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Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry

World journal of Gastroenterology 2013年第36期19卷 6011-6019页

作者： rehan j haidry Mohammed A Butt jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris john Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat Department of Surgery and Interventional Science National Medical Laser Centre UCL Department Gastroenterology University College Hospital NHS Foundation Trust Department Gastroenterology Guy’s and St Thomas’ Hospitals NHS Trust Institute for Medical Informatics Oslo University Hospital Department Gastroenterology Royal Liverpool University Hospital Merseyside Department Gastroenterology Princess Alexandra Hospital Cosham Department Gastroenterology Bradford Royal Infirmary Bradford Department Gastroenterology Central Manchester University Hospital Department Gastroenterology Glasgow Royal Infirmary Department Gastroenterology Addenbrooke’s Hospital Royal Infirmary Edinburgh

AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National ***:A Prospective cohort study from 8 tertiary referral centres in the United *** with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were *** lesions were removed by endoscopic mucosal resection(EMR)before *** initial RFA treatment,patients were followed up *** flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or *** main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse ***:Twenty patients with squamous HGD/ESCC completed treatment *** patients(25%)had EMR before starting RFA ***-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this *** per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 *** patients(20%)required endoscopic dilatations for symptomatic structuring after *** of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per *** other 2 patients required only a single dilatation to achieve an adequate symptomatic *** patient developed cancer during follow up after end of treatment ***:The role of RFA in these patients re-mains *** our series 50%patients responded at12 *** figures are lower than limited published data.

关键词： Squamous neoplasia Oesophageal cancer Endoscopic mucosal resection High-grade dysplasia Radiofrequency ablation

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Miniature gastrointestinal endoscopy: Now and the future

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World journal of Gastroenterology 2019年第30期25卷 4051-4060页

作者： john j McGoran Mark E McAlindon Prasad G Iyer Eric j Seibel rehan haidry Laurence B Lovat Sarmed S Sami Digestive Diseases Centre Leicester Royal InfirmaryLeicester LE1 5WWUnited Kingdom Department of Gastroenterology Royal Hallamshire HospitalSheffield S10 2JFUnited Kingdom Division of Gastroenterology and Hepatology Mayo Clinic RochesterMN 55905United States Department of Mechanical Engineering University of Washington4000 Mason StSeattleWA 98195United States Division of Surgery and Interventional Science University College LondonLondon WC1E 6BTUnited Kingdom

Since its original application,gastrointestinal(GI)endoscopy has undergone many innovative transformations aimed at expanding the scope,safety,accuracy,acceptability and cost-effectiveness of this area of clinical *** method of achieving this has been to reduce the caliber of endoscopic *** propose the collective term“Miniature GI Endoscopy”.In this Opinion Review,the innovations in this field are explored and *** progress and clinical use of the three main areas of miniature GI endoscopy(ultrathin endoscopy,wireless endoscopy and scanning fiber endoscopy)are *** opportunities presented by these technologies are set out in a clinical context,as are their current *** of the positive aspects of miniature endoscopy are clear,in that smaller devices provide access to potentially all of the alimentary canal,while conferring high patient *** must be balanced with the costs of new technologies and recognition of device specific *** on future application are also considered and the efforts being made to bring new innovations to a clinical platform are *** devices demonstrate that miniature GI endoscopy has a valuable place in investigation of symptoms,therapeutic intervention and *** technologies give promise that the potential for enhancing the investigation and management of GI complaints is significant.

关键词： Ultrathin endoscopy Capsule endoscopy Single fiber endoscopy

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水热法制备Sn掺杂TiO2纳米颗粒及其丙酮传感器应用

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功能材料 2020年第11期51卷 11175-11181页

作者：王哲殷文强谢利娟于淳义 Azhar Ali haidry 南京航空航天大学材料科学与技术学院南京210006

二氧化钛因为其优异的灵敏度和物化稳定性,被认为是挥发性有机气体(volatile organic chemicals,VOCs)传感应用的潜在候选者之一。中通过水热法合成(1%~5 mol%)Sn掺杂多孔TiO2纳米颗粒。通过测试基于Sn掺杂TiO2纳米颗粒传感器对丙酮的... 详细信息

二氧化钛因为其优异的灵敏度和物化稳定性,被认为是挥发性有机气体(volatile organic chemicals,VOCs)传感应用的潜在候选者之一。中通过水热法合成(1%~5 mol%)Sn掺杂多孔TiO2纳米颗粒。通过测试基于Sn掺杂TiO2纳米颗粒传感器对丙酮的气敏响应,研究其气敏性能,证明了Sn掺杂片状多孔TiO2纳米颗粒在气体传感器领域的潜在应用前景。例如,气敏测试结果表明:Sn-TiO2显著降低了工作温度,3 mol%Sn-对丙酮具有高响应(Rs^42.35),快速的响应(16 s),恢复时间(8 s),良好的选择性以及稳定性。通过XRD、XPS、EDS、SEM、TEM等手段对合成的Sn-TiO2纳米颗粒进行了结构和形貌表征,以了解和验证其传感机理,并在此基础上,讨论了一种合理的传感机制。

关键词：水热法 Sn掺杂多孔TiO2纳米粒子丙酮敏感性

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