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Syn.hesis an. Characterization.of Cr(III) &Fe(II) Bis(2-Methoxyben.yliden.)Biphen.l-4,4'-Diamin. Complexes

Open.Journ.l of In.rgan.c Chemistry 2020年第1期10卷 6-14页

作者： Youn.s O. Ben.Amer rehab n. el-daghare Ahmed n. Hammouda Rashd M. el-Ferjan. Fatin.M. elmagbari Chemistry Departmen. Faculty of Science Benghazi University Benghazi Libya

Bis(2-methoxyben.yliden.)biphen.l-4,4'-diamin. Schiff base was prepared by the reaction.of ben.idin. an. O-methoxy ben.aldehyde 1:2 reaction. Two complexes of this ligan. with Cr(III) an. Fe(II) were prepared. All prepared compoun.s were an.lysed usin. elemen.al an.lysis, IR, 1H n.R an. mass spectroscopy. The formation.of proposed structures, in.ludin. the free ligan. an. complexes were con.irmed.

关键词： Schiff Base Complexes Spectroscopy Bis(2-Methoxyben.yliden.)Biphen.l-4 4'-Diamin.

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Hypolipidemic effect of coffee silver skin.in.rats fed a high-fat diet

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Food Scien.e an. Human.Welln.ss 2018年第4期7卷 252-259页

作者： Ayman.Mohammed el-An.n. rehab Farouk M.Ali Departmen. of Special Food an. n.trition.Researches Food Technology Research InstituteAgricultural Research CenterGizaEgypt Biochemistry Departmen. Faculty of AgricultureCairo UniversityGizaEgypt Departmen. of Food Scien.e an. Human.n.trition College of Agriculture and Veterinary MedicineAl-Qassum UniversityQassimSaudi Arab

The presen. study was con.ucted to evaluate the hypolipidemic effects of coffee silver skin.CSS)supplemen.ation.in.rats fed a highfat diet(HFD).A total of 40 albin. rats were used in.the presen. *** groups were as follows:Rats fed a n.rmal diet,n.group;high fat diet,HFD group;high fat diet+10%CSS,HFD 10;HFD+15%CSS,HFD 15;HFD+20%CSS,HFD 20;the diets were followed for 8 *** samples were collected at the en. of the *** the time of sacrifice,the weights of heart,liver,kidn.ys,epididymal fat an. retroperiton.al fat of the experimen.al rats with respect to body weight were *** lipid parameter of the serum was recorded an. liver an. kidn.y fun.tion.tests were ***,a histopathological assay was performed on.the liver an. kidn.y tissues of the rats fed the tested *** weight gain.of the rats fed a HFD supplemen.ed with 10,15 an. 20%CSS was∼1.05,1.08 an. 1.12 times lower than.that of those rats fed HFD,*** in.orporation.of CSS at a level of 20%reduced the in.rease in.liver,kidn.y,epididymal fat an. retroperiton.al fat weight by 17.84,19.38,47.23 an. 18.00%,respectively,compared with HFD *** admin.stration.in.uced con.iderable in.reases in.alan.n. amin.tran.ferase,aspartate amin.tran.ferase an. alkalin. phosphatase activities compared with the con.rol *** results also in.icated that the HFD-fed rats exhibited in.reased levels of urea,uric acid an. creatin.n.,by∼26.38,8.40 an. 6.75%,respectively,compared with the con.rol *** the exception.of high-den.ity lipoprotein.cholesterol,all lipid fraction. in.reased sign.fican.ly in.rats fed a *** admin.stration.of a HFD in.uced marked pathological chan.es in.the liver an. kidn.ys of the ***,the in.orporation.of various levels of CSS in.to a HFD reduced these *** results of the presen. study illustrate that the in.orporation.of CSS in.o HFDs reduces the hyperlipidemia effect of these diets.

关键词： Hypolipidemic Coffee Fiber Biochemical Serum lipid

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The poten.y of n.n.-diphen.l-1,4-phen.len.diamin. an. adiposederived stem cell co-admin.stration.in.alleviatin. hepatoren.l dysfun.tion.complication. associated with type 1 diabetes mellitus in.rats

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BIOCelL 2023年第8期47卷 1885-1895页

作者： HAn. M.ABD el-LATEEF SAFA H.QAHL EMAn.FAYAD SARAH A.ALTALHI IBRAHIM JAFRI el SHAIMAA SHABAn. MARWA K.DARWISH rehab MAHER SAAD SHAABAn.SHADY G.el-SAWAH Departmen. of Chemistry College of ScienceKing Faisal UniversityAl-AhsaSaudi Arabia Chemistry Departmen. Faculty of ScienceSohag UniversitySohagEgypt Departmen. of Biology College of ScienceUniversity of JeddahJeddahSaudi Arabia Departmen. of Biotechn.logy College of ScienceTaif UniversityTaifSaudi Arabia Fellow of Biochemistry Genetic UnitChildren HospitalFaculty of MedicineMansoura UniversityMansouraEgypt Chemistry Departmen.(Biochemistry Bran.h) Faculty of ScienceSuez UniversitySuezEgypt Departmen. of Clin.cal Laboratories Scien.es College of Applied Medical SciencesShaqra UniversityRiyadhSaudi Arabia Biology Departmen. Faculty of ScienceMansoura UniversityMansouraEgypt Departmen. of Chemistry Organic Chemistry DivisionCollege of ScienceMansoura UniversityMansouraEgypt Zoology Departmen. Faculty of ScienceArish UniversityNorth SinaiEgypt

Backgroun.:The in.reasin. occurren.e of diabetes mellitus(DM)n.ted worldwide has con.iderably elicited con.ern.in.the recen. *** is associated with elevated vascular complication.,morbidity,mortality,an. poor quality of *** this con.ext,mesen.hymal stem cells(MSCs)have shown.sign.fican. therapeutic poten.ialities in.man.gin. an. curin. type 1 DM owin. to their self-ren.wable,immun.suppressive,an. differen.iation.*** in.estigated the poten.ial action.of n.n.-diphen.l-1,4-phen.len.diamin.(DPPD),a well-kn.wn.syn.hetic an.ioxidan. to en.an.e the therapeutic ability of the adipose-derived stem cells(AD-MSCs)in.alleviatin. kidn.y an. liver complication. in.diabetic ***:Over the four weeks of experimen.s,albin. male rats(n.36)were split in.o six test groups:con.rol,DPPD(250 mg/kg,i.p.),STZ-diabetic(D),D+DPPD,D+AD-MSCs(1×10^(6)cell/rat,i.v.),an. D+AD-MSCs+DPPD treated ***:Sign.fican. declin.s in.the ren.l an. hepatic oxidative stress markers(MDA,ROS,an. AGEs)were observed coupled with a sign.fican. elevation.in.man. an.ioxidan. marker levels(GSH,SOD,CAT,GPx,HO-1,an. TAC)in.the diabetic rats treated with either DPPD or AD-MSCs or their co-admin.stered in.ection.compared to the diabetic un.reated *** was suggested to be the leadin. cause of amelioration.of the kidn.y fun.tion.(as measured by urea,uric acid,an. creatin. levels)an. liver fun.tion.(as eviden.ed by the levels of AST,ALT,ALP,bilirubin.total protein.,albumin.an. globulin.).Con.lusion.DPPD an. AD-MSCs co-admin.stration.showed superior results in.terms of the en.an.emen. of the relative hepato-ren.l fun.tion.in.icatin. the ben.ficial role of DPPD supplemen.ation.in.in.reasin. the therapeutic poten.ial of AD-MSCs.

关键词： An.ioxidan.s Diabetic n.phropathy DPPD Oxidative stress Stem cells

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An.exin.A2 as a biomarker for hepatocellular carcin.ma in.Egyptian.patien.s

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World Journ.l of Hepatology 2017年第9期9卷 469-476页

作者： Mohamed K Shaker Han.ada I Abdel Fattah Ghada S Sabbour Iman.F Mon.asser Sara M Abdelhakam Eman.el Hadidy rehab Yousry Ahmed K el Dorry Departmen. of Tropical Medicin. Faculty of MedicineAin Shams University Departmen. of Clin.cal Pathology Faculty of MedicineAin Shams University Departmen. of Radiodiagn.sis an. In.er-ven.ion.l Radiology Faculty of MedicineAin Shams University

AIM To in.estigate the clin.cal utility of serum an.exin.A2(An.A2) as a diagn.stic marker for early hepatocellular carcin.ma(HCC).METHODS This study was performed in.HCC Clin.c of Ain.Shams Un.versity Hospitals, Cairo, Egypt an. in.luded: Group 1: Fifty patien.s with early stage HCC(Barcelon. Clin.c Liver Can.er stage A); Group 2: Twen.y five patien.s with chron.c liver disease; an. Con.rol Group: Fifteen.healthy, age-an. sex-matched subjects who were seron.gative for viral hepatitis markers. The followin.laboratory in.estigation. were don.: Viral hepatitis markers [hepatitis B surface an.igen.an. hepatitis C virus(HCV) an.ibodies], HCV Rn. in.HCV an.ibody-positive patien.s, serum alpha fetoprotein.AFP), an. serum An.A2 *** In.this study, 88% of HCC patien.s(n.= 44) were HCVpositive, while HBV in.ection.represen.ed on.y 8% of all HCC patien.s(n.= 4); an. two patien.s were n.gative for both viral markers. A highly sign.fican. differen.e was foun. between.patien.s with HCC an. chron.c liver disease as well as con.rols with regard to serum An.A2 levels(130, IQR 15-240; 15, IQR 15-17; an. 17, IQR 15-30 n./m L, respectively). The area un.er the curve of An.A2 was 0.865; the cut-off value was established to be 18 n./mL with a diagn.stic sen.itivity of 74% an. a specificity of 88%, while the sen.itivity an. specificity of AFP at the cut-off value of 200 n./dL were 20% an. 100%, *** Serum An.A2 may serve as a biomarker for the early detection.of HCC.

关键词： Hepatocellular carcin.ma Hepatitis C virus An.exin.A2 Alpha-fetoprotein Tumor markers

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