检索结果-南通市图书馆

Clinical and Technological Dependence Characteristics on a Series of Brazilian Cases with Infantile Onset Pompe Disease in enzyme Replacement Therapy

引用

Open Journal of Clinical Diagnostics 2019年第1期9卷 16-32页

作者： Paula De Almeida Thomazinho eliana Pelissari regina Celia Beltrao Duarte Carolina Fishinger Moura De Souza Heloise Helena Siqueira Borges Maria Da Gloria Cruvinel Horta Liane De Rosso Giuliani Ana Maria Martins Lilian Stewart Dafne Dain Gandelman Horovitz Juan Clinton Llerena Motor Physical Therapy Unit Fernandes Figueira National Institute/FIOCRUZRio de JaneiroBrazil Clinical Medical Unit Dr.Jeser Amarante Faria Children’s HospitalJoinvilleBrazil Pediatric Neurology Unit Santa Casa de Misericordia do Para FoundationBelemBrazil Sciences Medical Genetics Unit Service of Information on Inborn Errors of MetabolismHospital de Clínicas de Porto AlegrePorto AlegreBrazil Clinical Medical Unit University of Cuiaba UNICCuiabaBrazil Santa Casa de Belo Horizonte Belo HorizonteBrazil Genetics Unit Federal University of Mato Grosso do SulCampo GrandeBrazil Inborn errors of Metabolism and Genetics Unit Federal University of São PauloUNIFESPSão PauloBrazil Pediatric Intensive Care Unit State Institute of Cardiology of Rio de JaneiroIECACRio de JaneiroBrazil 1 Medical Genetics Unit Fernandes Figueira National Institute of WomenChildren and Adolescent Health/FIOCRUZRio de JaneiroBrasil

Pompe disease (PD) is a rare inborn error of metabolism due to an abnormal acid alpha-glucosidase (GAA) activity that comprises glycogen breakdown mainly in the lysosomes. Since the introduction of enzyme replacement therapy (eRT), with recombinant human GAA for the early onset PD patient, a relevant field of clinical research due to the benefits regarding survival rate has been widely documented worldwide. Objective: To describe the clinical characteristics and the eRT effects in a series of Brazilian patients with infantile onset PD (IOPD) under eRT. Methods: Brazilian patients diagnosed with IOPD under eRT were recruited through their physicians participating in the International Pompe Disease Registry from 2009 to 2017. Data were collected by an online survey. Results: 10 IOPD patients were identified through the survey with a death rate of 30% and technology dependency rate reported as 80% (motor, respiratory or nutritional fields) of the patients. After the third year of eRT, motor disabilities were lost in 50% of ambulated patients. The overall characteristics were similar to international studies. Conclusion: Despite eRT benefits in cardiac involvement, motor disabilities seem to be much more compromised in IOPD patients, with high technology dependence, especially after three years of age.

关键词： Motor Development Child Disability Glycogen Storage Disease Type II enzyme Replacement Therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bacterial Fecal Microbiota in Healthy Subjects and Inpatients with <i>Clostridium difficile</i>Infection

引用

Advances in Microbiology 2017年第1期7卷 10-21页

作者： Thaís Flecher Barbosa Danielle Angst Secco Raquel Silva Peixoto Alexandre Soares Rosado Flavia Lima do Carmo Hugo emiliano de Jesus Leandro Araujo Lobo Luis Caetano Martha Antunes Karla Rodrigues Miranda Geraldo Renato de Paula regina Maria Cavalcanti Pilotto Domingues Instituto de Microbiologia Paulo de Goes Universidade Federal do Rio de Janeiro Rio de Janeiro RJ Brazil escola Nacional de Saúde Pública Sergio Arouca Fundacao Oswaldo Cruz Rio de Janeiro RJ Brazil Faculdade de Farmácia Universidade Federal do Rio de Janeiro—Campus Macaé Macaé RJ Brazil Departamento de Tecnologia Farmacêutica Universidade Federal Fluminense Niterói RJ Brazil

Clostridium difficile is a nosocomial enteric pathogen, considered the main etiological agent of antibiotic-associated diarrhea in hospitals. C. difficile is resistant to several antimicrobial agents used in empiric treatment protocols, which confers selective advantages to this species as compared with other members of the intestinal microbiota. The aim of this study was to evaluate and identify possible alterations of the intestinal microbiota population resulting from the use of antimicrobials associated with infections by C. difficile (CDI). Denaturing Gradient Gel electrophoresis (DGGe) was used to evaluate fecal samples from two groups: healthy subjects and patients with C. difficile-associated diarrhea (CDAD). A decrease in bacterial diversity was highlighted by the low number of bands in samples from CDAD patients, compared with healthy subjects. This may indicate that antibiotic treatment would affect bacterial diversity, leading to a significant difference between the intestinal microbiota of these two groups, but further studies are still needed. Firmicutes and Verrucomicrobia phyla were detected mainly in healthy individuals, and these could be related to protection factors against the CDI. Klebsiella variicola/K. pneumoniae were found mostly in samples from CDI patients. This study shows the effects of antimicrobials and the CDI itself on human intestinal microbiota.

关键词： Clostridium difficile DGGe Microbiota CDAD Antimicrobials

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Semen analysis in chronic bacterial prostatitis： diagnostic and therapeutic implications

引用

Asian Journal of Andrology 2009年第4期11卷 461-477页

作者： Vittorio Magri Florian M. e. Wagenlehner emanuele Montanari emanuela Marras Viviana Orlandi Antonella Restelli erminio Torresani Kurt G. Naber Gianpaolo Perletti Urology and Sonography Primary Care Clinic Hospital：＂Istituti Clinici di Perfezionamento＂ Milano 20100 Italy Department of Urology and Pediatric Urology Justus-Liebig-University Giessen 35390 Germany Third Urological Clinic San Paolo Hospital University of Milan Milan 20142 Italy Laboratory of Toxicology and Pharmacology Department of Structural and Functional Biology University of Insubria Busto A. 21052 Italy Laboratory of Molecular and environmental Microbiology Department of Structural and Functional Biology University of lnsubria Varese 21100 Italy Microbiology Unit Hospital：＂Osp. Maggiore Policlinico Mangiagalli Regina Elena＂ Milano 20122 Italy Technical University Munich Munich 80333 Germany

The significance and diagnostic value of semen analysis in chronic bacterial prostatitis has been extensively debated and remains controversial. To investigate the diagnostic relevance of semen culture in the bacteriological workup of prostatitis patients, we retrospectively analyzed a clinical database of 696 symptomatic patients. All patients were routinely subjected to a four-glass test, followed by semen culture and analysis. This allowed to dissect from the database three different diagnostic scenarios, and to compare the ＇two-glass＇ pre-/post- massage test and the standard ＇four-glass＇ test with a ＇five-glass＇ test （four-glass plus post-VB3 semen culture）. The ＇five-glass＇ test showed 3.6- or 6.5-fold increases in relative sensitivity and lesser reductions （-13.2% or -14.7%） in relative specificity for traditional uropathogens （TUs） compared with the four-glass or two-glass test, respectively. The area under the ROC curve and Jouden＇s index were increased, whereas positive and negative likelihood ratios were lower than comparators, indicating that the ＇five-glass＇ assay may be superior in confirming the negative outcome of both standard tests. The five-, four-, and two-glass tests detected TUs （enterobacteriaceae, enterococci, etc.） in 120, 33, and 20 patients and unusual pathogens （Streptococci, other Gram-positive species, Mycoplasmata, and others） in 130, 56, and 45 patients, respectively. When patients were subjected to pharmacological treatment, including a combination of a fluoroquinolone and a macrolide, no differences in eradication rates were observed between groups diagnosed with different tests, irrespective of pathogen category. eradication was associated with long-term sign/symptom remission; no significant intergroup differences in sign/symptom scores were observed throughout a 24-month off-therapy follow-up period. In conclusion, our data support the usefulness of semen analysis in the diagnostic workup ofprostatitis patients when this test is u

关键词： alfuzosin azithromycin chronic bacterial prostatitis chronic pelvic pain syndrome ciprofloxacin Meares and Stamey test National Institutes of Health Chronic Prostatitis Symptom Index prostatitis semen analysis seminal fluid Serenoa repens

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

expression of the Genes OsNRT1.1, OsNRT2.1, OsNRT2.2, and Kinetics of Nitrate Uptake in Genetically Contrasting Rice Varieties

引用

American Journal of Plant Sciences 2015年第2期6卷 306-314页

作者： Osmário J. L. Araújo Milena S. Pinto Marcus V. L. Sperandio Leandro A. Santos elvia M. L. M. Stark Manlio S. Fernandes André Marques dos Santos Sonia regina de Souza Plant Nutrition Laboratory Department of Soil Universidade Federal Rural do Rio de Janeiro Seropédica Brazil Plant Biochemistry Laboratory Department of Chemistry Universidade Federal Rural do Rio de Janeiro Seropédica Brazil

Four genetically contrasting rice varieties (IAC-47, Bico Ganga, Arroz de Revenda and Manteiga) according to Random Amplified Polymorphic DNA (RAPD) analysis were assessed regarding expression of the genes OsNRT1.1, OsNRT2.1 and OsNRT2.2 and the nitrate uptake kinetics parameters (Km and Vmax). Up to 250-fold increases in the induction of gene expression after nitrate resupply were observed for the high-affinity transporter (OsNRT2.1 and OsNRT2.2). However, no significant variations in Vmax among the varieties were obtained. The lower value of Km of the IAC-47 cultivar in relation to the Arroz de Revenda variety suggests a greater role of high-affinity transporter genes. These results indicate that closer attention should be paid to the expression levels of these genes in selecting varieties aiming to enhance nitrogen uptake efficiency.

关键词： RAPD Nitrogen Nitrogen Use efficiency Oryza sativa L.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A MACRO-SCALe SeMI-DISTRIBUTeD HYDROLOGICAL MODeL AND APPLICATION TO THe DATONG RIVeR VALLeY

引用

Journal of Hydrodynamics 2005年第6期17卷 667-676页

作者： YANG Zhi-feng LIU Lu-liu SHeN Zhen-yao GORDON G. Huang State Key Laboratory of Water environmental Simulation School of Environment Beijing Normal Uni- versity Beijing 100875 China National Climate Center Beijing 100081 China Faculty of engineering University of Regina Canada

A daily distributed hydrological model was developed using routine hydro meteorological data on the basis of the raster DeM and land cover data. Then the model was used to model daily runoff of the Datong River Valley located in the upper catchment of the Yellow River Basin. The runoff comprises surface flow, subsurface flow and ground water flow. evapotranspiration comprises canopy evaporation, snow sublimation and soil evapotranspiration. The infiltration to the soil was estimated with improved Green-Ampt model, and the potential evapotranspiration is estimated with Morton CRAe method, which only needs the routine meteorological data. Simulation results and the comparison with semi distributed SLURP hydrological model show that the structure of the model presented herein is reasonable.

关键词： hydrological model Yellow River GIS runoff

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

利用花粉资料重建加拿大1ka来气温变化序列

引用

科学通报 2002年第13期47卷 1018-1021页

作者：于革 K.e.Xiankun 中国科学院南京地理与湖泊研究所南京210008 Departmentof Geography University of ReginaRegina

植物花粉资料用来恢复千年-万年尺度的气候变化是一种比较成熟的方法,并取得了大量的成果,但应用于十年至百年尺度的气候序列重建仍属探讨性研究.本文采用花粉资料,以 50 a为时间尺度单元,对加拿大过去1ka的温度进行了历史重建.近千年... 详细信息

植物花粉资料用来恢复千年-万年尺度的气候变化是一种比较成熟的方法,并取得了大量的成果,但应用于十年至百年尺度的气候序列重建仍属探讨性研究.本文采用花粉资料,以 50 a为时间尺度单元,对加拿大过去1ka的温度进行了历史重建.近千年来北美地区气候环境受人为干扰甚少,1～0.1ka尺度的气候变化主要受自然因子控制,因此可为认识和鉴定中国千年来气候变化序列中人为影响程度提供有价值的参照系.此外,本文所采用的花粉-气候转换法可以为中国的千年尺度的气候重建提供实用技术.

关键词：过去1ka 现代类比法加拿大气温重建花粉-气候转换法气候重建气温变化序列

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Assessment of educational Videos on the Prevention and Management of Infant Diarrhea:Documental Study

引用

Health 2015年第9期7卷 1215-1223页

作者： elizamar regina da Rocha Mendes Jardeliny Correa da Penha Ludmila Alves do Nascimento Leidiane Minervina Moraes de Sabino emanuella Silva Joventino Adria Marcela Vieira Ferreira Olinda Costa Mota Teixeira Maria de Fátima Pereira de Sousa Galvao Lorena Barbosa Ximenes Federal University of Ceará FortalezaBrazil Federal University of Piauí FlorianoBrazil University of International Integration of African-Brazilian Lusophony RedencaoBrazil

Objective: To evaluate the suitability of educational videos produced in Brazil that addressed aspects related to prevention and/or management of infant diarrhea according to content;language;graphic illustrations;stimulation for learning/motivation and cultural fit. Method: Documentary study, which evaluated six educational videos from an adapted and validated tool, the Suitability Assessment of Materials. Three nurses evaluated the videos. Data were processed using the Statistical Package for the Social Sciences, version 17.0, and presented in tables and graphics. Results: It was found that 4 (66.6%) of the educational videos were classified as appropriate, ranging from 60% to 63.3% of full approval, and 2 (33.3%) were assessed as higher, reaching up to 83.3% to 90% approval. Considering the socioeconomic and cultural contexts of the videos to the audience, they assigned notes ranging from 6 to 9 in a rating ranging from 0, the minimum score, to 10, the highest score. Conclusion: The educational videos were considered adequate, with positive results about the content on the prevention and management of infant diarrhea, being appropriate for the target audience. As a result, greater credibility is ratified as the use thereof, since these resources can contribute to health promotion and prevention of diarrhea in children.

关键词： Diarrhea Infantile educational Technology Child Health

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

人生教我的20个功课

引用

成才之路 2010年第11期 M0003-M0003页

作者： regina Brett

为了庆祝变得更老（下个月我这把老骨头就90岁了）：我写下人生教我的一些功课。这是我写过的最叫座的专栏。1．人生是不公平的，但还是好得很。2．怀疑的时候，为未来踏出一小步。3．人生太短，短到来不及浪费时间去恨任何一个人。4．... 详细信息

为了庆祝变得更老（下个月我这把老骨头就90岁了）：我写下人生教我的一些功课。这是我写过的最叫座的专栏。1．人生是不公平的，但还是好得很。2．怀疑的时候，为未来踏出一小步。3．人生太短，短到来不及浪费时间去恨任何一个人。4．生病的时候，你的工作不会照顾你，你的朋友和父母才会和你保持联络。5．每个月付清你的账单。6．你不需要每一次都吵赢，同意你原本不同意的。7．找人一起哭，这要比独自啜泣更能治疗伤痛。8．对上帝生气没有关系，他受得了。

关键词：人生功课不公平个人朋友

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

日本教师把落叶变成艺术品

引用

英语画刊(高中版) 2023年第6期 3-3页

作者： regina Sienra

对一些人来说，落叶是令人烦恼的东西，需要把它耙干净并收起来；对另一些人来说，它们为街道着色，预示着清爽天气的到来。然而，很少有人能像滨崎裕高那样看到秋天树叶的创作可能性。在过去的十年里，这位日本美术老师扫过学校操场上...

对一些人来说，落叶是令人烦恼的东西，需要把它耙干净并收起来；对另一些人来说，它们为街道着色，预示着清爽天气的到来。然而，很少有人能像滨崎裕高那样看到秋天树叶的创作可能性。在过去的十年里，这位日本美术老师扫过学校操场上的落叶和花瓣，创作了例如皮卡丘、星之卡比和小熊维尼等流行卡通人物的画像。滨崎开始这个土地艺术项目是为了让学生们培养对艺术的热爱。

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

无法改变的人类

引用

照明设计 2015年第5期 73-73页

作者： regina Lausell

随着我们越来越了解昼夜节律的刺激因素和作用，很多照明行业人士都开始怀疑照明设备的治疗意图和其控制人类行为的潜力之间不可调和的矛盾。具体来说，很多照明行业人士开始将光照疗法和昼夜校准的效果与“动态光”相结合。这个概念可... 详细信息

随着我们越来越了解昼夜节律的刺激因素和作用，很多照明行业人士都开始怀疑照明设备的治疗意图和其控制人类行为的潜力之间不可调和的矛盾。具体来说，很多照明行业人士开始将光照疗法和昼夜校准的效果与“动态光”相结合。这个概念可能会被误解的两个原因是：其一，并不是所有的动态光设备都能在生理上影响我们的身体，让我们可以实现昼夜校准：其二，尽管动态光有潜力成为能够影响我们生理方面的强大工具，光并不能直接影响人的念头或行为。

关键词：人类行为昼夜节律照明行业照明设备可调和光设备校准生理

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：