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Two Temperature Heat Flux of Semi Infinite Piezoelectric Ceramic Rod

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Engineering（科研） 2013年第3期5卷 277-291页

作者： Essam Bassiouny refaat sabry Hamdy Youssef Faculty of Science and Humanitarian Studies Salman Bin Abdulaziz University Al-Kharj KSA Mechanical Engineering Department Faculty of Engineering and Islamic Architecture Umm Al-Qura University Mecca KSA

The theory of two-temperature generalized thermoelasticity is used to solve the problem of heating a semi-infinite rod made of a piezoelectric ceramic material within the framework of generalized thermopiezoelasticity theory by supplying the rod a certain amount of heat uniformly distributed over a finite time period to the finite end of the rod. The Laplace transform formalism is used to solve the proposed model. Inverse Laplace transforms are computed numerically using a method based on Fourier expansion techniques. The physical parameters (i.e., conductive temperature, dynamical temperature, stress, strain, and displacement distributions) are investigated graphically.

关键词： Two Temperatures Generalized Thermoelasticity Thermopiezoelasticity Thermal Waves Ceramics Piezoelectric Materials—Heat Flux

The role of polymorphic cytochrome P450 gene(CYP2B6)in B-chronic lymphocytic leukemia(B-CLL)incidence and outcome among Egyptian patients

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Oncology Research 2024年第4期32卷 785-797页

作者： MENNA AL-ADL MAGDY MYOUSSEF AHMED EL-SEBAIE SHERIF refaat AFAF EL-SAID Division of Biochemistry Department of ChemistryFaculty of ScienceMansoura UniversityMansoura35511Egypt Hematology Unit Department of Clinical PathologyFaculty of MedicineMansoura UniversityMansoura35511Egypt Medical Oncology Unit Oncology Center Mansoura UniversityMansoura35511Egypt Department of Genetics Mansoura University Children’s HospitalMansoura35511Egypt

Cytochromes P450(CYPs)play a prominent role in catalyzing phase I xenobiotic biotransformation and account for about 75%of the total metabolism of commercially available drugs,including *** gene expression and enzyme activity of CYPs are variable between individuals,which subsequently leads to different patterns of susceptibility to carcinogenesis by genotoxic xenobiotics,as well as differences in the efficacy and toxicity of clinically used *** research aimed to examine the presence of the CYP2B6*9 polymorphism and its possible association with the incidence of B-CLL in Egyptian patients,as well as the clinical outcome after receiving cyclophosphamide *** was isolated from whole blood samples of 100 de novo B-CLL cases and also from 100 sex-and age-matched healthy *** presence of the CYP2B6*9(G516T)polymorphism was examined by PCR-based allele specific amplification(ASA).Patients were further indicated for receiving chemotherapy,and then they were followed *** CYP2B6*9 variant indicated a statistically significant higher risk of B-CLL under different genetic models,comprising allelic(T-allele vs.G-allele,OR=4.8,p<0.001)and dominant(GT+TT ***,OR=5.4,p<0.001)*** cyclophosphamide chemotherapy,we found that the patients with variant genotypes(GT+TT)were less likely to achieve remission compared to those with the wild-type genotype(GG),with a response percentage of(37.5%vs.83%,respectively).In conclusion,our findings showed that the CYP2B6*9(G516T)polymorphism is associated with B-CLL susceptibility among Egyptian *** variant greatly affected the clinical outcome and can serve as a good therapeutic marker in predicting response to cyclophosphamide treatment.

关键词： B-CLL Xenobiotics Cytochromes P450 CYP2B6

A Catalyst for Connected World

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ChinAfrica 2024年第9期16卷 18-19页

作者： MAGED refaat ABOULMAGD Egyptian Council for Foreign Affairs Egypt-China Friendship Association

China’s Belt and Road Initiative serves as an antidote to *** the last 10 years there has been calls for deglobalisation and decoupling as means to curb the so-called unbalanced trade,rein in immigration,and mend inequalities of asset and *** consider the world to have entered a period of deglobalisation,citing recent events such as Brexit,Trumpism,Russia-Ukraine conflicts,problems with supply chains,global energy crisis and decline in foreign direct investment.

关键词： chains global inequalities

Seroprevalence of hepatitis A antibodies among children in a Saudi community

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Asian Pacific Journal of Tropical Medicine 2010年第4期3卷 278-282页

作者： Abdel-Hady El-Gilany sabry Hammad Khaled refaat Reda Al-Enazi Family and Community Medicine Department College of Medicine in Al-HassaKing Faisal UniversitySaudi Arabia Preventive Medicine Directorate of Health of the Northern BordersSaudi Arabia Arar Central Hospital Saudi Arabia

Objective:To determine the current seroprevalence of antibodies against hepatitis A virus in selected group of children aged 1-6 years in Northern borders region,Saudi Arabia,and to identify risk factors for ***:A cross-sectional sero-epidemiological study of 950 children who attended 10 randomly selected primary health care centers(5 urban and 5 rural) was *** of all children were subjected to a questionnaire including sociodemographic and housing environmental *** determination of anti-HAV antibodies was carried out by ***:The prevalence of HAV-IgG was 33.8%overall,35.5%among males and 32.0%among females with no statistically significant *** logistic regression analysis revealed that increasing age,rural residence,non Saudi nationality,and non availability of safe municipal water source were the most important independent predictors for HAV seropositivity in the studied ***:There is a clear decrease in hepatitis A prevalence in the studied children particularly in urban areas and indicates that a transition may be underway to intermediate endemicity and possible shift of the risk to the adult age with increased ***,we recommend including Hepatitis A in the schedule of routine childhood vaccinations.

关键词： Hepatitis A Seroprevalence Risk factors

Predicting the impacts of climate change on the distribution of Moringa peregrina(Forssk.)Fiori-A conservation approach

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Journal of Mountain Science 2021年第5期18卷 1235-1245页

作者： Emad A.FARAHAT Aliaa M.refaat Botany and Microbiology Department Faculty of ScienceHelwan UniversityCairo 11795Egypt Botany Department Faculty of ScienceAin Shams UniversityCairo 11566Egypt

Climate change will affect the geographic distribution and richness of species at different spatial and temporal *** applied Maximum entropy(MaxEnt)modeling to predict the potential influence of climatic change on the current and future distribution of the important mountainous tree species Moringa peregrina(Forssk.)*** Maxent model performed better than random models for the species with the training and test AUC(Area Under the receiver-operating characteristic Curve)values of 0.96 and 0.90,*** test and response curves showed that the distribution of the species negatively correlates with higher altitudes and precipitation in October and ***,it positively correlates with the total annual precipitation and precipitation in *** current and future climatic conditions,our model predicted habitat gains for *** towards the coastal northern and southern limits of its *** potentially suitable habitats,under future climate projections,are currently characterized by elevations of<1000 m *** total annual precipitation of 80-225 mm/*** and high potential habitat suitability will increase by 5.6%-6%and 2.1%-2.3%,under RCP2.6 and RCP4.5 scenario,*** results indicated that the habitat suitability of *** would increase with increasing climate warming,particularly under RCP2.6 *** recommend sustainable conservation and cultivation of Moringa peregrina in its current habitats along the Red Sea mountains.

关键词： Climate change Conservation Max Ent Mountains Moringa peregrina Arid lands

Enteral nutrition and immune modulation of acute pancreatitis

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World Journal of Gastroenterology 2014年第43期20卷 16101-16105页

作者： refaat A Hegazi Tiffany De Witt Research and development division Abbott NutritionColumbusOH 43219United States

Enteral nutrition has been strongly recommended by major scientific societies for the nutritional management of patients with acute *** severe acute pancreatitis patients with enteral nutrition within the first 24-48 h of hospital admission can help improve outcomes compared to parenteral nutrition and no *** research is focusing in on when and what to feed to best improve outcomes for acute pancreatitis *** enteral nutrition have the potential to modulate the immune *** this consistent evidence of early enteral nutrition in patients with acute pancreatitis,clinical practice continues to vary due to individual clinician *** the immune modulating effects of enteral nutrition heavily depend on proper placement of the feeding tube and managing any tube feeding associated *** current article reviews the immune modulating effects of enteral nutrition and pro-and prebiotics and suggests some practical tools that help improve the patient adherence and tolerance to the tube *** selection of the type of the tube,close monitoring of the tube for its placement,patency and securing its proper placement and routine checking the gastric residual volume could all help improve the *** peptide-based and high medium chaintriglycerides feeding formulas help improving feeding tolerance.

关键词： Enteral nutrition Acute pancreatitis Immune modulating

Simple and sensitive method for the determination of trace amounts of thorium using a benzoquinone derivative

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Nuclear Science and Techniques 2019年第5期30卷 22-31页

作者： Mostafa M.Hamed refaat F.Aglan Hot Laboratories and Waste Management Center Atomic Energy Authority of Egypt

A novel simple, sensitive, rapid, direct, and spectrophotometry-based procedure was investigated to determine Th(IV) at trace amounts. The new method is based on Th(IV) chelation with 3,6-dichloro-2,5-dihydroxy-l,4-benzoquinone(DDBQ). The reagent reacts with Th(IV) in 0.1 M HCl to form an orange 1:2 complex. The stability constant value is 6.62×10~4 for the Th(IV)complex. The Th(IV)-DDBQ obtained shows one peak with a maximum at about 346 nm. The chelate forms immediately and the absorbance remains stable for over24 h. Beer's law was obeyed in the concentration range0–10 μg mL^(-1). The molar absorptivity and Sandell's sensitivity were 4.4×10~4 L mol^(-1)cm^(-1) and 0.0053 μg cm^(-2), respectively. Different analytical parameters were tested in detail. Interfering ion(cations and anions) effects were tested. Methods for Th(IV) determination by second and third-derivative spectrophotometry were also introduced at about 344 and 341 nm, respectively. These two derivative orders offer the feature of sensitivity without the necessity for solvent extraction,heating, or pre-concentration steps. Finally, the methods were successfully utilized for Th(IV) determination in monazite, environmental water, and wastewater samples.

关键词： Th(IV) determination p-benzoquinone derivative Spectrophotometry

Effect of Sirtuin 1 inhibition on matrix metalloproteinase 2 and Forkhead box O3a expression in breast cancer cells

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Genes & Diseases 2017年第4期4卷 240-246页

作者： Hanan Abdelmawgoud Rehab refaat El Awady Biochemistry Department Faculty of PharmacyAl-Azhar UniversityCairoEgypt

Breast cancer is the most common invasive cancer in women *** 1(SIRT1)has recently been shown to have implications in regulating cancer cell growth and ***1 regulates Forkhead box O3a(FOXO3a)by both inhibiting FOXO3-induced apoptosis and potentiating the ability of FOXO3a to resist oxidative *** metalloproteinase 2(MMP2)participates in tumor invasion and metastasis by degrading extracellular ***1 up regulates MMP2 expression by its deacetylation *** study aimed to investigate the expression of SIRT1,FOXO3a and MMP2 in breast tissues of women with breast *** addition,the effect of SIRT1 inhibition on both FOXO3a and MMP2 expression in breast cancer(MCF-7)cells was *** expression levels of SIRT1,FOXO3a and MMP2 in the breast tissues were determined by real-time PCR in 60 patients with malignant tumor and in 24 patients with benign *** SIRT1 inhibition,protein levels of SIRT1 and FOXO3a were assessed by Western Blot and levels of MMP2 by ELISA in MCF-7 *** expression levels of SIRT1,FOXO3a and MMP2 were significantly higher in breast cancer tissues compared to in benign breast tumor and adjacent normal ***1,MMP2 and FOXO3a expression were associated directly with each ***1 inhibition suppresses MMP2 and FOXO3a expression compared to control ***(SIRT1 inhibitor)effectively induced inhibition of MMP2 and FOXO3a expression in MCF-7 cells,indicating the promising therapeutic strategy of targeting SIRT1 for breast cancer.

关键词： Breast cancer FOXO3a MMP2 SIRT1 Sirtinol

Preparation and Antibacterial Activity of Superhydrophobic Modified ZnO/PVC Nanocomposite

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Journal of Bionic Engineering 2022年第1期19卷 139-154页

作者： Muntadher Ismail Rahmah Raad Saadon sabry Wisam Jafer Aziz Medical Instrumentation Engineering Department Al-Esraa University CollegeBaghdad10001Iraq Physics Department College of ScienceMustansiriyah UniversityBaghdad10001Iraq

We fabricated a superhydrophobic modified ZnO/PVC nanocomposite cluster with antibacterial properties using the chemical precipitation method and selected solvent/non-solvent(THF/ethanol)to *** effects of ethanol content(47%,50%,53%,and 56%)on nanocomposite morphology and Water Contact Angles(WCAs)were *** measurements confirmed the polycrystalline structure of ZnO with a wurtzite hexagonal phase,and EDX results indicated the presence of all element *** analysis of specimens revealed a rough surface structure resembling a cluster of NPs,and that structure was dominant when the ethanol content increased to 56%.The WCA increased on the superhydrophobic nanocomposite as ethanol content increased,and an optimum WCA(160°±2°)was obtained at an ethanol content of 56%.Antibacterial activity was tested on the superhydrophobic and hydrophobic states,and the superhydrophobic specimens showed good inhibition against Klebsiella *** Staphylococcus ***,the hydrophobic specimens demonstrated no antibacterial activity against *** promising results can inform the development of nanocomposites for many environmental applications.

关键词： ZnO PVC Superhydrophobicity Antibacterial WCA