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Hepatobiliary & Pancreatic Diseases International 2012年第5期11卷 542-544页

作者： Tan To Cheung Kenneth SH Chok regina cl lo William W Sharr See Ching Chan Ronnie TP Poon Sheung Tat Fan Chung Mau lo Department of Surgery The University of Hong Kong Department of Pathology The University of Hong Kong State Key Laboratory for Liver Research The University of Hong Kong

The scarcity of liver grafts in Asia leads to a significant dropout of patients from liver transplant waiting lists, particularly patients with hepatocellular carcinoma and a low model for end-stage liver disease score. In order to reduce dropping out, different bridging therapies are employed. We report the use of high-intensity focused ultrasound ablation as a bridging therapy for a patient with hepatocellular carcinoma of stage two and an extremely low platelet count (20×10 9 /L). The ablation was successful. Blood tests showed that his liver function was similar before and after the treatment. No adhesion was encountered in the liver transplantation performed six months later.

关键词： high-intensity focused ultrasound hepatocellular carcinoma liver cirrhosis liver transplantation bridging therapy

High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients

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World Journal of Gastroenterology 2013年第20期19卷 3083-3089页

作者： Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins regina cl lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau lo Department of Surgery the University of Hong Kong State Key Laboratory for Liver Research the University of Hong Kong Department of Diagnostic Radiology the University of Hong Kong Department of Anaesthesiology The University of Hong Kong Department of Pathology the University of Hong Kong Department of Medicine the University of Hong Kong

AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 ***-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before *** patients received HIFU ablation as a bridging *** five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for *** were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of ***:The HIFU group and TACE group showed no difference in terms of tumor size and tumor *** patient in the HIFU group and no patient in the TACE group had gross *** median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P clUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced *** may reduce the drop-out rate of liver transplant candidate.

关键词： Ablation Bridging therapy Cirrhosis Hepatocellular carcinoma High-intensity focused ultrasound Liver transplant New technology

Hepatocellular Tumors:Immunohistochemical Analyses for classification and Prognostication

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Chinese Journal of Cancer Research 2011年第4期23卷 245-253页

作者： regina Cheuk-Lam lo Irene Oi-Lin Ng Department of Pathology and State Key Laboratory for Liver Research The University of Hong Kong

Following the classification of hepatocellular nodules by the International Working Party in 1995 and further elaboration by the International Consensus Group for Hepatocellular Neoplasia in 2009, entities under the spectrum of hepatocellular nodules have been better characterized. Research work hence has been done to answer questions such as distinguishing high-grade dysplastic nodules from early hepatocellular carcinoma (HCC), delineating the tumor cell origin of HCC, identifying its prognostic markers, and subtyping hepatocellular adenomas. As a result, a copious amount of data at immunohistochemical and molecular levels has emerged. A panel of immunohistochemical markers including glypican-3, heat shock protein 70 and glutamine synthetase has been found to be of use in the diagnosis of small, well differentiated hepatocellular tumors and particularly of HCC. The use of liver fatty acid binding protein (L-FABP), β-catenin, glutamine synthetase, serum amyloid protein and C-reactive protein is found to be helpful in the subtyping of hepatocellular adenomas. The role of tissue biomarkers for prognostication in HCC and the use of biomarkers in subclassifying HCC based on tumor cell origin are also discussed.

关键词： Hepatocellular tumors Immunohistochemical classification

An update on the histological subtypes of hepatocellular carcinoma

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Hepatoma Research 2019年第11期5卷 17-23页

作者： regina Cheuk-Lam lo Department of Pathology The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Hepatocellular carcinoma(HCC)is one of the top-ranking cancers worldwide and in Southeast *** high propensity for tumor recurrence,distant metastasis and chemoresistance remain major hurdles in the treatment of *** advances on genetics and genomics research,molecular targeted therapies are emerging as a hope for better disease *** the histological perspective,microscopic review of clinical samples has led to subclassification of HCC and establishment of new *** this review,latest understanding on macrotrabecular-massive HCC,steatohepatitic HCC,lymphocyte-rich HCC,scirrhous HCC,fibrolamellar carcinoma and combined hepatocellular-cholangiocarcinoma will be discussed,emphasizing on the clinical relevance of these pathological *** delineation of the histological,immunohistochemical,molecular and biological phenotypes of primary liver cancer would to further enhance an integrated morphological-molecular classification that better predicts clinical outcome and guides clinical management.

关键词： Liver cancer subtype histology

Fabrication of patterned graphitized carbon wires using low voltage near-field electrospinning, pyrolysis, electrodeposition, and chemical vapor deposition

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Microsystems & Nanoengineering 2020年第1期6卷 1341-1352页

作者： Derosh George Adrian Garcia Quang Pham Mario Ramos Perez Jufeng Deng Michelle Trang Nguyen Tuo Zhou Sergio OMartinez-Chapa Yoonjin Won Chong Liu Roger clo regina Ragan Marc Madou Mechanical and Aerospace Engineering University of CaliforniaIrvineUSA Chemical Engineering and Materials Science University of CaliforniaIrvineUSA Materials and Manufacturing Technology University of CaliforniaIrvineUSA School of Engineering and Sciences Tecnologico de MonterreyMonterreyMexico Mechanical Engineering Dalian University of TechnologyDalianChina Chemical Engineering California State UniversityLong BeachUSA Present address:Mechanical Engineering Centro de Ensenanza Tecnica y Superior UniversidadMexicaliMexico

We herein report a high-resolution nanopatterning method using low voltage electromechanical spinning with a rotating collector to obtain aligned graphitized micro and nanowires for carbon nanomanufacturing.A small wire diameter and a small inter-wire spacing were obtained by controlling the electric field,the spinneret-to-collector distance,the pyrolysis parameters,the linear speed of the spinneret,the rotational speed of the *** a simple scaling analysis,we show how the straightness and the diameter of the wires can be controlled by the electric field and the distance of the spinneret to the collector.A small inter-wire spacing,as predicted by a simple model,was achieved by simultaneously controlling the linear speed of the spinneret and the rotational speed of the *** drying of the polymer nanowires enabled the facile fabrication of suspended wires over various *** polyacrylonitrile wires were carbonized using standard stabilization and pyrolysis to obtain carbon *** carbon nanowires with a diameter of<50 nm were *** also established a method for making patterned,highly graphitized structures by using the aforementioned carbon wire structures as a template for chemical vapor deposition of *** patterning technique offers high throughput for nano writing,which outperforms other existing nanopatterning techniques,making it a potential candidate for large-scale carbon nanomanufacturing.

关键词： nanowires carbon field

疏水化聚乙二醇/钾离子体系提高页岩稳定性机理

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石油勘探与开发 2021年第3期48卷 620-629页

作者： VILLABONA-ESTUPIÑAN Santiago de ALMEIDA RODRIGUES JUNIOR Jorge de ABREU Carolina Ferreira NASCIMENTO regina Sandra Veiga 哥伦比亚石油研究所布卡拉曼加681011哥伦比亚里约热内卢联邦大学化学研究所里约热内卢21941-614巴西

通过室内实验研究了疏水化聚乙二醇(PEG)/K^(+)体系抑制页岩水化的作用机理。通过岩屑热滚分散实验、膨润土性能测试和接触角测量,发现抑制剂体系的抑制能力随着接触角的增加和PEG浓度的增加而增强。改进岩屑热滚分散实验表明抑制剂并... 详细信息

通过室内实验研究了疏水化聚乙二醇(PEG)/K^(+)体系抑制页岩水化的作用机理。通过岩屑热滚分散实验、膨润土性能测试和接触角测量,发现抑制剂体系的抑制能力随着接触角的增加和PEG浓度的增加而增强。改进岩屑热滚分散实验表明抑制剂并未通过热活化钻井液乳化机理(TAME)机制发生作用。通过吸附量、傅立叶变换红外光谱(FT-IR)、X射线衍射(XRD)图谱和热重分析(TGA)研究了PEG/K^(+)体系与黏土样品的相互作用,吸附等温线分析表明K^(+)的存在增加了PEG对黏土表面的亲和力。FT-IR光谱、热重和微商热重分析证明,PEG的吸附可以减少黏土的含水率,即抑制性良好;XRD图谱分析K^(+)的存在使PEG的插层仅为一层,且连接在PEG链上的疏水尾增强了抑制水化的能力。最后采用添加PEG/K^(+)的水基钻井液进行了岩屑热滚分散实验,验证了PEG/K^(+)体系的抑制性能。

关键词：页岩水化水基钻井液水化抑制剂聚乙二醇页岩稳定性

Quantitative hepatitis B surface antigen in predicting recurrence of hepatitis B-related hepatocellular carcinoma after liver transplantation

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Hepatoma Research 2018年第9期4卷 159-170页

作者： James Fung Danny Ka-Ho Wong Yasuhito Tanaka regina lo Tiffany Wong Kenneth Siu-Ho Chok AIbert Chi-Yan Chan Tan-To Cheung Wing-Chiu Dai KeIvin Ng Kevin Ng Man Kwan Irene Ng Wai-Kay Seto Ching-Lung Lai Man-Fung Yuen Chung-Mau lo The Liver Transplant Center Queen Mary HospitalHong KongChina Department of Medicine the University of Hong KongHong KongChina State Key Laboratory for Liver Research the University of Hong KongHong KongChina Department of Virology and Liver Unit Graduate School of Medical sciencesNagoya City UniversityNagoya 467-8601Japan Department of Pathology the University of Hong KongHong KongChina Department of Surgery the University of Hong KongHong KongChina

Aim:Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) for chronic hepatitis B (CHB) can be associated with reappearance of hepatitis B surface antigen (HBsAg). The current study determined the significance of HBsAg qualitatively and quantitatively using a highly sensitive assay in recurrent HCC after transplantation. Methods:Consecutive patients with HBV-related HCC with LT were included. Oral nucleos(t)ide analogues without hepatitis B immune globulin were used as hepatitis B virus (HBV) prophylaxis. Quantitative HBsAg levels were performed at time of transplant, at 1 month, 3 and 6 months post transplant using a highly sensitive (hs)-HBsAg assay. Results:One hundred and fourteen patients were included, with a median follow-up of 80 months, with 24 cases of HCC recurrence, and a cumulative rate of 20.7% at 5 years. There was significant correlation between time of tumor recurrence and time of HBsAg reappearance (r = 0.551,P = 0.027). Early HCC recurrence was associated with higher median level of hs-HBsAg at the time of transplant (72.85vs. 69.70 IU/mL,P = 0.018). Using a hs-HBsAg cut-off level of 0.0005 IU/mL, patients with levels above this threshold at 3 and 6 months were associated with higher rate of early HCC recurrence (28.6%vs. 3.0% and 26.9%vs. 2.9% respectively, bothP =0.0006). There was no significant difference in HCC recurrence between positive and negative HBsAg using the conventional qualitative HBsAg assay. Conclusion:Serum hs-HBsAg levels of≥ 0.0005 IU/mL at 3 to 6 months after LT is associated with higher rates of early HCC recurrence, and may be useful as an early tumor marker.

关键词： Hepatitis B hepatocellular carcinoma transplantation hepatitis B surface antigen recurrence

Therapy for <i>H.</i><i>pylori</i>: Current concepts

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Open Journal of Gastroenterology 2013年第1期3卷 38-41页

作者： Giulia Fiorini Angelo Zullo Valentina Castelli Chiara Ricci Giovanna lo Re Ilaria Saracino Cristina Zaccaro Federico Maria Verardi Alessandra Reggi Dino Vaira Department of clinical and Surgical Science S.Orsola-Malpighi Hospital University of Bologna Bologna Italy Department of Internal Medicine Aging and Kidney Disease Alma Mater Studiorum University of Bologna Bologna Italy Gastroenterology and Digestive Endoscopy “Nuovo Regina Margherita” Hospital Rome Italy Gastroenterology Unit University of Brescia Brescia Italy

Helicobacter pylori plays an important role in the pathogenesis of chronic active gastritis, peptic ulcer and gastric mucosa-associated lymphoid tissue-lymphoma, and is also involved in carcinogenesis of the stomach. Since now no current first-line therapy is able to cure the infection in all treated patients. We evaluated data on the most successful therapy regimens—sequential, concomitant and quadruple therapies—and on the standard therapy available for H. pylori eradication. When therapy fails several factors may be involved: we reviewed both bacterial and host factors that can affect the eradication and that can be involved in therapeutic management of the H. pylori infection.

关键词： Helicobacter pylori Sequential Therapy Eradication

保定城区地表灰尘污染物分布特征及健康风险评价

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环境科学学报 2009年第10期29卷 2195-2202页

作者：郑小康李春晖黄国和杨志峰庞爱萍吕莹北京师范大学环境学院水沙科学教育部重点实验室北京100875 黄河勘测规划设计有限公司规划研究院郑州450003 北京师范大学环境学院水环境模拟国家重点实验室北京100875 Faculty of Engineering University of Regina

以河北省保定市城区为研究区域,采集了保定城区内办公区、商业区、居住区、工业区、交通区和屋顶6个类别共14个采样点的地表灰尘,分析了地表灰尘重金属和营养元素N、P在不同区域的分布特征,并分析了其可能来源.最后,应用重金属健康风险... 详细信息

以河北省保定市城区为研究区域,采集了保定城区内办公区、商业区、居住区、工业区、交通区和屋顶6个类别共14个采样点的地表灰尘,分析了地表灰尘重金属和营养元素N、P在不同区域的分布特征,并分析了其可能来源.最后,应用重金属健康风险评价模型(Chronic Daily Intake,CDI)对地表灰尘中Cd、Cr、Cu、Pb和Zn5种重金属进行了健康风险评价.结果表明,城市屋顶灰尘污染物质含量普遍高于其它区域,之后依次是商业区>交通区>工业区>办公区>居住区,Cd(5.10mg·kg-1)、Cr(470mg·kg-1)、Pb(997mg·kg-1)、Zn(1377mg·kg-1)和P(999mg·kg-1)的最大值均来自屋顶灰尘,而Cu(867mg·kg-1)和N(19.40mg·kg-1)的最大值则来自商业区的地表灰尘.重金属Cd和Cr具有复合污染特征,来源复杂且多样化;重金属Pb、Zn和Cu的含量在各区域中的变化趋势较一致且显著相关,主要来源于交通排放.Cd的平均致癌风险指数均达到了1.25×10-5,超过了美国EPA10-6的标准,由此将导致每百万人增加12.5个癌症患者,已对当地居民的身体健康造成了严重的威胁;各种重金属的平均叠加风险度达0.124,重金属摄入为慢性参考剂量的10%左右,不会对居民的身体健康产生较大的非致癌风险.

关键词：地表灰尘重金属营养元素健康风险评价

Bacteroides fragilis Supernatant Extracts Enriched in Phenylacetic Acid Induce a Cytotoxic Effect in Mammalian Cells

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Advances in Microbiology 2015年第10期5卷 730-736页

作者： Laís S.Falcao Eduardo N.F.Antunes Eliane O.Ferreira Heidi Pauer Maria Teresa V.Romanos Rossiane C.Vommaro Sérgio H.Seabra Daniela S.Alviano Celuta S.Alviano Antonio Jorge R.da Silva Leandro A.lobo regina Maria C.P.Domingues Departamento de Ciências Básicas Pólo Universitário de Nova FriburgoUniversidade Federal FluminenseNova FriburgoBrasil Instituto de Microbiologia Prof.Paulo de Góes Universidade Federal do Rio de JaneiroRio de JaneiroBrasil Instituto de Biofísica Carlos Chagas Filho Universidade Federal do Rio de JaneiroRio de JaneiroBrasil Centro Universitário Estadual da Zona Oeste—UEZO Rio de JaneiroBrasil Instituto de Pesquisa Produtos Naturais Universidade Federal do Rio de JaneiroRio de JaneiroBrasil

Bacteroides species are nearly half of the fecal flora community and some are host symbionts crucial to host nutrition and systemic immunity. Among Bacteroides species B. fragilis strains are considered to be the opportunistic ones, being the most isolated anaerobic bacteria in clinical samples. Cell-free supernatants of 65 B. fragilis strains were assayed and they were capable of inducing vacuolating phenotype on Vero cells lineage. The supernatant of the Bacteroides fragilis ATCC 23745 strain was elicited to have the strongest vacuolating effect on Vero cells monolayers and peritoneal macrophages. Some drastic cell alterations were observed, such as a general disorganization of cytoplasm and chromatin condensation, evidencing cell death. By transmission electron microscopy it was confirmed that the vacuoles observed were, in fact, swollen mitochondria. An immunocytochemical assay, TUNEL, was used to confirm this hypothesis and showed that Vero cells and peritoneal macrophages were dying by apoptotic process after exposition of B. fragilis cell-free supernatant. Physical analysis of the apoptotic factor has revealed properties similar to short-chain fatty acids. After gas chromatography and mass spectrometry analysis, phenylacetic acid (PA) was characterized as the major compound present in the most purified active fraction. We believe that the PA is responsible for the pro-apoptotic effect elicited by the supernatant of B. fragilis cultures.

关键词： Bacteroides fragilis Vacuolization Apoptosis Vero cells Lineage Peritoneal Macrophages Phenylacetic Acid