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Empirical model for fusion cross sections of Ca-induced reactions

Chinese Physics C 2024年第3期48卷 126-132页

作者： reddi ran..l N.Sowmya K.N Sridhar H C.Manjunatha M.M.Armstrong Arasu Department of Physics St.Joseph's College(Autonomous)Affiliated to Bharathidasan UniversityTiruchirappalli620002TNIndia Department of Physics Govt.First.Grade CollegeChikkaballapur-562101KarnatakaIndia Department of Physics Govt.First.Grade CollegeMalur-563160KarnatakaIndia Department of Physics Govt.First.Grade CollegeDevanahalli-562110KarnatakaIndia

A new empirical formula for the astrophysical S-factor has been suggested as a function of the Coulomb interaction parameter,center of mass energy,and barrier *** 22 fusion reactions with ^(40,48)Ca as projectiles were considered for different targets,leading to compound nuclei with atomic and mass numbers varying between 40≤Z≤≤Z≤112 and 88≤A≤27888≤A≤278,*** fusion cross-sections have been estimated using the geometric factor,the Gamow-Sommerfield factor,and the empirical formula for the *** study's findings showed better agreement with those of available experiments when compared to Wong's *** present work leads to a smaller standard deviation value than Wong's formula when used to correlate the experimental data of calcium-induced fusion ***'s formula provides a good approximation of fusion cross-sections when the center of mass energy is below the fusion barrier when compared to above the fusion barrier.

关键词： fusion cross-sections Wong formula Gamow-Sommerfield-factor Geometric-factor S-factor

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Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization

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Chinese Chemical letters 2022年第5期33卷 2550-2554页

作者： Anil Kumar Marapaka Priyanka Sankoju Guozhen Zhang Yongzheng Ding Chunhua Ma Vijaykumar Pillalamarri Renu Sudhakar Bharati reddi Puran Singh Sijwali Yingjie Zhang Anthony Addlagatta Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJi’nan 250012China Department Applied Biology CSIR-Indian Institute of Chemical TechnologyTarnakaHyderabadTelangana-500007India Academy of Scientific and Innovative Research(AcSIR) Ghaziabad-201002India CSIR-Centre for Cellular and Molecular Biology TarnakaHyderabadTelangana-500007India

Plasmodium parasites causing malaria have developed resistance to most of the antimalarials in use,in-cluding the artemisinin-based combinations,which are the last line of defense against *** ne-cessitates the discovery of new targets and the development of novel *** falciparum alanyl aminopeptidase(PfA-M1)and leucyl aminopeptidase(PfA-M17)belong to the M1 and M17 family of metalloproteases respectively and play critical roles in the asexual erythrocytic stage of *** enzymes have been suggested as potential antimalarial drug *** we describe the devel-opment of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual *** of the compounds described in this study display inhibition at sub-micromolar range against the recombinant PfA-M1 and *** importantly,compound 26 not only exhibits potent malarial aminopeptidases inhibitory activities(PfA-M1 K i=0.11±0.0002μmol/l,PfA-M17 K_(i)=0.05±0.005μmol/l),but also possesses remarkable selectivity over the mammalian counterpart(pAPN K_(i)=17.24±0.08μmol/l),which endows 26 with strong inhibition of the malarial parasite growth and negligible cytotoxicity on human cell *** structures of PfA-M1 at atomic resolution in complex with four different compounds including compound 26 establish the structural basis for their inhibitory ***,the terminal ureidoben-zyl group of 26 explores the S2' region where differences between the malarial and mammalian enzymes are apparent,which rationalizes the selectivity of ***,our data provide important insights for the rational and structure-based design of selective and dual inhibitors of malarial aminopeptidases that will likely lead to novel chemotherapeutics for the treatment of malaria.

关键词： Aminopeptidase Dual inhibitor Antimalaria Peptidomimetic Plasmodium falciparum

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