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Key Genes Involved in the Beneficial Mechanism of Hyperbaric Oxygen for Glioblastoma and Predictive Indicators of Hyperbaric Oxygen Prolonging Survival in Glioblastoma Patients

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Current Medical Science 2024年第5期44卷 1036-1046页

作者： Zi-qi ren ren-dong WANG Cong WANG Xiao-hui ren dong-guo LI Ya-ling LIU Qiu-hong YU Department of Hyperbaric Oxygen Beijing Tiantan HospitalCapital Medical UniversityBeijing100070China School of Biomedical Engineering Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical ApplicationCapital Medical UniversityBeijing100069China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing100070China

Objective The prognosis of glioblastoma is poor,and therapy-resistance is largely attributed to intratumor *** oxygen(HBO)effectively alleviates ***,the sole role of HBO in glioblastoma remains *** previously reported that HBO can promote apoptosis,shorten protrusions,and delay growth of glioblastoma,but the molecular mechanism is *** aimed to test candidate genes in HBO-exposed glioblastoma cells and to analyze their correlation with the survival of glioblastoma *** Glioblastoma cell lines exposed to repetitive HBO or normobaric air(NBA)were collected for RNA isolation and microarray data *** analysis,KEGG pathway analysis and survival analysis of the differentially expressed genes(DEGs)were *** HBO not only inhibited hypoxia-inducing genes including CA9,FGF11,PPFIA4,TCAF2 and SLC2A12,but also regulated vascularization by downregulating the expression of COL1A1,COL8A1,COL12A1,RHOJ and FILIP1L,ultimately attenuated hypoxic microenvironment of *** attenuated inflammatory microenvironment by reducing the expression of NLRP2,CARD8,MYD88 and *** prevented metastasis by downregulating the expression of NTM,CXCL12,CXCL13,CXCR4,CXCR5,CDC42,IGFBP3,IGFBP5,GPC6,MMP19,ADAMTS1,EFEMP1,PTBP3,NF1 and *** upregulated the expression of BAK1,PPIF,DDIT3,TP53I11 and FAS,whereas downregulated the expression of MDM4 and SIVA1,thus promoting *** upregulated the expression of CDC25A,MCM2,PCNA,RFC33,DSCC1 and CDC14A,whereas downregulated the expression of ASNS,CDK6,CDKN1B,PTBP3 and MAD2L1,thus inhibiting cell cycle *** these DEGs,17 indicator-genes of HBO prolonging survival were *** HBO is beneficial for *** patients with these predictive indicators may prolong survival with HBO *** potential therapeutic targets especially COL1A1,ADAMTS1 and PTBP3 deserve further validation.

关键词： glioblastoma hyperbaric oxygen differentially expressed gene gene enrichment analysis survival analysis

Effect of continuous annealing parameters on the mechanical properties and microstructures of a cold rolled dual phase steel

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International Journal of Minerals,Metallurgy and Materials 2009年第2期16卷 159-164页

作者： Shuang Kuang Yong-lin Kang Hao Yu ren-dong Liu School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Technology Center Anshan Iron ＆ Steel Group Corporation Anshan 114001 China

A cold rolled dual phase （DP） steel with the C-Si-Mn alloy system was trial-produced in the laboratory, utilizing a Gleeble-3800 thermal simulator. The effects of continuous annealing parameters on the mechanical properties and microstructures of the DP steel were investigated by mechanical testing and microstructure observation. The results show that soaking between 760 and 820℃ for more than 80 s, rapid cooling at the rate of more than 30℃/s from the quenching temperature between 620 and 680℃, and overaging lower than 300℃ are beneficial for the mechanical properties of DP steels. An appropriate proportion of the two phases is one of the key factors for the favorable properties of DP steels. If the volume fraction of martensite and, thereby, free dislocations are deficient, the tensile strength and n value of DP steels will decrease, whereas, the yield strength will increase. But if the volume fraction of martensite is excessive to make it become a dominant phase, the yield and tensile strength will increase, whereas, the elongation will decrease obviously. When rapid cooling rate is not fast enough, pearlite or cementite will appear, which will degrade the mechanical properties. Even though martensite is sufficient, if it is decomposed in high temperature tempering, the properties will he unsatisfied.

关键词： austenization intercritical annealing dual phase steel cold rolling diffusion

New fossil mayflies （Insecta： Ephemeroptera） from the Middle Jurassic of Daohugou, Inner Mongolia, China

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Insect Science 2008年第2期15卷 193-198页

作者： Jian-dong Huang dong ren Nina D. Sinitshenkova Chung-Kun Shih College of Life Science Capital Normal University Beijing China Palaeontological Institute of the Russian Academy of Sciences MoscowRussia

Abstract Jurassonurus amoenus, a new genus and species of Siphlonuridae s. I. is described from the Middle Jurassic Jiulongshan Formation of the Daohugou Village, Shantou Township, Ningcheng County, Inner Mongolia, China. The new species is estab- lished by more than 20 imago and subimago specimens in relatively good condition. Detailed description and illustration of the specimens along with a review of fossil Siphlonuridae s. I. are given. Comparing with two known dominant nymph species Fuyous gregarious Zhang and Kluge, 2007 and Shantous lacustri Zhang and Kluge, 2007 from the same locality, we could not find any relationship among them. The new species is another dominant species in Daohugou beds.

关键词： new genus new species Ephemeroptera Siphlonuridae fossil Daohugou,Middle Jurassic China

Stress-strain partitioning analysis of constituent phases in dual phase steel based on the modified law of mixture

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International Journal of Minerals,Metallurgy and Materials 2009年第4期16卷 393-398页

A more accurate estimation of stress-strain relationships for martensite and ferrite was developed, and the modified law of mixture was used to investigate the stress-strain partitioning of constituent phases in dual phase （DP） steels with two different martensite volume fractions. The results show that there exist great differences in the stress-strain contribution of martensite and ferrite to DP steel. The stress-strain partitioning coefficient is not constant in the whole strain range, but decreases with increasing the true strain of DP steel. The softening effect caused by the dilution of carbon concentration in martensite with the increase of martensite volume fraction has great influence on the strain contribution of martensite. The strain ratio of ferrite to martensite almost linearly increases with increasing the true strain of DP steel when the martensite volume fraction is 22%, because martensite always keeps elastic. But the strain ratio of ferrite to martensite varies indistinctively with the further increase in true strain of DP steel above 0.034 when the martensite volume fraction is 50%, because plastic deformation happens in martensite. The stress ratio ofmartensite to ferrite decreases monotonously with increasing the true strain of DP steel whether the martensite volume fraction is 22% or 50%.

关键词： stress and strain partitioning dual phase steel ferrite martensite

New Genus of the Subfamily Geotrupinae (Coleoptera:Scarabaeoidea:Geotrupindae) from the Jehol Biota

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Acta Geologica Sinica(English Edition) 2010年第4期84卷 673-675页

作者： Georgiy V. NIKOLAJEV ren dong College of Life Science. Capital Notreal University Beijing 100048 China Department of Biology AI-Farabi Kazakh National University Ahnaty 050038 Kazakhstan

Parageotrupes incanus gen. et sp. nov. （Scarabaeoidea： Geotrupidae： Geotrupinae） is described and illustrated from the Yixian Formation of western Liaoning province, China.

关键词： Coleoptera fossil Scarabaeoidea Geotrupidae Geotrupinae new genus new species Yixian Formation China

SCENARIOS SIMULATION OF COUPLING SYSTEM BETWEEN URBANIZATION AND ECO-ENVIRONMENT IN JIANGSU PROVINCE BASED ON SYSTEM DYNAMICS MODEL

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Chinese Geographical Science 2005年第3期15卷 219-226页

作者： LIU Yao-bin LI ren-dong LI Chun-hua School of Management China University of Mining and Technology Xuzhou 221008 P. R. China Institute of Geodesy and Geophysics Research Chinese Academy of Sciences Wuhan 430077 P. R. China Institute of Resource Beijing Normal University Beijing 100875 P. R. China

By means of ISM (Interpretative Structural Modeling) and SD (System Dynamics) methods, this paper made a system dynamics model of urbanization and eco-environment coupling in Jiangsu Province according to the implication and PSR (Pressure State Response) framework of urbanization and eco-environment coupling. Moreover, five typical scenarios during 2000-2015 have been simulated and analyzed based on the time serial statistical data during 1990-2003 in Jiangsu, which indicates: firstly, there are significant differences between the results and the scenarios, and the five coupling models all have comparative advantages and drawbacks; secondly, in terms of the characteristics and regional development disparities of Jiangsu and the general rule of world urbanization process, this paper reveals that only when either population urbanization model or social urbanization model to be correspondingly adopted, the sustainable development among population, economy, urbanization and eco-environment can be realized.

关键词： urbanization eco-environment system dynamics model simulation Jiangsu Province

New fossil evidence of the early diversification of scarabs： AIIoioscarabaeus cheni （Coleoptera： Scarabaeoidea） from the Middle Jurassic of Inner Mongolia, China

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Insect Science 2012年第2期19卷 159-171页

作者： Ming Bai Dirk Ahrens Xing-Ke Yang dong ren Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijingChina Zoologisches Forschungsmuseum Alexander Koenig BonnGermany College of Life Sciences Capital Normal UniversityBeijingChina

Scarabaeoidea are known from the Lower Jurassic and may have originated in the Triassic based on fossil evidence and phylogenetic research. However, the early diversification of Scarabaeoidea remains unclear due to the lack of high-quality fossil evidence. Here we describe an exceptionally well-preserved new fossil of Scarabaeoidea, Alloioscarabaeus cheni gen. et sp. nov from the Middle Jurassic Jiulongshan Formation of Inner Mongolia, China. Based on a morphometric analysis using 17 landmarks of the hind wing of Alloioscarabaeus and 10 scarabaeoid families, we found that Alloioscarabaeus cheni gen. et sp. nov clearly does not belong to any of the known scarabaeoid families and, consequently, is a new family, Alloioscarabaeidae fam. nov., was erected. The discovery of Alloioscarabaeus brought further evidence for the early diversification of major scarab lineages which could allow more detail in the palaeobiogeography of the Scarabaeoidea and Northeast of China which might be one of the originating places or an important radiation place during the evolution of Scarabaeoidea. Alloioscarabaeidae were very likely not good diggers and might have fed on decaying organic materials. Based on the evidence we have now, we tend to believe that most families and some subfamilies of Scarabaeoidea were present in the Jurassic period.

关键词： Alloioscarabaeidae Alloioscarabaeus China geometric morphometrics,Jiulongshan Formation new family

Chiral magnetic effect for chiral fermion system

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Chinese Physics C 2020年第7期44卷 126-134页

作者： ren-Da dong ren-Hong Fang De-Fu Hou Duan She Institute of Particle Physics and Key Laboratory of Quark and Lepton Physics(MOS) Central China Normal UniversityWuhan 430079China

The chiral magnetic effect is concisely derived by employing the Wigner function approach in the chiral fermion ***,the chiral magnetic effect is derived by solving the Landau levels of chiral fermions in *** second quantization and ensemble average leads to the equation of the chiral magnetic effect for righthand and lefthand fermion *** chiral magnetic effect arises uniquely from the contribution of the lowest Landau *** carefully analyze the lowest Landau level and find that all righthand(chirality is+1)fermions move along the direction of the magnetic field,whereas all lefthand(chirality is-1)fermions move in the opposite direction of the magnetic ***,the chiral magnetic effect can be explained clearly using a microscopic approach.

关键词： CME Landau levels chiral fermions

New Jurassic Pseudopolycentropodids from China (Insecta: Mecoptera)

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Acta Geologica Sinica(English Edition) 2010年第1期84卷 22-30页

作者： ren dong SHIH Chungkun Conrad C. LABANDEIRA College of Life Science Capital Normal University Beijing 100048 China Department ofPaleobiology Smithsonian Institution National Museum of Natural History Washington DC 20560 USA

In this paper two new species of fossil Pseudopolycentropus Handlirsch, 1906 are described： Pseudopolycentropus janeannae sp. nov. and P. novokshonovi, sp. nov. All of them were recovered from the Middle Jurassic non-marine sedimentary strata of northeastern China. The new material from China reveals that the early diversification of pseudopolycentropodids was well underway by the Middle Jurassic.

关键词： Pseudopolycentropodidae Mecoptera fossil new taxa Jurassic China