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DNA2 knockout aggravates cerebral ischemia/reperfusion injury by reducing postsynaptic Homer1a

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Zoological Research 2025年第01期 87-102页

作者： Ting Ma Yu-Meng Li Peng-Yu ren shi-quan wang xiang-Long Liu Wen-Bo Lv Wu-Gang Hou Wen-Qiang Zuo Wei-Qiang Lin Jian Sima An-Qi Geng Laboratory of Aging Neuroscience and Neuropharmacology School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University Research & Development Institute of Northwestern Polytechnical University in Shenzhen xi'an Key Laboratory of Stem Cell and Regenerative Medicine Xi'an Key Laboratory of Special Medicine and Health Engineering Institute of Medical Research Northwestern Polytechnical University Sanhang Institute for Brain Science and Technology Northwestern Polytechnical University Department of Anesthesiology and Perioperative Medicine Xijing Hospital Fourth Military Medical University College of Pharmacy Shaanxi University of Chinese Medicine International Institutes of Medicine Fourth Affiliated Hospital School of Medicine Zhejiang University

DNA2, a multifunctional enzyme with structure-specific nuclease, 5'-to-3' helicase, and DNA-dependent ATPase activities, plays a pivotal role in the cellular response to DNA damage. However, its involvement in cerebral ischemia/reperfusion(I/R) injury remains to be *** study investigated the involvement of DNA2 in cerebral I/R injury using conditional knockout(cKO) mice(Nestin-Cre) subjected to middle cerebral artery occlusion(MCAO), an established model of cerebral I/R. Results demonstrated a gradual up-regulation of DNA2 expression,peaking at 72 h post-MCAO. Notably, DNA2 cKO mice exhibited more pronounced brain injury, neurological deficits, and neuronal apoptosis within the penumbra following MCAO. Additionally, DNA2 expression was elevated in an oxygen-glucose deprivation/reoxygenation(OGD/R) cell culture model, and DNA2 knockdown(KD)exacerbated neuronal apoptosis and oxidative *** analysis of ischemic penumbra tissues via RNA sequencing revealed significant down-regulation of Homer1 in DNA2 cKO mice. Furthermore, in vitro experiments demonstrated that overexpression of Homer1a ameliorated DNA2 KD-induced neuronal apoptosis. Collectively, these findings demonstrate that DNA2 deficiency exacerbates cerebral I/R injury through the down-regulation of Homer1a, highlighting a novel regulatory axis in ischemic neuroprotection.

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不同温度条件下三组元HTPB推进剂细观脱湿行为实验及数值模拟

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含能材料 2025年第1期33卷 13-23页

作者：邹子杰强洪夫王哲君王学仁李世奇李易依火箭军工程大学智剑实验室陕西西安710025 火箭军工程大学导弹工程学院陕西西安710025 中国人民解放军96863部队河南洛阳471003

开展了宽温域单轴拉伸条件下HTPB推进剂的原位微CT细观结构表征实验,分析了在-20℃、20℃、50℃3种温度环境中推进剂的细观脱湿损伤行为,并基于HTPB推进剂的细观组分体积占比构建了三维细观代表体积单元模型,分析了模型在不同温度和不... 详细信息

开展了宽温域单轴拉伸条件下HTPB推进剂的原位微CT细观结构表征实验,分析了在-20℃、20℃、50℃3种温度环境中推进剂的细观脱湿损伤行为,并基于HTPB推进剂的细观组分体积占比构建了三维细观代表体积单元模型,分析了模型在不同温度和不同应变率条件下的应力-应变关系和脱湿率-应变关系。结果发现,HTPB推进剂在低温环境下(-20℃)脱湿更为严重,推进剂试件断裂时填料/基体界面脱湿率达到了30%,而孔隙率仅为6%。通过数值模拟发现推进剂在低温及高应变率条件下脱湿更为严重,对推进剂力学性能带来了极大的劣化。经实验和仿真结果对比,本研究所构造的数值模型能够有效预测推进剂的脱湿损伤行为及宏观力学性能。

关键词： HTPB推进剂细观结构力学性能脱湿损伤

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Escaping from Strange Sets in Discontinuous Circle Map

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Chinese Physics Letters 1996年第4期13卷 249-252页

作者： wang Bing-hong HE Da-ren JI xi-ping GUAN Shan SUN Jian-gang QU shi-xian Department of Modern Physics University of Science and Technology of ChinaHefei 230026 Department of Physics Northwestern UniversityXi'an 710069 Department of Basic Courses Xi'an Petroleum InstituteXian 710061

The leakage of iterations from chaotic attractor near crisis due to dynamical inter-action between discontinuity and noninvertibility has been *** scaling law of the mean life time is derived *** numerical result show... 详细信息

关键词： attractor chaotic scaling

A simple analytical model to predict liquid unloading in the horizontal gas well

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Journal of Hydrodynamics 2021年第5期33卷 1056-1064页

作者： Zhi-bin wang Jin-quan Ling Tian-li Sun hong-yan shi Guo Zhu State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChendu 610500China State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong UniversityXi'an 710049China No 2 Gas Production PlantSouthwest Oil and Gas CompanySINOPECLangzhong 637400China Infrastructure Department Southwest Oil and Gas CompanySINOPECChengdu 610041China

An accurate prediction of the critical gas velocity for the liquid loading is of great importance for operators to select the tubing diameter for the newly drilled gas wells,or to optimize the production rate for production *** is clear from previous experimental studies of the liquid entrainment rate in the gas core that the liquid is mainly carried in the form of film under the critical condition of the liquid loading *** is more reasonable to establish a mathematical model based on the film reversal rather than based on the droplet *** our previous paper entitled“Prediction of the critical gas velocity of liquid unloading in the horizontal gas well”,a new analytical model was established based on the force balance between the gas-liquid interfacial friction force and the bottom film gravity,but the model is not very convenient to use because of the complexity of calculating the average film *** the present study,a new method is proposed to calculate the average film thickness from the bubble drift velocity in the mixture,so the new analytical model becomes much easier to *** new analytical model is evaluated against 103 sets of experimental data,the data in 124 vertical gas wells and one horizontal gas ***,the effect ofthe liquid loading on the production of the horizontal gas well is also analyzed.

关键词： Horizontal gas well inclined annular flow liquid-film thickness liquid unloading

Hformer:highly efficient vision transformer for low-dose CT denoising

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Nuclear Science and Techniques 2023年第4期34卷 161-174页

作者： shi-Yu Zhang Zhao-Xuan wang Hai-Bo Yang Yi-Lun Chen Yang Li quan Pan hong-Kai wang Cheng-xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516003China School of Cybersecurity Northwestern Polytechnical UniversityXi’an 710072China School of Automation Northwestern Polytechnical UniversityXi’an 710072China Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021China

In this paper,we propose Hformer,a novel supervised learning model for low-dose computer tomography(LDCT)*** combines the strengths of convolutional neural networks for local feature extraction and transformer models for global feature *** performance of Hformer was verified and evaluated based on the AAPM-Mayo Clinic LDCT Grand Challenge *** with the former representative state-of-the-art(SOTA)model designs under different architectures,Hformer achieved optimal metrics without requiring a large number of learning parameters,with metrics of33.4405 PSNR,8.6956 RMSE,and 0.9163 *** experiments demonstrated designed Hformer is a SOTA model for noise suppression,structure preservation,and lesion detection.

关键词： Low-dose CT Deep learning Medical image Image denoising Convolutional neural networks Selfattention Residual network Auto-encoder

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The Relationship between Japanese Encephalitis and Environmental Factors in China Explored Using National Surveillance Data

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Biomedical and Environmental Sciences 2018年第3期31卷 227-232页

作者： HUANG xiao xia YAN Lei GAO xiao Yan ren Yu Huan FU shi hong CAO Yu xi HE Ying LEI Wen Wen LIANG Guo Dong wang shi Wen wang Huan Yu Office for Disease Control and Prevention National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention Harmacoepidemiology Asia-Pacific unit MSD R&D(China) Co.Ltd. Department of Viral Encephalitis National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention State Key Laboratory for Infectious Disease Prevention and Control Chinese Center for Disease Control and Prevention Institute of Remote Sensing and Digital Earth Chinese Academy of Sciences

Japanese encephalitis（JE）is a serious public health *** study was undertaken to better understand the relationship between JE distribution and environmental factors in *** data from 2005 to 2010 were retrieved from ... 详细信息

关键词： Japanese encephalitis Environmental factors Landscape

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Dramatic Impact of Auxiliary Ligands on the Dynamic Magnetic Relaxation in Tetranuclear Dy^(III)_(2)Zn^(II)_(2) Single Molecule Magnets

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Chinese Journal of Chemistry 2022年第20期40卷 2415-2420页

作者： Gao-Peng Li hong-Fang xie shi-Rui Yang Yun-Long Fu Yi-quan Zhang Yao-Yu wang Key Laboratory of Magnetic Molecules&Magnetic Information Materials of the Ministry of Education School of Chemistry&Material ScienceShanxi Normal UniversityTaiyuanShanxi030031 China Weinan Bureau of Natural Resources and Planning WeinanShaanxi714000 China Jiangsu Key Laboratory for NSLSCS School of Physical Science and TechnologyNanjing Normal UniversityNanjingJiangsu210023 China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education Shaanxi Key Laboratory of Physico-Inorganic ChemistryCollege of Chemistry and Materials ScienceNorthwest UniversityXi'anShaanxi710127 China

Better understanding the determining factors of dynamic magnetic relaxation in polynuclear lanthanide based single-molecule magnets(SMMs)remains a challenge due to the complexity of such architectures involving interactions between the magnetic *** address this issue,two structurally related heterometal Dy^(III)_(2)Zn^(II)_(2) SMMs,[Zn_(2)Dy_(2)(L)_(4)(Ac)_(2)(DMF)(CH_(3)OH)]·CH_(3)OH·2H_(2)O(1)and[Zn_(2)Dy_(2)(L)_(4)(Ac)_(2)(DMF)_(2)]·4CH_(3)CN(2)(H_(2)L=(E)-2-((2-hydroxy-3-methoxybenzylidene)amino)-4-methyphenol,DMF=N,N-dimethylformamide),are introduced and *** modifying the auxiliary ligands on one Dy^(III) site while retaining that on the other Dy^(III),the intramolecular magnetic interactions and relaxation dynamics in these two heterometallic-Dy^(III)_(2)Zn^(II)_(2) SMMs can be tuned,demonstrating a dramatic change in the magnet relaxation behavior with energy barrier changing from a negligible value for 1 to 305 K for *** initio calculations reveal that changing the coordination geometries on the Dy^(III) sites can significantly affect the magnetic interactions as well as single-ion anisotropy.

关键词： Single-molecule magnets Dynamic magnetic relaxation Dysprosium Auxiliary ligands Ab initio calculations

Mikania micrantha Kunth and its derived biochar impacts on heavy metal bioavailability and siderophore-related genes during chicken manure composting

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Biochar 2024年第1期6卷 989-1009页

作者： Yousif Abdelrahman Yousif Abdellah hong-Yu Chen shi-Wen Deng Wan-Ting Li Rong-Jie ren xi Yang Muhammad Shoaib Rana Shan-Shan Sun Jia-Jie Liu Rui-Long wang Guangdong Engineering Technology Research Centre of Modern Eco-Agriculture and Circular Agriculture Department of EcologyCollege of Natural Resources and EnvironmentSouth China Agricultural UniversityGuangzhou 510642China. The Germplasm Bank of Wild Species Yunnan Key Laboratory for Fungal Diversity and Green DevelopmentKunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina. Key Laboratory of Agro-Environment in the Tropics Ministry of Agriculture and Rural AffairsSouth China Agricultural UniversityGuangzhou 510642China. Faculty of Public and Environmental Health University of KhartoumKhartoum 11111Sudan. Engineering Research Center of Agricultural Microbiology Technology Ministry of Education and Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region and Key Laboratory of MicrobiologyCollege of Heilongjiang Province and School of Life SciencesHeilongjiang UniversityHarbin 150080China.

Biochar can potentially reduce heavy metals(HMs)mobility and bioavailability during ***,siderophores secreted by functional microbes might lead to the re-mobilization of metals like Cu and ***,this study intended to explore the impacts of Mikania micrantha Kunth(MM)and MM-derived biochar(MMB)in the reduction of Cu and Zn bioavailability,and siderophore-related gene abundances during *** with MM and corn straw(CS)composts,a significant decline was noticed in the extractable and reducible Cu[(2.3 mg kg^(−1)+12.1 mg kg^(−1)),and(3.3 mg kg^(−1)+14.6 mg kg^(−1))],and Zn[(103.1 mg kg^(−1)+110.1 mg kg^(−1)),and(109.6 mg kg^(−1)+117.2 mg kg^(−1))]in MMB and corn straw biochar(CSB)composts,***,the lowest relative abundance of HMs-resistant bacteria particularly Corynebacterium(0.40%),Pseudomonas(0.46%),and Enterobacter(0.47%),was noted in MMB ***,a significant increase in sesquiterpenoid and triterpenoid biosynthesis abundance(5.77%)accompanied by a reduction in the abundance of clusters related to siderophore transport,and siderophore transmembrane transporter activity was detected in MMB *** analysis labeled temperature,moisture content,total organic carbon,Corynebacterium,and Bacillus as the primary factors significantly correlated with the Cu and Zn bioavailability(−0.90≤r≤0.90,P<0.05).The structural equation model revealed that physicochemical parameters,microbial abundance,and siderophores exert a substantial influence on Cu and Zn ***,MM and its derived biochar are recommended as an effective approach for accelerating Cu and Zn bioavailability reduction and managing the growth and distribution of invasive plants.

关键词： Mikania micrantha Kunth Biochar Heavy metals Mikania micrantha Kunth-related phytochemicals Siderophore-related genes

Ultra-sensitive hybrid diamond nanothermometer

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National Science Review 2021年第5期8卷 76-84页

作者： Chu-Feng Liu Weng-Hang Leong Kangwei xia xi Feng Amit Finkler Andrej Denisenko J?rg Wrachtrup quan Li ren-Bao Liu Department of Physics The Chinese University of Hong Kong 3rd Institute of Physics and Center for Applied quantum Technologies University of Stuttgart Department of Chemical and Biological Physics Weizmann Institute of Science Max Planck Institute for Solid State Research The hong Kong Institute of quantum Information Science and Technology The Chinese University of Hong Kong

Nitrogen-vacancy（NV） centers in diamond are promising quantum sensors because of their long spin coherence time under ambient conditions. However, their spin resonances are relatively insensitive to non-magnetic parameters such as temperature. A magnetic-nanoparticle-nanodiamond hybrid thermometer, where the temperature change is converted to the magnetic field variation near the Curie temperature, were demonstrated to have enhanced temperature sensitivity(11 m K Hz-1/2)（wang N, Liu G-Q and Leong W-H et al. Phys Rev X 2018; 8: 011042）, but the sensitivity was limited by the large spectral broadening of ensemble spins in nanodiamonds. To overcome this limitation, here we show an improved design of a hybrid nanothermometer using a single NV center in a diamond nanopillar coupled with a single magnetic nanoparticle of copper-nickel alloy, and demonstrate a temperature sensitivity of 76 μK Hz-1/*** hybrid design enables detection of 2 m K temperature changes with temporal resolution of 5 ms. The ultra-sensitive nanothermometer offers a new tool to investigate thermal processes in nanoscale systems.

关键词： nano-thermometry diamond nitrogen-vacancy center quantum sensing magnetic nanoparticle