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Pulse oximeter as a home assessment tool:Knowledge and user experience among the community in Malaysia during the COVID-19 pandemic

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Asian Pacific Journal of Tropical Medicine 2022年第5期15卷 213-219页

作者： Siew-Keah Lee Jin Wei Ma Khai ying Chan yi Song Cheong Wan Ting Hong regine chew yi ong Wei Cheng Tay Ang-Lim Chua Faculty of Medicine and Health Sciences Universiti Tunku Abdul RahmanMalaysia Faculty of Medicine Universiti Teknologi MARAMalaysia

Objective:To determine the degree of knowledge in the usage of pulse oximeter as a home assessment tool among the community in ***:A cross-sectional survey was conducted in November *** questionnaire assessed the knowledge in using pulse oximeters,user experience and opinions in using pulse oximeter as a home assessment tool during the ***:A total of 504 respondents were included in the study,and the mean score in knowledge related to application of pulse oximetry was 73.00%,while the mean score in knowledge related to factors affecting pulse oximetry readings was only 38.51%.A total of 90.5% of the respondents recognised normal pulse rate and 88.5% knew the blood oxygen saturation levels of a healthy adult,while 69.4% recognised the definition of silent *** addition,the majority of the respondents agreed that factors such as poor blood circulation(71.2%),excessive movements(69.8%),and hand position(60.7%)affected oximetry ***,61.7%,81.7%,77.2% and 76.8% of the respondents could not identify nail polish,skin colour,skin thickness and tattoos as factors that may affect oximetry readings ***:The respondents showed a satisfactory level of knowledge related to application of pulse oximetry,but a poor level of knowledge related to factors affecting pulse oximetry readings among the community in *** efforts in educating the community on the correct use of pulse oximeters are crucial for appropriate home assessment and avoiding unnecessary stress.

关键词： COVID-19 Pulse oximetry SpO2 Home assessment tool Silent hypoxia

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Role of formyl peptide receptor 2(FPR2) in the normal brain and in neurological conditions

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Neural Regeneration Research 2019年第12期14卷 2071-2072页

作者： Wei-yi ong John Jia En Chua Department of Anatomy Yong Loo Lin School of Medicine National University of Singapore Singapore Life Sciences Institute Neurobiology Research Programme National University of Singapore Singapore Department of Physiology National University of SingaporeSingaporeInstitute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) Singapore

There is much recent interest in the role of the anti-inflammatory molecules and their receptors in the normal brain and in neurological disorders. The formyl peptide receptor (FPR) subfamily of G protein-coupled receptors play important roles in these processes. Binding to specific peptides triggers activation of FPRs, leading to signalling events that regulate inflammatory responses. One member of this subfamily of receptors is FPR2, also known as ALX (the lipoxin A4 (LXA4) receptor). FPR2 is specifically activated by LXA4 and resolvin D1 (RvD1)(Pirault and ***, 2018).

关键词： Role receptor normal brain

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Noise robustness of an operational modal-based structural damage-detection scheme using impact-synchronous modal analysis

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2023年第9期24卷 782-800页

作者： Pei yi SIOW Zhi Chao ong Shin Yee KHOO Kok-Sing LIM Department of Mechanical Engineering Faculty of EngineeringUniversiti MalayaKuala Lumpur 50603Malaysia Photonics Research Centre Deputy Vice Chancellor(Research and Innovation)OfficeUniversiti MalayaKuala Lumpur 50603Malaysia

Data-driven damage-detection schemes are usually unsupervised machine-learning models in practice,as these do not require any ***-based features are commonly used in these schemes but often require several other parameters to accurately correlate with damage,as they may not globally represent the model,making them less sensitive to *** data,such as frequency response functions(FRFs)and principal component analysis(PCA)reduced FRFs(PCA-FRFs),inherits the dynamic characteristics of the structure,and it changes when damage occurs,thus showing sensitivity to ***,noise from the environment or external sources such as wind,operating machines,or the in-service system itself,can reduce the modal data's sensitivity to damage if not handled properly,which affects damage-detection *** study proposes a noise-robust operational modal-based structural damage-detection scheme that uses impact-synchronous modal analysis(ISMA)to generate clean,static-like FRFs for damage *** allows modal data collection without requiring shutdown conditions,and its denoising feature aids in generating clean,static-like FRFs for damage *** results showed that the FRFs obtained through ISMA under noise conditions have frequency response assurance criterion(FRAC)and cross signature assurance criterion(CSAC)scores greater than 0.9 when compared with FRFs obtained through experimental modal analysis(EMA)under static conditions;this validates the denoising feature of *** the denoised FRFs are reduced to PCA-FRFs and used in an unsupervised learning-based damage-detection scheme,zero false alarms occur.

关键词： Impact-synchronous modal analysis(ISMA) Frequency response function(FRF) Principal component analysis(PCA) Unsupervised learning Damage detection

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Enhancing MXene-based supercapacitors:Role of synthesis and 3D architectures

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Journal of Energy Chemistry 2024年第4期91卷 1-26页

作者： Wen Siong Poh Wen Jie yiang Wee-Jun ong Pau Loke Show Chuan yi Foo School of Energy and Chemical Engineering Xiamen University MalaysiaSelangor Darul EhsanMalaysia&College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005FujianChina Kelip-kelip!Center of Excellence for Light Enabling Technologies Xiamen University MalaysiaSelangor Darul Ehsan 43900Malaysia Center of Excellence for NaNo Energy&Catalysis Technology(CONNECT) Xiamen University MalaysiaSelangor Darul Ehsan 43900Malaysia Department of Chemical Engineering Khalifa UniversityShakhbout Bin Sultan St-Zone 1Abu DhabiUnited Arab Emirates Zhejiang Provincial Key Laboratory for Subtropical Water Environment and Marine Biological Resources Protection Wenzhou UniversityWenzhou 325035ZhejiangChina Department of Chemical and Environmental Engineering Faculty of Science and EngineeringUniversity of Nottingham MalaysiaJalan Broga43500 SemenyihSelangor Darul EhsanMalaysia Department of Sustainable Engineering Saveetha School of EngineeringSIMATSChennai 602105India

MXene has been the limelight for studies on electrode active materials,aiming at developing supercapacitors with boosted energy density to meet the emerging influx of wearable and portable electronic *** its various desirable properties including intrinsic flexibility,high specific surface area,excellent metallic conductivity and unique abundance of surface functionalities,its full potential for electrochemical performance is hindered by the notorious restacking phenomenon of MXene *** to its two-dimensional(2D)nature and surface functional groups,inevitable Van der Waals interactions drive the agglomeration of nanosheets,ultimately reducing the exposure of electrochemically active sites to the electrolyte,as well as severely lengthening electrolyte ion transport *** a result,energy and power density deteriorate,limiting the application versatility of MXene-based *** 3D architectures using 2D nanosheets presents as a straightforward yet ingenious approach to mitigate the fatal flaws of ***,the sheer number of distinct methodologies reported,thus far,calls for a systematic review that unravels the rationale behind such 3D MXene structural ***,this review aims to serve this purpose while also scrutinizing the structure–property relationship to correlate such structural modifications to their ensuing electrochemical performance ***,the physicochemical properties of MXene play fundamental roles in determining the effective charge storage capabilities of 3D MXene-based *** largely depends on different MXene synthesis techniques and synthesis condition variations,hence,elucidated in this review as ***,the challenges and perspectives for achieving viable commercialization of MXene-based supercapacitor electrodes are highlighted.

关键词： MXene 3D architectures Synthesis design Supercapacitor Energy storage

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作者： yi-Ping ong.

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Melting mechanisms of Pt-based multimetallic spherical nanoparticles by molecular dynamics simulation

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Rare Metals 2023年第2期42卷 406-417页

作者： Chun-Yu Cheng Yuan-Yuan Guo yi-Ming Zou Amanda Jiamin ong Alfred ling Yoong Tok Shuzhou Li School of Materials Science and Engineering Nanyang Technological UniversitySingapore639798Singapore

The melting mechanisms of Pt-based multimetallic nanoparticles(NPs)are important to help determine their optimal melting *** understand the melting and coalescence behaviors of heterogeneous NPs(Pd-Pt NPs)with various sizes and compositions,molecular dynamics(MD)simulation was *** MD results for larger Pd-Pt NPs with an effective diameter of4.6-7.8 nm show that PtPd alloy can form at Pd/Pt interface before Pd NP melted completely,while for Pt-core/Pdshell NP and Pd-core/Pt-shell NP,PtPd alloy formed only after Pd portion melted *** smaller Pd-Pt NPs with an effective diameter of 2.5-4.0 nm,PdPt alloy is not formed until both Pd and Pt NPs melted ***,the coalescence process of Pd-Pt NPs depends on the melting temperature of Pt NP when Pt composition is higher than 20 at%.Furthermore,the melting mechanisms of Pd/Pt/Ir trimetallic NPs are investigated.A two-step melting process occurs in Pd-Pt-Ir NPs and Ir-core/Ptshell/Pd-shell NP,and the melting sequence of Pd-core/Ptshell/Ir-shell NP and Pt-core/Pd-shell/Ir-shell NP is different from Pd/Pt bimetallic NPs.

关键词： Molecular dynamics(MD) Melting mechanism Pt-based Multimetallic Heterogeneous structure

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Assessing the microstructure and in vitro degradation behavior of Mg-xGd screw implants using μCT

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Journal of Magnesium and Alloys 2021年第6期9卷 2208-2223页

作者： Diana Krüger Berit Zeller-Plumhoff Björn Wiese Sangbong yi Marcus Zuber D.C.Florian Wieland Julian Moosmann regine Willumeit-Römer Institute of Metallic Biomaterials Helmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany Institute of Material and Process Design Helmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany Institute for Photon Science and Synchrotron Radiation Karlsruhe Institute of TechnologyHerrmann-von-Helmholtz-Platz 1Eggenstein-Leopoldshafen 76344Germany Laboratory for Applications of Synchrotron Radiation Karlsruhe Institute of TechnologyKaiserstr.12KarlsruheGermany Institute of Materials Physics Helmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany

Biodegradable implants are taking an increasingly important role in the area of orthopedic implants with the aim to replace permanent implants for temporary bone healing *** the implant preparation process,the material’s surface and microstructure are being changed by stresses induced by *** degradable metal implants need to be fully characterized in terms of the influence of machining on the resulting microstructure and corrosion *** this study,micro-computed tomography(μCT)is used for the quantification of the degradation rate of biodegradable *** our best knowledge,for the first time quantitative measures are introduced to describe the degradation homogeneity in *** information enables a prediction in terms of implant stability during the degradation in the *** magnesium gadolinium alloys,Mg-5Gd and Mg-10 Gd(all alloy compositions are given in weight%unless otherwise stated),in the shape of M2 headless screws have been investigated for their microstructure and their degradation performance up to 56 *** the microstructure investigations particular attention was paid to the localized deformation of the alloys,due to the machining *** vitro immersion testing was performed to assess the degradation performance quantified by subsequent weight loss and volume loss(usingμCT)*** differences were observed in the degree of screw’s near surface microstructure being influenced from machining,the degradation rates of both materials appeared to be suitable for application in orthopedic *** the degradation homogeneity point of view no obvious contrast was detected between both ***,the higher degradation depth ratios between the crests and roots of Mg-5Gd ratios may indicated a less homogeneous degradation of the screws of these alloys on contract to the ones made of Mg-10Gd *** to its lower degradation rates,its more homogeneous microstructure,its weaker texture

关键词： Magnesium alloys Biodegradable implant Degradation rate Degradation homogeneity Micro-comptued tomography

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Segment 8 hepatic vein reconstruction in a living donor after left hepatectomy

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 579-582页

作者： Chih-yi Chen Chao-Long Chen Chee-Chien Yong Aldwin D.ong Liver Transplantation Center Department of SurgeryKaohsiung Chang Gung Memorial HospitalKaohsiungTaiwanChina

Liver transplantation(LT)has been accepted worldwide as standard of treatment for end-stage liver *** to expanding indications for LT and shortage of cadaveric donors,living donor liver transplantation(LDLT)has emerged as an important alternative to augment the donor pool(1).Justifiably,donor safety is the fundamental priority in LDLT.

关键词： donor Liver hepatic

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Differential regulation of cPLA2 and iPLA2 expression in the brain

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Frontiers in Biology 2012年第6期7卷 514-521页

作者： Kazuhiro TANAKA Nikhat J. SIDDIQI Abdullah S. ALHOMIDA Akhlaq A. FAROOQUI Wei-yi ong Neurobiology and Ageing Research Programme National University of Singapore Singapore 117456 Singapore Department of Biochemistry College of Science King Saud University Riyadh 11451 Saudi Arabia Department of Molecular and Cellular Biochemistry The Ohio State University Columbus OH 43210 USA Department of Anatomy National University of Singapore Singapore 119260 Singapore

The phospholipase A2 （PLA2） family members arc critical regulators of membrane structure and lipid composition and have been implicated in neuroinflammation, oxidative stress and neurodegeneration. Here, we review the published data describing regulation of cPLA2 and iPLA2 gene expression. Based on promoter sequence, cPLA2 expression can be regulated by glucocorticoid and pro-inflammatory cytokines, whereas transcription of iPLA2 can be controlled in response to sterol level. RNA degradation in 3＇ UTR and epigenetic mechanisms may be involved in the regulation of cPLA2 and iPLA2 expression, respectively. MicroRNA target sequences lie within cPLA2 and iPLA2 mRNAs. Together, these findings indicate differential regulation of cPLA2 and iPLA2 expression. It is hoped that determination of diverse regulatory mechanisms of the PLA2 family may open new doors for development of novel therapeutic compounds that modulate PLA2 expression and function in the treatment of brain diseases.

关键词： phospholipase A2 transcriptional regulation single nucleotide polymorphism miRNA

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Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats

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World Journal of Gastroenterology 2017年第21期23卷 3805-3814页

作者： yi Tan Jane Kim Jing Cheng Madeleine ong Wei-Guo Lao Xing-Liang Jin yi-Guang Lin Linda Xiao Xue-Qiong Zhu Xian-Qin Qu School of Medical and Molecular Biosciences University of Technology Sydney The Second Affiliated Hospital of Wenzhou Medical University

AIM To investigate protective effects and molecular mechanisms of green tea polyphenols(GTP) on nonalcoholic fatty liver disease(NAFLD) in Zucker fatty(ZF) *** Male ZF rats were fed a high-fat diet(HFD) for 2 wk then treated with GTP(200 mg/kg) or saline(5 m L/kg) for 8 wk, with Zucker lean rat as their control. At the end of experiment, serum and liver tissue were collected for measurement of metabolic parameters, alanine aminotransferase(ALT) and aspartate aminotransferase(AST), inflammatory cytokines and hepatic triglyceride and liver histology. Immunoblotting was used to detect phosphorylation of AMP-activated protein kinase(AMPK) acetyl-Co A carboxylase(ACC), and sterol regulatory element-binding protein 1c(SREBP1c). RESULTS Genetically obese ZF rats on a HFD presented with metabolic features of hepatic pathological changes comparable to human with NAFLD. GTP intervention decreased weight gain(10.1%, P = 0.052) and significantly lowered visceral fat(31.0%, P < 0.01). Compared with ZF-controls, GTP treatment significantly reduced fasting serum insulin, glucose and lipids levels. Reduction in serum ALT and AST levels(both P < 0.01) were observed in GTP-treated ZF rats. GTP treatment also attenuated the elevated TNFα and IL-6 in the circulation. The increased hepatic TG accumulation and cytoplasmic lipid droplet were attenuated by GTP treatment, associated with significantly increased expression of AMPK-Thr172(P < 0.05) and phosphorylated ACC and SREBP1c(both P < 0.05), indicating diminished hepatic lipogenesis and triglycerides out flux from liver in GTP treated rats. CONCLUSION The protective effects of GTP against HFD-induced NAFLD in genetically obese ZF rats are positively correlated to reduction in hepatic lipogenesis through upregulating the AMPK pathway.

关键词： Non-alcoholic fatty liver disease Green tea polyphenols Hepatic lipogenesis Inflammatory cytokines AMP-activated protein kinase

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