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High-pressure metamorphic rocks in the Borborema Province, Northeast Brazil: Reworking of Archean oceanic crust during proterozoic orogenies

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Geoscience Frontiers 2020年第6期11卷 2221-2242页

作者： Alanielson da câmara Dantas Ferreira Elton Luiz Dantas Ticiano JoséSaraiva dos Santos reinhardt A.Fuck Mahyra Tedeschi Instituto de Geociências Universidade de Brasília(UnB)70910-900Brasília-DFBrazil Instituto de Geociências Universidade Estadual de Campinas(UNICAMP)Departamento de Geologia e Recursos Naturais13083-970Campinas-SPBrazil Instituto de Geoci^encias Universidade Federal de Minas Gerais(UFMG)31270-901Belo HorizonteMGBrazil

We present the first evidence of Archean oceanic crust submitted to Proterozoic high-pressure(HP)metamorphism in the South American ***-Nd and Lu-Hf isotopic data combined with U-Pb geochronological data from the campo Grande area,Rio Grande do Norte domain,in the Northern Borborema Province,reflect a complex Archean(2.9 Ga and 2.6 Ga)and Paleoproterozoic(2.0 Ga)evolution,culminating in the Neoproterozoic Brasiliano/Pan-African orogeny(ca.600 Ma).The preserved mafic rocks contain massive poikiloblastic garnet and granoblastic amphibole with variable proportions of plagioclase+diopside in symplectitic texture,typical of high-pressure *** clinopyroxene-garnet amphibolites and the more common garnet amphibolites from the campo Grande area are exposed as rare lenses within an Archean migmatite *** amphibolite lenses represent 2.65 Ga juvenile tholeiitic magmatism derived from depleted mantle sources(positive values of+3.81 to+30.66)later enriched by mantle metasomatism(negative εNd(t)values of-7.97).chondrite and Primitive Mantle-normalized REE of analyzed samples and discriminant diagrams define two different oceanic affinities,with E-MORB and OIB *** Eu anomalies(Eu/Eu*=0.75-0.95)indicate depletion of plagioclase in the *** zircon cores of 3.0-2.9 Ga in analyzed samples indicate that the Neoarchean tholeiitic magmatism was emplaced into 2923±14 Ma old Mesoarchean crust(εNd(t)--2.58 and Nd TDM=3.2 Ga)of the Rio Grande do Norte *** age of retro-eclogite facies metamorphism is not yet completely *** suggest that two high-grade metamorphic events are recognized in the mafic rocks:the first at 2.0 Ga,recorded in some samples,and the second,at ca.600 Ma,stronger and more pervasive and recorded in several of the mafic rock *** Neoproterozoic zircon grains are found in symplectite texture as inclusions in the garnet grains and represent the age of HP conditions in the *** zircon grains show a

关键词： Archean oceanic crust Proterozoic orogens Borborema province

Influence of vascular endothelial growth factor and radiation on gap junctional intercellular communication in glioblastoma multiforme cell lines

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Neural Regeneration Research 2017年第11期12卷 1816-1822页

作者： reinhardt Krcek Pauline Latzer Irenaus Anton Adamietz Helmut Biihler carsten Theiss Institute of Anatomy Department of CytologyRuhr-University BochumBochumNorth Rhine-WestphaliaGermany Department of Radiotherapy and Radio-Oncology University Medical Centre MarienhospitalRuhr-University BochumHerneNorth Rhine-WestphaliaGermany Institute for Molecular Oncology Radio-Biology and Experimental RadiotherapyUniversity Medical Centre MarienhospitalRuhr-University BochumHerneNorth Rhine-WestphaliaGermany

Glioblastoma multiforme （GBM） is a highly aggressive glial brain tumor with an unfavorable prognosis despite all current therapies including surgery, radiation and chemotherapy. One characteristic of this tumor is a strong synthesis of vascular endothelial growth factor （VEGF）, an angiogenesis factor, followed by pronounced vascularization. VEGF became a target in the treatment of GBM, for example with bevacizumab or the tyrosine kinase inhibitor axitinib, which blocks VEGF receptors. To improve patients＇ prognosis, new targets in the treatment of GBM are under investigations. The role of gap junctions in GBM remains un- known, but some experimental therapies affect these intercellular channels to treat the tumor. Gap junctions are composed of connexins to allow the transport of small molecules between adjacent cells through gap junc- tional intercellular communication （GJIc）. Based on data derived from astrocytes in former studies, which show that VEGF is able to enhance GJIc, the current study analyzed the effects of VEGF, radiation therapy and VEGF receptor blockade by axitinib on GJIc in human GBM cell lines U-87 and U-251. While VEGF is able to induce GJIc in U-251 cells but not in U-87 cells, radiation enhances GJIc in both cell lines. VEGF reocptor blockade by axitinib diminishes radiation induced effects in U-251 partially, while increases GJIc in U-87 cells. Our data indicate that VEGF and radiation are both modifying components of GJ1c in pathologic brain tumor tissue.

关键词： cell communication vascular endothelial growth factor irradiation vascular endothelial growth factor-receptor blockade glioma neurobiotin connexin cell culture immunohistochemistry microinjection

Timing of Proterozoic magmatism in the Sunsas belt, Bolivian Precambrian Shield, SW Amazonian craton

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Geoscience Frontiers 2021年第6期12卷 277-293页

作者： Ingrid M.Nedel reinhardt A.Fuck Amarildo S.Ruiz Gerardo R.Matos-Salinas Alanielson da c.D.Ferreira Instituto de Geociências Universidade de Brasília(UnB)Brasília-DFBrazil Faculdade de Geociências Universidade Federal de Mato GrossoCuiabá-MTBrazil Instituto de Investigaciones Geológicas y del Medio Ambiente Universidad Mayor de San Andrés(UMSA)Pabellón GeologíaCalle 27Campus Universitario Cota CotaLa PazBolivia Department of Earth Sciences Stellenbosch UniversityPrivate Bag X1Matieland7602 StellenboschSouth Africa

We present new U–Pb zircon and monazite ages from the Sunsas belt granitic magmatism in Bolivia, SW Amazonian craton. The geochronological results revealed four major magmatic events recorded along the Sunsas belt domains. The older igneous event formed a granitic basement coeval to the Rio Apa Terrane(1.95–1.85 Ga) in the southern domain. The second magmatic episode is represented by 1.68 Ga granites associated to the Paraguá Terrane(1.69–1.66 Ga) in the northern domain. The 1.37–1.34 Ga granites related to San Ignacio orogeny represent the third and more pervasive magmatic event, recorded throughout the Sunsas belt. Moreover, magmatic ages of ~1.42 Ga revealed that the granitogenesis associated to the Santa Helena orogeny also affected the Sunsas belt, indicating that it was not restricted to the Jauru Terrane. Lastly, the 1.10–1.04 Ga youngest magmatism was developed during the Sunsas orogeny and represents the final magmatic evolution related to Rodinia assembly. Likewise, the 1.95–1.85 and 1.68 Ga inherited zircon cores obtained in the ~1.3 Ga and 1.0 Ga granite samples suggest strong partial melting of the Paleoproterozoic sources. The 1079 ± 14 Ma and 1018 ± 6 Ma monazite crystallization ages can be correlated to the collisional tectono-thermal event of the Sunsas orogeny, associated to reactions of medium-to high-grade metamorphism. Thus, the Sunsas belt was built by heterogeneous 1.95–1.85 Ga and 1.68 Ga crustal fragments that were reworked at 1.37–1.34 Ga and 1.10–1.04 Ga related to orogenic collages. Furthermore, the 1.01 Ga monazite age suggests that granites previously dated by zircon can bear evidence of a younger thermal history. Therefore, the geochronological evolution of the Sunsas belt may have been more complex than previously thought.

关键词： SW Amazonian craton Sunsas belt U–Pb geochronology Zircon Monazite

An exotic cretaceous kimberlite linked to metasomatized lithospheric mantle beneath the southwestern margin of the S?o Francisco craton,Brazil

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Geoscience Frontiers 2022年第1期13卷 182-203页

作者： Luísa D.V.carvalho Tiago Jalowitzki Ricardo Scholz Guilherme O.Gonçalves Marcelo Peres Rocha Rogério Silvestre Pereira cristiano Lana Marco Paulo de castro Gláucia Queiroga reinhardt A.Fuck Universidade Federal de Ouro Preto(UFOP) Escola de MinasDepartamento de GeologiaCampus Morro do Cruzeiro35400-000 Ouro PretoMGBrazil Universidade de Brasília(UnB) Instituto de GeociênciasCampus Universitário Darcy Ribeiro70910-900 BrasíliaDFBrazil Independent Geologist consultant

We present major and trace element compositions of mineral concentrates comprising garnet xenocrysts,ilmenite,phlogopite,spinel,zircon,and uncommon minerals(titanite,calzirtite,anatase,baddeleyite and pyrochlore)of a newly discovered Late cretaceous kimberlite(U-Pb zircon age 90.0±1.3 Ma;2σ)named Osvaldo Franca 1,located in the Alto Paranaíba Igneous Province(APIP),southeastern *** grains are lherzolitic(Lherz-1,Lherz-2 and Lherz-3),harzburgitic(Harz-3)and wehrlitic(Wehr-2).The pyrope xenocrysts cover a wide mantle column in the subcratonic lithosphere(66–143 km;20–43 kbar)at relatively low temperatures(811–875°c).The shallowest part of this mantle is represented by Lherz-1 pyropes(20–32 kbar),which have low-cr(cr_(2)O_(3)=1.74–6.89 wt.%)and fractionated middle to heavy rare earth elements(MREE-HREE)*** deepest samples are represented by Lherz-2,Lherz-3,Harz-3,and Wehr-2 pyropes(36–43 kbar).They contain high-cr contents(cr_(2)O_(3)=7.36–11.19 wt.%)and are characterized by sinusoidal(Lherz-2 and Wehr-2)and spoon-like(Lherz-3 and Harz-3)REE *** to their REE and trace elements,pyrope xenocrysts have enriched nature(e.g.,ce and Yb ***_(2)O_(3)),indicating that the cratonic lithosphere has been affected by a silicate melt with subalkaline/tholeiite composition due to their low Zr,Ti and Y *** minerals with typical kimberlitic signatures,such as ilmenite and zircon,the exotic compositions of phlogopite and ulvöspinel suggest an enriched component in the magma *** formation of rare mineral phases with strong enrichment of light-REE(LREE)and high field strength elements(HFSE)is attributed to the late-stage kimberlitic *** propose a tectonic model where a thermal anomaly,represented by the low-velocity seismic anomaly observed in P-wave seismic tomography images,supplied heat to activate the alkaline magmatism from a metasomatized cratonic mantle source during the late-stages of Gondwana fragmentation and conse

关键词： Osvaldo França 1 kimberlite Alto Paranaíba Igneous Province Metasomatized cratonic lithosphere Zircon U-Pb geochronology

氢激射器EFOS、NP、NX性能的最新测试结果

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宇航计测技术 1985年第S1期 41-46页

作者： V.reinhardt S.c.WartiP 曹晖

一、引言受国家航空和航天管理局(NASA)哥达德空间飞行中心(GSFc)的委托,本底克斯野外工程公司(BFEc)在一九八三年初测试了奥赛罗库兹(Oscilloquartz)的EFOS-2以及NASA的NX-3和NP-2氢激射器的性能,本文叙述了那次测试的结果。应国家射... 详细信息

一、引言受国家航空和航天管理局(NASA)哥达德空间飞行中心(GSFc)的委托,本底克斯野外工程公司(BFEc)在一九八三年初测试了奥赛罗库兹(Oscilloquartz)的EFOS-2以及NASA的NX-3和NP-2氢激射器的性能,本文叙述了那次测试的结果。应国家射电天文台(NRAO)买主的请求,Oscilloquartz厂的技术人员把氢激射器EFOS-2运到马里兰州哥仑比亚城BFEc的氢激射器实验室,图1为EFOS-2氢激射器到达实验室不久的照片(图1略,请见原文)。

关键词：激射器频率漂移恒温室量子放大器 EFOS 阿仑方差测试结果 NP NX

Generating Solitons by Phase Engineering of a Bose-Einstein condensate

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Generating Solitons by Phase Engineering of a Bose-Einstein ...

采用心肌声学造影量化绝对心肌灌注:算法与验证

ccAST“激光冷却：玻色—爱因斯坦凝聚和原子激射器”研讨会

作者： J.Denschlag J.E.Simsarian D.L.Feder c.W.clark L.A.collins J.cubizolles L.Deng E.W.Hagley K.Helmerson W.P.reinhardt S.L.Rolston B.I.Schneider W.D.Phillips National Institute of Standards and Technology (NIST.Gaithersburg MD 20899.USA. ~1National Institute of Standards and Technology(NIST.caithersburg MO 2O899 USA.~2University of Oxford parks Road.OXford OX1 3PU UK. Theoretical Division Mail Stop 3212.Los Alamos Natiooal Laboratory Los AlamosNM 87545USA National Inscitute of Standards and Technology(NIST.Gaithersbure MD 20899.USA. Ecole Normate Superieure 24 rue Lhomond 75231 Paris.France. National Institute of Standards and Technology (NIST.Gaithersburg.MO 20899. USA.Department of chemistry.University of Washington Seattle.WA 98 95.USA. Physics Division National Science Foundation ArjingtonVA 22230.USA

Quantum phase engineering is demonstrated with two novel techniques thatallow the spatial phase distribution of a Bose-Einstein condensate(BEc) to bewritten and read out.A quantum state was designed and produced by opticallyimprinting a phase pattern onto a BEc of sodium atoms,and matter-waveinterferometry with spatially resolved imaging was used to analyze the re-sultant phase *** appropriate phase imprint created *** experimental realization of this nonlinear phenomenon in a BEc Thesubsequent evolution of these excitations was investigated both experimentallyand theoretically.

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世界核心医学期刊文摘（心脏病学分册） 2005年第8期1卷 56-56页

作者： Vogel R. Indermü hle A. reinhardt J. c. Seiler 杜媛 Department of cardiology University Hospital Bern CH- 3010 Bern Switzerland

Objectives: We sought to test whether myocardial blood flow(MBF) can be quantified by myocardial contrast echocardiography(McE) using a volumetric model of ultrasound contrast agent(UcA) kinetics for the description of refill curves after ultrasound- induced microsphere destruction. Background: Absolute myocardial perfusion or MBF(ml· min- 1· g- 1) is the gold standard to assess myocardial blood supply, and so far it could not be obtained by ultrasound. Methods: The volumetric model yielded MBF=rBV· β /ρ T, where ρ T equals tissue density. The relative myocardial blood volume rBV and its exchange frequency β were derived from UcA refill sequences. Healthy volunteers underwent McE and positron emission tomography(PET) at rest(group I: n=15; group II: n=5) and during adenosine- induced hyperemia(group II). Fifteen patients with coronary artery disease underwent simultaneous McE and intracoronary Doppler measurements before and during intracoronary adenosine injection. Results: In vitro experiments confirmed the volumetric model and the reliable determination of rBV and β for physiologic flow velocities. In group I, 187 of 240 segments were analyzable by McE, and a linear relation was found between McE and PET perfusion data(y=0.899x + 0.079; r2=0.88). In group II, resting and hyperemic perfusion data showed good agreement between McE and PET(y=1.011x + 0.124; r2=0.92). In patients, coronary stenosis varied between 0% to 89% , and myocardial perfusion reserve was in good agreement with coronary flow velocity reserve(y=0.92x + 0.14; r2=0.73). conclusions: The volumetric model of UcA kinetics allows the quantification of MBF in humans using McE and provides the basis for the noninvasive and quantitative assessment of coronary artery disease.

关键词：心肌声学造影心肌灌注金指标心肌血流心肌血供超声造影剂超声心动图血流灌注血流速度再灌注

术前运动、体感和语言fMRI技术的可行性及局限性:13年随访491例病人

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国际医学放射学杂志 2017年第2期 232-232页

作者： A.J.Tyndall J.reinhardt V.Tronnier L.Mariani c.Stippich 陈皓 Division of Diagnostic and Interventional Neuroradiology University Hospital Basel

摘要目的针对一组颅脑肿瘤和癫病人分别进行1.5 T和3.0 T MR扫描,分析其术前f MRI的长期可行性和局限性。方法研究纳入2000—2012年间的491例病人,于5台

关键词：术前病人体感

唐氏综合征新生儿患者的一过性骨髓增生综合征:对来自AML-BFM和ESPED研究项目的115例患儿的综述和分析

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世界核心医学期刊文摘（儿科学分册） 2006年第8期2卷 55-55页

作者： Diekamp S. creutzig U. reinhardt D. Baumann-Khler M. 唐彦 AML-Studienzent-rale Klinik und Poliklinik für KinderheilkundePdiatrische Hmatologie/OnkologieAlbert-Schweitzer-Strafle 3348129 MünsterGermany Dr.

Transient myeloproliferative syndrome(TMS)is a disorder of neonates with Dow n syndrome(trisomy 21)and occurs at an incidence of up to 10%.Typical for th is entity is a proliferation of myeloid blasts with megakaryoblastic and/or eryt hroblastic features detectable in the peripheral *** the majority of cases TMS is asymptomatic,and only a small percentage of children show clinical symp toms due to hyperleukocytosis,thrombocytopenia,anemia,or *** all children will achieve spontaneous remission after 2-4 months(disappearanc e of myeloid blasts and regression of clinical symptoms).Patients with initial hyperleukocytosis and hepatomegaly,however,carry a particular risk of developi ng hepatopathy followed frequently by lethal liver *** with c ytarabine is indicated in patients with clinical symptoms of hyperleukocytosis o r early signs of *** the first 4 years the risk of developing ac ute myeloblastic leukemia(AML)is high at 20-30%;therefore,regular followup s are *** analysis is based on one of the largest databases for TMS.

关键词：骨髓增生综合征新生儿患者唐氏综合征一过性患儿 AML 白细胞增多 21三体综合征粒细胞性白血病项目