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Transcriptomic analysis reveals that NIBAN1 overexpression is associated with BRAF^(V600E)mutation and increases the aggressiveness of thyroid cancer

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Genes & Diseases 2024年第4期11卷 16-19页

作者： Paula Diana Thaise Nayane Ribeiro Carneiro Janete Maria Cerutti reginaldo Massanobu Kuroshu Gianna Maria Griz Carvalheira Division of Genetics Department of Morphology and GeneticsEscola Paulista de MedicinaUniversidade Federal de Sao PauloSao PauloRua Botucatu740Edificio Leitaoda Cunha1AndarSao PauloSP04023900Brazil Genetic Bases of Thyroid Tumors Laboratory Division of GeneticsDepartment of Morphology and GeneticsEscola Paulista de MedicinaUniversidade Federal de Sao PauloPedro de Toledo 66911AndarSao PauloSP 04039-032Brazil Institute of Science and Technology Universidade Federal de Sao PauloAv Cesare Mansueto Giulio Lattes1201Eugenio deMelloSaoJose dos CamposSP12247-014Brazil

NIBAN1 overexpression has been reported in a widerange of thyroid carcinoma subtypes,and in other cancers,while it is not expressed in thyroid benign lesions and normal thy-roid.1-3 However,the mechanism associated with its expression and prognostic value remains *** this study,six independent cohorts were enrolled,in which NIBAN1 expression was evaluated.A total of 583patients with thyroid tumors,326 patients with skin cancers,293 patients with colorectal carcinoma,and 189 patients with lung carcinoma were analyzed.

关键词： BRAF lesions BAN

Unsuccessful tuberculosis treatment outcomes across Brazil's geographical landscape before and during the COVID-19 pandemic:are we truly advancing toward the sustainable development/end TB goal?

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Infectious Diseases of Poverty 2024年第1期13卷 105-106页

作者： reginaldo Bazon Vaz Tavares Thais Zamboni Berra Yan Mathias Alves Marcela Antunes Paschoal Popolin Antonio Carlos Vieira Ramos Ariela Fehr Tartaro Clara Ferreira de Souza Ricardo Alexandre Arcencic Department of Maternal-Infant and Public Health Nursing University of São Paulo at Ribeirão Preto College of Nursing (USP/RPCN) Ribeirão Preto São Paulo Brazil Federal University of Tocantins Palmas Campus (FUT) Palmas Brazil State University of Minas Gerais Passos Campus (SUMG) Passos Brazil

Background Tuberculosis is one of the most significant infectious diseases for global public *** reallocation of healthcare resources and the restrictions imposed by the COVID-19 pandemic have hindered access to TB diag-nosis and *** in unfavorable outcomes of the disease have been observed in *** objective of this study was to analyze the spatial distribution of unfavorable TB treatment outcomes in Brazil before and during the *** An ecological study with spatial analysis was conducted with all 5569 municipalities in *** reported cases of tuberculosis between January 2010 and December 2021,as well as reported cases of COVID-19 from Febru-ary 2020 to December 2021,were *** outcomes studied encompass loss to follow-up,drug-resistant tuber-culosis,and *** Getis Ord GI*technique was employed to assess spatial association,and the Kernel density estimator was used to identify areas with concentrated increases or decreases in *** Local Moran's/was used to examine the spatial association between outcomes and cOVID-19 *** study was approved by the Research Ethics Committee of Ribeirao Preto Nursing School,University of Sao *** There were 134,394 cases of loss to follow-up,10,270 cases of drug resistance,and 37,863 *** of high and low values were identified for all three outcomes,indicating significant changes in the spatial distribu-tion *** in concentrations were observed for lost to follow-up cases in the Southeast,while reductions occurred in the Northeast,South,and ***-resistant tuberculosis experienced an increase in the Southern and Southeastern regions and a decrease in the Northeast and ***-related deaths showed notable concentra-tions in the Midwest,Northeast,South,and *** was an increase in high occurrence clusters for deaths after 2020 and 2021 in the *** The pandemic has brought additional chal

关键词： Tuberculosis COVID-19 Spatial analysis Ecological studies

A Differential Evolution Approach for Protein Folding Using a Lattice Model

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Journal of Computer Science & Technology 2007年第6期22卷 904-908页

作者： Heitor Silverio Lopes reginaldo Bitello Bioinformatics Laboratory Federal University of Technology-ParanáAv.7 de setembro3165 80230-901 CuritibaBrazil

Protein folding is a relevant computational problem in Bioinformatics, for which many heuristic algorithms have been proposed. This work presents a methodology for the application of differential evolution （DE） to the problem of protein folding, using the bi-dimensional hydrophobic-polar model. DE is a relatively recent evolutionary algorithm, and has been used successfully in several engineering optimization problems, usually with continuous variables. We introduce the concept of genotype-phenotype mapping in DE in order to provide a mapping between the real-valued vector and an actual folding. The methodology is detailed and several experiments with benchmarks are done. We compared the results with other similar implementations. The proposed DE has shown to be competitive, statistically consistent and very promising.

关键词： bioinformatics differential evolution evolutionary computation protein folding

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Oxidative reforming of methane for hydrogen and synthesis gas production:Thermodynamic equilibrium analysis

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Journal of Natural Gas Chemistry 2012年第5期21卷 571-580页

作者： Antonio C.D.Freitas reginaldo Guirardello School of Chemical Engineering University of Campinas (UNICAMP)Av.Albert Einstein 50013083-852Campinas-SPBrazil

A thermodynamic analysis of methane oxidative reforming was carried out by Gibbs energy minimization （at constant pressure and temperature） and entropy maximization （at constant pressure and enthalpy） methods,to determine the equilibrium compositions and equilibrium temperatures,*** cases were treated as optimization problems （non-linear programming formulation）.The GAMS 23.1 software and the CONOPT2 solver were used in the resolution of the proposed *** hydrogen and syngas production were favored at high temperatures and low pressures,and thus the oxygen to methane molar ratio （O 2 /CH 4） was the dominant factor to control the composition of the product *** O 2 /CH 4 molar ratios higher than 0.5,the oxidative reforming of methane presented autothermal behavior in the case of either utilizing O 2 or air as oxidant agent,but oxidation reaction with air possessed the advantage of avoiding peak temperatures in the system,due to change in the heat capacity of the system caused by the addition of *** calculated results were compared with previously published experimental and simulated data with a good agreement between them.

关键词： thermodynamic analysis methane oxidative reforming Gibbs energy minimization entropy maximization hydrogen and syngas production

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Litter removal impacts on soil biodiversity and eucalypt plantation development in the seasonal tropics

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Journal of Forestry Research 2023年第3期34卷 735-748页

作者： Jonas Inkotte Barbara Bomfim Sarah Camelo da Silva Marco Bruno Xavier Valadão Márcio Gonçalves da Rosa Roberta Batista Viana Alcides Gatto reginaldo SPereira Department of Forestry Engineering University of BrasiliaBrasíliaDistrito FederalBrazil Climate and Ecosystem Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA SESI/SENAI Social Service Industry Santa Catarina StateChapecóBrazil

The little layer of tree plantations provides primary nutrients for uptake,buff ers changes in soil moisture,and provides habitat and substrate to soil epigeic ***,this layer in eucalypt plantations is often removed to reduce fuel load during the fi re season in the Brazilian savanna(Cerrado).Therefore,it is necessary to quantify the eff ects of changes in litter dynamics on the function of these plantations,on key nutrient cycling processes and on epigeic fauna diversity and *** two adjacent stands(one juvenile and one mature),the consequences of two years of litter removal were quantifi ed as monthly litterfall,leaf and fi ne wood litter decomposition,epigeic fauna abundance and diversity,soil biogeochemical variables,and tree diameter and basal area *** litterfall rates in juvenile and mature stands did not change with litter removal over the study *** litterfall ranged from 4.1 to 4.9 Mg ha^(−1)a^(−1)in litter removal plots and from 3.9 to 4.8 Mg ha^(−1)a^(−1)in control *** wood litter decomposition was slower in litter removal plots compared to controls,while leaf decomposition rates were similar in *** years of litter removal in the juvenile stand did not aff ect topsoil biogeochemical parameters but decreased available phosphorus at 20–40 cm depth relative to *** the mature stand,total cation exchange capacity(0–20 cm)was higher in controls(6.4 cmol c dm^(−3))relative to litter removal plots(6.3 cmol c dm^(−3)),while soil moisture(0–40 cm depth)was lower in litter removal(25.45 m 3 m^(−3))compared to control plots(26 m^(3)m^(−3))in the dry season.A non-metric multidimensional scaling ordination revealed an increased homogeneity in epigeic fauna where litter was ***,decomposition,diameter increment,four soil physical parameters and fourteen chemical parameters at 0–20 and 20–40 cm depth explained the diff erences in soil epigeic fauna composition between litter removal and control p

关键词： Cerrado Nutrient cycling Soil ecology Soil epigeic fauna Plantation management

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A Method for Environmental Data Management Applied to Megasites in the State of Sao Paulo, Brazil

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Journal of Water Resource and Protection 2017年第3期9卷 322-338页

作者： Marcos Barbosa reginaldo A. Bertolo Ricardo Hirata University of Sao Paulo-USP Instituto de Geociências Sao Paulo Brazil

The management of contaminated areas with multiple sources of contamination (megasites) is among the biggest challenges for the Brazilian environmental agencies, especially because aquifers in big urban areas, like the Sao Paulo Metropolitan Region, are important sources of water for human supply purposes. One of the main reasons that hamper the proper management of urban environmental problems is a lack of a unified system where all information can be easily integrated into regional studies. To address this problem, a method for data integration and management using a Geographic Information System (GIS) was developed. This method was applied to the case of a regional contamination of an aquifer by chlorinated solvents at a former industrial district in Sao Paulo city, named Jurubatuba, but the final product might also be used for data management of contaminated areas for the entire State of Sao Paulo. The main result obtained was that the site-by-site approach for aquifer contamination management is ineffective. Furthermore, there are many other suspected and potential sources of contamination without any information available after more than 10 years since the contamination problem was discovered at the FIZ 131.

关键词： Megasite Chlorinated Organics Geographic Information System

IMMEDIATE MUSCLE-TENDON PAIN RELIEF THROUGH JING(WELL) POINTS

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Journal of Integrative Medicine 2014年第3期 303-304页

作者： Ferno Luquis reginaldo Silva Filho Cibelle Adiana Bela EBRAMEC

Introduction: The pain, or Bi syndrome, is a phenomenon described by traditional Chinese medicine as stagnation caused by the free flow of qi and blood(xue) through the body, thus causing discomfort and impairment of motor functions, especially the legs and ***: The aim of this study was to demonstrate the analgesia technique in Jing(Well) points of muscle-tendon ***: This treatment was performed on 50 subjects via muscle-tendon secondary channels, which through Jingpoint *** cases of pain caused by a deficiency or cold, manipulation was carried out in *** procedure was performed by inserting the needle perpendicularly or obliquely on average from 0.1 to 0.2 ***: The technique was effective in cases of Bi syndrome due to excess or deficiency of qi and *** an average of 3 min of needling performed with dispersion or toning, the patients felt total or partial analgesia of the pain in the affected *** case study was performed in fifty patients, being effective in 100% of ***: In general, this technique is based on reduction of pain with a smaller number of *** treatment, the patient regains good conditioning function of the affected area, with relief of pain and *** pain is also gradually eliminated, with qi and blood circulation improved and possible stagnation in the affected area relieved.

关键词： WELL POINTS IMMEDIATE MUSCLE-TENDON PAIN RELIEF THROUGH JING

Application of Geophysical Logging and Straddle Packers for the Investigation of a Fractured Aquifer in a Contaminated Area by Chlorinated Solvents in Sao Paulo State, Brazil

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Journal of Water Resource and Protection 2017年第10期9卷 1145-1168页

作者： Aline Fanti reginaldo Bertolo Fabiana Vogado Fabiana Cagnon Ana Paula Queiroz Waterloo Brasil Consulting Ltda Sao Paulo Brazil CEPAS Groundwater Research Center University of Sao Paulo Sao Paulo Brazil

The investigation of contaminated areas in fractured aquifers represents a great technical challenge, due to the frequent conditions of heterogeneity and anisotropy of these environments, which often make it difficult to identify and predict pathways of subsurface contamination. This work aims to contribute to the development of this subject, through the presentation of the results of an investigation in which geophysical logging tools and straddle packers were used, which allowed the development of a more suitable hydrogeological conceptual model of the study area. Two boreholes were drilled and geophysical logging (gamma, caliper and high resolution acoustic televiewer) were used for the geological-structural characterization of the aquifer. Heatpulse flowmeter and straddle packers were then used to obtain data on hydraulic potentials and flows and for the collection of discrete water samples for chemical analysis. Two types of gneiss rocks were identified below the weathering zone (thickness >30 m), one with predominance of mafic bands, more weathered and with a higher fracture density, up to 65 m, and another deeper one, with the predominance of felsic bands. Seven groups of fractures were defined, being those of Group 1, with low dip angles, the most frequent and important for flow until 65 m, and Group 2 (N to NE-SW with high dips to W and NW) more frequent in deeper felsic gneisses. Downward hydraulic potentials were identified down to 65 m and upward potentials from the bottom up to 65 m. A hydraulic test allowed identifying the occurrence of hydraulic connection between the shallow weathering zone and the underlying fractured aquifer.

关键词： Fractured Aquifer Contaminated Areas Conceptual Model

Natural Regeneration in Tropical Secondary Forest in Southern Amazonia, Brazil

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Open Journal of Forestry 2014年第2期4卷 151-160页

作者： Alexandre Ebert Leandro Ribeiro Teixeira Adriana Zanirato Contini da Silva reginaldo Brito da Costa Faculty of Forestry Engineering Federal University of Mato Grosso Cuiabá Brazil

The study aimed to establish floral composition, diversity levels, category size, phytosociological structure, commercial use and ecological group of species present in the regeneration of open ombrophile forest in southern Amazon, Brazil. Data were collected at S?o Nicolau farm, in the municipality of Cotrigua?u, northwest of Mato Grosso state, coordinates 51°9'19.5"S and 58°14'53"W. One hundred plots of 10 × 10 m were allocated. All individuals between 29.9 and 59.9 cm had circumference at breast height (CAP) measure, with sub-plots of 5 × 5 m which were measured in all subjects between 1:50 m in height 29.9 cm CAP and sub-plots of 2 × 2 m for individuals between 0.30 to 1.5 m tall. The information obtained in the field were processed in excel spreadsheet. The results showed the occurrence of 610 individuals belonging to 82 species, 34 plant families, with a diversity index of Shannon & Weaver’s 2.77. The index of value of importance showed species Protium robustum, Maquira calophilla and Inga fagifolium with greater ecological importance in fitocenose. The higher values for Natural Regeneration were the species Protium robustum, Maquira calophilla and Inga fagifolium with 16.42, 8.03 and 7.76 respectively.

关键词： Vertical Structure Ecological Analysis Forest Management