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Forecasting and mapping dengue fever epidemics in China: a spatiotemporal analysis

Infectious Diseases of Poverty 2024年第4期13卷 14-28页

作者： hongyan ren Nankang Xu State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

Background Dengue fever(DF)has emerged as a significant public health concern in *** spatiotemporal patterns and underlying influencing its spread,however,remain *** study aims to identify the factors driving these variations and to assess the city-level risk of DF epidemics in *** We analyzed the frequency,intensity,and distribution of DF cases in China from 2003 to 2022 and evalu-ated 11 natural and socioeconomic factors as potential *** the random forest(RF)model,we assessed the contributions of these factors to local DF epidemics and predicted the corresponding city-level *** Between 2003 and 2022,there was a notable correlation between local and imported DF epidemics in case numbers(r=0.41,Prence has increased from five to eight months per year,with case numbers spanning from 14 to 6641 per *** spatial distribution of city-level DF epidemics aligns with the geographical divisions defined by the Huhuanyong Line(Hu Line)and Qin Mountain-Huai River Line(Q-H Line)and matched well with the city-level time windows for either mosquito vector activity(83.59%)or DF transmission(95.74%).The RF models achieved a high performance(AUC=0.92)when considering the time ***,they identified imported cases as the primary influencing factor,contributing significantly(24.82%)to local DF epidemics at the city level in the eastern region of the Hu Line(E-H region).Moreover,imported cases were found to have a linear promoting impact on local epidemics,while five climatic and six socioeconomic factors exhibited nonlinear effects(promoting or inhibiting)with varying inflection ***,this model demonstrated outstanding accuracy(hitting ratio=95.56%)in predicting the city-level risks of local epidemics *** China is experiencing an incr

关键词： Dengue fever Imported case Inevitability Occasionality Time window Random forest China

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Theoretical Analysis on the Air-Condition Cabin Technique for Satellite Temperature Adjustment on the Ground

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Journal of Thermal Science 2004年第1期13卷 80-84页

作者： Jiaxun Zhang Sujun Yang hongyan ren Jindong Li Chinese Acad Space Technol Beijing 100086 Peoples R China

The aim of this paper is to study the heat transfer mechanism of the air-condition cabin technique for satellite temperature adjustment on the ground before the launch of those satellites with pressurized structure. By the study, the temperature of the satellite can be set appropriately, and this is very important to the initial satellite temperature after the satellite operates in orbit. In the paper, the simplified physical model is provided and the mathematical equations are obtained, thereafter, the experimental data are compared with the theoretical analysis. The quantitative conclusions from the theoretical analysis can be used to direct the design or the experiment of the temperature adjustment. Finally, we can conclude that, the temperature variation rule of the satellite is exponential, and the temperature adjustment process can be predicted by the exponential formula, which is obtained from the theoretical analysis.

关键词： thermal control spacecraft temperature adjustment on the ground.

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Performance and microbial response during the fast reactivation of Anammox system by hydrodynamic stress control

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Journal of Environmental Sciences 2014年第9期26卷 1861-1868页

作者： Yuan Li Zhenxing Huang Wenquan Ruan hongyan ren Hengfeng Miao School of Environment and Civil Engineering Jiangnan University

Anaerobic ammonium oxidation （Anammox） has become a promising method for biological nitrogen removal. However, this biotechnology application is always limited due to the low growth rate and biomass yield of Anammox bacteria. This study investigated the process of fast reactivation of an Anammox consortium idled for 2 years uia hydrodynamic stress control. The results showed that the Anammox system was efficiently and quickly reactivated by shortening of the hydraulic retention time （I-IRT） of the reactor from 12 to 6 hr within 68 days of operation. Moreover, at a 4-hr HRT with an influent total nitrogen loading rate of 1.2 kg N/（***）, the reactor maintained high biological performance with an ammonium removal loading rate of 0.52 kg N/（***） and a nitrite removal rate of 0.59 kg N/（***）. In the reactivated Anammox reaction, the stoichiometric coefficients of NH4-N to NOE-N and NH4-N to NO4-N were 1：1.04± 0.08 and 1：0.31 ± 0.03, respectively. The specific Anammox activity and hydrazine oxidoreductase activity, both of which represent the degree of Anammox bacteria present, increased as the hydrodynamic stress increased and were maximally （125.38 ± 3.01 mg N/（g ***） and 339.42 ± 6.83 μmol/（min.g VSS）, respectively） at 4-hr HRT. Microbial response analysis showed that the dominant microbial community was obviously shifted and the dominance of Anammox bacteria was enhanced durinR the hydrodynamic selection.

关键词： Anaerobic ammonium oxidationHydrodynamic stressFast reactivationHydrazine oxidoreductase

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Identical full-scale biogas-lift reactors(BLRs) with anaerobic granular sludge and residual activated sludge for brewery wastewater treatment and kinetic modeling

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Journal of Environmental Sciences 2013年第10期25卷 2031-2040页

作者： Fu Xu Zhenxing Huang Hengfeng Miao hongyan ren Mingxing Zhao Wenquan Ruan School of Environment and Civil Engineering Jiangnan University

Two identical full-scale biogas-lift reactors treating brewery wastewater were inoculated with different types of sludge to compare their operational conditions, sludge characteristics, and kinetic models at a mesophilic temperature. One reactor （R1） started up with anaerobic granular sludge in 12 weeks and obtained a continuously average organic loading rate （OLR） of 7.4 kg chemical oxygen demand （COD）/（***）, COD removal efficiency of 80%, and effluent COD of 450 mg/L. The other reactor （R2） started up with residual activated sludge in 30 weeks and granulation accomplished when the reactor reached an average OLR of 8.3 kg COD/（m^3·day）, COD removal efficiency of 90%, and effluent COD of 240 mg/L. Differences in sludge characteristics,biogas compositions, and biogas- lift processes may be accounted for the superior efficiency of the treatment performance of R2 over R1. Grau second-order and modified StoverKincannon models based on influent and effluent concentrations as well as hydraulic retention time were successfully used to develop kinetic parameters of the experimental data with high correlation coefficients （R2 〉 0.95）, which further showed that R2 had higher treatment performance than R1. These results demonstrated that residual activated sludge could be used effectively instead of anaerobic granular sludge despite the need for a longer time.

关键词： anaerobic granular sludge residual activated sludge biogas-lift reactor brewery wastewater kinetic modeling

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KINETIC　STUDY　ON　THE　REMOVAL　OF　LEAD　AND　SILVERFROMCRUDEBISMUTHBYANODEREFINING

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Journal of Central South University 1994年第1期6卷 59-62页

作者： Zhang Yongjian ren hongyan Xie Zhong(Department of Non-Ferrous Metallurgy, Central South University of Technology, Changsha, 410083, China) Department of Non-Ferrous Metallurgy Central South University of Technology Changsha China

The anode refining process to remove lead and silver from crude bismuth was studied. The study was carried out with chloride melts at 400 ℃ in a crucible-in-crucible type pyrex glass electrolyzer. The kinetic regularity of the removal of lead and silver was found to be in accordance with the equation:Inc=b-kt. Values of constant k were determined for different current *** relationship between the purity of refined bismuth and its direct yield wasalso determined. A two-stage anode refining method was established. The firststage. was to remove most part of lead (about 90%) at higher current density ;the second stage was used for removing silver and the remains of lead at lowercurrent density. Under appropriate conditions high purity (WPb < 0.001%,WAd<0.004%) of bismuth could be obtained from crude bismuth with the direct yield of bismuth up to 98%.

关键词： refine of bismuth molten salts electrorefining anode refining

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Depression and stress levels increase risk of liver cancer through epigenetic downregulation of hypocretin

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Genes & Diseases 2022年第4期9卷 1024-1037页

作者： Chunyun Pu Shaorong Tian Sanxiu He Weihong Chen Yuanyuan He hongyan ren Jing Zhu Jun Tang Xiaolan Huang Ying Xiang Yixiao Fu Tingxiu Xiang Key Laboratory of Molecular Oncology and Epigenetics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China Department of Urinary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China Department of Oncology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China Ph.D Research Center for Medical and Social Development Chongqing Medical UniversityChongqing 400016PR China Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China

Recent studies suggest that Hypocretin (HCRT, Orexin) are involved in stress regulation of depression through the hypothalamic-pituitary-adrenal (HPA) axis. However, the molecular mechanism by which Hypocretin regulate neurobiological responses is unknown. Herein, the effects of chronic stress on the epigenetic modification of HCRT and its association with depression were explored with regard to a potential role in cancer progression. In the study, Sprague Dawley (SD) rats were used to establish an animal model of cancer with depression by administrating n-nitrosodiethylamine (DEN) and chronic unpredictable mild stress (CUMS). RNA-sequencing was used to detect differentially expressed genes in the hippocampus of rats and quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate the results of RNA-sequencing. The status of HCRT promoter methylation was assessed by methylation specific polymerase chain reaction. Behavioral tests showed that rats exposed to CUMS had significant depressive-like behaviors. The number of liver tumors and tumor load in depressed rats exposed to CUMS was higher than in SD rats without CUMS. RNA-sequencing revealed that HCRT was one of the most siginificantly downregulated gene in the hippocampus of SD rats with CUMS compared to non-stressed group, which was validated by qRT-PCR. HCRT mRNA expression was downregulated and the promoter for HCRT was hyper-methylated in those with depression. These results identified a critical role for chronic psychological stressors in tumorigenesis and cancer progression, via epigenetic HCRT downregulation. Such epigenetic downregulation may be the molecular basis for the association of cancer with depression.

关键词： Cancer Chronic unpredictability mild stress CpG methylation Depressi on Hypocretin

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2013年度生命科学部重大国际(地区)合作研究项目申请、评审与资助浅析

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中国科学基金 2014年第4期28卷 289-291页

作者：任红艳国家自然科学基金委员会生命科学部 100085

在科学基金各类项目的资助下,我国科学家开展合作研究的领域不断拓宽,合作方式越来越多元化,实质性合作研究逐步深入。为有效利用国际资源,进一步提高我国科学研究水平和国际竞争力,基金委于2005年5月通过了《重大国际(地区)合作研究项... 详细信息

在科学基金各类项目的资助下,我国科学家开展合作研究的领域不断拓宽,合作方式越来越多元化,实质性合作研究逐步深入。为有效利用国际资源,进一步提高我国科学研究水平和国际竞争力,基金委于2005年5月通过了《重大国际(地区)合作研究项目资助管理办法》,重大国际(地区)合作研究项目成为正式的一类资助项目,从2006年起开始受理申请。1生命科学部重大国际(地区)合作研究项目资助简况生命科学部在加强调研的基础上。

关键词：生命科学国际合作评审

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断裂与复归:德育视角下农村寄宿制学校的三层童年议题

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教育科学研究 2021年第6期 73-80页

作者：任虹燕贵州民族大学民族文化与认知科学学院 550025

农村儿童大部分时间生活在寄宿制学校并度过德性成长关键的童年期,凸显童年议题的重要性。农村儿童的童年有三个层面的德育价值,包括农村家庭中的情感童年、村落习俗中的文化童年、人类命运中的乡土童年。农村寄宿制学校使儿童脱离家庭... 详细信息

农村儿童大部分时间生活在寄宿制学校并度过德性成长关键的童年期,凸显童年议题的重要性。农村儿童的童年有三个层面的德育价值,包括农村家庭中的情感童年、村落习俗中的文化童年、人类命运中的乡土童年。农村寄宿制学校使儿童脱离家庭、村落并进入集镇导致童年断裂,对农村儿童德性成长造成不良影响,具体表现为:"宿而不家"的寄宿生活分离儿童与家庭使情感童年转向寄宿童年;"教化上移"的现代学校分离儿童与习俗生活使文化童年转向知识童年;"离乡离土"的寄宿制学校分离儿童与村落使乡土童年转向城市童年。农村寄宿制学校应从三方面复归童年:通过"寄宿而家"关爱童年营造道德的寄宿生活;通过"教化平移"拓展童年生长的地方文化空间;通过"重建乡土"守护人类童年的乡土伦理根基。

关键词：学校德育童年农村寄宿制学校农村儿童

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Meta-analysis of Cohort Studies on Clinical Efficacy of Icodextrin Peritoneal Dialysate

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Asian Journal of Social Pharmacy 2024年第3期19卷 279-290页

作者： ren hongyan Wang Yaoling Hui Xu Li Xue Zhao Kun Huang Zhe School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China China National Health Develo-pment Research Center Beijing 100000China School of Business Health Lanzhou UniversityLanzhou 730000China

Objective To evaluate the effect of real-world practices for icodextrin peritoneal dialysis solution on patients with end-stage renal disease(ESRD)by *** The PubMed and Embase databases were systematically searched for real-world research literature on icodextrin peritoneal dialysate in the treatment of ESRD patients,and RevMan5.4 statistical software was used for *** and Conclusion 12 studies with 114656 patients were ***-analysis results showed that icodextrin peritoneal dialysis had good effects on mortality[RR=0.72,95%CI(0.62,0.83),Prence in PD technical failure rate[RR=0.67,95%CI(0.44,1.00),P=0.05],peritonitis[RR=1.02,95%CI(0.99,1.05),P=0.14],cardiovascular and cerebrovascular diseases[RR=0.79,95%CI(0.59,1.05),P=0.10],coronary artery disease[RR=0.99,95%CI(0.92,1.07),P=0.80],stroke[RR=0.86,95%CI(0.66,1.10),P=0.23],and atrial fibrillation[RR=0.73,95%CI(0.37,1.44),P=0.36].However,it might increase the risk of hypertension[RR=1.05,95%CI(1.03,1.07),P<0.001].Therefore,icodextrin can effectively reduce the risk of mortality,congestive heart failure,and new-onset diabetes,which is beneficial to ESRD patients.

关键词： icodextrin peritoneal dialysis fluid peritoneal dialysis end-stage renal disease mortality Meta-analysis

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由非洲猪瘟引发的对科学基金申请与资助的思考

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中国科学基金 2019年第4期33卷 375-379页

作者：任红艳国家自然科学基金委员会生命科学部

自2018年8月3日辽宁省确诊首例非洲猪瘟疫情以来,短短10个月,我国大陆已有包括海南等有天然地理屏障地区在内的所有31个省、自治区和直辖市发生非洲猪瘟疫情。非洲猪瘟是重大动物疫病,威胁一个万亿元产值、上亿人从业的产业,威胁我国的... 详细信息

自2018年8月3日辽宁省确诊首例非洲猪瘟疫情以来,短短10个月,我国大陆已有包括海南等有天然地理屏障地区在内的所有31个省、自治区和直辖市发生非洲猪瘟疫情。非洲猪瘟是重大动物疫病,威胁一个万亿元产值、上亿人从业的产业,威胁我国的粮食安全。在我国尽快控制非洲猪瘟需要过硬的科技支撑。基于这样的大背景,本文分析探讨科学家对科研选题的独立思考和基金申请以及基金委面向国家重大需求项目的前瞻布局与资助。

关键词：前瞻性布局重大动物疫病非洲猪瘟基金申请项目资助

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