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prevention of renal dysfunction by nutraceuticals prepared from oil rich plant foods

Asian Pacific Journal of Tropical Biomedicine 2014年第8期4卷 618-626页

作者： Sahar Y.Al-Okbi Doha A.Mohamed Thanaa E.Hamed reham sh.esmail Souria M.Donya Food Sciences and Nutrition Department National Research CentreDokkiCairoEgypt Pathology Department National Research CentreDokkiCairoEgypt Cytogenetic Department National Research CentreDokkiCairoEgypt

Objective:To investigate the protective effect of extracts prepared from avocado,walnut,flaxseed and Eruca sativa seeds in a rat model of kidney dysfunction induced by intraperitoneal ***:Ethanol and petroleum ether extracts mixture was prepared from each *** groups of rats were conducted:control healthy,cisplatin group and four test groups where rats were given daily oral dose of each extract mixture before cisplatin *** biochemical and cytogenetic parameters and kidney histopathology were *** toxicity was tested for the *** phenolic contents,faity acids(FA) and unsaponifiable matter were assessed in the ***:Walnut ethanol extract showed the highest content of total *** analysis revealed that all the studied plants were rich in unsaturated ***-liquid chromatographic investigation of the unsaponifiable matter showed the presence of *** and β—sitosterol in all the studied *** treatment induced significant increase in plasma urea,creatinine and malondialdehyde along with significant reduction of plasma albumin,total protein,calalase and total antioxidant as well as reduction in creatinine *** examination proved the induction of kidney *** sorts of chromosomal aberration and spermshape abnormalities were noticed after cisplatin *** of extracts mixtures produced improvements in biochemical,histopathological and cytogenetic ***:Administration of the studied nutraceuticals proved to possess protective role against cisplatin—induced nephrotoxicity,chromosomal aberration and abnormal *** studied uutraceuticals showed complete safety.

关键词： Nutraccutical Cisplatin Kidney dysfunction Rats Oxidative stress

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