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Dietary curcumin alleviates intestinal damage induced by ochratoxin A in juvenile grass carp (Ctenopharyngodon idella): Necroptosis and inflammatory responses

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ANIMAL NUTRITION 2024年第3期18卷 119-132页

作者： Zhao, Piao Jiang, Wei-Dan Wu, Pei Liu, Yang ren, hong-mei Jin, Xiao-Wan Feng, Lin Zhou, Xiao-Qiu Sichuan Agr Univ Anim Nutr Inst Chengdu 611130 Sichuan Peoples R China Sichuan Agr Univ Fish Nutr & Safety Prod Univ Key Lab Sichuan Prov Chengdu 611130 Sichuan Peoples R China Minist Agr & Rural Affairs Minist Educ Key Lab Anim Dis Resistance Nutr Key Lab Sichuan Prov Beijing 611130 Sichuan Peoples R China

Ochratoxin A (OTA) is one of the most common pollutants in aquatic feed. As a first line of defense, intestinal barriers could be utilized against OTA in order to prevent disorders. Natural product supplementation is one of the most popular strategies to alleviate toxicity induced by mycotoxins, but there is a lack of knowledge about how it functions in the teleost intestine. In this study, 720 juvenile grass carp of about 11 g were selected and four treatment groups (control group, OTA group, curcumin [Cur] group, and OTA + Cur group) were set up to conduct a 60-day growth test. After the test, the growth performance and intestinal health related indexes of grass carp were investigated. The addition of dietary Cur could have the following main results: (1) inhibit absorption and promote efflux transporters mRNA expression, reducing the residuals of OTA, (2) decrease oxidative stress by reducing oxidative damage and enhancing the expression of antioxidant enzymes, (3) promote mitochondrial fusion proteins to inhibit the expression of mitotic proteins and mitochondrial autophagy proteins and enhance mitochondrial function, (4) reduce necroptosis-related gene expression through inhibiting the tumor necrotic factor receptor-interacting protein kinase/mixed lineage kinase domain-like pathway, (5) reduce the expression of pro-inflammatory factors by inhibiting the Toll-like receptor 4/nuclear factor-kappa B signaling pathway to alleviate the intestinal inflammatory response. In summary, the results suggested that Cur could alleviate OTA-induced intestinal damage by enhancing antioxidant capacity and mitochondrial function as well as reducing necroptosis and inflammation in the grass carp intestine. This study provided a theoretical basis and production implications for dietary Cur that could improve growth performance and alleviate the intestinal damage induced by OTA in fish. (c) 2024 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co.

关键词： Curcumin Ochratoxin A Grass carp growth performance Mid-intestine mitochondria function Necroptosis NF-KAPPA-B GROWTH-PERFORMANCE FISH METABOLISM TOXICITY EXPOSURE IMMUNITY MODEL

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Dietary copper improves intestinal structural integrity in juvenile grass carp (Ctenopharyngodon idella) probably related to its increased intestinal antioxidant capacity and apical junction complex

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ANIMAL NUTRITION 2024年第3期18卷 96-106页

作者： Ma, Rui Feng, Lin Wu, Pei Liu, Yang ren, hong-mei Jin, Xiao-Wan Li, Shu-Wei Tang, Ling Zhou, Xiao-Qiu Jiang, Wei-Dan Sichuan Agr Univ Anim Nutr Inst Chengdu 611130 Peoples R China Sichuan Agr Univ Fish Nutr & Safety Prod Univ Key Lab Sichuan Prov Chengdu 611130 Peoples R China Minist Agr & Rural Affairs Minist Educ Key Lab Anim Dis Resistance Nutr Key Lab Sichuan Prov Chengdu 611130 Peoples R China Sichuan Animtech Feed Co Ltd Anim Nutr Inst Sichuan Acad Anim Sci Chengdu 610066 Peoples R China

This research evaluated the effects of copper (Cu) on intestinal antioxidant capacity and apical junctional complex (AJC) in juvenile grass carp. A total of 1080 healthy juvenile grass carp (11.16 +/- 0.01 g) were fed six diets including different dosages of Cu, namely 0, 2, 4, 6, 8 mg/kg (Cu citrate [CuCit] as Cu source) and 3 mg/kg (CuSO4 center dot 5H(2)O as Cu source). The trial lasted for 9 weeks. The findings revealed that dietary optimal Cu supplementation (2.2 to 4.1 mg/kg) promoted intestinal growth, including intestinal length, intestinal length index, intestinal weight, and intestinal somatic index (P 0.05). On the other hand, optimal Cu increased intestinal tight junction (TJ) proteins (except for claudin 15b) and adherens junction (AJ) proteins (E-cadherin, alpha-catenin, beta-catenin, nectin and afadin) mRNA levels (P < 0.05), which could be connected to the signaling pathway formed by the Ras homolog gene family, member A (RhoA), Rho-associated kinase (ROCK), and myosin light chain kinase (MLCK). Finally, based on serum indicator D-lactate and intestinal oxidative damage index (ROS), Cu requirement (CuCit as Cu source) for juvenile grass carp from initial weight to final weight (from 11 to 173 g) was determined to be 4.14 and 4.12 mg/kg diet, respectively. This work may provide a theoretical foundation for identifying putative Cu regulation pathways on fish intestinal he

关键词： Copper Ctenopharyngodon idella Structural integrity Intestine NF-KAPPA-B GROWTH-PERFORMANCE ENZYME-ACTIVITIES DIAMINE OXIDASE IMMUNE FUNCTION DEFICIENCY SUPPLEMENTATION REQUIREMENT NRF2 PHOSPHORUS

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上海市高速公路养护定额修编探究

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中国市政工程 2024年第4期 137-139,161,162页

作者：任红梅上海浦江桥隧运营管理有限公司上海200231

文章通过对高速公路养护费用控制模式、上海市高速公路养护定额发展及存在问题的分析,论证绩效式费用控制模式更能节约养护周期内成本。上海市高速公路养护定额由于政策调整、行业改革、技术创新等因素,已亟待进行修订。同时结合数据实... 详细信息

文章通过对高速公路养护费用控制模式、上海市高速公路养护定额发展及存在问题的分析,论证绩效式费用控制模式更能节约养护周期内成本。上海市高速公路养护定额由于政策调整、行业改革、技术创新等因素,已亟待进行修订。同时结合数据实例测算,建议养护定额修订可根据地理位置、路龄、交通量、重车比例等因素进行调整,确保各路段的养护经费更有针对性。

关键词：高速公路养护定额小修保养率

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Prenatal cytogenetic diagnosis study of 2782 cases of high-risk pregnant women

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Chinese Medical Journal 2010年第4期123卷 423-430页

作者： ZHANG Lin ZHANG Xiao-hong LIANG mei-ying ren mei-hong Prenatal Diagnosis Center Peking University People's Hospital Beijing 100044 China

Background Prenatal diagnoses are extremely advantageous for pregnant women with high-risk indicators and can help prevent the birth of malformed infants. However, no large-scale statistical study analyzing the correlation between fetal chromosome disorders and abnormal indicators during pregnancy has been done in China. The objectives of this study were to diagnose and analyze fetal chromosome abnormalities, determine the feasibility of the various prenatal test methods and establish diagnostic guidelines for the early, middle, and late trimesters. Methods From January 2004 to May 2009, 2782 pregnant women at high-risk underwent prenatal diagnoses. Categorized data expressed as either actual counts or percentages were analyzed by the chi-square or Fisher＇s exact test. Chorionic villus sampling was performed in the early-trimester （10-12 weeks of gestation）, amniocentesis in mid-trimester （16-28 weeks of gestation）, and umbilical cord blood collection in mid- or late-trimester （16-37 weeks of gestation）. In 51 cases either autopsy samples from intrauterine fetal deaths or placental tissues from aborted fetuses were tested. Results Chromosomal abnormalities were observed in 3.99% （111/2782） of the samples. Overall, the success rate of cytogenetic analysis for high-risk pregnancy groups was 98.17% （2731/2782）. It was significantly less successful when used to analyze data from the chorionic villus sampling compared with that from amniocentesis and umbilical cord blood （P=-0.000）. Abnormal chromosome carriers had the highest percentage of abnormal chromosomes （67.86%） when compared with chromosomal abnormalities in patients with ultra-sonographic ＂soft markers＂（11.81%）, advanced maternal age （4.51%） and those who had positive serum screening results （P=-0.000）. Conclusions Invasive prenatal diagnostic techniques are feasible tools for confirming fetal chromosomal abnormalities. Abnormal chromosomes detected in one of the parents carrying abnormal chromosome, ultrasoun

关键词： chorionic villus sampling amniocentesis umbilical cord blood collection chromosomal karyotype prenatal diagnosis

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Synthesizing high-resolution satellite salinity data based on multi-fractal fusion

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Acta Oceanologica Sinica 2024年第7期43卷 112-124页

作者： Hengqian Yan Jian Shi ren Zhang Wangjiang Hu Yongchui Zhang mei hong College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China

The spaceborne platform has unprecedently provided the global eddy-permitting(typically about 0.25°)products of sea surface salinity(SSS),however the existing SSS products can hardly resolve mesoscale motions due to the heavy noises therein and the over-smoothing in denoising *** means of the multi-fractal fusion(MFF),the high-resolution SSS product is synthesized with the template of sea surface temperature(SST).Two low-resolution SSS products and four SST products are considered as the source data and the templates respectively to determine the best *** fused products are validated by the in situ observations and intercompared via SSS maps,Singularity Exponent maps and wavenumber *** results demonstrate that the MFF can perform a good work in mitigating the noises and improving the *** combination of the climate change initiative SSS and the remote sensing system SST can produce the 0.1°denoised product whose global mean standard derivation of salinity against Argo is 0.21 and the feature resolution can reach 30−40 km.

关键词： sea surface salinity multi-fractal fusion high resolution

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Oligomerization of drug transporters:Forms,functions,and mechanisms

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1924-1938页

作者： Chunxu Ni mei hong College of Life Sciences South China Agricultural UniversityGuangzhou 510642China Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms South China Agricultural UniversityGuangzhou 510642China

Drug transporters are essential players in the transmembrane transport of a wide variety of clinical *** broad substrate spectra and versatile distribution pattern of these membrane proteins infer their pharmacological and clinical *** our accumulating knowledge on the three-dimensional structure of drug transporters,their oligomerization status has become a topic of intense study due to the possible functional roles carried out by such kind of post-translational modification(PTM).In-depth studies of oligomeric complexes formed among drug transporters as well as their interactions with other regulatory proteins can help us better understand the regulatory mechanisms of these membrane proteins,provide clues for the development of novel drugs,and improve the therapeutic *** this review,we describe different oligomerization forms as well as their structural basis of major drug transporters in the ATP-binding cassette and solute carrier superfamilies,summarize our current knowledge on the influence of oligomerization for protein expression level and transport function of these membrane proteins,and discuss the regulatory mechanisms of ***,we highlight the challenges associated with the current oligomerization studies and propose some thoughts on the pharmaceutical application of this important drug transporter PTM.

关键词： Drug development Drug transporters Oligomerization Protein expression Protein–protein interaction Regulatory mechanism Structural basis Transport function

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R-matrix for the 8-Dimensional Spin Representation of Uq(so7)

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Acta Mathematica Sinica,English Series 2024年第2期40卷 485-497页

作者： hong mei HU Nai hong HU School of Mathematical Sciences Suzhou University of Science and TechnologySuzhou 215009P.R.China School of Mathematical Sciences MOE Key Laboratory of Mathematics and Engineering Applications&Shanghai Key Laboratory of PMMPEast China Normal UniversityShanghai 200241P.R.China

The purpose of the paper is to describe the solution to the quantum Yang-Baxter equation associated with the 8-dimensional spin representation Tsp of Uq(so7).The self-duality of Tsp and the symmetry of the corresponding braiding matrix are ***,the minimal polynomial of the braiding R-matrix of Tsp is presented explicitly in an ingenious method by taking advantage of nice features of the spin representation Tsp.

关键词： Braiding R-matrix spin module minimal polynomial

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Characterizations of semihoops based on derivations

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 291-310页

作者： WANG mei ZHANG Xiao-hong School of Electrical and Control Engineering Shaanxi University of Science and TechnologyXi'an 710021China School of Arts and Sciences Shaanxi University of Science and TechnologyXi'an 710021China School of Mathematics and Statistics Weinan Normal UniversityWeinan 714099China

In this paper,we discuss the related properties of some particular derivations in semihoops and give some characterizations of ***,we prove that every Heyting algebra is isomorphic to the algebra of all multiplicative derivations and show that every Boolean algebra is isomorphic to the algebra of all implicative ***,we show that the sets of multiplicative and implicative derivations on bounded regular idempotent semihoops are in oneto-one correspondence.

关键词： (prelinear)semihoop derivation Heyting algebra Galois connection

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Type I interferon pathway in pediatric systemic lupus erythematosus

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World Journal of Pediatrics 2024年第7期20卷 653-668页

作者： Yu Zhou hong‑mei Song Department of Pediatrics Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College HospitalBeijingChina

Background The role of type I interferon(IFN-I)signaling in systemic lupus erythematosus(SLE)has been well ***,unanswered questions remain regarding the applicability of these findings to pediatric-onset *** aim of this review is to provide an overview of the novel discoveries on IFN-I signaling in pediatric-onset *** sources A literature search was conducted in the PubMed database using the following keywords:“pediatric systemic lupus erythematosus”and“type I interferon”.Results IFN-I signaling is increased in pediatric SLE,largely due to the presence of plasmacytoid dendritic cells and pathways such as cyclic GMP-AMP synthase–stimulator of interferon genes–TANK-binding kinase 1 and Toll-like receptor(TLR)4/*** extracellular traps and oxidative DNA damage further stimulate IFN-I *** variants in IFN-I-related genes,such as IFN-regulatory factor 5 and tyrosine kinase 2,are linked to SLE susceptibility in pediatric *** addition,type I interferonopathies,characterized by sustained IFN-I activation,can mimic SLE symptoms and are thus important to *** on interferonopathies also contribute to exploring the pathogenesis of *** IFN-I activation is crucial for SLE diagnosis and *** IFNstimulated gene expression and serum IFN-α2 levels are common *** cytometry markers such as CD169 and galectin-9 are promising ***-IFN therapies,such as sifalimumab and anifrolumab,show promise in adult patients with SLE,but their efficacy in pediatric patients requires further *** kinase inhibitors are another treatment option for severe pediatric SLE *** This review presents an overview of the IFN-I pathway in pediatric *** the intricate relationship between IFN-I and pediatric SLE may help to identify potential diagnostic markers and targeted therapies,paving the way for improved patient care and outcomes.

关键词： Interferonopathies Pediatric systemic lupus erythematosus Type I interferon

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复杂不均匀地层中地下结构波动响应频域分析

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大连理工大学学报 2008年第1期48卷 105-111页

作者：林皋任红梅大连理工大学土木水利学院辽宁大连116024

研究了不均匀岩土介质中隧洞衬砌的波动响应.比例边界有限元法被用来求解这一类问题.这种方法的优点是只需在边界上用有限元进行离散;无限介质的辐射条件自动得到满足;对一般不均匀介质的分析可不增加额外的工作量.方法的有效性得到二... 详细信息

研究了不均匀岩土介质中隧洞衬砌的波动响应.比例边界有限元法被用来求解这一类问题.这种方法的优点是只需在边界上用有限元进行离散;无限介质的辐射条件自动得到满足;对一般不均匀介质的分析可不增加额外的工作量.方法的有效性得到二维无限空间中圆形孔洞在水平向SV波入射作用下波动响应的验证.计算了马蹄形隧洞衬砌周边的应力分布.不均匀的围岩介质包含几种情况:一是含两种不同特性介质的不连续界面;另一是围岩中含软弱夹层.数值结果表明:在两种不同特性介质的不连续界面附近,以及在软弱夹层附近都会出现应力集中现象.两种介质特性差别愈大,应力集中程度愈高.此外入射波的频率愈高,应力集中现象也愈明显.这些结论对于地下结构的抗震设计将具有重要参考价值.

关键词：比例边界有限元法地下结构波动响应不均匀岩土介质

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