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Effects of melatonin on the oxidative damage and pancreatic antioxidant defenses in ceruleininduced acute pancreatitis in rats

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Hepatobiliary & Pancreatic diseases International 2014年第4期13卷 442-446页

作者： Cristina Carrasco Ana Beatriz rodríguez José A Pariente department of Physiology Neuroimmunophysiology and Chrononutrition Research Group University of Extremadura

BACKGROUNd： Oxidative stress is recognized as a pivotal effector of several pathogenic processes, including acute pancreatitis. Reactive oxygen species not just cause damage on the main cellular components, but also influence the expression of antioxidant system genes. Antioxidant molecules, such as melatonin, could be good candidates for the treatment of this multidimensional disease. The present study was to evaluate the chemopreventive effect of melatonin in a rat model of ceruleininduced acute ***： Four subcutaneous injections of cerulein（20 μg/kg body weight） were given to Wistar rats at two hours intervals;melatonin was injected intraperitoneally（25 mg/kg body weight）30 minutes before each injection of cerulein. Lipid peroxidation,protein oxidation（carbonyl groups）, total antioxidant status,and glutathione peroxidase activity were determined in pancreatic tissue using commercial ***： The chemopreventive administration of melatonin caused a reduction in lipid peroxidation and protein oxidation due to injections of cerulein. Additionally, melatonin treatment was also able to revert glutathione peroxidase activity and total antioxidant status near to control levels, suggesting that melatonin could prevent from oxidative phenomena in the pancreas, such as lipid peroxidation and protein oxidation,and could stimulate, directly or indirectly, the expression of antioxidant ***： Melatonin, a polyvalent antioxidant, protected the pancreatic damage via the decrease of oxidative stress andincrease of the activities of antioxidant enzymes in ceruleininduced acute pancreatitis.

关键词： acute pancreatitis antioxidants cerulein melatonin oxidative stress

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Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

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digital Social Connectedness as a Lifeline for Older People: Use and Non-use of VinclesBCN during the Pandemic

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International Journal of disaster Risk Science 2024年第2期15卷 251-264页

作者： Israel rodríguez‑Giralt daniel López‑Gómez Roser Beneito‑Montagut Carenet IN3Universitat Oberta de Catalunya08018 BarcelonaSpain School of Social Sciences Cardif UniversityCardif CF103NSWalesUK

This article presents the results of a study that evaluated VinclesBCN during COVId-19. This digital-based public social service aims to prevent loneliness and isolation in +65-year-old adults living in Barcelona. Through service user(N = 12) and professional(N = 6) interviews and a questionnaire with service users(N = 255), we demonstrate the pivotal role of digital connectedness in transforming VinclesBCN into a lifeline during the pandemic. The analysis revealed the importance of sociability, social support, and, especially, entertainment in coping with pandemic fatigue and facilitating social connectivity and support among users. Users engaged in activities such as sharing images, songs, memes, and daily greetings to provide proximity, sociability, and care among users, whether they belonged to preexisting groups or were newly introduced to the platform. It also facilitated the identification of individuals who needed companionship, comfort, or more specialized support. The findings emphasize the significance of entertainment as a resilience-building strategy during times of uncertainty. despite the positive impact, not all users equally used the platform. Non-use was strongly associated with being a woman, having a low educational level, having preexisting social relationships, less time of enrolment in the platform, as well as a high perception of loneliness, poor self-reported health, and low mood. The article underscores the need for further research into older adults' digital engagement during crises, its role in building resilience, and advocating for inclusive digital interventions that take into account diverse older adults' needs and experiences in crisis contexts.

关键词： Barcelona COVId-19 pandemic digital social connectedness Entertainment Older adult resilience Public digital service

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determination of the ground vibration attenuation law from a singleblast: A particular case of trench blasting

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第5期13卷 1182-1192页

作者： Rafael rodríguez Laura García de Marina Marc Bascompta Cristóbal Lombardía department of Mining Exploitation and Prospecting School of MiningEnergy and Materials EngineeringUniversity of OviedoIndependencia 13Oviedo33004Spain department of Mining Industrial and ICT EngineeringPolytechnic University of Catalonia(UPC)ManresaAv.Bases de Manresa61-73Barcelona08242Spain Perforaciones Noroeste S.A Longoria Carbajal No.3Oviedo33004Spain

The general transmissivity law of ground vibrations was studied,and a user-friendly methodology for determining the behavior of vibrations generated in any rock mass is *** study was based on a single blast in a trench excavation,analyzing the vibration components recorded from two fixed *** attenuation law and the main variables according to the legal requirements,frequency and peak particle velocity(PPV),are defined with this novel method,achieving a high confidence level in a simple *** proposed approach can also have an important impact in terms of reducing the potential consequences of vibrations for the surrounding construction and achieving the required definition of rock *** the cost and time in many projects where blasting techniques are applied is particularly useful for the design of future blasts.

关键词： Empirical analysis Blasting Ground vibration Trenching Wave propagation

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development and postnatal neurogenesis in the retina: a comparison between altricial and precocial bird species

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Neural Regeneration Research 2021年第1期16卷 16-20页

作者： Guadalupe Álvarez-Hernán José Antonio de Mera-rodríguez Yolanda Gañán Jorge Solana-Fajardo Gervasio Martín-Partido Joaquín rodríguez-León Javier Francisco-Morcillo Área de Biología Celular Departamento de AnatomíaBiología Celular y ZoologíaFacultad de CienciasUniversidad de ExtremaduraBadajozSpain Área de Anatomía Humana Departamento de AnatomíaBiología Celular y ZoologíaFacultad de MedicinaUniversidad de ExtremaduraBadajozSpain Servicio de Oftalmología Complejo Hospitalario Universitario de BadajozBadajozSpain

The visual system is affected by neurodegenerative diseases caused by the degeneration of specific retinal neurons,the leading cause of irreversible blindness in *** vertebrate phylogeny,the retina has two kinds of specialized niches of constitutive neurogenesis:the retinal progenitors located in the circumferential marginal zone and Müller *** proliferative activity in the retinal progenitors located in the circumferential marginal zone in precocial birds such as the chicken,the commonest bird model used in developmental and regenerative studies,is very *** region adds only a few retinal cells to the peripheral edge of the retina during several months after hatching,but does not seem to be involved in retinal regeneration.Müller cells in the chicken retina are not proliferative under physiological conditions,but after acute damage some of them undergo a reprogramming event,dedifferentiating into retinal stem cells and generating new retinal ***,regenerative response after injury occurs with low efficiency in the precocial avian *** contrast,it has recently been shown that neurogenesis is intense in the retina of altricial birds at *** particular,abundant proliferative activity is detected both in the circumferential marginal zone and in the outer half of the inner nuclear ***,stem cell niches are very active in the retina of altricial *** more extensive research is needed to assess the potential of proliferating cells in the adult retina of altricial birds,it emerges as an attractive model for studying different aspects of neurogenesis and neural regeneration in vertebrates.

关键词： altricial birds circumferential marginal zone Müller glia postnatal neurogenesis precocial regeneration retinogenesis

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New insights into Wnt signaling alterations in amyotrophic lateral sclerosis: a potential therapeutic target?

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Neural Regeneration Research 2020年第9期15卷 1580-1589页

作者： Carlos González-Fernández Pau González Francisco Javier rodríguez Laboratory of Molecular Neurology Hospital Nacional de Parapléjicos (HNP)

Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder characterized by upper and lower motor neuron degeneration, which leads to progressive paralysis of skeletal muscles and, ultimately, respiratory failure between 2–5 years after symptom onset. Unfortunately, currently accepted treatments for amyotrophic lateral sclerosis are extremely scarce and only provide modest benefit. As a consequence, a great effort is being done by the scientific community in order to achieve a better understanding of the different molecular and cellular processes that influence the progression and/or outcome of this neuropathological condition and, therefore, unravel new potential targets for therapeutic intervention. Interestingly, a growing number of experimental evidences have recently shown that, besides its well-known physiological roles in the developing and adult central nervous system, the Wnt family of proteins is involved in different neuropathologica conditions, including amyotrophic lateral sclerosis. These proteins are able to modulate, at least, three different signaling pathways, usually known as canonical(β-catenin dependent) and non-canonical(β-catenin independent) signaling pathways. In the present review, we aim to provide a general overview of the current knowledge that supports the relationship between the Wnt family of proteins and its associated signaling pathways and amyotrophic lateral sclerosis pathology, as well as their possible mechanisms of action. Altogether, the currently available knowledge suggests that Wnt signaling modulation might be a promising therapeutic approach to ameliorate the histopathological and functional deficits associated to amyotrophic lateral sclerosis, and thus improve the progression and outcome of this neuropathology.

关键词： ALS astrocytes Frizzled human microglia motor neuron neurodegeneration neuroinflammation spinal cord Wnt

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Isolation and Characterization of Cellulose Nanofibers from Argentine Tacuara Cane(Guadua Angustifolia Kunth)

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Journal of renewable Materials 2019年第4期7卷 373-381页

作者： C.A.rodríguez Ramírez Fleur Rol Julien Bras Alain dufresne Nancy Lis Garcia Norma d'Accorso Universidad de Buenos Aires Facultad de Ciencias Exactas y NaturalesDepartamento de Química OrgánicaBuenos Aires Argentina CONICET-Universidad de Buenos Aires.Centro de Investigación en Hidratos de Carbono(CIHIdECAR).Buenos Aires Argentina Univ.Grenoble Alpes CNRSGrenoble INPLGP2F-38000France

New trends in the area of material improvement are the use of natural nano-charges from renewable biomass,improving the value and sustainability of our country’s natural *** is widely used in many countries of the world,although in Argentina,despite being commercialized and exported for the manufacture of wood floors,it goes unnoticed despite having native ***,researchers identified the native and exotic species present in our country and are working on novel *** this context,it is proposed the Argentine Tacuara Cane(Guadua Angustifolia Kunth),endemic plant as a new source of nanocellulosic materials,where stem fibers have been isolated using a green method achieving with yield of 45.9%of *** cellulose nanofibrils(CNF)were obtained using a green homogenization *** CNF exhibited web-like long fibrous structure with the diameter of 10-20 *** crystallinity was 65.5%,as for the onset temperature of thermal decomposition was 212°*** nanocellulose isolated from the Tacuara Cane seed fibers has a high potential to be used as a new source of cellulose-based nanofiller for the reinforcement of bionanocomposite films.

关键词： Cellulose nanofibers green valorization

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Large-Scale Group decision Making:A Systematic Review and a Critical Analysis

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IEEE/CAA Journal of Automatica Sinica 2022年第6期9卷 949-966页

作者： diego García-Zamora Alvaro Labella Weiping ding Rosa M.rodríguez Luis Martínez department of Computer Science University of JaénJaén 23071Spain IEEE School of Information Science and Technology Nantong UniversityNantong 226019China

The society in the digital transformation era demands new decision schemes such as e-democracy or based on social *** novel decision schemes require the participation of many experts/decision makers/stakeholders in the decision *** a result,large-scale group decision making(LSGdM)has attracted the attention of many researchers in the last decade and many studies have been conducted in order to face the challenges associated with the ***,this paper aims at reviewing the most relevant studies about LSGdM,identifying the most profitable research trends and analyzing them from a critical point of *** do so,the Web of Science database has been consulted by using different *** these results a total of 241 contributions were found and a selection process regarding language,type of contribution and actual relation with the studied topic was then carried *** 87 contributions finally selected for this review have been analyzed from four points of view that have been highly remarked in the topic,such as the preference structure in which decision-makers’opinions are modeled,the group decision rules used to define the decision making process,the techniques applied to verify the quality of these models and their applications to real world problems ***,a critical analysis of the main limitations of the existing proposals is ***,taking into account these limitations,new research lines for LSGdM are proposed and the main challenges are stressed out.

关键词： Challenges large-scale consensus models large-scale group decision making(LSGdM) systematic review

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Non-steroidal anti-inflammatory drugs(NSAIds) and neuroprotection in the elderly a view from the mitochondria

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Neural Regeneration Research 2015年第9期10卷 1371-1372页

作者： María Calvo-rodríguez Lucía Nú?ez Carlos Villalobos Instituto de Biologíay Genética Molecular (IBGM) Consejo Superior de Investigaciones Científicas (CSIC) and Universidad de Valladolid

The most important risk factor for stroke and neurodegeneration is aging. In fact, survival after stroke diminishes largely with aging. In fact, recovery after brain artery occlusion is dramatically worsened by aging, even normal aging is associated with neuron damage and cognitive decline. Mechanisms involved in aging-related, cognitive decline and susceptibility to neuron damage in stroke and neurode- generation are largely unknown. One of the most important mech- anisms contributing to neural dysfunction and death is excitotox- icity. This process is based on the fact that the excessive glutamate receptor stimulation may lead to neuronal damage. This overstim- ulation may be due to increased concentration of glutamate, or the prolonged activation of receptors.

关键词： NSAIds Non-steroidal anti-inflammatory drugs and neuroprotection in the elderly a view from the mitochondria view

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Constructing 2d bismuth-based heterostructure for highly efficient photocatalytic CO2 reduction

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Tungsten 2025年第1期7卷 71-79页

作者： Ruo-Hang Xu Hao-Yu Jiang dan-dan Cui Kun-Rong du Hong-Run Zhang Sheng-Jie Xu Ya-Qi Li Zhi-Zhen ren Liang Wang Wei-Chang Hao Yi du School of Physics and BUAA-UOW Joint Research Centre Beihang University Shenzhen Institute of Beihang University Centre for Catalysis and Clean Energy School of Environment and Science Griffith University

Reforming carbon dioxide（CO2） into fuels and valuable chemicals using solar energy holds significant potential for emission reduction and addressing energy supply *** recombination of photocarriers remains a major obstacle,however,to enhancing solar energy conversion efficiency in the photocatalytic reaction *** two-dimensional materials,constructing heterogeneous structures has emerged as an effective strategy to enhance the separation of photoexcited carriers by leveraging the internal electric field at the heterogeneous ***,we present a facile strategy for preparing Bi4NbO8Br/Bi2WO6plate-on-plate Z-scheme junctions with a strong internal electric field by in situ *** unique heterostructure facilitates efficient separation and transport of photoexcited charges by harnessing the internal electric field induced by chemical bonding at the lateral ***,the Bi4NbO8Br/Bi2WO6heterostructure exhibits enhanced CO2photoreduction properties,along with a CO yield rate of approximately 35 μmol·g-1·h-1under full light *** work offers novel insights into the synthesis of unique hetero structures intended to enhance the efficiency of photocatalytic CO2reduction.

关键词： Bi4NbO8Br/Bi2WO6 CO2 reduction Heterostructures Photocatalysts

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