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Rapid commentary:Ethical implications for clinical trialists and patients associated with COVID-19 research

World Journal of Psychiatry 2021年第3期11卷 58-62页

作者： Gayathri Delanerolle Shanaya Rathod Kathryn Elliot rema ramakrishnan Tony Thayanandan Natasha Sandle Nyla Haque Vanessa Raymont Peter Phiri Department of Psychiatry University of OxfordOxford OX37JXUnited Kingdom Research and Development Department Southern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom Nuffield Department of Women's and Reproductive Health University of OxfordOxford OX37JXUnited Kingdom Primary Care Population Sciences and Medical EducationFaculty of MedicineUniversity of SouthamptonSouthampton SO165STUnited Kingdom

Pandemics disrupt clinical trials worldwide,with lasting effects on *** can severely impact clinical trialists ability to conduct safe and ethically uncompromised ***,the mounting pressure results in ethically and morally distressing decisions faced by clinical trial professionals during pandemic *** clinical trialists attempt to think about preparedness and responses during a pandemic,the need to have an ethical framework that has real-world applicability is *** are a challenging time for all,however,the safety and access to support for clinical trialists and patients within clinical trials should be at the forefront for their organisations and the government.

关键词： COVID-19 Pandemic Ethics Clinical trials Patients Trialists

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Mental health impact of the Middle East respiratory syndrome,SARS,and COVID-19:A comparative systematic review and metaanalysis

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World Journal of Psychiatry 2022年第5期12卷 739-765页

作者： Gayathri Delanerolle Yutian Zeng Jian-Qing Shi Xuzhi Yeng Will Goodison Ashish Shetty Suchith Shetty Nyla Haque Kathryn Elliot Sandali Ranaweera rema ramakrishnan Vanessa Raymont Shanaya Rathod Peter Phiri Nuffield Department of Primary Health Care Science University of OxfordOxford OX26EDUnited Kingdom Southern University of Science and Technology Shenzhen 518055Guangdong ProvinceChina The Alan Turing Institute London NW12DBUnited Kingdom University College London Hospital NHS Foundation Trust London NW12PGUnited Kingdom University College London London WC1E 6BTUnited Kingdom Department of Research and Innovation Southern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom Department of Psychiatry University of OxfordOxford OX26EDUnited Kingdom Department of BioSystems Technology University of Sri JayewardenepuraNugegoda 10100Sri Lanka National Perinatal Epidemiology Unit University of OxfordOxford OX37JXUnited Kingdom Faculty of Environmental and Life Sciences Psychology DepartmentUniversity of SouthamptonSouthampton SO171PSUnited Kingdom

BACKGROUND Over the last few decades,3 pathogenic pandemics have impacted the global population;severe acute respiratory syndrome coronavirus(SARS-CoV),Middle East respiratory syndrome coronavirus(MERS-CoV)and *** global disease burden has attributed to millions of deaths and morbidities,with the majority being attributed to *** such,the evaluation of the mental health(MH)impact across healthcare professionals(HCPs),patients and the general public would be an important facet to evaluate to better understand short,medium and long-term *** To identify and report:(1)MH conditions commonly observed across all 3 pandemics;(2)Impact of MH outcomes across HCPs,patients and the general public associated with all 3 pandemics;and(3)The prevalence of the MH impact and clinical epidemiological *** A systematic methodology was developed and published on PROSPERO(CRD42021228697).The databases PubMed,EMBASE,ScienceDirect and the Cochrane Central Register of Controlled Trials were used as part of the data extraction process,and publications from January 1,1990 to August 1,2021 were *** terms and keywords used included Mood disorders,PTSD,Anxiety,Depression,Psychological stress,Psychosis,Bipolar,Mental Health,Unipolar,Self-harm,BAME,Psychiatry disorders and Psychological *** terms were expanded with a‘snowballing’***-regression and the Monte-Carlo simulation method was used in addition to I2 and Egger’s tests to determine heterogeneity and publication *** In comparison to MERS and SARS-CoV,it is evident SAR-CoV-2 has an ongoing MH impact,with emphasis on depression,anxiety and post-traumatic stress *** It was evident MH studies during MERS and SARS-CoV was limited in comparison to SARS-CoV-2,with much emphasis on reporting symptoms of depression,anxiety,stress and sleep *** lack of comprehensive studies conducted during previous pandemics have introduced limitations to the

关键词： COVID-19 Middle East respiratory syndrome SARS-CoV SARS-CoV-2 Mental health Wellbeing Psychiatry Healthcare professionals Patients Physical health Public health Outbreaks and pandemics

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