resistance Antimicrobial peptides Design methods Peptidomimetics Artificial intelligence

Bioactive peptides from scorpion venoms:therapeutic scaffolds and pharmacological tools

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Chinese Journal of Natural Medicines 2023年第1期21卷 19-35页

作者： Peter Muiruri Kamau ZHONG Jian YAO Bing lai ren LUO Lei Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Center for Non-Human PrimatesKunming Primate Research CenterNational Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Sino-African Joint Research Centerand Engineering Laboratory of PeptidesKunming Institute of ZoologyKunming 650107China Kunming College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Reproductive Medicine Affiliated Jinling HospitalNanjing Medical UniversityNanjing 210002China Department of Gynecology Women’s Hospital of Nanjing Medical UniversityNanjing 210004China Center for Evolution and Conservation Biology Southern Marine Science and Engineering Guangdong LaboratoryGuangzhou 511458China

Evolution and natural selection have endowed animal venoms,including scorpion venoms,with a wide range of pharmacological ***,scorpions,their venoms,and/or their body parts have been used since time immemorial in traditional medicines,especially in Africa and *** respect to their pharmacological potential,bioactive peptides from scorpion venoms have become an important source of scientific *** the rapid increase in the characterization of various components from scorpion venoms,a large number of peptides are identified with an aim of combating a myriad of emerging global health ***,some scorpion venom-derived peptides have been established as potential scaffolds helpful for drug *** this review,we summarize the promising scorpion venoms-derived peptides as drug ***,we highlight the data and knowledge needed for continuous characterization and development of additional natural peptides from scorpion venoms,as potential drugs that can treat related diseases.

关键词： Scorpion venoms Scorpion venom-derived peptides Pharmacological properties Drug development

A note on the discovery of a 2M_⊙ pulsar

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Research in Astronomy and Astrophysics 2011年第6期11卷 687-691页

作者： Xiao-Yu lai ren-Xin Xu School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking University Beijing 100871 China

It is conventionally thought that the state equation of dense matter softens and thus cannot result in high maximum mass if pulsars are quark stars and that a recently discovered 2M⊙ pulsar （PSR J1614–2230） may make pulsars unlikely to be quark stars. However, this standard point of view would be revisited and updated if quark clustering could occur in cold quark matter because of the strong coupling be- tween quarks at realistic baryon densities in compact stars. It can be argued that the state equation of clustered quark matter stiffens to support compact stars with maxi- mum mass Mmax 2M⊙. In this brief note, it is demonstrated that large parameter space ranges are allowed for Mmax 2M⊙ in a Lennard-Jones model of clustered quark matter and the newly measured highest mass of PSR J1614–2230 would be meaningful for constraining the number of quarks inside a single quark-cluster to be Nq ≤ 103.

关键词： dense matter — elementary particles — pulsars: general — stars: neutron

An All Fiber 1.94µm Nanosecond Pulse Laser Amplified by Highly Tm^(3+)-Doped Silicon Fibers

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Chinese Physics Letters 2013年第5期30卷 78-81页

作者： ZHOU ren-lai ren Jian-Cun YANG Chao JU You-Lun WANG Yue-Zhu National Key Laboratory of Tunable Laser Technology Harbin Institute of TechnologyHarbin 150080 Naval Aeronautical&Astronautical University Yantai 264000

We present an all-fiber 1.94μm nanosecond pulse laser in master oscillation-power amplifier configuration.A dual-FBGs gain-switched Tm^(3+)-doped fiber laser is built and is used as the seed *** output characteristics of the amplifier are studied at different pulse repetition rates,and the maximum output energy of 500μJ is achieved under incident pump power of 39 *** emitting spectra are checked at 5 and 10 kHz,and no obvious nonlinear effects are observed in the spectrum of the amplified *** beam quality factor is M^(2)=2.1±0.03 measured by the traveling knife-edge method,and the laser beam spot is also monitored by an infrared vidicon camera.

关键词： amplifier fiber switched

Crystal structure and function of Rbj: A constitutively GTP-bound small G protein with an extra DnaJ domain

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Protein & Cell 2019年第10期10卷 760-763页

作者： Zhengrong Gao Chang Zhang Jianxun Qi Liang Wang Shan Gao ren lai Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences Kunming Institute of ZoologyKunming 650223China CAS Key Laboratory of Bio-medical Diagnostics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163China University of Chinese Academy of Sciences Beijing 100049China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Dear Editor,The Ras superfamily of GTPases are conserved in eukary?otes from yeast to humans,and play essential roles in the regulation of a variety of key cellular processes,including cell differentiation and proliferation,membrane trafficking,nuclear import and export,cytoskeletal remodeling and mitogenic signaling(Karnoub and Weinberg,2008).Notably,numerous studies have shown that many members of the Ras-related small GTPases are involved in diverse aspects of tumorigenesis and tumor progress!on(Chen et al.,2014;Liu et al.,2017).

关键词： Crystal function constitutive

Two neuropeptides from synganglia of the hard tick, Ixodes sinensis (Acari: Ixodidae)

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Chinese Science Bulletin 2006年第22期51卷 2743-2747页

作者： LI Jianxu LIU Tongguang YANG Hailong XU Xueqing LIU Zhigang lai ren Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China Graduate School of the Chinese Academy of Sciences Beijing 100009 China Shengyang Orthopaedic Hospital Shengyang 110044 China College of Biological Sciences Shenzhen University Shenzhen518060 China

二 neuropeptides 从 synganglia (中央神经系统) 被孤立努力滴答响， Ixodes sinensis。他们的主要序列被建立 asLeu-Val-Val-Tyr “ Pro-Trp-Thr-Lys 和 Trp-Glu-Lys-Leu-Gly-Ser-Met-Glu-Thr-Leu。由热板生物鉴定， neuropeptide 在由剂量依赖者行为的老鼠的显示的强壮的 antinociceptive 效果， whileneuropeptide b 在孤立的老鼠长带上有一些弛缓的效果。这些 neuropeptides 可能涉及下面调整主人“ s 防御反应。

关键词：神经肽弛缓效应第一序列生物化学