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Cation-exchange high-performance liquid chromatography for variant hemoglobins and HbF/A2:What must hematopathologists know about methodology?

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World Journal of Methodology 2016年第1期6卷 20-24页

作者： Prashant Sharma reena Das Department of Hematology Level 5Research Block APostgraduate Institute of Medical Education and Research

Cation-exchange high-performance liquid chromatography(CE-HPLC) is a widely used laboratory test to detect variant hemoglobins as well as quantify hemoglobins F and A2 for the diagnosis of thalassemia syndromes. It's versatility, speed, reproducibility and convenience have made CE-HPLC the method of choice to initially screen for hemoglobin disorders. Despite its popularity, several methodological aspects of the technology remain obscure to pathologists and this may have consequences in specific situations. This paper discusses the basic principles of the technique, the initial quality control steps and the interpretation of various controls and variables that are available on the instrument output. Subsequent sections are devoted to methodological considerations that arise during reporting of cases. For instance, common problems of misidentified peaks, totals crossing 100%, causes of total area being above or below acceptable limits and the importance of pre-integration region peaks are dealt with. Ultimately, CE-HPLC remains an investigation, the reporting of which combines in-depth knowledge of the biological basics with more than a working knowledge of the technological aspects of the technique.

关键词： Anemia Diagnosis Hematological disorders Hematopathology Hemoglobin Hemoglobinopathies High-performance liquid chromatography Laboratory instrumentation Red blood cells Thalassemia

消化道胶囊内镜——从三级医疗中心到初级保健

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英国医学杂志中文版 2006年第3期9卷 158-161页

作者： reena Sidhu David S Sanders Mark E McAlindon 夏志伟（译） Royal Hallarnshire Hospital Sheffeld S10 2JF 不详

1907年,布鲁日开始应用第一台内镜来观察人的上消化道,最初是硬的直管内镜,需要全身麻醉.40年后,可屈式内镜诞生,只需要局部麻醉或轻度镇静就可以进行内镜检查.随后20年的技术进步催生了第一台肠镜的出现.1999年,又实现了一个巨大的飞跃... 详细信息

1907年,布鲁日开始应用第一台内镜来观察人的上消化道,最初是硬的直管内镜,需要全身麻醉.40年后,可屈式内镜诞生,只需要局部麻醉或轻度镇静就可以进行内镜检查.随后20年的技术进步催生了第一台肠镜的出现.1999年,又实现了一个巨大的飞跃,胶囊内镜可以全面观察整个小肠.胶囊被咽下后,在肠道的蠕动推进下经过所有肠道,胶囊内镜具有成像装置,可将肠道内的影像传输给腹部的接收装置.

关键词：胶囊内镜上消化道三级医疗中心初级保健成像装置肠道内全身麻醉内镜检查局部麻醉全面观察

Studies on Water Absorbency of Polyacrylamide Hydrogels

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材料科学与工程（中英文B版） 2015年第11期5卷 399-405页

作者： Bhadani reena Mitra Uttam Kumar Department of Chemistry Ranchi Women's College Ranchi University Ranchi-834001 India Department of Chemistry Gossner College Ranchi University Ranchi- 834001 India

The polymerization was carried out under the different concentrations of acrylamide and crosslinker in an aqueous solution of NO2 gas as initiator at 50 oC. The resulting polyacrylamide was saponified with NaOH solution. The hydrolysed polymers show high degree of water swelling (> 500) than that of unhydrolysed polymers (< 100). Swell ability of the gel decreases with the increasing concentration of N, N"- methylene bisacrylamide – a crosslinker which enhances the degree of crosslinking in the polymer chains. The increased crosslinking restricts the expansion of polymer network which causes the lowering of the water absorbency. It was observed that polymer hydration increased with the molar mass of polyacrylamide. The swell ability of polyacrylamide hydrogels is greatly lowered by the addition of ionic salts in the swelling medium. Both ionic strength and valency of the salts are responsible to decrease the water uptaking capacity of the gels which remain unaffected by nondessociating nature of urea. The hydrogels, so prepared, are stable and quite able to undergo swelling - deswelling cycles suggesting their reversible characters.

关键词：聚丙烯酰胺水凝胶吸水性能亚甲基双丙烯酰胺聚合物链吸水膨胀 NaOH溶液凝胶能力离子强度

Is there a role for arterial reconstruction in surgery for pancreatic cancer?

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World Journal of Gastrointestinal Surgery 2013年第3期5卷 27-29页

作者： reena Ravikumar David Holroyd Giuseppe Fusai Department of Hepatopancreato-biliary and Liver Transplant Surgery Royal Free London Hospital NHS Foundation Trust

Surgery remains the only potentially curative treatment for patients with pancreatic cancer. Locally advanced pancreatic cancer with vascular involvement remains a surgical challenge because high perioperative risk and the uncertainty of a survival benefit. Whilst portal vein resection has started to gather momentum because the perioperative morbidity and long term survival is comparable to standard pancreatectomy, there isn't yet a consensus on arterial resections. There have been various reports and case series of arterial resections in pancreatic cancer, with mixed survival results. Mollberg et al have appraised the heterogeneous published literature available on arterial resection in pancreatic cancer in an attempt to compare this to standard pancreatectomy. In this article, we discuss the results of this systematic review and meta-analysis, and the limitations associated with analysing results from heterogenous data. We have outlined the important features in surgery for pancreatic cancer and specifically to arterial resections, and compared arterial resections to the published literature on venous resections.

关键词： Arterial resection Pancreatic cancer Vascular resection Hepatic artery Coeliac axis Pancreatectomy

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来自新兴市场的灵感

商业周刊（中文版） 2009年第5期 61-63页

作者：里娜·贾纳（reena Jana）夏芳（译）

今年3月，通用电气医疗集团（GE Healthcare）开始在美国市场为其最新款心电图仪MAC800造势。这款电池供电的仪器应用了最新技术，仅重6镑．相当于目前市面上最小的心电图仪的一半。它的零售价格将仅仅定在2500美元，比类似产品的标价低... 详细信息

今年3月，通用电气医疗集团（GE Healthcare）开始在美国市场为其最新款心电图仪MAC800造势。这款电池供电的仪器应用了最新技术，仅重6镑．相当于目前市面上最小的心电图仪的一半。它的零售价格将仅仅定在2500美元，比类似产品的标价低了80％。但是MAC800心电图仪真正与众不同的是它的出处，这款仪器与通用电气医疗集团2008年专为印度和中国医生开发的机型基本同出一门。

关键词：新兴市场灵感通用电气心电图美国市场零售价格新技术集团

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为服装设计申请专利

商业周刊（中文版） 2008年第7期 79-80页

作者：里娜·贾纳（reena Jana）夏芳（译）

在***网站上，制鞋设计师斯图尔特·韦茨曼看到一双带扣平跟鞋与自己设计的一款几乎一模一样，但前者标价45．99美元，而后者则为215美元，此时他作出的反应与越来越多的设计师一样：打官司。

关键词：服装设计申请专利斯图尔特设计师制鞋美元

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让惠普紧追潮流

商业周刊（中文版） 2008年第1期 32-36页

作者：瑞娜·詹娜（reena Jana）陈晓宇（译者）

在位于加利福尼亚州帕洛阿尔托市的惠普公司综合办公大楼里，精心保留着公司创始人威廉·休利特和戴维·帕卡德曾经使用过的办公室，在其下方的地下室里有一个洞穴般的房间，看上去像一个乱糟糟的初创公司的办公室，到处摆满了桌子和椅... 详细信息

在位于加利福尼亚州帕洛阿尔托市的惠普公司综合办公大楼里，精心保留着公司创始人威廉·休利特和戴维·帕卡德曾经使用过的办公室，在其下方的地下室里有一个洞穴般的房间，看上去像一个乱糟糟的初创公司的办公室，到处摆满了桌子和椅子，一个巨大的临时摆放的屏幕占据了整个一面墙，连墙角都围在了里面。惠普公司用于演示的投影仪码放了一排，将巨大的电视游戏的影像投放在墙上，真人般大小的画面是如此清晰逼真，以至于你感觉差不多可以走进去参与到“疯狂橄榄球”的比赛或是“Halo 3”的战斗．之中。

关键词：惠普公司加利福尼亚州办公大楼电视游戏办公室创始人地下室投影仪

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点子的成本是不是太高了？

商业周刊（中文版） 2009年第6期 22-24页

作者：里娜·贾纳（reena jana）杨鸣娟（译）

就在不久前，创新还是商界必须处理的头等要务。如今研究与开发似乎更像是度假屋和新车，换言之，它们都是繁荣时期才能享受的奢侈品。“创新很容易就会成为众矢之的，”位于达特茅斯的塔克商学院的教授维杰伊·戈文达拉扬说，“研发资... 详细信息

就在不久前，创新还是商界必须处理的头等要务。如今研究与开发似乎更像是度假屋和新车，换言之，它们都是繁荣时期才能享受的奢侈品。“创新很容易就会成为众矢之的，”位于达特茅斯的塔克商学院的教授维杰伊·戈文达拉扬说，“研发资金显然会导致不确定的结果。公司不希望在困难时期遭遇失败。”

关键词：成本点子研究与开发塔克商学院研发资金困难时期奢侈品商界

Multiple z-Score Based Method for Noninvasive Prenatal Test Using Cell-Free DNA in Maternal Plasma

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Open Journal of Genetics 2017年第1期7卷 1-8页

作者： Hyuk Jung Kwon Amit Goyal Heesu Im Kichan Lee Seon Young Yun Yoon Hee Kim Sungjong Lee Mi-Gyeong Lee Hyuna Lee reena Garg Boram Park Soyoung Choi Joungsu Joo Jin-Sik Bae Min-Jeong Kim Min Seob Lee Sunghoon Lee EONE-DIAGNOMICS Genome Center Co. Ltd. Inchon Korea

Objective: To improve the detecting accuracy of chromosomal aneuploidy of fetus by non-invasive prenatal testing (NIPT) using next generation sequencing data of pregnant women’s cell-free DNA. Methods: We proposed the multi-Z method which uses 21 z-scores for each autosomal chromosome to detect aneuploidy of the chromosome, while the conventional NIPT method uses only one z-score. To do this, mapped read numbers of a certain chromosome were normalized by those of the other 21 chromosomes. Average and standard deviation (SD), which are used for calculating z-score of each sample, were obtained with normalized values between all autosomal chromosomes of control samples. In this way, multiple z-scores can be calculated for 21 autosomal chromosomes except oneself. Results: Multi-Z method showed 100% sensitivity and specificity for 187 samples sequenced to 3 M reads while the conventional NIPT method showed 95.1% specificity. Similarly, for 216 samples sequenced to 1 M reads, Multi-Z method showed 100% sensitivity and 95.6% specificity and the conventional NIPT method showed a result of 75.1% specificity. Conclusion: Multi-Z method showed higher accuracy and robust results than the conventional method even at low coverage reads.

关键词： Cell-Free DNA z-Score Multiple Thresholds Coefficient of Variance Noninvasive Prenatal Testing NIPT