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Reserpine-Induced Progressive Parkinsonism in Mice Predisposed and Non-Predisposed to Depressive-Like Beh.vior

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Journal of Beh.vioral and Brain Science 2021年第11期11卷 267-279页

作者： Manuela B. L. Soares Leonardo B. Lopes-silva Marcela Becegato Vinicius S. Bioni Alvaro C. Lima Gabriela M. Ferreira Ywlliane Meurer regina h. silva Beh.vioral Neuroscience Laboratory Department of Pharmacology Federal University of S&atilde o Paulo S&atilde o Paulo Brazil Memory and Cognition Studies Laboratory Post-Graduate Program of Cognitive Neuroscience and Behavior Department of Psychology Federal University of Paraíba Jo&atilde o Pessoa Brazil

Parkinson’s disease (PD) is a progressive degenerative condition th.t mainly affects th. elderly. Th. disease comprises motor symptoms such.as tremors at rest, loss of voluntary movement, decreased muscle strength. propensity to lean forward and acceleration of th. walking pace. Th.se signs are related to th. degeneration of th. nigrostriatal dopaminergic path.ay. Patients also h.ve non-motor symptoms, among wh.ch.sleep alterations, cognitive deficits, fatigue, pain and depression stand out. Alth.ugh.depression h.s been described as th. most prevalent non-motor symptom, it is not clear wh.th.r th.s mood disorder is due to PD or patients would already h.ve a greater predisposition. Th. present study evaluated th. relationsh.p between th. predisposition to depressive-like beh.vior and th. development of motor alterations in a progressive ph.rmacological model of PD in mice. Mice were classified into groups of depressive-like propensities and submitted to th. ph.rmacological model. Reserpine was administrated at 0.1 mg/kg on alternate days for 40 days. Th. catalepsy and oral movement tests were used to evaluate motor alterations, th. sucrose preference test was used to evaluate anh.donia, and th. open field test was applied to evaluate general activity. Reserpine promoted parkinsonian motor impairments, and th.re were no differences between animals from different depressive-like beh.vior profiles. Th.s, it was not possible to find a relationsh.p between parkinsonism and th. propensity to depression based on th. basal sucrose preference test. More studies with.oth.r evaluations of depressive-like beh.vior are needed to confirm th. results found in our study.

关键词： Parkinson’s Disease Depression Reserpine Mice

Effect of radiative loss mech.nisms on FIR th.rmometric parameters of Nd^(3+)-doped lith.um tellurite glasses

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Journal of Rare Earth. 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.Morassuti A.P.L silva L.A.O.Nunes S.M.Lima L.h.C.Andrade Optical and Ph.toth.rmal Spectroscopy Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Arch.r Information Tech.ology Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Ph.sics of São Carlos University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tellurite glasses are promising materials for th.rmometers based on th. fluorescence intensity ratio(FIR)***,at h.gh.Nd^(3+)concentrations,energy transfer(ET)processes such.as optical reabsorption and cross-relaxation can affect th. Nd^(3+)emission,wh.ch.h.s been little explored in th. ***,th. present work investigated th. use of Nd^(3+)-doped tellurite glass(samples doped with.Nd^(3+)at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%)in fluorescence th.rmometers,in th. temperature range from 299 to 371 *** results indicate a strong dependence of th. FIR parameters on th. Nd^(3+)concentration,due to ch.nges in th. emission band profiles caused by optical reabsorption of th. Nd^(3+)emissions and cross-relaxation processes.A decrease of th. relative sensitivity of th. ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for samples doped with.h.gh.r amounts of Nd^(3+).Th. maximum relative sensitivity at 299 K is 3.00%/K,wh.ch.is th. h.gh.st value among th. reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tellurite glass Fluorescence intensity ratio Optical th.rmometry Judd-Ofelt Rare earth.

Evaluation of th. Antibacterial and Antifungal Capacity of Nanoemulsions Loaded with.Synth.tic Ch.lcone Derivatives Di-Benzyl Cinnamaldeh.de and Benzyl 4-Aminoch.lcone

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Journal of Renewable Materials 2024年第2期12卷 285-304页

作者： Flavia Oliveira Monteiro da silva Abreu Taysse h.landa Joice Farias do Nascimento h.nety Nascimento Pinh.iro Rach.l Menezes Castelo h.lcio silva dos Santos Th.is Benincá Patrícia da silva Malh.iros Júlio César Sousa Prado Raquel de Oliveira Fontenelle Maria Madalena de Camargo Forte Natural Polymers Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Polymeric Materials Laboratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Product Ch.mistry Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Food h.giene and Microbiology Laboratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Microbiology Laboratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With.th. increase in antimicrobial resistance,it h.s become necessary to explore alternative approach.s for combating and preventing ***-cinnamaldeh.de(CNM)and Benzyl4-amino(B4AM)are bioactive compounds derived from ch.lcones but with.restricted solubility in aqueous *** can enh.nce th. solubility of compounds and can be a promising alternative in th. development of novel antimicrobials,with.reduced side effects and prolonged *** objective of th.s study was to evaluate th. stability of oil-in-water nanoemulsions loaded with.two distinct types of ch.lcones at two different dosages,to propose a stable formulation with.antimicrobial *** sh.wed th.t nanoemulsions presented h.gh.encapsulation efficiency,low polydispersity index(PDI)and particle size below 200 nm,indicating th.t emulsification was a suitable meth.d for nanoemulsion *** with.h.gh.r dosages exh.bited significant antimicrobial effects wh.n compared to free ch.lcones and positive ***,B4AM nanoemulsions at h.gh.r dosages sh.wed expressive activity against Salmonella minnesota,with.a 420%greater inh.bitory response compared to th. free form and sh.wing equivalence to th. positive *** nanoemulsions sh.wed excellent inh.bitory activity at th. h.gh.st dosage,equivalent to th. positive control against *** and Staph.lococcus *** greater number of conjugated bonds in CNM increased th. antimicrobial activity in comparison with.B4AM,and th. formation of nanometric domains enh.nced th. bioavailability,being a promising alternative for antimicrobial applications.

关键词： Polysacch.ride nanoemulsions S.aureus S.minnesota ch.lcones alginate

ENSO impacts on litter stocks and water h.lding capacity in secondary forests in eastern Amazonia

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Journal of Forestry Research 2024年第1期35卷 83-89页

作者： Julia Isabella de Matos Rodrigues Walmer Bruno Roch. Martins Victor Pereira de Oliveira Myriam Suelen da silva Wanzerley h.lio Brito dos Santos Júnior Francisco de Assis Oliveira Graduate Program in Forestry Sciences Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural University of Amazonia Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural University of Amazonia Tv.Pau-AmareloCapitão PoçoPará68650-000Brazil National Institute of Amazonia Research Av.Constelação Cruzeiro do SulManausAmazonas 69060-062Brazil

Among th. impacts of climate ch.nge,th.re is th. intensification of ph.nomena such.as th. El Niño South.ern Oscillation(ENSO)responsible for El Niño and La Niñ***,understanding th.ir effects on th. functional pro-cesses of forests is ***,th.s study evaluated th. effects of ENSO on litter stock and water h.lding capac-ity(Wh.)in a successional forest in eastern *** occurred in periods with.th. most rainfall in El Niño(2019)and least in La Niña(2021)*** permanent plots were used to sample *** effects were evident for Wh.,h.gh.r during El Niñ***,th.s influence was not clear for litter,as only in th. rainy season effects were *** was a positive correlation of Wh. with.precipitation and h.midity,wh.le litter stocks were negatively correlated with.temperature and wind *** th. subject of th.s study requires long-term assessments,preliminary results suggests th.t,depending on th. intensity of ENSO,forest functional processes can be strongly impacted and *** conclusion reinforces warnings by th. scientific community about th. impacts of climate ch.nge on th. maintenance of litter stocks,decomposition and,consequently,th. biogeoch.mical cycle and essential ecosystem services for th. maintenance of Amazonia *** need to develop long-term research.to understand th. effects of climatic ch.nge on litter stocks and water h.lding capacity is h.gh.igh.ed,especially in Amazonia.

关键词： Seasonality Climate ch.nge Succession ecosystem Biogeoch.mical cycle Amazonia biodiversity

Maternal supplementation with.n-3 fatty acids affects placental lipid metabolism, inflammation, oxidative stress, th. endocannabinoid system, and th. neonate cytokine concentrations in dairy cows

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Journal of Animal Science and Biotech.ology 2024年第5期15卷 2012-2030页

作者： Priscila dos Santos silva Gitit Kra Yana Butenko Jayasimh. Rayalu Daddam Yish.i Levin Maya Zach.t Department of Ruminant Science Institute of Animal SciencesARO Volcani InstituteRishon LeZionIsrael Department of Animal Science The Robert H.Smith Faculty of AgricultureFood and EnvironmentThe Hebrew University of JerusalemRehovotIsrael Department of Animal Sciences Michigan State UniversityEast LansingMIUSA Th. Nancy and Steph.n Grand Israel National Center for Personalized Medicine Weizmann Institute of ScienceRehovotIsrael

Background Th. placenta plays a crucial role in supporting and influencing fetal *** compared th. effects of prepartum supplementation with.omega-3(n-3)fatty acid(FA)sources,flaxseed oil(FLX)and fish.oil(FO),on th. expression of genes and proteins related to lipid metabolism,inflammation,oxidative stress,and th. endocannabinoid system(ECS)in th. expelled placenta,as well as on FA profile and inflammatory response of ***-pregnant h.lstein dairy cows were supplemented with.saturated fat(CTL),FLX,or *** cotyledons(n=5)were collected immediately after expulsion,and extracted RNA and proteins were analyzed by RTPCR and proteomic *** blood was assessed for FA composition and concentrations of inflammatory *** FO increased th. gene expression of fatty acid binding protein 4(FABP4),interleukin 10(IL-10),catalase(CAT),cannabinoid receptor 1(CNR1),and cannabinoid receptor 2(CNR2)compared with.CTL *** expression of ECS-enzyme FA-amide h.drolase(FAAh.was lower in FLX and FO th.n in *** analysis identified 3,974 proteins;of th.se,51–59 were differentially abundant between treatments(P≤0.05,|fold ch.nge|≥1.5).Top canonical path.ays enrich.d in FLX *** and in FO *** were triglyceride metabolism and inflammatory *** n-3 FA increased th. placental abundance of FA binding proteins(FABPs)3 and *** abundance of CNR1 cannabinoid-receptor-interacting-protein-1(CNRIP1)was reduced in FO *** silico modeling affirmed th.t bovine FABPs bind to *** FLX increased th. abundance of inflammatory CD44-antigen and secreted-ph.sph.protein-1,wh.reas prostaglandin-endoperoxide synth.se 2 was decreased in FO *** *** FO enrich.d neonatal plasma with.n-3 FAs,and both.FLX and FO reduced interleukin-6 concentrations compared with.*** Maternal n-3 FA from FLX and FO differentially affected th. bovine placenta;both.enh.nced lipid metabolism and modulated oxidative s

关键词： Antioxidants Dairy cows Endocannabinoid system Inflammation Omega-3 fatty acids Placenta

A single session of strength.training ch.nged plasma levels of resistin,but not leptin in overweigh. and obese men

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Sports Medicine and h.alth.Science 2024年第4期6卷 324-330页

作者： Yago Martins Fortes Antonio Felipe Souza-Gomes Alessandro Roberto Silveira Moreira Leo Nogueira Campos Samara silva de Moura Lucelia Scarabeli silva Barroso Marcelo h.nrique Salviano de Faria h.liana de Barros Fernandes Aline silva de Miranda h.go Cesar Martins-Costa Ana Cristina Simoes e silva Janaina Matos Moreira Albena Nunes-silva Laboratory of Inflammation and Exercise Immunology Department of Physical EducationSchool of Physical EducationFederal University of Ouro PretoOuro PretoMGBrazil Postgraduate Program in h.alth.and Nutrition Nutrition SchoolFederal University of Ouro PretoOuro PretoMGBrazil Interdisciplinary Medical Research.Laboratory Faculty of MedicineFederal University of Minas GeraisBelo HorizonteMGBrazil Neurobiology Laboratory Institute of Biological SciencesFederal University of Minas GeraisBelo HorizonteMGBrazil Department of Ph.sical Education Pontifical Catholic University of Minas GeraisBrazil Department of Pediatrics Faculty of MedicineFederal University of Minas Gerais(UFMG)Belo HorizonteMGBrazil

Obesity h.s a complex multifactorial etiology and is ch.racterized by excessive accumulation of adipose *** adipose tissue h.s deleterious effects on h.alth.because it secretes large amounts of inflammatory *** calorie restriction associated with.strength.training may be useful in managing ch.onic systemic *** study aimed to evaluate th. acute effect of a single strength.training session on plasma adipokine levels in sedentary,overweigh.,and obese young *** study included twelve men(Age:[34.95±9.77]years;h.igh.:[174.16±3.66]centimeter[cm];Weigh.:[97.83±12.87]kilogram(kg);body mass index[BMI]:[32.30±4.51]kg/m2),wh. performed a single strength.training *** strength.training protocol consisted of 4 sets of 12 repetitions in th. following six exercises,45°leg press,bench.press,leg extension,mach.ne row,leg curl,and sh.ulder *** samples were collected before,immediately after,and 1-h.subsequent after strength.*** plasma levels of resistin and leptin were measured.A significant decrease in resistin levels were found 1 h.after th. strength.training session if compared to levels before th. training session(pre-[before][2390±1199]picograms per milliliter[pg/mL]vs post-1 h.1-h.subsequent][1523±798],6 pg/mL,p=0.0028).Th. plasma leptin levels did not differ at any time *** conclusion,a very well controlled single session of strength.training significantly decreased th. plasma levels of resistin with.ut altering th. concentration of leptin in overweigh. and obese *** effect,at least in part,supports th. benefits of exercise by reducing th. low grade inflammation and insulin resistance in obesity.

关键词： Strength.training Adipose tissue Obesity Ch.onicinflammation Resistin Leptin

h.man leukocyte antigen compatibility and incidence of donorspecific antibodies in pediatric liver transplant recipients

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World Journal of Gastroenterology 2024年第33期30卷 3837-3845页

作者： Melina U Melere Flavia h.Feier Jorge Neumann Antônio N Kalil Juliana de M Montagner Luiza S Nader Carolina S da silva Marco Aurélio F Junior Gabriela P Coral Guilh.rme P Bobsin Cristina T Ferreira Department of h.patology and Liver Transplantation Santa Casa de Porto AlegrePorto Alegre 90050170Rio Grande do SulBrazil Department of h.pato-biliary-pancreatic Surgery and Liver Transplantation Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil Postgraduation Program in Medicine:h.patology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil Laboratory of Transplantation Immunology Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil

BACKGROUND Antibody-mediated rejection following liver transplantation(LT)h.s been increasingly recognized,particularly with.respect to th. emergence of de novo donor-specific antibodies(DSAs)and th.ir impact on graft *** substantial evidence for adult populations exists,research.focusing on pediatric LT outcomes remains *** To investigate th. prevalence of h.man leukocyte antigen(h.A)mismatch.s and DSA and evaluate th.ir association with.rejection episodes after pediatric *** A coh.rt of pediatric LT recipients underwent h.A testing at Santa Casa de Porto Alegre,Brazil,between December 2013 and December *** patients wh. survived for>30 days after LT with.at least one DSA analysis were *** classes I and II and cross-match.s were *** presence of de novo DSA(dnDSA)was evaluated at least 3 month. after LT using th. Luminex®single antigen bead meth.d,with.a positive reaction th.esh.ld set at 1000 *** episodes were confirmed by liver *** Overall,67 transplanted ch.ldren were analyzed;61 received grafts from living donors,85%of wh.m were related to ***-transplant DSA(class I or II)was detected in 28.3%of patients,and dnDSA was detected in 48.4%.Th. median time to DSA detection after LT was 19.7[interquartile range(IQR):4.3-35.6]*** rejection occurred in 13 patients at follow-up,with.C4d positivity observed in 5/13 Liver *** median time to rejection was 7.8(IQR:5.7-12.8)*** presence of dnDSA was significantly associated with.rejection(36%vs 3%,Ph. rejection-free survival rates at 12 and 24 month. were 76%vs 100%and 58%vs 95%for patients with.dnDSA anti-DQ vs th.se with.ut,*** Our findings h.gh.igh. th. importance of incorporating DSA assessment into pre-and post-transplantation protocols for pediatric LT *** implications may include immunosuppression minimization strategies based on th.s analysis in pediatric LT recip

关键词： h.man leukocyte antigens Donor-specific antibodies Liver transplantation Pediatric Rejection

Sedimentary records of contaminant inputs in Frobish.r Bay,Nunavut

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Environmental Science and Ecotech.ology 2024年第2期18卷 28-42页

作者： Meagh.n C.Bartley Tommy Tremblay Amila O.De silva CMich.lle Kamula Steph.n Ciastek Zou Zou A.Kuzyk Centre for Earth.Observation Science Clayton H.Riddell Faculty of EnvironmentEarth and ResourcesUniversity of ManitobaWinnipegManitobaR3T 2N2Canada Department of Environment and Geograph. Clayton H.Riddell Faculty of EnvironmentEarth and ResourcesUniversity of ManitobaWinnipegManitobaR3T 2N2Canada Canada-Nunavut Geoscience Office IqaluitNunavutX0A 0H0Canada Environment and Climate Ch.nge Canada BurlingtonOntarioL7S 1A1Canada Department of Earth.Sciences Clayton H.Riddell Faculty of EnvironmentEarth and ResourcesUniversity of ManitobaWinnipegManitobaR3T 2N2Canada

Contaminants,such.as polych.orinated biph.nyls(PCBs),polycyclic aromatic h.drocarbons(PAh.),h.avy metals,and per and polyfluoroalkyl substances(PFASs),primarily reach.th. Arctic th.ough.long-range atmosph.ric and oceanic ***,local sources with.n th. Arctic also contribute to th. levels observed in th. environment,including legacy sources and new sources th.t arise from activities associated with.increasing commercial and industrial *** City of Iqaluit in Frobish.r Bay,Nunavut(Canada),h.s seen rapid population growth.and associated development during recent decades yet remains a site of interest for ocean protection,wh.re Inuit continue to h.rvest country *** th. present study,seven dated marine sediment cores collected in Koojesse Inlet near Iqaluit,and from sites in inner and outer Frobish.r Bay,respectively,were analyzed for total mercury(Th.),major and trace elements,PAh.,PCBs,and *** sedimentary record in Koojesse Inlet sh.ws a period of Aroclor 1260-like PCB input concurrent with.military site presence in th. 1950e60s,followed by decades of input of pyrogenic PAh.,averaging about ten times background ***-surface sediments in Koojesse Inlet also sh.w evidence of transient local-source inputs of Th. and PFASs,and recycling or continued slow release of PCBs from legacy land-based *** in PFAS congener composition clearly distinguish.th. local sources from long-range *** Koojesse Inlet but still in inner Frobish.r Bay,9.2 km from Iqaluit,sediments sh.wed evidence of both.local source(PCB)and longrange *** outer Frobish.r Bay,an up-core increase in Th. and PFASs in sediments may be explained by ongoing inputs of th.se contaminants from long-range *** context for ocean protection and country food h.rvesting in th.s region of th. Arctic clearly involves both.local sources and long-range transport,with.past h.man activities leaving a long legacy insofar as levels of persistent o

关键词： Arctic sediments Mercury Polycyclic aromatic h.drocarbons(PAh.) Polych.orinated biph.nyls(PCBs) Per and polyfluoroalkyl substances(PFASs) Persistent organic pollutants(POPs)

Is it possible to run after positive affective experiences instead of h.alth.benefits with.ut tackling social inequalities?

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Journal of Sport and h.alth.Science 2024年第6期13卷 756-758页

作者： Raph.el h.O.Araujo Andre O.Werneck Gilmar M.de Jesus Danilo R.P.silva Graduation Program in h.alth.Sciences Londrina State UniversityLondrina 86057-970Brazil Sch.ol of Public h.alth The University of QueenslandBrisbane QLD 4006Australia Center for Epidemiological Research.in Nutrition and h.alth Department of NutritionSchool of Public HealthUniversidade de Sao Paulo(USP)Sao Paulo 01246-904Brazil Department of Psych.logical Medicine Institute of PsychiatryPsychology and NeuroscienceKing’s College LondonLondon SE58AFUK Public h.alth.Post-Graduate Program State University of Feira de SantanaFeira de Santana 44036-900Brazil Department of Ph.sical Education Federal University of SergipeSao Cristovao 490100-000Brazil

We recently read th. opinion piece titled“Wh. people sh.uld run after positive affective experiences instead of h.alth.benefits”,wh.ch.was carried out by Maltagliati et al.^(1)and publish.d in th. Journal of Sport and h.alth.*** article started an important discussion about a ph.sical activity(PA)promotion approach.th.t encourages th. use of affective experience to PA *** we agree with.th. auth.rs’point of view and believe th.t its message can generate an important insigh. for PA promotion,th. auth.rs presented a scenario wh.re beh.vior ch.nge seems to be exclusively dependent on th. *** th. existence of oth.r barriers to an active lifestyle(e.g.,social inequalities)could enh.nce th. auth.rs’suggested approach.because many people live in conditions th.t reduce th.ir opportunities to engage in affective experiences related to PA;furth.rmore,affective experiences can vary depending on individual context.

关键词： promotion inequalities furth.rmore