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serological surveillance for sARs-coV-2 antibodies among students,faculty and staff within a large university system during the pandemic

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World Journal of Virology 2025年第1期14卷 99-107页

作者： Marcos G Pinheiro Gabriela G O Alves Maria Eduarda R conde sofia L costa regina c s sant’anna Isa M F Antunes Mônica c carneiro Fabio s Ronzei Julia c scaffo Felipe R Pinheiro Lialyz s Andre Helvecio c Povoa Valéria T Baltar Fabíola Giordani Eduarda s Hemerly Gisele c Alexandre Karla c de Paula Márcio Watanabe Antonio claudio L da Nóbrega Jackeline christiane P Lobato Fabio Aguiar-Alves Laboratory of Molecular Epidemiology and Biotechnology Rodolpho Albino University LaboratoryFluminense Federal UniversityNiterói 24241000Rio de JaneiroBrazil Estácio de sáUniversity Nova Friburgo 28611135Rio de JaneiroBrazil Pathology Program Medicine schoolFluminense Federal UniversityNiterói 24070090Rio de JaneiroBrazil Department of Pharmaceutical sciences Lloyd L.Gregory School of PharmacyPalm Beach Atlantic UniversityWest Palm BeachFL 33401United States Health Institute of Nova Friburgo Fluminense Federal UniversityNova Friburgo 28613001Rio de JaneiroBrazil Department of Epidemiology and Biostatistics Institute of Collective Health(ISC)Fluminense Federal UniversityNiterói 24033900Rio de JaneiroBrazil Institute of Physical Education Fluminense Federal UniversityNiterói 24020005Rio de JaneiroBrazil Department of statistics Fluminense Federal UniversityNiterói 24210200Rio de JaneiroBrazil Department of Physiology and Pharmacology Fluminense Federal UniversityNiterói 24210130Rio de JaneiroBrazil

BAcKGROUND At the end of December 2019,the world faced severe acute respiratory syndrome-coronavirus 2(sARs-coV-2),which led to the outbreak of coronavirus disease 2019(cOVID-19),associated with respiratory *** virus has shown significant challenges,especially for senior citizens,patients with other underlying illnesses,or those with a sedentary *** tests conducted early on have helped identify how the virus is transmitted and how to curb its *** study hypothesis was that the rapid serological test for sARs-coV-2 antibodies could indicate the immunoreactive profile during the cOVID-19 pandemic in a university *** To conduct active surveillance for serological expression of anti-sARs-coV-2 antibodies in individuals within a university setting during the cOVID-19 *** This sectional study by convenience sampling was conducted in a large university in Niteroi-RJ,Brazil,from March 2021 to July *** study population consisted of students,faculty,and administrative staff employed by the university.A total of 3433 faculty members,60703 students,and 3812 administrative staff were invited to *** were gathered through rapid serological tests to detect immunoglobulin(Ig)M and IgG against ***χ²or Fisher's exact test was used to conduct statistical analysis.A 0.20 significance level was adopted for variable selection in a multiple logistic regression model to evaluate *** A total of 1648 individuals were enrolled in the *** proportion of cOVID-19 positivity was 164/1648(9.8%).The adjusted logistic model indicate a positive association between the expression of IgM or IgG and age[odds ratio(OR)=1.16,95%cI:1.02-1.31](Ps who had been in contact with a cOVID-19-positive case(OR=3.49,95%cI:2.34-5.37)(Pse who had received the cOVID-19 vaccine(OR=2.33,95%cI:1.61-3.35)(Psocial isolation(OR=0.59,95%cI:0.41-0.84)(Psho

关键词： serological surveillance sARs-coV-2 antibodies cOVID-19 serological rapid test Risk factors for cOVID-19

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Evaluation of soil Quality Indicators in sugarcane Management in sandy Loam soil

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Pedosphere 2009年第3期19卷 312-322页

作者： s.A.c.sant'anna M.F.FERNANDEs W.M.P.M.IVO J.L.s.cOsTA Brazilian Agricultural Research corporation (Embrapa coastal Tablelands) Av. Beira Mar 3250 Aracaju SE 49025- 040 (Brazil) Departament of Physiology Universidade Federal de Sergipe So Cristóvo SE 49100-000 (Brazil) Brazilian Agricultural Research corporation (Embrapa coastal Tablelands) Av. Beira Mar 3250 Aracaju SE 49025-040 (Brazil) Brazilian Agricultural Research corporation (Embrapa) Brasília DF 70770-901 (Brazil)

An important factor for the sustainability of soils highly susceptible to degradation is the use of monitoring tools that promptly and realistically reflect changes imposed on soil by different cropping systems. To select soil quality indicator variables in sugarcane (saccharum officinarum L.) production areas that fulfill the criteria of sensitivity to management practices and between-season consistency in the management discrimination, ten composite soil samples (0–10 cm) were collected in July 2005 (rainy season) and again in March 2006 (dry season) from areas under cultivation of organic sugarcane (Os), green sugarcane (Gs), burned sugarcane (Bs) and from an adjacent native forest (NF) area at Usina Triunfo, Boca da Mata, Alagoas, Brazil. Microbial biomass-c (MBc), total organic c (TOc), soil enzyme activity expressed as the rate of fluorescein diacetate (FDA) hydrolysis, mean weight diameter of water-stable soil aggregates (MWD), and percentage of water-stable macroaggregates (PWsA) were analyzed. Although MBc and TOc were higher in NF than in the cultivated areas, no differences were observed in these c pools between the three sugarcane systems. The response of FDA to the site management was dependent on the sampling time. In the rainy period, the activity followed the order: NF > Os > Gs > Bs, whereas in the dry season, only NF differed from the other treatments. Irrespective of the sampling time, MWD and PWsA decreased in the order NF > Os = Gs > Bs. The variables MWD and PWsA are quite sensitive for discriminating between site management histories regardless the sampling season.

关键词： fiuorescein diacetate green-sugarcane organic matter management sugarcane (saccharum oJficinarum L.) sustainable agricultural use

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Effect of special Hungarian probiotic kefir on faecal microflora

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World Journal of Gastroenterology 2006年第7期12卷 1129-1132页

作者： MáriaFigler GyulaMózsik Bélaschaffer BeátaGasztonyi Pongrác cs Bélaszili regina Rab sándorszakály Department First Hungarian Faculty

AIM： To investigate the effect of a four-week consumption of a special Hungarian probiotic agent （Biofir） on the faecal microflora in human healthy subjects.METHODs： The effect of Biofir with 10^6/cm^3 initial germs on the faecal microflora was studied in 120 healthy volunteers （71 females, 49 males）. The traditional Russian type kefir was used as control. The various germ groups and pH values were determined in wk 2, 4 and 6.REsULTs： The number of all microbes increased during the 4-week probiotic treatment. The number of microbes increased 4,3-fold in the control group and 6.8-fold in Biofir-treated group. The probiotic kefir caused multiplication of the probiotic flora, meanwhile the undesired bacteria multiplied in the control group. No significant change of pH values of the faeces was found in both groups.cONcLUsION： The Hungarian probiotic keflr （Biofir） is capable of promoting multiplication of probiotic bacterial flora in the large bowel.

关键词： Hungarian probiotic agent (Biofir) Faecal microflora Large bowel

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In vitro and in vivo evaluation of cerium oxide nanoparticles in respiratory syncytial virus infection

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Bioactive Materials 2023年第6期24卷 124-135页

作者： Akhil Patel Jessica Kosanovich sameera sansare sricharani Balmuri Vinayak sant Kerry M.Empey shilpa sant Department of Pharmaceutical sciences School of PharmacyUniversity of PittsburghPittsburghPA15261USA center for clinical Pharmaceutical sciences Department of Pharmacy and TherapeuticsSchool of PharmacyClinical and Translational Science InstituteDepartment of ImmunologySchool of MedicineUniversity of PittsburghPittsburghPA15261USA Department of Bioengineering Swanson School of EngineeringMcGowan Institute for Regenerative MedicineUPMC Hillman Cancer CenterUniversity of PittsburghPittsburghPA15261USA

Respiratory syncytial virus(RsV)is the most common cause of viral bronchiolitis among children worldwide,yet there is no vaccine for RsV *** study investigates the potential of cube and sphere-shaped cerium oxide nanoparticles(cNP)to modulate reactive oxygen(ROs)and nitrogen(RNs)species and immune cell phenotypes in the presence of RsV infection in vitro and in *** and sphere-shaped cNP were synthesized by hydrothermal and ultrasonication methods,***-chemical characterization confirmed the shape of sphere and cube cNP and effect of various parameters on their particle size distribution and zeta *** vitro results revealed that sphere and cube cNP differentially modulated ROs and RNs levels in J774 ***,cube cNP significantly reduced RsV-induced ROs levels without affecting RNs levels while sphere cNP increased RsV-induced RNs levels with minimal effect on ROs *** cNP drove an M1 phenotype in RsV-infected macrophages in vitro by increasing macrophage surface expression of cD80 and cD86 with a concomitant increase in TNFαand IL-12p70,while simultaneously decreasing M2 cD206 *** administration of sphere and cube-cNP were well-tolerated with no observed toxicity in BALB/c ***,cube cNP preferentially accumulated in murine alveolar macrophages and induced their activation,avoiding enhanced uptake and activation of other inflammatory cells such as neutrophils,which are associated with RsV-mediated *** conclusion,we report that sphere and cube cNP modulate macrophage polarization and innate cellular responses during RsV infection.

关键词： cerium oxide nanoparticles Reactive oxygen species Respiratory syncytial virus Macrophage phenotypes Immunomodulation Nanoparticle shape Bioactive nanoparticles

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Optimizing the use of open chambers to measure ammonia volatilization in field plots amended with urea

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Pedosphere 2021年第2期31卷 243-254页

作者： Márcio R.MARTINs Leonardo F.sARKIs selenobaldo A.c.sant’anna camila A.santOs Karla E.ARAUJO Ricardo c.santOs Ednaldo s.ARAÚJO Bruno J.R.ALVEs claudia P.JANTALIA Robert M.BODDEY Mohammad ZAMAN segundo URQUIAGA Embrapa Agrobiology Rod.BR 465km 7Seropédica RJ CEP 23891-000(Brazil) Federal Rural University of Rio de Janeiro(UFRRJ) Rod.BR 465km 7Seropédica RJ CEP 23891-000(Brazil) Agroscope Research Division Agroecology and EnvironmentClimate and Agriculture GroupReckenholzstrasse 191Zurich 8046(Switzerland) soil and Water Management&crop Nutrition Joint FAO/IAEA Division of Nuclear Techniques in Food&AgricultureP.O.Box 100Vienna A-1400(Austria)

Measuring ammonia(NH_(3))volatilization from urea-fertilized soils is crucial for evaluation of practices that reduce gaseous nitrogen(N)losses in *** small area of chambers used for NH_(3)volatilization measurements compared with the size of field plots may cause significant errors if inadequate sampling strategies are *** aims were:i)to investigate the effect of using multiple open chambers on the variability in the measurement of NH_(3)volatilization in urea-amended field plots and ii)to define the critical period of NH_(3)-N losses during which the concentration of sampling effort is capable of reducing *** use of only one chamber covering 0.015%of the plot(51.84 m^(2))generates a value of NH_(3)-N loss within an expected margin of error of 30%around the true *** reduce the error margin by half(15%),3–7 chambers were required with a mean of 5 chambers per *** the sampling efforts in the first two weeks after urea application,which is usually the most critical period of N losses and associated errors,represents an efficient strategy to lessen uncertainty in the measurements of NH_(3)*** strategy enhances the power of detection of NH_(3)-N loss abatement in field experiments using chambers.

关键词： chamber method experimental error gas emission low-cost chamber nitrogen cycling nitrogen loss soil variability

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Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease:two triggers, one disease

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Neural Regeneration Research 2021年第6期16卷 1127-1130页

作者： sofia Ferreira Ana F.Raimundo regina Menezes Ivo c.Martins iBET-Instituto de Biologia Experimental e Tecnológica OeirasPortugal cEDOc-chronic Diseases Research center Faculdade de Ciências MédicasUniversidade Nova de LisboaLisboaPortugal ITQB-NOVA Instituto de Tecnologia Química e Biológica António XavierUniversidade Nova de LisboaOeirasPortugal Instituto de Medicina Molecular Faculdade de MedicinaUniversidade de LisboaLisbonPortugal

Alzheimer’s disease(AD)is a neurodegenerative disorder that affects millions *** to population ageing,the incidence of AD is *** patients develop cognitive decline and dementia,features for which is known,requiring permanent *** poses a major socio-economic burden on healthcare systems as AD patients’relatives and healthcare workers are forced to cope with rising numbers of affected *** recent advances,AD pathological mechanisms are not fully ***,it is clear that the amyloid beta(Aβ)peptide,which forms amyloid plaques in AD patients’brains,plays a key *** 2 diabetes,the most common form of diabetes,affects hundreds of million people *** amyloid polypeptide(IAPP)is a hormone coproduced and secreted with insulin in pancreatic β-cells,with a key role in diabetes,as it helps regulate glucose levels and control adiposity and *** to Aβ,IAPP is very amyloidogenic,generating intracellular amyloid deposits that causeβ-cell dysfunction and *** is now clear that IAPP can also have a pathological role in AD,decreasing cognitive *** harms the blood-brain barrier,directly interacts and co-deposits with Aβ,promoting diabetes-associated *** can cause a metabolic dysfunction in the brain,leading to other diabetes-related forms of ***,here we discuss IAPP association with diabetes,Aβand dementia,in the context of what we designate a“diabetes brain phenotype”AD *** approach helps to set a conceptual framework for future IAPP-based drugs against AD.

关键词： aggregation Alzheimer amylin amyloid diabetes islet amyloid polypeptide

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A simple and easy method to measure ammonia volatilization:Accuracy under field conditions

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Pedosphere 2021年第2期31卷 255-264页

作者： Márcio R.MARTINs Leonardo F.sARKIs Roni F.GUAREscHI camila A.santOs selenobaldo A.c.sant’anna Mohammad ZAMAN claudia P.JANTALIA Bruno J.R.ALVEs Robert M.BODDEY Ednaldo s.ARAÚJO segundo URQUIAGA Embrapa Agrobiology Rod.BR 465km 7Seropédica RJ CEP 23891-000(Brazil) Agroscope Research Division Agroecology and EnvironmentClimate and Agriculture GroupReckenholzstrasse 191Zurich 8046(Switzerland) Federal Rural University of Rio de Janeiro(UFRRJ) Rod.BR 465km 7Seropédica RJ CEP 23891-000(Brazil) soil and Water Management&crop Nutrition Joint FAO/IAEA Division of Nuclear Techniques in Food&AgricultureP.O.Box 100Vienna A-1400(Austria)

Field studies on soil ammonia(NH_(3))volatilization are restricted in many countries owing to the high costs commonly demanded for accurate *** assessed the accuracy of a simple,open chamber design to capture NH_(3)under field conditions,as affected by different chamber placement ***-15 N was surface applied to lysimeters installed in the spaces between maize *** chambers made from plastic bottles were installed on each lysimeter with variations in i)N rates(3,8,13,and 18 g m^(-2)),ii)the height of the chamber above the soil surface(0,5,and 10 mm),and iii)chamber relocation(static ***).Reference lysimeters without chambers were used to measure NH_(3)losses by^(15)*** of NH_(3)-N accounted for more than 50%of the applied *** of the chambers had no impact on their NH_(3)-trapping efficiencies,proving to be an unnecessary *** in the height of the chambers above the soil surface affected the capture of NH_(3),but the results still maintained high linearity with the NH_(3)losses quantified by the reference method(R^(2)>0.98).When the same placement scheme used in the introductory study describing the chamber was utilized(static and touching the soil surface),we found a trapping efficiency of 60%,which was very similar to that(57%)obtained in the previous *** results show that this simple,open chamber design can be used with satisfactory accuracy under field conditions,provided that simple,standardized procedures are warranted.

关键词： ammonia collector chamber method field sampler gas emission low-cost chamber nitrogen cycling

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comparative study of polyhydroxyalkanoates production from acidified and anaerobically treated brewery wastewater using enriched mixed microbial culture

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Journal of Environmental sciences 2019年第4期31卷 137-146页

作者： Pravesh Tamang Rintu Banerjee stephan K?ster regina Nogueira Institute for sanitary Engineering and Waste Management Leibniz Universitat Hannover Welfengarten 1D-30167 HannoverGermany Indian Institute of Technology Kharagpur Department of Agricultural and Food Engineering721302 KharagpurIndia

The production of polyhydroxyalkanoates(PHA) from wastewaters using microbial mixed cultures(MMc) has been attracting increased interest because of PHA's biodegradability characteristics. Production of PHA by an MMc enriched with PHA-accumulating bacteria was compared using anaerobically treated and acidified brewery wastewaters under various feeding strategies, namely pulse and batch feed addition. To obtain an enriched MMc, a sequencing batch reactor was inoculated with activated sludge fed with acetate and subjected to aerobic dynamic feeding. The enriched MMc was able to accumulate PHA up to 72.6% of cell dry weight(cDW) with pulse addition of acetate controlled by the dissolved oxygen(DO) concentration in the reactor. In a batch accumulation experiment with acetate,the PHA content achieved(28.5% cDW) was less than that of the pulse feeding strategy with the same amount of acetate(～2000 mg c/L). Using anaerobically treated and acidified brewery wastewater fed in pulses, the maximum PHA accumulated by the enriched MMc was similar for both wastewaters(45% cDW), in spite of the higher volatile fatty acid concentration in acidified brewery wastewater. The pulse feed addition controlled by the DO concentration was difficult to implement for wastewater as compared to acetate because the difference in DO concentration between substrate availability and depletion was low. For the batch addition of acidified wastewater, a slightly lower PHA content(39%cDW) was obtained. These results show that both brewery wastewaters can be utilized for PHA production with a similar maximum PHA storage capacity.

关键词： Polyhydroxyalkanoates PHA-accumulating bacteria Microbial mixed culture Brewery wastewater Aerobic dynamic feeding Pulse feeding and batch feeding

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Vitamin D deficiency,functional status,and balance in older adults with osteoarthritis

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World Journal of clinical cases 2021年第31期9卷 9491-9499页

作者： cláudia N Montemor Marcos Tadeu P Fernandes Audrey s Marquez regina célia Poli-Frederico Rubens Alexandre da silva Karen B P Fernandes Laboratory of Rehabilitation Research Doctoral Program of Rehabilitation SciencesUniversity Pitágoras Unopar(UNOPAR)Londrina 86041-140ParanaBrazil Department of Anesthesiology Irmandade da Santa Casa de LondrinaLondrina 86010-160ParanaBrazil Health sciences Research center University Pitágoras Unopar(UNOPAR)Londrina 86041-140ParanaBrazil Doctoral Program of Rehabilitation sciences University Pitagoras Unopar(UNOPAR)Londrina 86041-140ParanaBrazil Département des sciences de la santé Centre intersectoriel en santédurableLaboratoire de recherche BioNRUniversitédu QuébecàChicoutimi(UQAC)SaguenayG7H 2B1QuébecCanada centre intégréde santéet services sociaux du saguenay-Lac-saint-Jean(cIUsss sLsJ) Hôpital de La Baie-Services gériatriques spécialisésSaguenayQuébecG7H 7K9Canada

BAcKGROUND Low vitamin D levels are associated with a more severe case of knee osteoarthritis(OA).However,there are few published reports concerning an association between vitamin D deficiency and functional status of individuals with OA and no reports about postural balance in this *** To analyze the relationship between vitamin D deficiency and severity,functional status,and balance in elderly patients with *** In this cross-sectional study,105 elderly patients with hip and knee OA were *** severity was assessed by the Kellgren-Lawrence *** functional status was assessed with the Lequesne *** balance was assessed using a force platform,and center-of-pressure parameters(velocity at anteroposterior and mediolateral axis)were used as the balance *** 25(OH)vitamin D levels were measured using a chemiluminescence *** Most of the patients(mean age:70.6±6.5 years)were female(n=78,74.3%).In the group with vitamin D deficiency,43 patients(56.6%)had severe OA,while 33 patients(43.4%)had mild or moderate OA(χ^(2) test,P=0.04).Patients with vitamin D deficiency showed a higher Lequesne index score(Mann-Whitney test,P=0.04),indicating a worse functional impairment when compared to individuals with normal vitamin D ***,patients with vitamin D deficiency had worse postural balance according to the Mann-Whitney test(P=0.03).cONcLUsION Vitamin D deficiency is associated with worse severity,functional status,and postural balance in patients with OA.

关键词： Osteoarthritis Elderly Vitamin D Disability severity Balance

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Hepatocellular Tumors:Immunohistochemical Analyses for classification and Prognostication

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chinese Journal of cancer Research 2011年第4期23卷 245-253页

作者： regina cheuk-Lam Lo Irene Oi-Lin Ng Department of Pathology and state Key Laboratory for Liver Research The University of Hong Kong

Following the classification of hepatocellular nodules by the International Working Party in 1995 and further elaboration by the International consensus Group for Hepatocellular Neoplasia in 2009, entities under the spectrum of hepatocellular nodules have been better characterized. Research work hence has been done to answer questions such as distinguishing high-grade dysplastic nodules from early hepatocellular carcinoma (Hcc), delineating the tumor cell origin of Hcc, identifying its prognostic markers, and subtyping hepatocellular adenomas. As a result, a copious amount of data at immunohistochemical and molecular levels has emerged. A panel of immunohistochemical markers including glypican-3, heat shock protein 70 and glutamine synthetase has been found to be of use in the diagnosis of small, well differentiated hepatocellular tumors and particularly of Hcc. The use of liver fatty acid binding protein (L-FABP), β-catenin, glutamine synthetase, serum amyloid protein and c-reactive protein is found to be helpful in the subtyping of hepatocellular adenomas. The role of tissue biomarkers for prognostication in Hcc and the use of biomarkers in subclassifying Hcc based on tumor cell origin are also discussed.

关键词： Hepatocellular tumors Immunohistochemical classification

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