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高炉本体冷却系统的制造、选择及应用依据

涟钢科技与管理 2001年第6期 57-61页

作者： Albert J.Dzermejko reinoud van laar 李曙霞

铸铜冷却单元在高炉上广泛应用，如冷却板、风口、风口冷却器(风口大套和二套)等。但严重的热负荷和热震在冷却器内能产生很大的应力，这些应力在小铸造缺陷、小夹杂处产生裂纹而引起冷却器漏水。另外周期性的热应力在冷却水通道焊接接... 详细信息

铸铜冷却单元在高炉上广泛应用，如冷却板、风口、风口冷却器(风口大套和二套)等。但严重的热负荷和热震在冷却器内能产生很大的应力，这些应力在小铸造缺陷、小夹杂处产生裂纹而引起冷却器漏水。另外周期性的热应力在冷却水通道焊接接口处产生疲劳裂纹，而导致漏水。探测和找到这些漏水是一件十分困难但又很危急的任务。因为检漏不出，就会使炉衬过早地蚀损。

关键词：高炉风口冷却板夹杂蚀损炉衬冷却器铸造缺陷热震焊接

Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

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Neural Regeneration Research 2025年第1期20卷 82-92页

作者： Stiven Roytman Rebecca Paalanen Giulia Carli Uros Marusic Prabesh Kanel Teus van laar Nico I.Bohnen Department of Radiology University of MichiganAnn ArborMIUSA Department of Neurology University of MichiganAnn ArborMIUSA Morris K.Udall Center of Excellence for Parkinson’s Disease Research University of MichiganAnn ArborMIUSA Institute for Kinesiology Research Science and Research Centre KoperKoperSlovenia Department of Health Sciences Alma Mater Europaea–ECMMariborSlovenia Parkinson’s Foundation Research Center of Excellence University of MichiganAnn ArborMIUSA Department of Neurology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Neurology Service and GRECC VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging *** and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous *** effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory *** mechanisms which underpin the integration of these multisensory signals are the principal topic of the present *** multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older *** emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and *** the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s *** also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older ***,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

关键词： aging balance encephalography functional magnetic resonance imaging gait multisensory integration Parkinson’s disease positron emission tomography somatosensory vestibular visual

The Monumentenwacht model for preventive conservation of built heritage:A case study of Monumentenwacht Vlaanderen in Belgium

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Frontiers of Architectural Research 2021年第1期10卷 92-107页

作者： Meiping Wu Birgit van laar Department of Architecture Built Environment and Construction EngineerinsPolytechnic University of MilanMilan20133Italy Key Laboratory of Urban and Architectural Heritage Conservation Southeast UniversityNanjing210096China

Monumentenwacht(Monument Watch)is an organization that specializes in the periodic inspection of built heritage to raise awareness among owners and caretakers of the importance of proper maintenance and preventive *** originated in the Netherlands in *** was later established in Belgium,Germany,the UK,Denmark,Hungary,Italy,Slovak,Spain,France,and Portugal in the form of similar organizations and projects with similar *** organization promotes the idea of,fprevention is better than cureM by offering periodic inspection,monitoring,and minor urgent repair and writing independent professional inspection reports as a reference for owners and users for further maintenance and conservation *** study explores the working mode of Monumentenwacht in Flanders,Belgium,including its historical development,organizational structure,inspection team configuration,professional inspection report,database,reporting system,and technical manuals.A brief analysis of other similar organizations and projects in various European countries is included to reveal efficient ways to promote this model while respecting different cultural,economic,social,legal,and political contexts.

关键词： Monum entenwacht Preventive conservation Maintenance Periodic inspection Built heritage

APP and APLP1 are degraded through autophagy in response to proteasome inhibition in neuronal cells

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Protein & Cell 2011年第5期2卷 377-383页

作者： Fangfang Zhou Theo van laar Huizhe Huang Long Zhang Faculty of Basic Medical Sciences Medical College of Chongqing Medical UniversityChongqing 400016China Leiden University Medical Center Department of Molecular Cell Biology2333 ZA Leidenthe Netherland

Amyloid beta(Aβ)precursor protein(APP)is a key protein in the pathogenesis of Alzheimer’s disease(AD).Both APP and its paralogue APLP1(amyloid beta precursor-like protein 1)have multiple functions in cell adhesion and *** it was thought that autophagy is a novel beta-amyloid peptide(Aβ)-generating pathway activated in ***,the protein proteolysis of APLP1 is still largely *** present study shows that APLP1 is rapidly degraded in neuronal cells in response to stresses,such as proteasome *** of the endoplasmic reticulum(ER)stress by proteasome inhibitors induces autophagy,causing reduction of mature APLP1/*** autophagy or JNK stress kinase rescues the protein expression for both APP and ***,our results suggest that APP/APLP1 is degraded through autophagy and the APLP1 proteolysis is mainly mediated by autophagy-lysosome pathway.

关键词： amyloid beta precursor-like protein 1(APLP1) amyloid precursor protein(APP) proteasome inhibition endoplasmic reticulum stress autophagy neuronal cells

可满足高炉严格使用要求的高性能MTT金属管铸铜冷却壁

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钢铁 2007年第3期42卷 79-82页

作者： E.van Stein Callenfels R.van laar 达涅利康力斯

达涅利康力斯推出一种新的冷却概念,它将铜冷却壁与浇铸在其中的蒙乃尔铜-镍合金管结合为一个整体。蒙乃尔铜-镍合金管构成冷却水通道。它不仅可使冷却水拥有一条光滑的无泄漏通道,而且具有足够的尺寸灵活性,以满足躲避现有高炉炉壳开... 详细信息

达涅利康力斯推出一种新的冷却概念,它将铜冷却壁与浇铸在其中的蒙乃尔铜-镍合金管结合为一个整体。蒙乃尔铜-镍合金管构成冷却水通道。它不仅可使冷却水拥有一条光滑的无泄漏通道,而且具有足够的尺寸灵活性,以满足躲避现有高炉炉壳开口的要求,还可以省去在高炉炉壳内的任何焊接。

关键词：高炉长寿冷却壁

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高炉炉衬和冷却技术

钢铁 2004年第10期39卷 15-19页

作者： R.Stokman E.van Stein Callenfels R.van laar 达涅利康力斯

介绍了达涅利康力斯板式冷却器炉衬和冷却概念 ,并介绍炉役期已达 16年的康力斯 IJm uiden6号高炉。在连续生产 3430万 t铁水之后 ,最近对这座高炉的炉底和炉缸区进行大修。康力斯 IJmuiden6号高炉炉腹上部区、炉腰区和炉身区的设计表... 详细信息

介绍了达涅利康力斯板式冷却器炉衬和冷却概念 ,并介绍炉役期已达 16年的康力斯 IJm uiden6号高炉。在连续生产 3430万 t铁水之后 ,最近对这座高炉的炉底和炉缸区进行大修。康力斯 IJmuiden6号高炉炉腹上部区、炉腰区和炉身区的设计表现非常好 ,仅在上述部分看到轻微的侵蚀现象。达涅利康力斯在其他许多高炉上也采用同样的设计 ,达到很长的炉龄。康力斯 IJm uiden6号高炉达到这样长的炉龄 ,证明了采用具有良好传热性能的耐火材料结合板式冷却器设计 ,具有很高的可靠性。

关键词：高炉长寿铜板冷却器一体化炉衬

Management of extracranial carotid artery stenosis during endovascular treatment for acute ischaemic stroke:results from the MR CLEAN Registry

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Stroke & Vascular Neurology 2023年第3期8卷 229-237,I0074-I0085页

作者： Sabine L Collette Michael P Rodgers Marianne A A van Walderveen Kars C J Compagne Paul J Nederkoorn Jeannette Hofmeijer Jasper M Martens Gert J de Borst Gert Jan R Luijckx Charles B L M Majoie Aad van der Lugt reinoud P H Bokkers Maarten Uyttenboogaart University Medical Centre Groningen University of GroningenGroningenThe Netherlands Leiden University Medical Centre LeidenThe Netherlands Erasmus MC University Medical CentreRotterdamThe Netherlands Amsterdam University Medical Centres University of AmsterdamAmsterdamThe Netherlands Rijnstate Hospital ArnhemThe Netherlands University Medical Centre Utrecht University of UtrechtUtrechtThe Netherlands

Background The optimal management of ipsilateral extracranial internal carotid artery(ICA)stenosis during endovascular treatment(EVT)is *** compared the outcomes of two different strategies:EVT with vs without carotid artery stenting(CAS).Methods In this observational study,we included patients who had an acute ischaemic stroke undergoing EVT and a concomitant ipsilateral extracranial ICA stenosis of≥50%or occlusion of presumed atherosclerotic origin,from the Dutch Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands(MR CLEAN)Registry(2014-2017).The primary endpoint was a good functional outcome at 90 days,defined as a modified Rankin Scale score≤*** endpoints were successful intracranial reperfusion,new clot in a different vascular territory,symptomatic intracranial haemorrhage,recurrent ischaemic stroke and any serious adverse *** Of the 433 included patients,169(39%)underwent EVT with *** 123/168(73%)patients,CAS was performed before intracranial *** 42/224(19%)patients who underwent EVT without CAS,a deferred carotid endarterectomy or CAS was *** with and without CAS were associated with similar proportions of good functional outcome(47%vs 42%,respectively;adjusted OR(aOR),0.90;95%CI,0.50 to 1.62).There were no major differences between the groups in any of the secondary endpoints,except for the increased odds of a new clot in a different vascular territory in the EVT with CAS group(aOR,2.96;95%CI,1.07 to 8.21).Conclusions Functional outcomes were comparable after EVT with and without *** during EVT might be a feasible option to treat the extracranial ICA stenosis but randomised studies are warranted to prove non-inferiority or superiority.

关键词： stenosis carotid treatment

Intra-arterial thrombolytics during endovascular thrombectomy for acute ischaemic stroke in the MR CLEAN Registry

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Stroke & Vascular Neurology 2023年第1期8卷 17-25页

作者： Sabine L Collette reinoud P H Bokkers Aryan Mazuri Geert J LycklamaàNijeholt Robert J van Oostenbrugge Natalie E LeCouffe Faysal Benali Charles B L M Majoie Jan Cees de Groot Gert Jan R Luijckx Maarten Uyttenboogaart 无 Department of Radiology Medical Imaging CentreUniversity Medical Centre GroningenUniversity of GroningenGroningenthe Netherlands Department of Radiology Haaglanden Medical CentreThe Haguethe Netherlands Department of Neurology Cardiovascular Research Institute Maastricht(CARIM)Maastricht University Medical CentreMaastrichtthe Netherlands Department of Neurology Amsterdam UMCUniversity of AmsterdamAmsterdam NeuroscienceAmsterdamthe Netherlands Department of Radiology Maastricht University Medical CentreMaastrichtthe Netherlands Department of Radiology and Nuclear Medicine Amsterdam UMCUniversity of AmsterdamAmsterdam NeuroscienceAmsterdamthe Netherlands Department of Neurology University Medical Centre GroningenUniversity of GroningenGroningenthe Netherlands On behalf of the MR CLEAN Registry investigators

Introduction The efficacy and safety of local intra-arterial(IA)thrombolytics during endovascular thrombectomy(EVT)for large-vessel occlusions is *** analysed how often IA thrombolytics were administered in the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands(MR CLEAN)Registry,whether it was associated with improved functional outcome and assessed technical and safety outcomes compared with EVT without IA *** In this observational study,we included patients undergoing EVT for an acute ischaemic stroke in the anterior circulation from the MR CLEAN Registry(March 2014-November 2017).The primary endpoint was favourable functional outcome,defined as an modified Rankin Scale score≤2 at 90 *** endpoints were reperfusion status,early neurological recovery and symptomatic intracranial haemorrhage(sICH).Subgroup analyses for IA thrombolytics as primary versus adjuvant revascularisation attempt were *** Of the 2263 included patients,95(4.2%)received IA thrombolytics during *** IA thrombolytics administered were urokinase(median dose,250000 IU(IQR,193750-250000))or alteplase(median dose,20 mg(IQR,12-20)).No association was found between IA thrombolytics and favourable functional outcome(adjusted OR(aOR),1.16;95%CI 0.71 to 1.90).Successful reperfusion was less often observed in those patients treated with IA thrombolytics(aOR,0.57;95%CI 0.36 to 0.90).The odds of sICH(aOR,0.82;95%CI 0.32 to 2.10)and early neurological recovery were comparable between patients treated with and without IA *** primary and adjuvant revascularisation attempts,IA thrombolytics were more often administered for proximal than for distal *** outcomes were comparable for patients receiving IA thrombolytics as a primary versus adjuvant revascularisation *** Local IA thrombolytics were rarely used in the MR CLEAN *** the relatively small st

关键词： arterial throm acute

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高炉热风炉系统的选择与设计

武钢技术 1989年第10期27卷 28-32页

作者： J.van laar 夏红

设计现代化的高炉热风炉,不仅要考虑炉龄应达到30年左右,还应考虑在能源价格和焦炭使用率出现大波动时,能适应经济要求。霍戈文热风炉系统的历史和发展过程,为未来的热风炉设计和操作特性适应上述条件奠定了基础。一、霍戈文钢铁公司的... 详细信息

设计现代化的高炉热风炉,不仅要考虑炉龄应达到30年左右,还应考虑在能源价格和焦炭使用率出现大波动时,能适应经济要求。霍戈文热风炉系统的历史和发展过程,为未来的热风炉设计和操作特性适应上述条件奠定了基础。一、霍戈文钢铁公司的经验 1.历史及其发展过程以前,该公司4号、5号高炉(炉缸直径8.5米)采用普通型热风炉,最高风温只有900℃。

关键词：高炉热风炉设计