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Better Management of Adverse Events Favors Sorafenib Treatment of HCC Patients and Impact on Survival

Journal of Cancer Therapy 2016年第4期7卷 275-284页

作者： regiane S. S. M. Alencar Luciana Kikuchi Cláudia M. Tani Aline L. Chagas Cinira C. Camargo Túlio E. F. Pfiffer Paulo M. G. Hoff Flair J. Carrilho Sao Paulo Clínicas Liver Cancer Group Instituto do Cancer do Estado de Sao Paulo (ICESP) Hospital das Clínicas Department of Gastroenterology University of Sao Paulo School of Medicine Sao Paulo Brazil Medical Oncology Instituto do Cancer do Estado de Sao Paulo (ICESP) Sao Paulo Brazil

Introduction: Sorafenib is an orally active multikinase inhibitor approved for the treatment of advanced hepatocellular carcinoma (HCC) and is the only systemic treatment associated with a survival benefit in advanced stage. The aims of this study were to evaluate the tolerance and survival of sorafenib-treated patients, and to identify potential prognostic factors of survival. Methods: A total of 88 HCC patients treated with sorafenib from June 2010 to January 2014 were retrospectively reviewed. Tumour stage, liver function and adverse events to sorafenib were analyzed. Univariate and multivariate analysis were carried out to identify predictors of survival in patients with advanced HCC treated with sorafenib. Results: There were 64 (73%) males included in this study, with a median age of 61.16 years. Eight (91%) patients had Child-Pugh class A cirrhosis. Most patients were classified as BCLC C (82%). Hepatitis C virus was the predominant cause of HCC (68%). Sorafenib was the initial treatment modality in 43%. Median time of sorafenib therapy was 8.23 months. Overall survival in 1 year was 57.3% and 36.7% in 2 years. The median survival was 16.3 months. In the univariate analysis of the OS based on Child-Pugh score did not demonstrate a significant difference in our study (p = 0.62). The presence of dermatologic adverse event predicted a better overall survival in the multivariate analysis. Better survival was also observed in patients with AFP level <100 ng/ml in the start of sorafenib therapy (p = 0.001). Patients that used Sorafenib for ≥6 months had shown better outcome. None of the patients discontinued sorafenib because of adverse effects. Conclusions: Advanced HCC patients treated with sorafenib who experienced dermatologic adverse event and low AFP level <100 ng/ml showed better overall survival. As expected, longer sorafenib therapy (≥6 months) was associated to better survival. Even in the presence of adverse events, the use of sorafenib should be continu

关键词： Management of Adverse Event Hepatocellular Carcinoma Sorafenib Therapy Predictors of Overall Survival Dermatologic Adverse Event

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Use of Initial Modified RECIST Tumor Response Evaluation Criteria for Predicting Survival in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization with Drug-Eluting Beads

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Journal of Cancer Therapy 2015年第13期6卷 1115-1123页

作者： Natália Sousa Freitas Queiroz Luciana Kikuchi Regis Otaviano Franca Bezerra regiane S. S. M. Alencar Aline Lopes Chagas Cláudia Megumi Tani Márcio Augusto Diniz Aline Cristine Barbosa Santos Airton Mota Moreira Manoel de Souza Rocha Luiz Augusto Carneiro D’Albuquerque Francisco César Carnevale Flair José Carrilho Sao Paulo Clínicas Liver Cancer Group Instituto do Cancer do Estado de Sao Paulo Hospital das Clínicas Department of Gastroenterology University of Sao Paulo School of Medicine Sao Paulo Brazil Sao Paulo Clínicas Liver Cancer Group Instituto do Cancer do Estado de Sao Paulo Hospital das Clínicas Department of Radiology University of Sao Paulo School of Medicine Sao Paulo Brazil

Introduction: Transarterial chemoembolization (TACE) reduces tumor growth and increases survival in patients with hepatocellular carcinoma (HCC). Drug-eluting beads (DEB) deliver slow-release chemotherapy and reduce systemic toxicity during TACE. This study correlated initial tumor response according to modified RECIST (mRECIST) criteria and 1-year survival in patients with HCC treated with TACE-DEB, and identified predictors of tumor response. Methods: Fifty-two patients with HCC received TACE-DEB loaded with doxorubicin 75 mg during a 6-month period. Tumor response was evaluated 1 month after the procedure according to mRECIST criteria. Results: Most patients were cirrhotic and etiology of liver disease was hepatitis C in 26/52 (50%). Similar numbers of patients had Barcelona Clinic Liver Cancer (BCLC) A and BCLC B disease. Most patients had one nodule (66%). Complete response (CR) was achieved in 12/52 (23%), partial response in 19/52 (37%), stable disease in 4/52 (8%) and progressive disease in 17/52 (32%). Largest HCC ≤58 mm and BCLC stage A were associated with CR. The 1-year survival was 74%, with survival rates of 95% and 56% in the BCLC A and B groups, respectively. Variables reflecting tumor extension were associated with better survival. CR according to mRECIST criteria was a predictor of better 1-year survival (100% vs. 64%, P < 0.05). Conclusion: BCLC A and CR according to mRECIST criteria predict improved 1-year survival in patients with HCC treated with TACE-DEB. Further studies are needed to evaluate other predictors of survival and to determine if tumor response predicts long-term survival.

关键词： Hepatocellular Carcinoma mRECIST Criteria Transarterial Chemoembolization Overall Survival Drug-Eluting Beads

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玉米赤霉烯酮、脱氧雪腐镰刀菌烯醇及其衍生物在母猪哺乳期从母体向仔猪的传递(上)

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猪业科学 2023年第12期40卷 18-21页

作者：朱秋凤张永静黄强(编译) 中国农业大学动物科技学院动物营养学国家重点实验室北京100193 禾丰食品股份有限公司辽宁沈阳110164

0引言玉米赤霉烯酮(ZEN)和脱氧雪腐镰刀菌烯醇(DON)是食品和饲料中最常见的霉菌毒素,尤其常见于玉米和甜菜粕。众所周知,采食高浓度的ZEN或DON饲粮会导致这些毒素传递至母乳中。在之前的一项研究中,已发现母猪在妊娠期和哺乳期饲喂含不... 详细信息

0引言玉米赤霉烯酮(ZEN)和脱氧雪腐镰刀菌烯醇(DON)是食品和饲料中最常见的霉菌毒素,尤其常见于玉米和甜菜粕。众所周知,采食高浓度的ZEN或DON饲粮会导致这些毒素传递至母乳中。在之前的一项研究中,已发现母猪在妊娠期和哺乳期饲喂含不同水平ZEN(200~1000μg/kg)污染的饲粮会有不利影响,即导致仔猪卵巢功能受损。

关键词：玉米赤霉烯酮脱氧雪腐镰刀菌烯醇霉菌毒素哺乳期甜菜粕仔猪母猪

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Highlighting COVID-19:What the imaging exams show about the disease

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World Journal of Radiology 2021年第5期13卷 122-136页

作者： Lorena Sousa de Carvalho Ronaldo Teixeira da Silva Júnior Bruna Vieira Silva Oliveira Yasmin Silva de Miranda Nara Lúcia Fonseca Rebouças Matheus Sande Loureiro Samuel Luca Rocha Pinheiro regiane Santos da Silva Paulo Victor Silva Lima Medrado Correia Maria José Souza Silva Sabrina Neves Ribeiro Filipe Antônio França da Silva Breno Bittencourt de Brito Maria Luísa Cordeiro Santos Rafael Augusto Oliveira Sodré Leal Márcio Vasconcelos Oliveira Fabrício Freire de Melo Department of Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Coronavirus disease 2019(COVID-19),a global emergency,is caused by severe acute respiratory syndrome coronavirus *** gold standard for its diagnosis is the reverse transcription polymerase chain reaction,but considering the high number of infected people,the low availability of this diagnostic tool in some contexts,and the limitations of the test,other tools that aid in the identification of the disease are *** this scenario,imaging exams such as chest X-ray(CXR)and computed tomography(CT)have played important *** is useful for assessing disease progression because it allows the detection of extensive consolidations,besides being a fast and cheap *** the other hand,CT is more sensitive for detecting lung changes in the early stages of the disease and is also useful for assessing disease *** note,ground-glass opacities are the main COVID-19-related CT *** emission tomography combined with CT can be used to evaluate chronic and substantial damage to the lungs and other organs;however,it is an expensive *** ultrasound(LUS)has been shown to be a promising technique in that context as well,being useful in the screening and monitoring of patients,disease classification,and management related to mechanical ***,LUS is an inexpensive alternative available at the ***,magnetic resonance imaging,although not usually requested,allows the detection of pulmonary,cardiovascular,and neurological abnormalities associated with ***,it is important to consider the challenges faced in the radiology field in the adoption of control measures to prevent infection and in the follow-up of post-COVID-19 patients.

关键词： SARS-CoV-2 COVID-19 Pneumonia Pandemic Radiology Tomography

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