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Prenatal and pubertal testosterone exposure imprint permanent modifications in the prostate that predispose to the development of lesions in old mongolian gerbils

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Asian Journal of Andrology 2017年第2期19卷 160-167页

作者： manoel F Biancardi Ana PS Perez Cassia RS Caires Luiz R Falleiros Jr rejane m goes Patricia SL Vilamaior Diogenes R Freitas Jr Fernanda CA Santos Sebastiao R Taboga Department of Structural and Functional State University of Campinas Av. Bertrand Russel s/n Campinas Sao Paulo 13084864 Brazil 2Department of Histology Embryology and Cell BiologyFederal University of Goias Samambaia II Goiania Goias 74001970 Brazil University Estadual Paulista - UNESP Department of Biology Laboratory of Microscopy and Microanalysis Rua Cristovao Colombo 2265 Sao Jose do Rio Preto Sao Paulo 15054000 Brazil medical School Federal University of Goias Colemar Natal e Silva Goiania Goias 74001970 Brazil

The prostate is an accessory sex gland that develops under precise androgenic control. It is known that hormonal imbalance may disrupt its development predisposing this gland to develop diseases during aging. Although the hypothesis regarding earlier origins of prostate diseases was proposed many years ago, the mechanisms underlying this complex phenomenon are poorly understood. Therefore, the aim of this study was to evaluate the prostates of old male gerbils exposed to testosterone during intrauterine and postnatal life using morphological, biometrical, stereological, Kariometric, immunohistochemical, and immunofluorescence analyses. Our findings demonstrate that prenatal and pubertal exposure to testosterone increases the susceptibility to the development of prostate diseases during aging. The presence of a more proliferative gland associated with foci of adenomatous hyperplasia in animals exposed to testosterone during the prenatal and pubertal phase show that the utero life and the pubertal period are important phases for prostatic morphophysiology establishment, which is a determinant for the health of the gland during aging. Therefore, these findings reinforce the idea that prostate disease may result from hormonal disruptions in early events during prostate development, which imprint permanently on the gland predisposing it to develop lesions in later stages of life.

关键词： adenomatous hyperplasia endocrine-disrupting chemicals gerbil prostate development testosterone

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Investigating local corrosion processes of magnesium alloys with scanning probe electrochemical techniques: A review

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Journal of magnesium and Alloys 2022年第11期10卷 2997-3030页

作者： mara Cristina Lopes de Oliveira rejane maria Pereira da Silva Ricardo m.Souto Renato Altobelli Antunes Federal University of ABC Center for EngineeringModeling and Applied Social SciencesAv.Dos Estados500109210-580Santo AndréSP Brazil Instituto de Pesquisas Energéticas e Nucleares IPEN/CNENAv.Prof.Lineu Prestes2242São PauloBrazil Institute of material Science and Nanotechnology University of La LagunaP.O.Box 456La LagunaTenerife 38200Spain

The study of corrosion of magnesium and its alloys has emerged a hot topic in the applications of lightweight structural materials. The inherently high electrochemical activity of bare magnesium surfaces still lacks a convincing mechanism to describe the observed experimental characteristics, and it has prompted the development of various types of protective coatings with the aim of slowing metal dissolution. In recent years, new instruments and techniques have been developed to study with spatial resolution the local corrosion processes that occur in metallic materials in general, and for magnesium and its alloys in particular, both for bare surfaces and coated. Scanning microelectrochemical techniques, such as local electrochemical impedance spectroscopy(LEIS), scanning electrochemical microscopy(SECm), scanning vibrating electrode technique(SVET), scanning ion-selective electrode technique(SIET) and scanning Kelvin probe(SKP) can provide information about the local electrochemical activity of metallic surfaces. In the present work, the applications of these techniques in corrosion studies of magnesium and its alloys are reviewed. Assessment of corrosion mechanisms, barrier properties of conventional coatings and active corrosion behavior of self-healing coatings are examined. Limitations and future developments in this area are discussed.

关键词： magnesium alloys LEIS SECm SVET SIET SKP

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The new kid on the block in insect pest management:sprayable RNAi goes commercial

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Science China(Life Sciences) 2024年第8期67卷 1766-1768页

作者： Junjie Yan Ralf Nauen Stuart Reitz Andrei Alyokhin Jiang Zhang David mota-Sanchez Yonggyun Kim Subba Reddy Palli Silvia I.Rondon Brian A.Nault Juan Luis Jurat-Fuentes michael S.Crossley William E.Snyder Angharad m.R.Gatehouse myron P.Zalucki Bruce E.Tabashnik Yulin Gao State Key Laboratory for Biology of Plant Disease and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Bayer AG Crop Science DivisionR&DPest ControlMonheim 40789Germany Department of Crop and Soil Science Oregon State UniversityOntario 97914USA School of Biology and Ecology University of MaineOrono 04469USA Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China Department of Entomology Michigan State UniversityEast Lansing 48864USA Department of Plant medicals Andong National UniversityAndong 36729Republic of Korea Department of Entomology University of KentuckyLexington 40503USA Oregon State University Oregon Integrated Pest Management CenterCorvallis 97838USA Department of Entomology Cornell UniversityCornell AgriTechGeneva 14456USA Department of Entomology and Plant Pathology University of TennesseeKnoxville 37996USA Department of Entomology and Wildlife Ecology University of DelawareNewark 19716USA Department of Entomology University of GeorgiaAthensGeorgia 30602USA School of Natural and Environmental Sciences Newcastle UniversityNewcastle upon TyneNE17RUUK School of the Environment University of QueenslandBrisbane 4072Australia Shandong Engineering Research Center for Environment-Friendly Agricultural Pest management College of Plant Health and MedicineQingdao Agricultural UniversityQingdao 266109China Department of Entomology University of ArizonaTucson 85721USA National Center of Excellence for Tuber and Root Crop Research Chinese Academy of Agricultural SciencesBeijing 100081China

Insect pest damage to crops is a threat to global food security(Tilman et al.,2011).Climate change,the evolution of insecticide resistance,and the phasing out of insecticides due to environmental and safety concerns exacerbate this *** urgently need safe and effective crop protection tools to sustainably generate yields that meet ever-increasing global demand.

关键词： crops damage pest

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Galvanic and asymmetry effects on the local electrochemical behavior of the 2098-T351 alloy welded by friction stir welding

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Journal of materials Science & Technology 2020年第10期42卷 162-175页

作者： mariana X.milagre Uyime Donatus Naga V.mogili rejane maria PSilva Barbara Victoria Gde Viveiros Victor F.Pereira Renato A.Antunes Caruline S.Cmachado Joao Victor S.Araujo Isolda Costa Instituto de Pesquisas Energeticas e Nucleares IPEN/CNENAv.Prof.Lineu Prestes2242Sao PauloBrazil Laboratorio Nacional de Nanotecnologia LNNano/CNPENRua Giuseppe Maximo Scolfaro10.000Polo II deAlta Tecnologia de CampinasBrazil Centro de Engenharia Modelagem e Ciencias Sociais AplicadasUFABCAv.dos Estados 5001Santo AndreBrazil

Scanning electrochemical microscopy(SECm)and scanning vibrating electrode technique(SVET)were used to investigate the electrochemical behaviour of the top surface of the 2098-T351 alloy welded by friction stir welding(FSW).The SVET technique was efficient in identifying the cathodic and anodic weld *** welding joint(WJ),which comprises the thermomechanically affected zone(TmAZ)and the stir zone(SZ),was cathodic relative to the heated affected zone(HAZ)and the base metal(Bm).The reactivities of the welding joint at the advancing side(AS)and the retreating side(RS)were analyzed and compared using SECm technique in the competition mode by monitoring the dissolved oxygen as a redox mediator in 0.005 mol L^-1 NaCl *** RS was more electrochemically active than the AS,and these results were correlated with the microstructural features of the welded alloy.

关键词： Aluminum alloys Friction stir welding Localized corrosion

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Use of Coal Waste as Fine Aggregates in Concrete Paving Blocks

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Geomaterials 2013年第2期3卷 54-59页

作者： Cassiano Rossi dos Santos Juarez Ramos do Amaral Filho rejane maria Candiota Tubino Ivo André Homrich Schneider Federal University of Rio Grande do Sul—UFRGS Post Graduate Programme in Mining Metallurgical and Materials Engineering—PPGE3M Porto Alegre Brazil

The aim of this work was to study the use of coal waste to produce concrete paving blocks. The methodology considered the following steps: sampling of a coal mining waste;gravity separation of the fraction with specific gravity between 2.4 and 2.8;comminution of the material and particle size analysis;technological characterization of the material and the production of concrete paving blocks. The results showed that the coal waste considered in this work can be used to replace conventional sand as a fine aggregate for concrete paving blocks. This practice can collaborate in a cleaner coal production.

关键词： Coal Waste Recycling Environment Concrete

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On the experimental characterization of the fluid volume influence on the friction between rough surfaces

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Friction 2023年第7期11卷 1334-1348页

作者： Lukas STAHL michael mÜLLER Georg-Peter OSTERmEYER Institute of Dynamics and Vibrations Technische Universität BraunschweigBraunschweig 37106Germany

The load-bearing behaviour of lubricated contacts depends primarily on the normal force,the relative velocity,and the ***,with the aid of the Stribeck curve,it is usually well possible to characterize whether hydrodynamics,mixed friction,or boundary friction is more likely to be *** fact that the load regime can also depend on the fluid quantity is obvious,but has hardly been systematically investigated so *** for contacts with microscopic roughness,the defined application of a very small amount of fluid is a very challenging *** this paper,a very fundamental study shows how a pin-on-disc tribometer can be used to achieve the transition from dry friction via mixed friction to predominant hydrodynamics by the amount of supplied *** experiments are carried out on samples filed with different *** addition,the simultaneous influence of partial filling and normal force as well as relative velocity is also *** good reproducibility has been practically reached over the entire range of the *** the quantities for the coefficient of friction(COF),it was concluded that close to full filling,a reduction of the fluid quantity has a similar effect on the COF as the reduction of the *** property goes along with the common theory of starved lubricated *** behaviour was not observed to the same extent for the normal *** the vicinity of smaller fluid quantities,the COF increases very rapidly with further reduction in fluid quantity,far more disproportionately than that with reduction in *** a deeper understanding of this problem,various practical issues such as idling or the run-up process in bearings can also be studied in a more focused manner.

关键词： starved lubrication Stribeck curve pin-on-disc tribometer fluid supply experimental studies

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The Response of the Earth's Lower Ionosphere to Gamma-Ray Solar Flares and their Associated X-ray

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Research in Astronomy and Astrophysics 2022年第4期22卷 137-152页

作者： mahmoud mohery Hussein m.Farid Alaa Ali Dept.of Phys College of ScienceUniversity of JeddahJeddahSaudi Arabia Astronomy Space Science&Meteorology DepartmentFaculty of ScienceCairo UniversityGiza 12613Egypt Astronomy Dept. Faculty of ScienceKing Abdulaziz University21589 JeddahSaudi Arabia

The present work aims to explore the impact of solar gamma-ray fiares(GRFs),detected by the Fermi-Large Area Telescope(LAT),and their associated X-ray fiares(XRFs)on the Earth’s lower *** data of ionospheric parameter fmin were collected from the Yamagawa mid-latitude ionosonde station in *** most of the GRFs used in this study are associated with soft X-ray(SXR)emissions,detected by the Geostationary Operational Environmental Satellite(goes),we classified them into three types:simultaneous(S),delayed(D)and not associated(N),refiecting the phase occurrence of the solar ***,the ionospheric D layer responds strongly to XRFs more than *** temporal profiles of the ionospheric parameter fmin show distinct behaviors as a response to the various GRF *** the case of the S-type,a single strong peak,with an average value of 5.2 mHz,emanates in the fmin profile within an average interval of time of less than half an *** the case of the D-type,two successive peaks appear in the fmin profile,with an average value of 6.0 mHz for the second peak through a time interval of one hour after the onset of gamma-ray(GR)*** response of the fmin parameter to the N-type fiares appears as a single peak with an average value of 4.8 mHz within about an *** notice that the difference between the fmin peak values and the corresponding reference ones(dfmin)is more convenient and representative than the fmin values,where the median GR fiux of the S-,D-and N-types tends to increase as the average dfmin increases.

关键词： Sun:X-rays gamma-rays Earth:ionosphere satellites

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Effect of Freshwater Influx on Phytoplankton in the mandovi Estuary (Goa, India) during monsoon Season: Chemotaxonomy

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Journal of Water Resource and Protection 2013年第3期5卷 349-361页

作者： Sushma G. Parab S. G. Prabhu matondkar Helga do R. Gomes Joaquim I. goes Lamont Doherty Earth Observatory at Columbia University New York USA National Institute of Oceanography Dona Paula Goa India

The mandovi estuary is a prominent water body that runs along the west coast ofIndia. It forms an estuarine network with the adjacent Zuari estuary, connected via the Cumbharjua canal. The physico-chemical conditions seen in the mandovi estuary are influenced by two factors: the fresh water runoff during the monsoon season (June-September) and the tidal influx of coastal seawater during the summer (October to may) season. However, the effects of monsoon related changes on the phytoplankton of the mandovi estuary are not yet fully understood. An attempt to understand the same has been made here by applying the process of daily sampling at a fixed station throughout the monsoon season. It was noticed that the onset of the monsoon is responsible for an increase in nitrate levels upto 26 μm from a (chl a) as high as 14 μg·L-1 during the same period. The phytoplankton population was observed through both chemotaxonomy and microscopy and was found to be composed mainly of diatoms. CHEmTAX analysis further uncovers the presence of several other groups of phytoplankton, the presence of which is yet to be reported in many other tropical estuaries. It includes chrysophytes, cyanobacteria, prasinophytes, prymnesiophytes and chlorophytes. The appearance of phytoplankton groups at various stages of the monsoon was recorded, and this data is discussed in relation to environmental changes in the mandovi estuary during the monsoon season.

关键词： Phytoplankton Pigment Analysis monsoon Freshwater Runoff CHEmTAX

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Labor Pain through the Eyes of Brazilian Women and Delivery Nurses

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Open Journal of Nursing 2018年第1期8卷 78-92页

作者： Rafaela Feitosa Coutinho Taiane da Silva Alves Alecssandra de Fátima Silva Viduedo rejane Antonello Griboski Casandra G. R. m. P. de Leon Juliana machado Schardosim School of Ceilandia University of Brasília Brasília Brazil maternity Hospital Brasília Brasília Brazil The Undergraduate Program in Nursing School of Ceilandia University of Brasília Brasília Brazil

Objective: Understanding the perception of women who have recently given birth in a Brazilian hospital regarding labor pain and nursing involvement in the labor process. methodology: exploratory, descriptive and qualitative study carried out in a maternity part of the supplementary health system in the Federal District (DF). Data were collected between may and July 2015 through interviews using a semi-structured questionnaire. The sample consisted of 16 mothers and data analysis followed Bardin methodology in three phases. Results: The pain experienced during labor is surrounded by feelings and expectations. Both positive and negative feelings experienced by mothers were identified in the interviews and unanimous opinion was the fact that the second stage is the most painful period as continuous pain is experienced. Some of the participants compared pain with strong menstrual cramps, renal colic and back pain;others, said labor pain was the strongest ever experienced. The immediate contact with the newborn was referred to as a reward for coping with breast pain and suffering. Other factors such as the importance of follow-up, support and coping with the pain and care provided by health staff were also highlighted. Conclusion: empowerment of the mother and family through knowledge is considered an important tool to fight pain and cope with the birth process in a positive and physiological way, which in the long run promotes a cultural change in the population regarding the importance of vaginal birth.

关键词： Labor Pain Supplementary Health Birth Humanization Obstetrical Nursing Nursing Care

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Why 2022 is a revolutionary year for potato genomics

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molecular Plant 2022年第8期15卷 1257-1259页

作者： m.Timothy Rabanus-Wallace Nils Stein Leibniz Institute of Plant Genetics and Crop Plant Research(IPK) Stadt SeelandGermany Center for Integrated Breeding Research Georg-August-University Gottingen37075 GottingenGermany

While the humble spud may seem simple enough boiled on a plate,a lot of thought and effort goes into producing the varieties we like to *** lovers are conservative:the Russet Burbank,for instance,has produced our favorite French fries since 1902(Bethke et al.,2014).Cultivars need to be genetically stable-a state that is achieved in self-pollinating crop species like wheat and barley by repeated inbreeding.

关键词： favorite varieties instance

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