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Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy

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Bone Research 2024年第1期12卷 95-106页

作者： Tian Nie Varun S.Venkatesh Suzanne Golub Kathryn S.Stok Haniyeh Hemmatian reena Desai David J.Handelsman Jeffrey D.Zajac Mathis Grossmann Rachel A.Davey Department of Medicine Austin HealthUniversity of MelbourneHeidelbergVIC 3084Australia Department of Biomedical Engineering University of MelbourneParkvilleVIC 3010Australia ANZAC Research Institute University of Sydney and AndrologyConcord Repatriation General HospitalConcordNSW 2137Australia

The effects of gender-affirming hormone therapy on the skeletal integrity and fracture risk in transitioning adolescent trans girls are *** address this knowledge gap,we developed a mouse model to simulate male-to-female transition in human adolescents in whom puberty is first arrested by using gonadotrophin-releasing hormone analogs with subsequent estradiol *** was suppressed by orchidectomy in male mice at 5 weeks of *** 3 weeks post-surgery,male-to-female mice were treated with a high dose of estradiol(~0.85 mg)by intraperitoneal silastic implantation for 12 *** included intact and orchidectomized males at 3 weeks post-surgery,vehicle-treated intact males,intact females and orchidectomized males at 12 weeks *** to male controls,orchidectomized males exhibited decreased peak bone mass accrual and a decreased maximal force the bone could withstand prior to *** treatment in orchidectomized male-to-female mice compared to mice in all control groups was associated with an increased cortical thickness in the mid-diaphysis,while the periosteal circumference increased to a level that was intermediate between intact male and female controls,resulting in increased maximal force and *** trabecular bone,estradiol treatment increased newly formed trabeculae arising from the growth plate as well as mineralizing surface/bone surface and bone formation rate,consistent with the anabolic action of estradiol on osteoblast *** data support the concept that skeletal integrity can be preserved and that long-term fractures may be prevented in trans girls treated with GnRHa and a sufficiently high dose of *** study is needed to identify an optimal dose of estradiol that protects the bone without adverse side effects.

关键词： treatment treatment strength

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Tuning of Optical Properties via Annealing of Bismuth Ferrite (BiFeO3) Thin Films

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Open Journal of Composite Materials 2024年第3期14卷 124-131页

作者： Harish Kumar Meena Khushbu Meena reena Verma Karishma Jain Sushil Kumar Jain Kedar Babu Sharma Balram Tripathi Department of Physics S S Jain Subodh PG College Jaipur India Department of Physics University of Rajasthan Jaipur India Department of Physics School of Physical Sciences Manipal University Jaipur Jaipur India

In this study we are reporting annealing induced optical properties of bismuth ferrite (BiFeO3) thin films deposited on glass substrate via spin coating at 5000 rpm. The structural, optical and surface morphology of BiFeO3 (BFO) thin films have been studied via X-ray diffraction (XRD), Fourier transform infrared (FT-IR), Optical absorption (UV-Vis) and Photoluminescence (PL) spectroscopy. XRD spectra confirm annealing induced phase formation of BiFeO3 possessing a rhombohedral R3c structure. The films are dense and without cracks, although the presence of porosity in BFO/glass was observed. Moreover, optical absorption spectra indicate annealing induced effect on the energy band structure in comparison to pristine BiFeO3. It is observed that annealing effect shows an intense shift in the UV-Vis spectra as diffuse absorption together with the variation in the optical band gap. The evaluated optical band gap values are approximately equal to the bulk band gap value of BiFeO3.

关键词： Optical Properties Annealing Ferroelectrics Photo Luminescence BFO Thin Films

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Impact of phytoconstituents on oral health practices:a post COVID-19 observation

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Food Science and Human Wellness 2024年第5期13卷 2386-2400页

作者： Harsh Kumar reena Singh Daljeet Singh Dhanjal Chirag Chopra Natália Cruz-Martins Gheyath K.Nasrallah Amin F.Majdalawieh Sivakumar Manickam Shahida Anusha Siddiqui Dinesh Kumar Indu Sharma Varun Sharma School of Bioengineering&Food Technology Shoolini University of Biotechnology and Management SciencesSolan 173229India School of Bioengineering and Biosciences Lovely Professional UniversityPunjab 144402India Faculty of Medicine University of PortoPorto 4200-319Portugal Institute for Research and Innovation in Health(i3S) University of PortoPorto 4200-135Portugal Institute of Research and Advanced Training in Health Sciences and Technologies(CESPU) RuaCentral de GandraGandra 4585-116Portugal TOXRUN-Toxicology Research Unit University Institute of Health SciencesCESPUCRLGandra 4585-116Portugal Biomedical Research Center Qatar UniversityDoha 2713Qatar Department of Biomedical Science College of Health SciencesQatar UniversityDoha 2713Qatar Department of Biology Chemistryand Environmental SciencesCollege of Arts and SciencesAmerican University of SharjahSharjah 26666United Arab Emirates Petroleum and Chemical Engineering Faculty of EngineeringUniversiti Teknologi BruneiBandar Seri Begawan BE1410Brunei Campus Straubing for Biotechnology and Sustainability Technical University of MunichStraubing 94315Germany Genetic Heritage Group New York UniversityAbu Dhabi 129188United Arab Emirates Bioinformatics Division NMC Genetics India Pvt.Ltd.Gurugram 122001India

Appropriate oral hygiene significantly reduces the possibility of oral ***,dental caries and periodontal diseases are major oral health issues causing chronic diseases due to poor oral ***,herbal compounds have gained interest in maintaining oral *** of burdock root(Arctium),noni fruit(Morinda citrifolia),and neem leaf(Azadirachta indica)are now used as intracanal medicaments in endodontics and *** amboinicus species and other plants produces essential oil likeβ-caryophyllene,p-cymene,andγ-terpinene can exhibit antibacterial activity;highlighting phytoconstituents plays a vital role in oral *** COVID-19 pandemic highlighted the importance of hygiene and sanitization,to curb *** cavity is among the gateways for virus entry into *** is a potential reservoir of SARS-CoV-2,and there is an increased risk of infection if there is any fissure in the *** enables entry of virus into the vascular system through gingival or periodontal pocket,possibly reaching lung periphery then to lung vessels by interacting with endothelial surface receptors triggering pulmonary vasoconstriction and lung damage due to endothelial *** review aims to draw attention to the possible route of SARS-CoV-2 infection via the oral cavity and the importance of oral hygiene against COVID-19.

关键词： COVID-19 SARS-CoV-2 Oral Hygiene Microbiota Phytochemicals

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Solvent induced shape change in CePO_4:Dy^(3+) nanophosphors and effect of metal ions: A photoluminescence study

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Journal of Rare Earths 2012年第12期30卷 1217-1224页

作者： reena Okram N.Rajmuhon Singh Department of Chemistry Manipur University

The influence of different solvents and metal ions （Li^＋, Ba^2＋, Bi^3＋） on the crystallization behaviour, morphology and enhancement in photoluminescence intensity of Dy^3＋ doped CePO4 were investigated. Highly crystalline luminescent nanophosphors of CePO4：DY^3＋ re-dispersible in polar solvents were successfully prepared via a simple polyol route at 140 ℃. As-prepared Dy^3＋ doped CePO4 nanophosphors prepared in EG and DMF appeared to have crystalline monoclinic phase but exhibited hexagonal phase when prepared in water and water mixed solvents, The hexagonal phase transformed to monoclinic phase after heating at 900 ℃. TEM study revealed different shapes of the synthesized nanophosphors with change of solvents. The luminescence intensity of 4F9/2→6H15/2 at 478 nm （blue） was found to be more prominent than 4F9/2→6H13/2 at 572 nm （yellow）. The introduction of metal ions （Li＋, Ba2＋ and Bi3＋） in CePO4：Dy3＋ led to considerable luminescent enhancement. The nanophosphors were subsequently incorporated in polymer films of PVA which showed the characteristic emissions of Dy3＋. It also served as an effective method to improve the performance of polymer materials and brought about novel properties in them.

关键词： enhanced luminescence rare earth point defects nanophosphor re-dispersible

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Effect of protease inhibitor from Agaricus bisporus on glucose uptake and oxidative stress in 3T3-L1 adipocytes

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Asian Pacific Journal of Tropical Biomedicine 2020年第3期10卷 136-146页

作者： reena Vishvakarma Abha Mishra School of Biochemical Engineering Indian Institute of Technology(Banaras Hindu University)VaranasiUttar Pradesh-221005India

Objective:To explore the effect of the protease inhibitor from Agaricus bisporus(***)Imbach(AbPI)on glucose uptake and oxidative stress in 3 T3-L1 ***:Adipocytes were differentiated and stained with OilRed-O staining to confirm *** toxic/protective effect of AbPI on the adipocytes was determined by MTT assay,intracellular reactive oxygen species generation through flow cytometry,and morphologically through confocal microscopy using propidium iodide,4,6-diamino-2-phenylindol dihydrochloride,and 2’,7’-dichlorofluorescein diacetate *** uptake of fluorescent glucose analog,2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose by adipocytes was also studied through confocal ***:MTT assay showed that the cell survival rate was(28.00±3.00)%,(92.33±2.60)%,and(71.34±2.10)%in the presence of 2 mM H2O2,AbPI alone,and AbPI and H2O2 both,respectively,in comparison to the ***-Red-O staining indicated that Ab PI enhanced *** stimulated the glucose uptake by adipocytes similar to the drug rosiglitazone,and showed insulinsensitizing effect in the presence of insulin,but failed to stimulate the uptake in the absence of *** reactive oxygen species generation was reduced in differentiating adipocytes upon Ab PI *** microscopy showed that the damaged cell population rose to 3.50%,117.84%,and 261.50%in the presence of Ab PI alone,AbPI with H2O2,and H2O2 alone,***:The protease inhibitor enhances glucose uptake by adipocytes and exhibits a cytoprotective effect on them.

关键词： Protease inhibitor Agaricus bisporus 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose Oxidative stress Hydrogen peroxide 3T3-L1 adipocytes

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Suppression of Ambipolar Conduction in Schottky Barrier Carbon Nanotube Field Effect Transistors:Modeling,Optimization Using Particle Swarm Intelligence,and Fabrication

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Computer Modeling in Engineering & Sciences 2019年第6期119卷 577-591页

作者： P.reena Monica V.T.Sreedevi School of Electronics Engineering VIT ChennaiVandalur-Kelambakkam RoadChennai603103India School of Electrical Engineering VIT ChennaiVandalur-Kelambakkam RoadChennai603103India

A mathematical model and experimental analysis of the impact of oxide thickness on the ambipolar conduction in Schottky Barrier Carbon Nanotubes(CNTs)Field Effect Transistor(SB CNTFETs)is *** of ambipolar conduction in SB CNTFETs is imperative in order to establish them as the future of IC *** ambipolar nature of SB CNTFETs leads to a great amount of leakage *** a gate oxide dielectric of thickness,tox^50 nm suppresses the ambipolar *** an SB CNTFET,it is the electric field at the source/drain contacts that control the conductance and the band bending length at the contacts is defined by ***,tox is the prime parameter that influences the width of the Schottky barrier and the current in the subthreshold *** to the wide SB,there is a loss in on-current due to tunneling,but the current due to thermionic emission is increased by employing a high-κdielectric such as Zirconium dioxide(ZrO2).This work proposes an approach to suppress ambipolar behavior in SB CNTFETs without decreasing the on *** thickness and dielectric constant of the gate oxide are optimized using the particle swarm optimization(PSO)algorithm to achieve suppression of ambipolar conduction without any loss in *** proposed SB CNTFET was modeled using *** demonstration of the suppression of ambipolar property is also *** SB CNTFETs are fabricated using high-κdielectric such as ZrO2 with different thickness.A device with thin(~5 nm)gate oxide and another device with thick(~50 nm)gate oxide were *** the experimental results,it is observed that the device with the thin gate oxide exhibited ambipolar characteristics and the device with the thick gate oxide did not exhibit ambipolar *** increase in thickness,tox,ensures suppression of ambipolar behavior.

关键词： Ambipolar conduction Carbon nanotubes high-κgate oxide Schottky barrier

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Subcutaneous sarcoidosis of the upper and lower extremities: A case report and review of the literature

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World Journal of Clinical Cases 2019年第17期7卷 2505-2512页

作者： Raman Mehrzad Julia Festa reena Bhatt Department of Plastic and Reconstructive Surgery Rhode Island Hospital the Warren Alpert Medical School of Brown University

BACKGROUND Sarcoidosis is a granulomatous disease of unknown etiology that most often impacts the *** manifestations of sarcoidosis are seen among 9%- 37% of *** sarcoidosis is a rare presentation of cutaneous sarcoidosis with estimates of frequency ranging from 1.4%-16%.To date,very few articles and case reports have been written about this *** this paper,we describe a case of subcutaneous sarcoidosis and perform a review of the literature to determine if there are commonalities among patients who present with subcutaneous *** SUMMARY A 38-year-old female,with a past medical history of arthritis and recurrent nephrolithiasis,presents with an 8-mo history of 4 firm,asymptomatic,skincolored nodules on her left and right upper extremities and *** biopsy and post-excisional pathology report both revealed well-formed,dense,noncaseating granulomas localized to the subcutaneous *** computed tomography revealed mild mediastinal lymphadenopathy.A diagnosis of subcutaneous sarcoidosis was made,and the lesions were surgically *** Commonalities among patients presenting with subcutaneous sarcoidosis include: middle-aged female,lesions localizing to the upper or lower limbs,lymphadenopathy or pulmonary infiltration on chest imaging,elevated serum angiotensin-converting enzyme.

关键词： Subcutaneous sarcoidosis Upper extremity Granulomatous disease Case report

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Early Detection of Pancreatic Cancer Using Jaundiced Eye Images

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Computer Systems Science & Engineering 2022年第5期41卷 677-688页

作者： R.reena Roy G.S.Anandha Mala Department of Information Technology Easwari Engineering CollegeChennaiTamilnadu600089India

Pancreatic cancer is one of the deadliest cancers,with less than 9%survival *** Ductal Adeno Carcinoma(PDAC)is common with the general public affecting most people older than *** detection of PDAC is often challenging because cancer symptoms will progress only at later stages(advanced stage).One of the earlier symptoms of PDAC is *** with diabetes,obesity,and alcohol consumption are also at higher risk of having pancreatic cancer.A decision support system is developed to detect pancreatic cancer at an earlier stage to address this *** such as Mean Hue,Mean Saturation,Mean Value,and Mean Standard Deviation are computed after color space conversion from RGB to *** k-Nearest Neighbor(F-kNN)is designed for *** system proposed is trained and tested using features extracted from jaundiced eye *** proposed system results indicate that this model can predict pancreatic cancer as earlier as possible,helping clinicians make better decisions for surgical planning.

关键词： Pancreatic adeno carcinoma fuzzy-based classifier jaundiced eye classification system

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Capsule endoscopy:Current practice and future directions

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World Journal of Gastroenterology 2014年第24期20卷 7752-7759页

作者： Melissa F Hale reena Sidhu Mark E McAlindon Department of Gastroenterology Royal Hallamshire HospitalSheffield S10 2JFUnited Kingdom

Capsule endoscopy (CE) has transformed investigation of the small bowel providing a non-invasive, well tolerated means of accurately visualising the distal duodenum, jejunum and ileum. Since the introduction of small bowel CE thirteen years ago a high volume of literature on indications, diagnostic yields and safety profile has been presented. Inclusion in national and international guidelines has placed small bowel capsule endoscopy at the forefront of investigation into suspected diseases of the small bowel. Most commonly, small bowel CE is used in patients with suspected bleeding or to identify evidence of active Crohn’s disease (CD) (in patients with or without a prior history of CD). Typically, CE is undertaken after upper and lower gastrointestinal flexible endoscopy has failed to identify a diagnosis. Small bowel radiology or a patency capsule test should be considered prior to CE in those at high risk of strictures (such as patients known to have CD or presenting with obstructive symptoms) to reduce the risk of capsule retention. CE also has a role in patients with coeliac disease, suspected small bowel tumours and other small bowel disorders. Since the advent of small bowel CE, dedicated oesophageal and colon capsule endoscopes have expanded the fields of application to include the investigation of upper and lower gastrointestinal disorders. Oesophageal CE may be used to diagnose oesophagitis, Barrett’s oesophagus and varices but reliability in identifying gastroduodenal pathology is unknown and it does not have biopsy capability. Colon CE provides an alternative to conventional colonoscopy for symptomatic patients, while a possible role in colorectal cancer screening is a fascinating prospect. Current research is already addressing the possibility of controlling capsule movement and developing capsules which allow tissue sampling and the administration of therapy.

关键词： Capsule endoscopy Small bowel Indications Technology Oesophageal Colon

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Treatment of colonic varices with a superior mesenteric venous stent:a case report describing a unique approach

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Gastroenterology Report 2021年第6期9卷 597-599页

作者： Sandra Naffouj Mustafa Al-Shammari reena Salgia Department of Internal Medicine Henry Ford HospitalDetroitMIUSA Division of Gastroenterology and Hepatology Department of MedicineHenry Ford HospitalDetroitMIUSA

Introduction Ectopic varices are a rare cause of gastrointestinal(GI)bleeding that may occur in the GI tract outside the esophageal and gastric distribution[1].The majority of these cases are rectal varices in cirrhotic patients with portal *** varices(CV)are less common than rectal,duodenal,and smallbowel varices[2].There are no clear guidelines for managing CV given the rarity of this finding[3].We report a case of massive lower-GI bleeding due to CV in a patient with non-alcoholic steatohepatitis(NASH)without cirrhosis or portal hypertension secondary to porto-mesenteric venous thrombosis that was successfully treated with superior mesenteric venous(SMV)*** the extent of the mesenteric thrombosis,treatment modalities like transjugular intrahepatic portosystemic shunt(TIPS)and balloon-occluded retrograde transvenous obliteration(BRTO)were not possible.

关键词： venous varices balloon

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