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Native and prosthetic septic arthritis in a university hospital in Saudi Arabia:A retrospective study

World Journal of Orthopedics 2024年第8期15卷 722-733页

作者： reham Kaki Department of Internal Medicine King Abdulaziz UniversityJeddah 22230Saudi Arabia

BACKGROUND Septic arthritis,whether native or prosthetic,poses a significant challenge in clinical practice due to its potentially devastating *** its clinical importance,there remains a dearth of comprehensive studies and standardized diagnostic criteria,particularly in the Kingdom of Saudi *** To investigate the epidemiology,microbiological profiles,and clinical characteristics of native and prosthetic septic joints in the Saudi Arabian *** Medical records of patients diagnosed with septic arthritis between January 1,2015,and December 31,2022,were retrospectively *** regarding patient demographics,clinical presentation,microbiological cultures,treatment modalities,and outcomes were *** In a retrospective review of 52 cases of septic arthritis,a balanced gender distribution was observed(1:1 ratio),with the knee being the most commonly affected joint(80.8%).Methicillin-resistant Staphylococcus aureus predominated in native joints(24.2%),while Brucella *** more prevalent in prosthetic joints(21.1%).Joint preservation was achieved in most cases(84.6%),with no significant difference in clinical features between native and prosthetic ***,certain comorbidities were more common in native joint cases,including renal impairment(P=0.002),hemodialysis(P=0.004),heart disease(P=0.013),and chronic liver disease(P=0.048).At the same time,osteoarthritis was more prevalent in prosthetic joint cases(P=0.013).Vancomycin was the most frequently used antibiotic(26.9%),and most patients received antibiotics before joint aspiration(57.7%).Surgical intervention,predominantly arthrotomy,was required in most cases(32.7%).Notably,a significant association was found between joint type and mortality(odds ratio=0.587,P=0.048),as well as the Charlson comorbidity index and mortality(P=0.001).CONCLUSION This study highlighted distinctive microbiological profiles and etiological factors in septic arthritis cases in the Sau

关键词： Septic arthritis Native joint Prosthetic joint Epidemiology Diagnostic criteria Saudi Arabia

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Experimental validation of double-fed induction generator in oscillating water column using circulatory system-based optimization

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Clean Energy 2024年第2期8卷 127-143页

作者： Basem E.Elnaghi Ahmed M.Ismaiel Fathy El Sayed Abdel-Kader reham H.Mohammed M.N.Abelwhab Electrical Power and Machine Department Suez Canal UniversityIsmailiaEgypt Electrical Power and Machine Department Menoufia UniversityMenoufiaEgypt Computer and Control Department Suez Canal UniversityIsmailiaEgypt

This paper validates the optimal operation for a grid-connected double-fed induction generator(DFIG)in an oscillating water column power plant(OWCPP).This study presents a novel optimization technique called the circulatory system-based optimization(CSBO)approach to develop six adaptive fuzzy logic controllers(AFLCs)with 30 parameters and compare them to chaotic-billiards optimization(C-BO)and genetic algorithm(GA).The proposed controller is also compared with a proportional-integral differential(PID)controller based on a self-adaptive global-best harmony search(SGHS).CSBO-based AFLCs are fully investigated under different scenarios and experimented with using a real-time interface *** results of using CSBO-AFLCs revealed a fast time response,fast convergence,less overshoot and minimal error compared with those achieved with C-BO-AFLC,SGHS-PID and GA-AFLC during different case *** CSBO-based AFLCs ensure maximum power from the DFIG in an OWCPP and enhance dynamic response with very low *** results show that the CSBO shows better power tracking by 25%as compared with C-BO,by 45%when compared with the GA and by 56%when compared with ***,the integral absolute errors of six controllers are investigated to demonstrate the feasibility of *** root mean square of the errors of six controllers using CSBO is improved by 68.27%when compared with GA,by 22.57%when compared with C-BO and by 38.42%when compared with *** indicators demonstrate the feasibility of CSBO when compared with other algorithms with the same OWCPP.

关键词： circulatory system-based optimization approach adaptive fuzzy logic controller grid-tied oscillating water column power plant maximum power point tracking

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The Protective Effect of Moringa oleifera Leaves Extract on Paracetamol Hepatotoxicity in Male Rats

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Journal of Biomedical Science and Engineering 2024年第3期17卷 72-82页

作者： reham M. Al-Sultan Noorah Saleh Al-Sowayan Department of Biology College of Science Qassim University Buraydah Saudi Arabia

In recent years, there has been an increase in concern regarding the effects of paracetamol poisoning on liver tissues, particularly when consumed in large amounts. Some studies have estimated that paracetamol is involved in 56% of acute liver diseases, whereas 0.4% of paracetamol overdose cases result in fatal-ity. In this study, the effects of Moringa oleifera on paracetamol toxicity in the liver were explored. It has been demonstrated that Moringa oleifera is highly nu-tritious, contains bioactive molecules, and is therapeutically beneficial. Many studies have shown that Moringa oleifera leaves possess a wide range of biologi-cal properties, including antioxidant, tissue protection, analgesic, antihyperten-sive, and immunomodulatory activities. This study highlights the protective role of Moringa oleifera on handling possible paracetamol hepatotoxicity in male rats. .

关键词： Moringa oleifera Paracetamol Hepatotoxicity Oxidative Stress

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Occupational health risks among healthcare workers during the COVID-19 pandemic in Saudi Arabia: preparing for the future pandemics

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Nursing Communications 2024年第2期8卷 1-5页

作者： reham Suliman Al Kharyef Aisha Ali Al Harbi Mohammed Abdelhamied Genedy Mohamed K.M.Khalil Suliman Mohamed Al Eidi Ministry of Health Riyadh 13352Saudi Arabia Consultant Public Health and Research Development.Cairo 11728 Egypt

Background:This study aimed to assess the occupational risks encountered by Healthcare Workers(HCWs)in Saudi Arabia during the COVID-19 ***:A cross-sectional survey was carried out from May to October *** a multi-stage stratified random sampling technique,an online questionnaire was sent to the recruited HCWs,across Saudi ***:Of the 768 HCWs recruited,702 participated in the survey.A significant majority(over 80%)reported working beyond 8 hours ***-19 infection,confirmed via PCR,was identified in 25%of the ***,infection was significantly correlated with direct or close contact(p=0.0007).Psychological distress was reported by 81%,with anxiety being the most prevalent(33%),followed by stress(19%),depression(17%),and insomnia(12%).Around 20%experienced headaches post-PPE use,while 14%reported adverse skin reactions,predominantly allergy and dermatitis.A concerning one-third of respondents reported exposure to ***:High infection rate,physical and psychological risks among HCWs especially those in direct contact with patients,reflect the need for enhancing the entirety of outbreak preparedness and response,specifically *** surveillance system,is crucial to adequately monitor and support HCWs during pandemic scenarios.

关键词： COVID-19 pandemic healthcare worker risk Saudi Arabia

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Constrained Groove Pressing(CGP):Die Design,Material Processing and Mechanical Characterization

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Fluid Dynamics & Materials Processing 2019年第3期15卷 171-185页

作者： reham Reda Faculty of Engineering Suez UniversitySuez 43721Egypt

Constrained groove pressing(CGP)is a severe plastic deformation(SPD)technique used as a strengthening method for sheet *** the current work,an optimal/cost-saving design for CGP dies was attained using the stress analysis tool in SolidWorks Simulation Xpress *** study examined low-cost and widely industrially applied aluminium materials,i.e.,pure 1050 Al and 5052 Al *** material was subjected to three passes of the CGP process using a 150 tons capacity *** both materials,inter-pass annealing treatment was undertaken before the third *** effect of the number of CGP passes on the microstructure and tensile properties was studied after each *** CGPed pure 1050 Al with respect to the as-received material,the ultimate tensile strength(UTS),yield strength(YS)and YS/UTS ratio increased with an increasing number of CGP passes until the second pass,while elongation decreased with the number of *** CGPed 5052 Al alloy,the UTS and YS increased after the first pass and then decreased after the second *** in the elongation and YS/UTS ratio of 5052 Al alloy after the CGP process were *** inter-pass annealing and applying the third CGP pass,the strength of pure 1050 Al decreased,and that of 5052 Al alloy increased,which was attributed to the influence of composition on their *** strength-ductility balance decreased with an increasing number of CGP passes in both materials.

关键词： CGP die design 1050 Al 5052 Al processing microstructure tensile properties

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Intelligent Multiclass Skin Cancer Detection Using Convolution Neural Networks

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Computers, Materials & Continua 2021年第10期69卷 831-847页

作者： reham Alabduljabbar Hala Alshamlan Department of Information Technology College of Computer and Information SciencesKing Saud UniversityRiyadhSaudi Arabia

The worldwide mortality rate due to cancer is second only to cardiovascular *** discovery of image processing,latest artificial intelligence techniques,and upcoming algorithms can be used to effectively diagnose and prognose cancer faster and reduce the mortality *** applying these latest techniques has increased the survival chances during recent *** research community is making significant continuous progress in developing automated tools to assist dermatologists in decision *** datasets used for the experimentation and analysis are ISBI 2016,ISBI 2017,and HAM *** this work pertained models are used to extract the efficient *** pertained models applied are ResNet,InceptionV3,and classical feature extraction *** that,efficient preprocessing is conducted on dermoscopic images by applying various data augmentation ***,for classification,convolution neural networks were *** classify dermoscopic images on HAM 1000 Dataset,the maximum attained accuracy is 89.30%for the proposed *** other parameters for measuring the performance attained 87.34%(Sen),86.33%(Pre),88.44%(F1-S),and 11.30%false-negative rate(FNR).The class with the highest TP rate is 97.6%for Melanoma;whereas,the lowest TP rate was for the Dermatofibroma *** dataset ISBI2016,the accuracy achieved is 97.0%with the proposed classifier,whereas the other parameters for validation are 96.12%(Sen),97.01%(Pre),96.3%(F1-S),and further 3.7%(FNR).For the experiment with the ISBI2017 dataset,Sen,Pre,F1-S,and FNR were 93.9%,94.9%,93.9%,and 5.2%,respectively.

关键词： Convolution neural networks skin cancer artificial intelligence dermoscopy feature extraction classification

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Natural antibacterial remedy for respiratory tract infections

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Asian Pacific Journal of Tropical Biomedicine 2016年第3期6卷 270-274页

作者： reham F.El-Kased Department of Microbiology and Immunology Faculty of Pharmacy the British University in Egypt

Objective: To evaluate the antibacterial activity of Egyptian honey against bacteria causing respiratory tract ***: Sputum and throat swab specimens were used, from which five bacterial species were isolated, namely, Klebsiella pneumonia, Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa and Streptococcus pneumonia were isolated,identified and grown on suitable media for further identification or confirmation. Different concentrations(100%, 75% and 25%) of honey and simulated honey solution were used for activity assay and estimation of minimum inhibitory concentration and minimum bactericidal ***: All the tested bacterial isolates were completely susceptible to the 75%concentrations of honey and to the 100% concentration of the simulated honey solution. This may be due to the high osmotic pressure exerted by the high sugar content in both honey samples. Moderate susceptibility of the isolated bacteria to honey at 100%v/v concentration, and resistance to honey at 25% concentration and the 75% and 25%concentrations of simulated honey solution, indicated the presence of other antimicrobial components responsible for the activity other than the osmotic ***, it was suggested that honey showed distinguished antibacterial activities against the most common bacteria causing respiratory infections with varied ***: Honey, a non-toxic, nutritious, safe for human consumption and cheap natural antibacterial agent, should be globalized.

关键词： Klebsiella pneumonia Staphylococcus aureus Streptococcus pyogenes Pseudomonas aeruginosa Streptococcus pneumonia Honey MIC MBC Antibacterial activity

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Galectins dysregulation: A way for cancer cells to invade and pervade

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Oncology Research 2022年第3期30卷 129-135页

作者： MAHMOUD M.ABDELFATTAH reham HELWA Molecular Cancer Biology Group Zoology DepartmentFaculty of ScienceAin Shams UniversityCairoEgypt Faculty of Basic Science King Salman International UniversitySouth SinaiEgypt

Galectins are sticky molecules that bind toβ-*** interactions render them essential players in many cellular *** imbalance of galectin expression was reported in many *** cancer,galectins interact with the extracellular matrix,evade the immune system,and potentially have broad interactions with blood *** the last ten years,since 2010,we did focus on galectin research in different cancer ***ﬁndings showed an interaction between cancer cells and erythrocytes via ***,we found that upregulation of galectins was associated with lymph node metastasis in ovarian ***,with this,we shortly review some important aspects of galectins and their potential importance in more profound understanding of cancer progression and theﬁeld of cancer biomarkers.

关键词： Galectins Cancer Metastasis Erythrocytes Invasion

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Effect of supplementing layer hen diet with phytogenic feed additives on laying performance, egg quality, egg lipid peroxidation and blood biochemical constituents

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Animal Nutrition 2018年第4期4卷 394-400页

作者： reham Abou-Elkhair Shaimaa Selim Eman hussei. Department of Nutrition and Clinical Nutrition Faculty of Veterinary Medicine University of Sadat City Department of Nutrition and Clinical Nutrition Faculty of Veterinary Medicine University of Menoufia Department of Poultry Production Faculty of Agriculture University of Menoufia

This study was conducted to evaluate the effects of supplementing laying hen diet with phytogenic additives on laying performance, egg quality, blood constituents and egg lipid peroxidation. Two hundred Lohmann Brown Lite laying hens were randomly allotted to 4 dietary treatments: control(without phytogenic additive), fennel seeds(5 g/kg), black cumin seeds(5 g/kg) and hot red pepper(5 g/kg).Each of the 4 diets was fed to 5 replicates of 10 hens for 8 weeks. No significant differences were observed in body weight or feed intake between the groups. Dietary inclusion of fennel followed by red pepper improved(P < 0.05) egg weight, egg production, egg mass and feed conversion ratio compared with control. Higher yolk shape index, shell and albumen weight percentages and Haugh unit(P < 0.05)were recorded in the fennel supplemented group compared with control. The egg yolk color score increased by the addition of fennel or hot red pepper in laying hen diets compared with control. The inclusion of black cumin or hot red pepper decreased serum and egg yolk cholesterol and malondialdehyde concentrations(P < 0.05) compared with control. Serum aspartate aminotransferase concentration was lower in black cumin group(P < 0.05) than in other treatments. In conclusion, the best laying performance and egg quality were obtained by dietary inclusion of fennel, followed by hot red pepper and black cumin. Dietary supplementation of black cumin or red pepper may lead to the development of low-cholesterol concentration and better antioxidant capacity of eggs.

关键词： Phytogenic additives Egg quality Hepatoprotective activity Lipid peroxidation Cholesterol Laying hens

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Strategies to overcome drug resistance using SHP2 inhibitors

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3908-3924页

作者： Meng Liu Shan Gao reham M.Elhassan Xuben Hou Hao Fang School of Pharmaceutical Sciences Cheeloo College of MedicineShandong UniversityJinan 250012China

Encoded by PTPN11,the SHP2(Src homology-2 domain-containing protein tyrosine phosphatase-2)is widely recognized as a carcinogenic *** a promising anti-cancer drug target,SHP2 regulates many signaling pathways such as RAS-RAF-ERK,PI3 K-AKT and ***,SHP2 plays a significant role in regulating immune cell function in the tumor ***,five SHP2 allosteric inhibitors have been recruited in clinical studies for the treatment of *** recently,studies have proved the therapeutic potential of SHP2 inhibitor in overcoming drug resistance of kinase inhibitors and programmed cell death-1(PD-1)***,we review the structure,function and small molecular inhibitors of SHP2,and highlight recent progress in overcoming drug resistance using SHP2 *** hope this review would facilitate the future clinical development of SHP2 inhibitors.

关键词： SHP2 inhibitor Allosteric inhibitor Anti-cancer Drug resistance

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