检索结果-南通市图书馆

The effect of bladder function on the efficacy of transurethral prostatectomy in patients with benign prostatic hyperplasia:a retrospective,single-center study

引用

Asian Journal of Andrology 2024年第1期26卷 112-118页

作者： Jin Li Xian-Yan-Ling Yi Ze-Yu Chen Bo Chen Yin Huang Da-Zhou liao Pu-Ze Wang De-Hong Cao Jian-Zhong Ai Liang-ren Liu West China School of Medicine Sichuan UniversityChengdu 610041China Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China

We investigated the impact and predictive value of bladder function in patients with benign prostatic hyperplasia(BPH)on the efficacy of transurethral ***,imaging,and urodynamic data of patients who underwent transurethral prostatectomy at West China Hospital of Sichuan University(Chengdu,China)from July 2019 to December 2021 were ***-up data included the quality of life(QoL),International Prostate Symptom Score(IPSS),and IPSS storage and voiding(IPSS-s and IPSS-v).Moreover,urinary creatinine(Cr),nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF),and prostaglandin estradiol(PGE2)were measured in 30 patients with BPH and 30 healthy *** indicators were determined by subgroup analyses and receiver operating characteristic(ROC)curve *** the 313 patients with BPH included,patients with severe micturition problems had more improvements but higher micturition grades postoperatively than those with moderate ***,good bladder sensation,compliance,and detrusor contractility(Dc)were predictors of low postoperative IPSS and *** urinary concentrations of BDNF/Cr,NGF/Cr,and PGE2/Cr in patients were significantly higher than those in healthy participants(all P<***1).After evaluation,only DC was significantly related to both urinary indicators and postoperative recovery of *** with good DC,as predicted by urinary indicators,had lower IPSS and IPSS-v than those with reduced DC at the 1st month postoperatively(both P<0.05).In summary,patients with impaired bladder function had poor *** combined levels of urinary BDNF/Cr,NGF/Cr,and PGE2/Cr in patients with BPH may be valid predictors of preoperative bladderfunction and postoperative recovery.

关键词： BPH function of bladder IPSS:urodynamics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study on Refined Forecast Method of Daily Maximum Temperature in Wugang City from July to September

引用

Meteorological and Environmental Research 2012年第3期3卷 6-8页

作者： liao ren-guo LV Xiao-hua LIU Xu-lin HE Wei-hui DAI Chuan-hong Wugang Meteorological Bureau Wugang 422400 China Shaoyang Meteorological Bureau Shaoyang 422000 China

[Objective] The aim was to study the refined forecast method of daily highest temperature in Wugang City from July to September. IM[ethod] By dint of ECMWF mode product and T231 in 2009 and 2010 and daily maximum temperature in the station in corresponding period, multi-factors similar forecast method to select forecast sample, multivariate regression multi-mode integration MOS method, after dynamic corrected mode error and regression error, dynamic forecast equation was concluded to formulate the daily maximum temperature forecast in 24 -120 h in Wugang City from July to September. [ Result] Through selection, error correction, the daily maximum temperature equation in Wugang City from July to September was concluded. Through multiple random sampling, F test was made to pass test with significant test of 0.1. [ Conclusionl The method integrated domestic and foreign forecast mode, made full use of useful information of many modes, absorbed each others advantages, con- sidered local regional environment, lessen mode and regression error, and improved forecast accuracy.

关键词： Daily maximum temperature Multi-mode integration MOS method Dynamic forecast equatio China

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical constituents from Kalanchoe hybrida and their cytotoxicity

引用

Chinese Herbal Medicines 2018年第2期10卷 231-235页

作者： Ping-chung Kuo Hsin-yi Hung Yu-ren liao Yu-yi Chan Tian-shung Wu School of Pharmacy College of Medicine National Cheng Kung University Department of Biotechnology Southern Taiwan University of Technology Department of Pharmacy College of Pharmacy and Health Care Tajen University

Objective：Kalanchoe hybrida（Crassulaceae）is naturalized throughout all the island of Taiwan in *** preliminary bioassay-guided fractionation of the crude extract of *** exhibited that the chloroform and n-butanol fractions possessed potent cytotoxicity against MCF-7,NCI-H460,and SF-268 tumor cell lines at 50μg/m L ***,*** was selected as a target and the chemical constituents from the chloroform and n-butanol fractions of the crude extracts of *** were *** potential constituents were examined for their cytotoxicity against the tumor cell ***：A combination of conventional chromatographic techniques was performed on the crude extract of *** chemical structures of the purified constituents were identified on the basis of spectroscopic and spectrometric ***：The purification results had led to the characterization of totally 37 *** isolated compounds 1,2,and 4–12 were examined for their cytotoxicity in vitro,and bufadienolides 4–8 and flavonol glycoside 11 displayed significant cytotoxicity towards all the tested tumor cell lines among these tested ***：The results indicated that these principles should be responsible for the bioactivity of corresponding partial *** potential constituents could be further investigated to explore the new natural lead drugs.

关键词： bufadienolide Crassulaceae cytotoxicity flavonol glycoside Kalanchoe hybrida(J. D. Hooker)Vilmorin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

TP53-specific mutations serve as a potential biomarker for homologous recombination deficiency in breast cancer:a clinical next-generation sequencing study

引用

Precision Clinical Medicine 2024年第2期7卷 122-131页

作者： Yongsheng Huang Shuwei ren Linxiaoxiao Ding Yuanling jiang Jiahuan Luo Jinghua Huang Xinke Yin Jianli Zhao Sha Fu Jianwei liao Cellular&Molecular Diagnostics Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Clinical Laboratory The Sixth Affliated HospitalSun Yat-sen UniversityGuangzhou 510655China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Guangzhou Regenerative Medicine and Health Guangdong LaboratorySun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Background:TP53 mutations and homologous recombination deficiency(HRD)occur frequently in breast ***,the characteristics of TP53 pathogenic mutations in breast cancer patients with/without HRD are not ***:Clinical next-generation sequencing(NGS)of both tumor and paired blood DNA from 119 breast cancer patients(BRCA-119 cohort)was performed with a 520-gene ***,tumor mutation burden(TMB),and genomic HRD scores were assessed from NGS *** data from 47 breast cancer patients in the HRD test cohort were analyzed for further ***:All TP53 pathogenic mutations in patients had somatic origin,which was associated with the protein expression of estrogen receptor and progestogen *** to patients without TP53 pathologic mutations,patients with TP53 pathologic mutations had higher levels of HRD scores and different genomic *** frequency of TP53 pathologic mutation was higher in the HRDhigh group(HRD score≥42)relative to that in the HRD-low group(HRD scorerent mutational characteristics between the HRD-low and HRD-high ***53-specific mutation subgroups had diverse genomic features and ***,TP53 pathogenic mutations predicted the HRD status of breast cancer patients with an area under the curve(AUC)of ***53-specific mutations,namely HRD-low mutation,HRD-high mutation,and HRD common mutation,predicted the HRD status of breast cancer patients with AUC values of 0.32,0.72,and 0.58,***,TP53 HRD-high mutation and HRD common mutation combinations showed the highest AUC values(0.80)in predicting HRD ***:TP53-specific mutation combinations predict the HRD status of patients,indicating that TP53 pathogenic mutations could serve as a potential biomarker for poly-ADP-ribose polymerase(PARP)inhibitors in breast cancer patients.

关键词： next-generation sequencing homologous recombination deficiency TP53 breast cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

激发艺术设计构思之联想式教学

引用

装饰 2009年第5期 139-140页

作者：任彝廖国华浙江工业大学艺术学院杭州科技职业技术学院

如何以一种生动、新颖、有效的教学模式,去发掘那些有志于从事艺术设计学生的潜在能力,是教师所面临的重要课题。本文以"不同媒介对个体所产生的刺激与反应"为线索,以设计心理学为基础,设计教学实践为平台,去尝试一种全新的教学模式,即... 详细信息

如何以一种生动、新颖、有效的教学模式,去发掘那些有志于从事艺术设计学生的潜在能力,是教师所面临的重要课题。本文以"不同媒介对个体所产生的刺激与反应"为线索,以设计心理学为基础,设计教学实践为平台,去尝试一种全新的教学模式,即激发艺术设计构思之联想式教学,以培养学生的创造性思维及创新能力。

关键词：联想式教学静态媒介动态媒介

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transferrin Is Up-Regulated by Microbes and Acts as a Negative Regulator of Immunity to Induce Intestinal Immunotolerance

引用

Research 2024年第3期7卷 761-774页

作者： Xiaopeng Tang Mingqian Fang Ruomei Cheng Junkun Niu Xiaoshan Huang Kuanhong Xu Gan Wang Yang Sun Zhiyi liao Zhiye Zhang James Mwangi Qiumin Lu Aili Wang Longbao Lv Chao Liu Yinglei Miao ren Lai Engineering Laboratory of Peptides of Chinese Academy of Sciences Key Laboratory of Bioactive Peptides of Yunnan ProvinceKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Center for Non-Human PrimatesNational Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)and Sino-African Joint Research CenterNew Cornerstone Science InstituteKunming Institute of Zoologythe Chinese Academy of SciencesNo.17 Longxin RoadKunmingYunnan650201China School of Basic Medicine Qingdao UniversityQingdao 266071ShandongChina. Department of Gastroenterology First Affiliated Hospital of Kunming Medical UniversityYunnan Institute of Digestive DiseaseKunming 650032YunnanChina Yunnan Province Clinical Research Center for Digestive Diseases Kunming 650032YunnanChina Kunming College of Life Science University of Chinese Academy of SciencesKunming 650204YunnanChina Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences University of Science and Technology of ChinaHefei 230027AnhuiChina Center for Evolution and Conservation Biology Southern Marine Science and Engineering Guangdong LaboratoryGuangzhou 511458GuangdongChina.

Cross-talks (e.g., host-driven iron withdrawal and microbial iron uptake between host gastrointestinal tract and commensal microbes) regulate immunotolerance and intestinal homeostasis. However, underlying mechanisms that regulate the cross-talks remain poorly understood. Here, we show that bacterial products up-regulate iron-transporter transferrin and transferrin acts as an immunosuppressor by interacting with cluster of differentiation 14 (CD14) to inhibit pattern recognition receptor (PRR) signaling and induce host immunotolerance. Decreased intestinal transferrin is found in germ-free mice and human patients with ulcerative colitis, which are characterized by impaired intestinal immunotolerance. Intestinal transferrin and host immunotolerance are returned to normal when germ-free mice get normal microbial commensalism, suggesting an association between microbial commensalism, transferrin, and host immunotolerance. Mouse colitis models show that transferrin shortage impairs host’s tolerogenic responses, while its supplementation promotes immunotolerance. Designed peptide blocking transferrin–CD14 interaction inhibits immunosuppressive effects of transferrin. In monkeys with idiopathic chronic diarrhea, transferrin shows comparable or even better therapeutic effects than hydrocortisone. Our findings reveal that by up-regulating host transferrin to silence PRR signaling, commensal bacteria counteract immune activation induced by themselves to shape host immunity and contribute for intestinal tolerance.

关键词： impaired immunity tolerance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

氯胺酮诱导不同年龄大鼠脑海马区热休克蛋白70表达的量效依赖性(英文)

引用

中国临床康复 2005年第32期9卷 242-244页

作者：廖刃王泉云张兰四川大学华西医院麻醉学与危重医学教研室四川省成都市610041

背景:研究证实,热休克蛋白70家族的蛋白质对细胞有保护作用。氯胺酮可导致患者出现幻觉、谵妄等精神症状,可对大鼠边缘系统神经元产生损害,在这些受损的神经元内用免疫组化染色方法可检测到热休克蛋白70的表达。目的:观察不同剂量的氯... 详细信息

背景:研究证实,热休克蛋白70家族的蛋白质对细胞有保护作用。氯胺酮可导致患者出现幻觉、谵妄等精神症状,可对大鼠边缘系统神经元产生损害,在这些受损的神经元内用免疫组化染色方法可检测到热休克蛋白70的表达。目的:观察不同剂量的氯胺酮在不同年龄大鼠海马中诱导热休克蛋白70的表达,探讨氯胺酮对神经损害的作用。设计:随机对照实验。单位:四川大学华西医院麻醉学与危重医学教研室。材料:实验于2000-01/05在四川大学华西医院麻醉学与危重医学教研室实验室完成。选择SD大鼠70只,雌雄不限,清洁级。方法:35只成年SD大鼠随机分为对照组和氯胺酮20.0,40.0,60.0,80.0,100.0,120.0mg/kg6个实验组,每组5只,分别给予生理盐水和氯胺酮20.0,40.0,60.0,80.0,100.0,120.0mg/kg腹腔内注射。另取0～10,11～20,21～30,31～45,46～60,61～90,91～120d年龄阶段大鼠35只,每个年龄段5只,分别腹腔内注射氯胺酮80.0mg/kg。给药后正常喂养24h后,在麻醉状态下快速断头取脑,于海马取5μm冠状切面切片,应用免疫组化染色检测大鼠海马中热休克蛋白70的表达。主要观察指标:大鼠海马热休克蛋白70阳性细胞百分率、密度和灰度值。结果:70只大鼠均进入结果分析。①不同剂量氯胺酮对大鼠脑海马区热休克蛋白70表达:对照组,20.0,40.0,60.0,80.0,100.0,120.0mg/kg剂量氯胺酮组诱导热休克蛋白70表达的阳性细胞密度分别为0,8.12±1.82,27.07±5.98,45.35±5.84,78.51±7.34,74.16±8.17,60.84±6.27。可见氯胺酮剂量在80.0mg/kg以内,随剂量的增加,热休克蛋白70阳性细胞密度显著增加(P0.05)。结论:氯胺酮可诱导热休克蛋白70在大鼠脑海马区表达,提示海马区的神经元可能受到损害;随剂量的增加,其损害作用加强;氯胺酮对成年大鼠的脑损害作用大于幼鼠。

关键词：脑海马氯胺酮热休克蛋白质类

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

化学联合调控对玉米光合特性及产量的影响

引用

干旱地区农业研究 2016年第1期34卷 193-200页

作者：朱元浩杨培岭廖人宽任树梅中国农业大学水利与土木工程学院北京100083

在水分胁迫条件下,结合有机-无机复合型土壤保水剂(SAP)与膜反射型抗蒸腾剂黄腐酸(FA)两种化学制剂,探究联合调控与单一调控下春玉米光合作用的响应规律及其产量驱动机理。试验采用随机区组设计,设置了CK,SAP,SAP+FA,FA 4个处理。结果表... 详细信息

在水分胁迫条件下,结合有机-无机复合型土壤保水剂(SAP)与膜反射型抗蒸腾剂黄腐酸(FA)两种化学制剂,探究联合调控与单一调控下春玉米光合作用的响应规律及其产量驱动机理。试验采用随机区组设计,设置了CK,SAP,SAP+FA,FA 4个处理。结果表明:SAP是调蓄土壤含水量的控制因素,较CK增加12%以上;化控制剂有其有效作用期,SAP作用于整个玉米生育期,而FA在拔节中后期对光合的促进最明显;SAP+FA处理比CK产量增加21.3%,比FA和SAP分别增加9.3%、11.7%,与光合强度呈现出一致性。

关键词： SAP 黄腐酸(FA) 光合特性水分胁迫玉米产量

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

关于“单位GDP碳排放”概念的探析

引用

湖南大学学报（社会科学版） 2010年第5期24卷 74-76页

作者：张文婧廖进中廖任飞湖南大学经济与贸易学院湖南长沙410082

中国政府公布的基于"单位GDP碳排放"概念的相对减排目标,体现了发展中国家在面对气候变化时"发展优先"的原则,但由于没有将非国民因素产生的收益及碳排放予以剔除而具有局限性。基于此,本文提出"单位GNI碳排放"概念。它结合国民总收入... 详细信息

中国政府公布的基于"单位GDP碳排放"概念的相对减排目标,体现了发展中国家在面对气候变化时"发展优先"的原则,但由于没有将非国民因素产生的收益及碳排放予以剔除而具有局限性。基于此,本文提出"单位GNI碳排放"概念。它结合国民总收入这一反映国家经济发展真实水平和国民福利水平的指标,能更科学地体现中国实际经济发展和温室气体排放水平。

关键词：气候危机单位GDP碳排放单位GNI碳排放

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

论大学生信息素质评估体系的建立

引用

图书馆论坛 2006年第1期26卷 60-63页

作者：廖仁光臧凤梅广州大学图书馆广东广州510405

大学生信息素质培养的不可或缺性已为人们所共识。但无论是国内还是国外,当代大学生的信息素质仍然不高。为此,笔者提出了大学生信息素质评估体系的构建原则及内涵,并制定了一个经过文检课教学实践检验,比较成功的大学生信息素质评估标... 详细信息

大学生信息素质培养的不可或缺性已为人们所共识。但无论是国内还是国外,当代大学生的信息素质仍然不高。为此,笔者提出了大学生信息素质评估体系的构建原则及内涵,并制定了一个经过文检课教学实践检验,比较成功的大学生信息素质评估标准体系。

关键词：信息素质评估体系建立

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：