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Corneal esthesiometry and sub-basal nerves morphological changes in herpes simplex virus keratitis/uveitis patients

International Journal of Ophthalmology(English edition) 2019年第3期12卷 407-411页

作者： reda zemaitiene Modesta Rakauskiene Viliija Danileviciene Violeta Use Loresa Kriauciuniene Dalia Zaliuniene Department of Ophthalmology Medical Academy Lithuanian University of Health Sciences Department of Langueges and Educology Medical Academy Lithuanian University of Health Sciences Neuroscience Institute Medical Academy Lithuanian University of Health Sciences

AIM: To describe and compare corneal sensation and morphological changes of sub-basal corneal nerves by in vivo laser scanning confocal microscopy(LSCM) in herpes simplex virus(HSV) keratitis/uveitis and contralateral, clinically unaffected eyes. METHODS: A prospective clinical study included 30 HSV eyes and 30 contralateral eyes of 30 patients, diagnosed with unilateral HSV keratitis/uveitis. Both eyes underwent a complete ophthalmological examination, Cochet-Bonnet aesthesiometry and LSCM of the central cornea, using the Heidelberg Retina Tomograph III Rostock Cornea Module. After 6 mo, the same examination of the HSV affected and contralateral, clinically unaffected eyes was ***: HSV eyes, as compared to contralateral eyes, demonstrated a significant decrease in mean corneal sensation(3.1±1.6 vs 5.3±0.8 cm), total nerve fibres number(5.7±4.4 vs 15.1±5.4), nerve branches(3.4±3.0 vs 8.4±4.7), main nerve trunks(2.3±1.6 vs 5.8±2.2), and nerve fibres density(7.5±5.6 vs 18.1±5.3 mm/mm2, P<0.05). There was no significant difference between keratitis and uveitis eyes in mean corneal sensation and nerve fibres parameters. After 6 mo, corneal sensation and sub-basal nerve fibres parameters were increased significantly, but did not reach the parameters of contralateral, clinically unaffected ***: Corneal aesthesiometry and LSCM in HSV affected eyes reveals a significant decrease of corneal sensation and sub-basal nerve fibres which recovers at6 mo but does not reach the normal level.

关键词： aesthesiometry confocal microscopy herpes simplex virus keratitis uveitis

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MMP-2 Rs24386(C-->T) gene polymorphism and the phenotype of age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1349-1353页

作者： Rasa Liutkeviciene Vaiva Lesauskaite Giedre Sinkunaite-Marsalkiene Sandrita Simonyte reda zemaitiene Loresa Kriauciuniene Dalia Zaliuniene Department of Ophthalmology Lithuanian University of Health SciencesMedical AcademyKaunas LT-50161Lithuania Neuroscience Institute Lithuanian University of Health SciencesMedical AcademyKaunas LT-50161Lithuania Intitute of Cardiology Lithuanian University of Health SciencesMedical AcademyKaunas LT-50161Lithuania

AIM：To examine the MMP-2（-1306 C/T）gene polymorphism and the phenotype characterized by soft and hard drusen of early age-related macular degeneration（AMD）and geographic atrophy of late AMD ***：The study enrolled 850 investigations（290AMD patients with soft and hard drusen,34 with geographic atrophy and a random sample of the population n=526）.Early AMD was classified according to the International Classification and Grading *** geographic atrophy diagnosis the Age-Related Eye Disease Study classification was *** potential association with single nucleotide polymorphisms on MMP-2 Rs243865 was evaluated for all patients,adjusted for age and *** genotyping test of MMP-2 Rs243865（C--〉T）was conducted using the real-time polymerase chain reaction ***：MMP-2（-1306 C/T）C/C genotype was more frequently detected in AMD patients with hard drusen than the soft drusen or control group（66.43%vs 53.74%,vs54.94%,P=0.047）.Logistic regression analysis showed that the MMP-2（-1306）C/C genotype increased the likelihood to develop hard drusen in AMD patients（OR=1.7,95%CI：1.06-2.74;P=0.028）.No association between MMP-2（-1306C/T）gene polymorphism in patients with atrophic AMD and control group was found（54.94%,37.64%,7.41%vs50%,38.24%,11.76%;P=0.6）.CONCLUSION：The MMP-2 Rs24386（C--〉T）polymorphism is found to be associated with the development of hard drusen in patients with AMD.

关键词： age-related macular degeneration phenotype matrix metalloproteinases gene polymorphism

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