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Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia

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Signal Transduction and Targeted Therapy 2022年第3期7卷 856-868页

作者： Qi Zhang Bridget Riley-Gillis Lina Han Yanan Jia Alessia Lodi Haijiao Zhang Saravanan Ganesan Rongqing Pan Sergej N.Konoplev Shannon R.Sweeney Jeremy A.Ryan Yulia Jitkova Kenneth Dunner Jr Shaun E.Grosskurth Priyanka Vijay Sujana Ghosh Charles Lu Wencai Ma Stephen Kurtz Vivian R.Ruvolo Helen Ma Connie CWeng Cassandra LRamage Natalia Baran Ce Shi Tianyu Cai Richard Eric Davis Venkata L.Battula Yingchang Mi Jing Wang Courtney D.DiNardo Michael Andreeff Jeffery W.Tyner Aaron Schimmer Anthony Letai Rose Ann Padua Carlos E.Bueso-Ramos Stefano Tiziani Joel Leverson relja.popovic Marina Konopleva Department of Leukemia The University of Texas MD Anderson Cancer CenterHoustonTXUSA AbbVie Inc. North ChicagoILUSA Institute of Hematology Chinese Academy of Medical Sciences&Peking Union Medical CollegeTianjinChina Department of Nutritional Sciences Department of PediatricsDepartment of OncologyDell Medical SchoolThe University of Texas at AustinAustinTX 78712USA Department of Cell Developmental&Cancer BiologyDivision of Hematology&Medical OncologyKnight Cancer InstituteOregon Health&Science UniversityPortlandORUSA Universite de Paris Institut de la Recherche Saint-Louis(IRSL)Inserm Unit 1131ParisFrance Dana-Farber Cancer Institute BostonMAUSA Department of Hematopathology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Princess Margaret Cancer Center TorontoONCanada High Resolution Electron Microscopy Facility The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Bioinformatics&Computational Biology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Hematology The First Hospital Affiliated Harbin Medical UniversityHarbinChina Department of Lymphoma&Myeloma Research The University of Texas MD Anderson Cancer CenterHoustonTXUSA

Despite high initial response rates,acute myeloid leukemia(AML)treated with the BCL-2-selective inhibitor venetoclax(VEN)alone or in combinations commonly acquires *** performed gene/protein expression,metabolomic and methylation analyses of isogenic AML cell lines sensitive or resistant to VEN,and identified the activation of RAS/MAPK pathway,leading to increased stability and higher levels of MCL-1 protein,as a major acquired mechanism of VEN resistance.

关键词： acute myeloid acquired

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Correction: Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia

引用

Signal Transduction and Targeted Therapy 2022年第5期7卷 1860-1860页

作者： Qi Zhang Bridget Riley-Gillis Lina Han Yannan Jia Alessia Lodi Haijiao Zhang Saravanan Ganesan Rongqing Pan Sergej N.Konoplev Shannon R.Sweeney Jeremy A.Ryan Yulia Jitkova Kenneth Dunner Jr Shaun E.Grosskurth Priyanka Vijay Sujana Ghosh Charles Lu Wencai Ma Stephen Kurtz Vivian R.Ruvolo Helen Ma Connie C.Weng Cassandra L.Ramage Natalia Baran Ce Shi Tianyu Cai Richard Eric Davis Venkata L.Battula Yingchang Mi Jing Wang Courtney D.DiNardo Michael Andreeff Jeffery W.Tyner Aaron Schimmer Anthony Letai Rose Ann Padua Carlos E.Bueso-Ramos Stefano Tiziani Joel Leverson relja.popovic Marina Konopleva Department of Leukemia The University of Texas MD Anderson Cancer Center Houston TX USA Institute of Hematology Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China Department of Hematology The First Hospital Affiliated Harbin Medical University Harbin China AbbVie Inc. North Chicago IL USA Department of Nutritional Sciences Department of Pediatrics Department of Oncology Dell Medical School The University of Texas at Austin Austin TX 78712 USA Department of Cell Developmental & Cancer Biology Division of Hematology & Medical Oncology Knight Cancer Institute Oregon Health & Science University Portland OR USA Université de Paris Institut de la Recherche Saint-Louis (IRSL) Inserm Unit 1131 Paris France Dana-Farber Cancer Institute Boston MA USA Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA Princess Margaret Cancer Center Toronto ON Canada High Resolution Electron Microscopy Facility The University of Texas MD Anderson Cancer Center Houston TX USA Department of Bioinformatics & Computational Biology The University of Texas MD Anderson Cancer Center Houston TX USA Department of Lymphoma & Myeloma Research The University of Texas MD Anderson Cancer Center Houston TX USA

Correction to:Signal Transduction and Targeted Therapy(2022)7:1–13,https://***/10.1038/s41392-021-00870-3 In the original version of this article,given name of 4th author Yannan Jia was incorrectly published as Yanan *** original article has been *** Access This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source.

关键词： myeloid Therapy resistance

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