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Pickering emulsion transport in skeletal muscle tissue:A dissipative particle dynamics simulation approach

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Chinese Journal of Chemical Engineering 2024年第4期68卷 65-75页

作者： Xuwei Liu Wei Chen Yufei Xia Guanghui Ma reiji Noda Wei Ge State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Division of Environmental Engineering Science Graduate School of Science and TechnologyGunma University1-5-1 Tenjin-choKiryuGunma 376-8515Japan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China

Lymph node targeting is a commonly used strategy for particulate vaccines,particularly for Pickering ***,extensive research on the internal delivery mechanisms of these emulsions,especially the complex intercellular interactions of deformable Pickering emulsions,has been surprisingly *** gap in knowledge holds significant potential for enhancing vaccine *** study aims to address this by summarizing the process of lymph-node-targeting transport and introducing a dissipative particle dynamics simulation method to evaluate the dynamic processes within cell *** transport of Pickering emulsions in skeletal muscle tissue is specifically investigated as a case *** factors impacting the transport process are explored,including local cellular tissue environmental factors and the properties of the Pickering emulsion *** simulation results primarily demonstrate that an increase in radial repulsive interaction between emulsion particles can decrease the transport ***,larger intercellular gaps also diminish the transport efficiency of emulsion droplet particles due to the increased motion complexity within the intricate transport space compared to a single *** study sheds light on the nuanced interplay between engineered and biological systems influencing the transport dynamics of Pickering *** insights hold valuable potential for optimizing transport processes in practical biomedical applications such as drug ***,the desired transport efficiency varies depending on the specific *** instance,while a more rapid transport might be crucial for lymph-node-targeted drug delivery,certain applications requiring a slower release of active components could benefit from the reduced transport efficiency observed with increased particle repulsion or larger intercellular gaps.

关键词： Pickering emulsion Skeletal muscular cells Transport phenomena Dissipative particle dynamics Drug delivery

The Research Existing Condition and Application of Solid Waste Disposal in Japan

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四川大学学报（工程科学版） 2009年第S1期41卷 62-69页

作者： TANAKA reiji KITATSUJI Masafumi Faculty of Eng. Tohoku Inst.e of Technol. Miyagi Univ.

Japan lacked resources is a large import country and also a large consuming *** it is turned society structure system of consumption goods stocked in domestic,which leads to 450 millions ton waste ***,because of continuing development of intermediate handling and recycled utilization technology,finally disposed waste materials approximately 30 millions *** quantity of concrete product is consumed 300 millions ton per year unprecedented,beau case of large scope,it is expected valid and large absorption industry of recycled material. The purpose of this paper is to do a report on applied present status and future assignment of recycled material and building structure in Japan.

关键词： inorganic waste recycled aggregate circumstance security precast concrete product reinforced concrete structure

Diffusion-weighted MRI in abdominal oncology:Clinical applications

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World Journal of Gastroenterology 2010年第7期16卷 832-836页

作者： reiji Sugita Kei Ito Naotaka Fujita Shoki Takahashi Department of Radiology Sendai City Medical CenterSendai 983-0824Japan Department of Gastroenterology Sendai City Medical CenterSendai 983-0824Japan Department of Diagnostic Radiology Graduate School of MedicineTohoku UniversitySendai 980-8574Japan

Diffusion-weighted magnetic resonance imaging(DWI) provides image contrast that is different from that obtained by conventional magnetic resonance *** previously,DWI has been used to evaluate various diseases of the central nervous system,several technical advances have expanded the clinical applications of DWI beyond the central nervous *** a result,many reports have been published on the use of DWI in abdominal ***,abdominal DWI has now being focused on evaluation of patients with abdominal *** can be used for pretreatment tumor detection,characterization including predicting tumor response to therapy,monitoring tumor response during therapy,and follow-up study after treatment to detect possible tumor recurrence.

关键词： Diffusion weighted magnetic resonance imaging Abdominal neoplasms

Molecular dynamics simulations of ovalbumin adsorption at squalene/water interface

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Chinese Journal of Chemical Engineering 2022年第10期50卷 369-378页

作者： Qingxia Xiong Ying Ren Yufei Xia Guanghui Ma reiji Noda Wei Ge State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Division of Environmental Engineering Science Graduate School of Science and TechnologyGunma University1-5-1 Tenjin-choKiryuGunma 376-8515Japan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China

The adsorption of protein molecules to oil/water(O/W)interface is of critical importance for the product design in a wide range of technologies and industries such as biotechnology,food industry and pharmaceutical *** this work,with ovalbumin(OVA)as the model protein,the adsorption conformations at the O/W interface and the adsorption stability have been systematically studied via multiple simulation methods,including all-atom molecular dynamic(AAMD)simulations,coarse-grained molecular dynamic(CGMD)simulations and enhanced sampling *** computational results of AAMD and CGMD show that the hydrophobic tail of OVA tends to be folded under long time relaxation in aqueous phase,and multiple adsorption conformations can exist at the interface due to heterogeneous interactions raising from oil and water *** further study the adsorption sites of the protein,the adsorption kinetics of OVA at the O/W interface is simulated using metadynamics method combined with CGMD simulations,and the result suggests the existence of multiple adsorption conformations of OVA at interface with the head-on conformation as the most stable *** all,this work focuses on the adsorption behaviors of OVA at squalene/water interface,and provides a theoretical basis for further functionalization of the proteins in emulsion-based products and engineering.

关键词： Molecular dynamicssimulation Metadynamics Protein adsorption Structural stability Ovalbumin

Relationships between soil moisture and dust emissions in a bare sandy soil of Mongolia

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Particuology 2016年第5期14卷 131-137页

作者： Erdenebayar Munkhtsetseg Masato Shinoda John A. Gillies reiji Kimura James King George Nikolich National University of Mongolia Peace Avenue 14/3 Sukhbaatar District 8 Ulaanbaatar 14191 Mongolia Nagoya University Furo-cho Chikusa-ku Nagoya 464-8601 Nagoya Japan Desert Research Institute 2215 Raggio Parkway Reno NV 89512 USA Arid Land Research Center Tottori University Hamasaka 1390 Tottori 680-0001 Japan Departement de geographie Universite de Montreal Pavilion 520 chemin de la Cote-Sainte-Catherine Montreal QC H3 C 3J7 Canada Desert Research Institute 755 E. Flamingo Road Las Vegas NV 89119. USA

This study presents experimental results of the change in threshold friction velocity and dust emission strength as a function of soil moisture content. The dust and soil moisture data were obtained from irrigated plots of a bare, sandy soil （no vegetation） situated in the Mongolian steppe. Dust flux was measured using the PI-SWERL^（R） device, while soil moisture was measured using gravimetric methods. Our results demonstrate the strong controlling effects of soil moisture on both the threshold friction velocity and dust emission strengths. Threshold friction velocity increased from 0.44 m/s for dry soil （0.002 g/g） to 0.67 m/s for wet soil （0.06 g/g）, confirming the importance of soil moisture for controlling dust events. Dust emission strength was significantly depressed for wet soils, starting at a soil moisture value of 0.02 g/g. From these results, we developed a simple dust diagram that may be useful as part of a warning system to identify initial sensitivity to threshold conditions as well as conditions that could lead to potentially significant dust emissions. Overall, the research findings in this study could be used to provide foreknowledge of conditions that would be conducive to high dust emissions for this area of Mongolia.

关键词： Threshold friction velocity Simple dust diagram Dust emission Absence of vegetation Mini wind tunnel

Automatic registration of MLS point clouds and SfM meshes of urban area

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Geo-Spatial Information Science 2016年第3期19卷 171-181页

作者： reiji Yoshimura Hiroaki Date Satoshi Kanai Ryohei Honma Kazuo Oda Tatsuya Ikeda Graduate School of Information Science and Technology Hokkaido UniversitySapporoJapan Asia Air Survey Co. LtdKawasakiJapan

Recent advances in 3D scanning technologies allow us to acquire accurate and dense 3D scan data of large-scale environments ***,there are various methods for acquiring largescale 3D scan data,such as Mobile Laser Scanning(MLS),Airborne Laser Scanning,Terrestrial Laser Scanning,photogrammetry and Structure from Motion(SfM).Especially,MLS is useful to acquire dense point clouds of road and road-side objects,and SfM is a powerful technique to reconstruct meshes with textures from a set of digital *** this research,a registration method of point clouds from vehicle-based MLS(MLS point cloud),and textured meshes from the SfM of aerial photographs(SfM mesh),is proposed for creating high-quality surface models of urban areas by combining *** general,SfM mesh has non-scale information;therefore,scale,position,and orientation of the SfM mesh are adjusted in the registration *** our method,first,2D feature points are extracted from both SfM mesh and MLS point *** process consists of ground-and building-plane extraction by region growing,random sample consensus and least square method,vertical edge extraction by detecting intersections between the planes,and feature point extraction by intersection tests between the ground plane and the ***,the corresponding feature points between the MLS point cloud and the SfM mesh are searched efficiently,using similarity invariant features and ***,the coordinate transformation is applied to the SfM mesh so that the ground planes and corresponding feature points are ***,scaling Iterative Closest Point algorithm is applied for accurate *** results for three data-sets show that our method is effective for the registration of SfM mesh and MLS point cloud of urban areas including buildings.

关键词： Registration MLS point clouds SfM mesh urban area hash similarity invariant feature

Brachiocephalic to left brachial vein thrombotic vasculitis accompanying mediastinal pancreatic fistula:A case report

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World Journal of Clinical Cases 2022年第32期10卷 11882-11888页

作者： reiji Kokubo Daisuke Yunaiyama Yu Tajima Natsumi Kugai Mitsuru Okubo Kazuhiro Saito Takayoshi Tsuchiya Takao Itoi Department of Radiology Tokyo Medical UniversityTokyo 160-0023Japan Department of Gastroenterology and Hepatology Tokyo Medical UniversityTokyo 160-0023Japan

BACKGROUND Pancreatitis is a severe inflammatory pancreatic disease commonly due to bile duct stones or excessive alcohol usage,with clinical manifestations of abdominal pain,nausea,fever,and fluid *** persons with less symptomatic pancreatitis are quite ***,we report a case of a patient with an undetermined onset of pancreatitis mimicking left arm cellulitis due to thrombotic vasculitis of the brachiocephalic *** SUMMARY A 50-year-old woman visited our hospital for tenderness in the left arm over several recent *** was diagnosed with cellulitis on the left arm due to left elbow *** antibiotics administration did not improve symptoms and laboratory data worsened;thus,chest and abdominal computed tomography(CT)was *** demonstrated pancreatitis with pseudocyst around the pancreas extending to the *** vasculitis of the brachiocephalic to left brachial vein was observed,which could be the cause of left elbow pain.A pancreatic fistula was found in the head of the pancreas by endoscopic retrograde cholangiopancreatography,so a pancreatic cyst drainage tube via the duodenum was placed in the *** content culture was positive for Escherichia coli *** symptoms,imaging findings,and inflammatory reactions resolved gradually after starting therapeutic *** mediastinal pancreatic pseudocysts shrunk,and the venous thrombi remained but *** The case of a patient with pancreatitis with an undetermined onset that mimics left arm cellulitis is *** vein thrombosis should be kept in mind when treating patients with severe inflammatory disease.

关键词： Pancreatic fistula Thrombotic vasculitis Pancreatitis Computed tomography Case report

Field Studies of Frontal Area Index in Rangeland of Mongolia

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Journal of Environmental Science and Engineering(A) 2013年第6期2卷 359-363页

作者： reiji Kimura Arid Land Research Center Tottori University Tottori 6800001 Japan

Field observation was conducted at typical rangeland in Mongolia to examine the frontal area index. Frontal area index is the characteristics of surface roughness elements affecting sand transport. The frontal area was strongly correlated with the effective shelter length on sand transport in both short grasses and shrubs. The frontal area index was 0.031 and the relationship between the roughness length and frontal area index in this site agreed with past studies.

关键词： Arid region frontal area index roughness length Asian dust.

Analysis and Improvement of Standing-Up Action for Elderly People from a Chair Using a Cushion-Type Support Tool

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Computer Technology and Application 2012年第11期3卷 713-722页

作者： Masakazu Takahashi reiji Nanba Graduate School of Medical and Engineering University of Yamanashi Kofu Yamanashi 400-8511 Japan Faculty of Engineering Daiichi University Kirishima Kagoshima 899-4385 Japan

This paper reports the problems that elderly people have when they stand up from a chair, and proposes an adequate standing-up procedure that solves these problems. The important points for an adequate standing-up procedure are ＂leaning the upper body forward＂ and ＂pulling the legs to the side＂. Furthermore, this paper proposes a standing-up support tool. The characteristics of the support tool are a cushion-type shape with an adjustable flange and an air-pressure-driven mechanism. When the proposed standing-up procedure and support tool are applied to elderly people, the measured values related to standing-up, such as maximum acceleration, arm force, standing-up time, heel position and forward-bending angle, are improved. Furthermore, elderly people felt that it made the standing-up action easy. We could confirm the effectiveness of the proposed standing-up procedure and support tool.

关键词： Elderly people standing-up procedure standing-up support tool cushion-type shape air-pressure-driven mechanism.