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A Prototype for Diagnosis of Psoriasis in Traditional Chinese Medicine

Computers, Materials & Continua 2022年第12期73卷 5197-5217页

作者： Hai Long Zhe Wang Yidi Cui Junhui Wang Bo Gao Chao Chen Yan Zhu heinrich Herre Institute of Medical Informatics Statistics and EpidemiologyUniversity of LeipzigLeipzig04107Germany Zhejiang Academy of Traditional Chinese Medicine Hangzhou310007China Tongde Hospital of Zhejiang Province Hangzhou310007China Guang’anmen Hospital China Academy of Chinese Medical SciencesBeijing100053China Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing100700China

Psoriasis is a chronic,non-communicable,painful,disfiguring and disabling disease for which there is no cure,with great negative impact on patients’quality of life(QoL).Diagnosis and treatment with traditional Chinese medical technique based on syndrome differentiation has been used in practice for a long time and proven effective,though,up to now,there are only a few available studies about the use of semantic technologies and the knowledge systems that use Traditional Chinese Medicine(TCM)-syndrome differentiation for information retrieval and automated *** this paper we use semantic techniques based on ontologies to develop a prototypical system for the diagnosis of *** this purpose,a domain ontology is developed for syndrome differentiation of psoriasis vulgaris(PV).This ontology is founded on an adapted version of the general formal ontology(GFO),with the evidence-based clinical practice guideline of TCM for psoriasis vulgaris(Guideline 2013)as the primary data *** implemented prototype,called ONTOPV,contains this domain ontology and is aimed at a decision support system for diagnosis and treatment of *** system uses a case-database for Case Based Reasoning(CBR),combined with fuzzy pattern *** results show that the ONTOPV realizes the basic functionalities of data collection,querying,browsing and navigation,and supports rule-based knowledge reasoning,and integrates fuzzy pattern *** can provide users with clinical decision support for TCM syndrome differentiation in diagnosis of psoriasis.

关键词： Clinical guideline knowledge base GFO ontology TCM CBR fuzzy pattern recognition psoriasis vulgaris

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Priority areas for watershed service conservation in the Guapi-Macacu region of Rio de Janeiro,Atlantic Forest,Brazil

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Ecological Processes 2014年第1期3卷 95-115页

作者： Vanesa Rodriguez Osuna Jan Borner Udo Nehren Rachel Bardy Prado Hartmut Gaese Jurgen heinrich Center for Development Research(ZEF) Department of Economic and Technological ChangeUniversity of BonnWalter-Flex-Str.353117 BonnGermany Institute for Technology and Resources Management in the Tropics and Subtropics(ITT) Cologne University of Applied SciencesBetzdorfer Str.250679 CologneGermany Empresa Brasileira de Pesquisa Agropecuária(EMBRAPA Soils) Brazilian Enterprise for Agricultural ResearchGeotechnologies and Environmental MonitoringRua Jardim BotanicoCEP 22460-000 Rio de JaneiroBrazil Institute for Geography Department of Physical GeographyUniversity of LeipzigJohannisallee 19a04103 LeipzigGermany

Introduction:Land use intensification and urbanisation processes are degrading hydrological ecosystem services in the Guapi-Macacu watershed of Rio de Janeiro.A proposal to pay farmers to restore natural watershed services might be an alternative to securing the water supply in the long-term for the around 2.5 million urban water users in the study *** study quantifies the costs of changing current land use patterns to enhance watershed services and compares these costs to the avoided costs associated with water treatment for public ***:We use farm-household data to estimate the opportunity costs of abandoning current land uses for the recovery of natural vegetation;a process that is very likely to improve water quality in terms of turbidity due to reduced inputs from *** cost estimates are extrapolated to the watershed scale based on remote sensing land use classifications and vulnerability analysis to identify priority zones for watershed management *** assess the potential demand for watershed services,we analyse water quality and treatment cost data from the main local water treatment ***:Changing agricultural land uses for watershed services provision generally comes at high opportunity costs in our study area near to the metropolis of Rio de *** low cost watershed conservation options do exist in the livestock production *** options have the potential to directly reduce the amount of sediments and nutrients reaching the water bodies,and in turn decrease the costs of treatment needed for drinking *** cover changes at the scale needed to improve water quality will,nonetheless,likely exceed the cost of additional investments in water ***:The state water utility company’s willingness to pay for watershed services alone will not be enough to induce provision of additional watershed *** conclude that monetary incentives conditioned on specific adjustme

关键词： Water services Drinking water treatment Water quality Incentive-based watershed management

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Hypercalcaemia after treatment with denosumab in children:bisphosphonates as an option for therapy and prevention?

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World Journal of Pediatrics 2020年第5期16卷 520-527页

作者： Carmen Sydlik Hans Roland Dürr Susanne Bechtold-Dalla Pozza Claudia Weiβenbacher Julia Roeb heinrich Schmidt Department of Pediatric Endocrinology Dr.v.Haunersches Children's HospitalLudwig-Maximilian-University of MunichLindwurmstr.480337 MunichGermany Department of Orthopaedics Physical Medicine and RehabilitationUniversity HospitalLudwig-Maximilian-University of MunichMunichGermany

Background Pharmacologic options for treatment of osteolytic diseases especially in children are *** not licensed for use,denosumab,a fully humanized antibody to RANKL,is used in children with good *** others,one possible indication are giant cell tumors and aneurysmatic bone ***,there are reports of severe hypercalcemia during weeks to months after termination of denosumab,that are rarely seen in *** We collected data of four patients,aged 6-17 years,who experienced severe hypercalcemia after completion of treatment with denosumab for unresectable giant cell tumors of bone or aneurysmal bone cysts and methods of their *** detailed case information were *** One patient was treated with long-term,high-dose steroid therapy,leading to typical Cushing's *** patient was restarted on denosumab repeatedly due to relapses of hypercalcemia after every ***,in two patients,hypercalcemia ceased definitely after treatment with ***,several applications were necessary to stabilize calcium *** There is a considerable risk of hypercalcemia as an adverse effect after denosumab treatment in *** and,preferably,preventive strategies are *** seem to be an option for both,but effective proceedings still remain to be established.

关键词： Aneurysmatic bone cyst Bisphosphonates Calcium homeostasis Denosumab Giant cell tumor of the bone

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Fighting Climatic Change by NASEM with Help of Non-thermal Optical Laser Pressure

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Journal of Energy and Power Engineering 2021年第5期15卷 163-168页

作者： heinrich Hora University of NSW and HB11 HoldingSydneyAustralia

For de-carbonisation of chemical energy generation,the use of ten million times higher nuclear energy per reaction is considered by the report of NASEM(National Academies of Science,Engineering and Medicine)of the *** is considered with nuclear fusion reactions needing thermal pressures at many million *** difficulty can be overcome by recent results of non-thermal pressures from very extreme CPA(Chirped Pulse Acceleration)laser pressures,with the clean fusion of hydrogen and boron=11 eliminating nuclear radiation problems.

关键词： Nuclear fusion using CPA lasers clean fusion of H with 11B non-thermal pressure

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Model of the Pulsing Atom

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Advances in Materials Physics and Chemistry 2017年第5期7卷 188-197页

作者： heinrich Ehrlich Chemical Department Lomonosov Moscow State University Moscow Russia

In this work, we reanalyzed the movement of an electron in the electrostatic field of nucleus. The trajectory of the electron’s motion is an ellipse with a minor semiaxis, tending towards zero. From a mathematical point of view the movement of an electron in such an orbit will be equivalent to the oscillation of an electron. The action produced by electrons in movement between stationary points is discrete and proportional to a Planck constant. This condition sets the allowable values of the electron energy and the radius of their orbit. Electrons on the same shell perform symmetric synchronous oscillations. Their frequency is of the order of 1016 Hz. Most of the time the electrons are located on the periphery of the atom, periodically they simultaneously rush to the nucleus, the atom rapidly compresses and immediately decompresses, i.e. pulsates. The model gives Bohr formula for the energy of single-electron atom and suitable values of ionization potentials of the atoms of the second period of the Periodic Table.

关键词： Atom Structure Quantum Theory Oscillation Bohr-Sommerfeld Model Ionization Potentials

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Comparative eye-tracking evaluation of scatterplots and parallel coordinates

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Visual Informatics 2017年第2期1卷 118-131页

作者： Rudolf Netzel Jenny Vuong Ulrich Engelke Seán O’Donoghue Daniel Weiskopf Julian heinrich Visualization Research Center(VISUS) University of StuttgartStuttgartGermany Commonwealth Scientific and Industrial Research Organisation(CSIRO)(Sydney Hobart)Australia University of Tübingen TübingenGermany

We investigate task performance and reading characteristics for scatterplots(Cartesian coordinates)and parallel *** a controlled eye-tracking study,we asked 24 participants to assess the relative distance of points in multidimensional space,depending on the diagram type(parallel coordinates or a horizontal collection of scatterplots),the number of data dimensions(2,4,6,or 8),and the relative distance between points(15%,20%,or 25%).For a given reference point and two target points,we instructed participants to choose the target point that was closer to the reference point in multidimensional *** present a visual scanning model that describes different strategies to solve this retrieval task for both diagram types,and propose corresponding hypotheses that we test using task completion time,accuracy,and gaze positions as dependent *** results show that scatterplots outperform parallel coordinates significantly in 2 dimensions,however,the task was solved more quickly and more accurately with parallel coordinates in 8 *** eye-tracking data further shows significant differences between Cartesian and parallel coordinates,as well as between different numbers of *** parallel coordinates,there is a clear trend toward shorter fixations and longer saccades with increasing number of *** an area-of-interest(AOI)based approach,we identify different reading strategies for each diagram type:For parallel coordinates,the participants’gaze frequently jumped back and forth between pairs of axes,while axes were rarely focused on when viewing Cartesian *** further found that participants’attention is biased:toward the center of the whole plot for parallel coordinates and skewed to the center/left side for Cartesian *** anticipate that these results may support the design of more effective visualizations for multidimensional data.

关键词： Parallel coordinates Scatterplots Cartesian coordinates Eye tracking Controlled laboratory user study

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Entropy, Biological Evolution and the Psychological Arrow of Time

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Journal of Modern Physics 2016年第2期7卷 228-236页

作者： Torsten heinrich Benjamin Knopp heinrich Päs Institute for Institutional and Innovation Economics University of Bremen Bremen Germany Fachbereich Physik AG Neurophysik Philipps-Universit&#228 t Marburg Marburg Germany Fakultä t für Physik Technische Universit&#228 t Dortmund Dortmund Germany

We argue that in Universes where future and past differ only by the entropy content a psychological arrow of time pointing in the direction of entropy increase can arise from natural selection in biological evolution. We show that this effect can be demonstrated in very simple toy computer simulations of evolution in an entropy increasing or decreasing environment.

关键词： Arrow of Time Time Asymmetry Entropy Evolution

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Influence of zone formation on stability of continuous fluidized bed layering granulation with external product classification

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Particuology 2015年第6期13卷 1-7页

作者： C. Dreyschultze C. Neugebauer S. Palis A. Buck E. Tsotsas S. heinrich A. Kienle Otto yon Guericke University Universit~tsplatz 2 D-39106 Magdeburg Germany Max Planck Institute for Dynamics of Complex Technical Systems Sandtorstraabe 1 D-39106 Magdeburg Germanyc Hamburg University of Technology Denickestrae 15 D-21073 Hamburg Germany

Continuous fluidized bed layering granulation with external product classification and a sieve-mill cycle can show instability in the form of self-sustained nonlinear oscillations of the particle size distribution. In the present study, the stability and bifurcation analysis of this process is presented. The underlying process models explicitly account for compartmentalization of the fluidized bed into a granulation and a drying zone, which is an important feature of many technical processes. Implications for plant operations are discussed with the help of stability diagrams as a function of zone size, residence time within different zones, the addition of external seeds and particular properties of the sieve-mill cycle.

关键词： Fluidized bed Granulation Population balance Stability Bifurcation

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Forest-grassland biodiversity hotspot under siege:land conversion counteracts nature conservation

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Ecosystem Health and Sustainability 2016年第6期2卷 1-12页

作者： Julia-Maria Hermann Marion Lang Juliana Gonçalves heinrich Hasenack Technische Universitat München Freising85354 Germany Universidade Federal do Rio Grande do Sul Porto Alegre91501-970 Brazil

We report extent and rate of land use/land cover change in a forest-grassland mosaic of Rio Grande do Sul,Brazil,during a recent period of increasing conflicts between native habitat protection and *** area is part of the Atlantic rain forest biome,a Global Biodiversity *** Landsat and Google Earth imagery,and calculating an effective conservation risk index(ECRI)as ratio of converted to remnant area,we specifically compared the effectiveness of designated fully protected areas(FP-PAs)and Sustainable Use areas(SU-PAs)in preventing conversion of native forest and grassland hab-itats for agri-and silviculture,relative to areas *** area decreased by 17%,corresponding to a net loss of 59,671 ha,in the entire *** gains exceeded losses,and ECRI was zero inside Full Protection ***-native tree plantation area increased by 94%over the entire study area;cropland increased by 7%.Conversion for silviculture predominated outside the designated PAs and conversion for agriculture predominated inside the designated *** was generally higher for grassland than forest,and in SU-PAs,grassland ECRI was several times higher than in areas without any protection *** developments are in stark contrast to the high standards of the Brazilian protected area system and corre-sponding International Union for Conservation of Nature and Natural Resources *** are due to protracted regularization of land conversion and establishment of designated protection ***-more,they reveal the dilemma of previously managed grasslands in strictly protected areas being eventually succeeded by forest,and the hazards of broad interpretation of the term“sustainable development”.

关键词： conservation risk protected area strict protection sustainable use temperate grasslands

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Extreme CPA Laser Pulses for Igniting Nuclear Fusion of Hydrogen with Boron-11 by Non-thermal Pressures for Avoiding Ultrahigh Temperatures

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Journal of Energy and Power Engineering 2020年第5期14卷 156-177页

作者： heinrich Hora Department of Theoretical Physics University of New South WalesSydney 2052Australia HB11 Energy Holding Pty/Ltd Freshwater 2096Australia

Ten million times more compact energy than from burning carbon can be obtained from nuclear fusion reactions corresponding to equilibrium temperature reactions in the range above 100 million *** the energy gain in stars,one has to gain nuclear energy from slamming very light nuclei where however the extremely high temperatures above 100 million degrees are needed for the sufficient pressures at thermal equilibrium ignition.A radically new option works with non-thermal pressures of picosecond laser pulses at ultrahigh optical powers by nonlinear forces of *** nuclear fusion of hydrogen with the isotope 11 of boron produces primarily harmless helium and has no problems with dangerous radioactive waste and excludes any catastrophic melt-down as fission reactors,it has the potential to be of low costs and can supply the Earth for more than 10,000 years with electricity.

关键词： Laser boron fusion non-thermal ignition plasma block acceleration CPA pulses

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