检索结果-南通市图书馆

The impact of fluorination on both donor polymer and non-fullerene acceptor:The more fluorine,the merrier

在线全文

学校读者我要写书评

暂无评论

Nano Research 2019年第9期12卷 2400-2405页

作者： Nicole Bauer Qianqian Zhang j.romy j.mes rech Shuixing Dai Zhengxing Peng Harald Ade j.ayu Wang Xiaowei Zhan Wei You Department of Chemistry University of North Carolina at Chapel HillNorth Carolina 27599USA Department of Materials Science and Engineering College of EngineeringKey Laboratory of Polymer Chemistry and Physics of Ministry EducationPeking UniversityBeijing 100871China Department of Physics and ORaCEL North Carolina State UniversityRaleighNorth Carolina 27695USA

Fluorination of the donor polymer or non-fullerene acceptor (NFA) in an organic photovoltaic device is an effective method to improve device *** there have been many studies on donor polymer fluorination,blends containing both a fluorinated donor and fluorinated NFA have rarely been *** this study,we use two donor polymers (4'-FT-HTAZ and 4'-FT-FTAZ) and two NFAs (ITIC-Th and ITIC-Th1) with different amounts of fluorine (from 2F to 6F) to investigate how the degree of fluorination in a blend impacts device *** find that fluorinating the NFA leads to a higher short-circuit current density (j.c) and fill factor (FF),however,the open-circuit voltage (Voc) is decreased due to a depressed lowest unoccupied molecular orbital (LUMO) *** additional fluorine to the donor polymer does not have a large effect on the j.c or FF,but it does lead to an improved *** fluorinating the NFA and having more fluorine on the donor polymer,we obtain both a high j.c and Voc simultaneously,leading to a power conversion efficiency over 10% in the case of 4'-FT-FTAZ:ITIC-Th1,which has the most amount of fluorine (6F).

关键词： organic solar cells non-fullerene acceptors fluorination bulk heteroj.nction

Association of interferon lambda-4 rs12979860 polymorphism with hepatocellular carcinoma in patients with chronic hepatitis C infection

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World j.urnal of Hepatology 2021年第1期13卷 109-119页

作者： j.ice Teixeira de Bitencorte Tássia Flores rech Vagner Ricardo Lunge Deivid Cruz dos Santos Mário ReisÁlvares-da-Silva Daniel Simon PPG Biologia Celular e Molecular AplicadaàSaúde Universidade Luterana do BrasilCanoas 92425-900Rio Grande do SulBrazil Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil

BACKGROUND Hepatitis C virus(HCV)infection is a public health concern *** factors,including genetic polymorphisms,may be evolved in the progression of HCV infection to liver *** lambdas(IFNLs)modulate the immune response during viral *** induce antiviral activity,interfering in the viral replication by promoting the expression of several genes that regulate immunological *** interferon lambda-4(IFNL4)rs12979860 polymorphism,which is characterized by a C to T transition in intron 1,is associated with spontaneous and treatment-induced clearance of HCV infection and may play a role in the development of HCV-associated liver diseases,including hepatocellular carcinoma(HCC).AIM To investigate the association of IFNL4 rs12979860 polymorphism with fibrosis,cirrhosis,and HCC in patients with chronic HCV *** This study was comprised of 305 chronic HCV-infected patients(53 fibrosis,154 cirrhosis,and 98 HCC cases).The control group was comprised of 260 HCVnegative healthy *** IFNL4 rs12979860 polymorphism was genotyped using the TaqMan *** was diagnosed based on liver biopsy findings,while cirrhosis was diagnosed through clinical,laboratory,anatomopathological,and/or imaging *** was diagnosed through imaging tests,tumor,and/or anatomopathological *** The T allele was observed in the three groups of patients(fibrosis,cirrhosis,and HCC)at a significantly higher frequency when compared with the control group(P=0.047,P<0.001,and P=0.01,respectively).Also,genotype frequencies presented significant differences between the control group and cirrhosis patients(P<0.001)as well as HCC patients(P=0.002).The risk analysis was performed using the codominant and dominant T allele *** the codominant model,it was observed that the CT genotype showed an increased risk of developing cirrhosis in comparison with the CC genotype[odds ratio(OR)=2.53;95%confidence interval(CI):1.55-4.15;

关键词： Hepatitis C Hepatitis C virus Cirrhosis Hepatocellular carcinoma Genetic polymorphism Interferon-lambda

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

DNA直接导入植物细胞

生物工程进展 1991年第2期11卷 37-45页

作者： M.R.Davey E.L.rech B.j.Mulligan 王善平诺金汉大学植物系植物遗传工程组植物遗传工程组

现在已经有一系列体细胞技术和分子技术来补充常规的植物育种技术。外源基因的引入和表达现在被用于:调整植物生理和发育的一些基本过程;向植物引入商业上重要的性状如抗虫、抗除草剂等,插入一些在体细胞杂交时有用的可选择的显性标记... 详细信息

现在已经有一系列体细胞技术和分子技术来补充常规的植物育种技术。外源基因的引入和表达现在被用于:调整植物生理和发育的一些基本过程;向植物引入商业上重要的性状如抗虫、抗除草剂等,插入一些在体细胞杂交时有用的可选择的显性标记基因。一些DNA直接转移的技术已经建立,包括将DNA用化学法或电激法导入分离的原生质体中,及用注射和高速离子将DNA导入整个组织中。DNA直接转移法适用于稳定和瞬间基因表达研究,并且运用了各种各样的载体,包括那些用作基因克隆的载体。虽然用DNA直接转化法时稳定转化的频率相当低,但是它适用于那些对农杆菌转化无效的植物,尤其是单子叶植物。

关键词：脱氧核糖核酸植物细胞

第三组份端基对有机太阳能电池性能的影响（英文）

在线全文

学校读者我要写书评

暂无评论

物理化学学报 2019年第3期35卷 275-283页

作者：薛佩瑶张俊祥辛景明 rech j.romy 李腾飞孟凯鑫王嘉宇马伟尤为 MARDER Seth R. 韩平畴占肖卫北京大学工学院材料科学与工程系教育部高分子化学与物理重点实验室北京100871 美国佐治亚理工大学化学与生物化学学院有机光电中心西安交通大学金属材料强度国家重点实验室西安710049 美国北卡罗来纳大学教堂山分校化学系

我们用宽带隙聚合物FTAZ(苯并二噻吩-二氟苯并氮三唑共聚物)作为给体,窄带隙稠环电子受体FOIC(六噻吩稠环-氟代腈基茚酮类化合物)作为受体,中带隙稠环电子受体IDT-IC (引达醒-腈基茚酮类化合物)和IDT-NC (引达醒-腈基苯并茚酮类化合物)... 详细信息

我们用宽带隙聚合物FTAZ(苯并二噻吩-二氟苯并氮三唑共聚物)作为给体,窄带隙稠环电子受体FOIC(六噻吩稠环-氟代腈基茚酮类化合物)作为受体,中带隙稠环电子受体IDT-IC (引达醒-腈基茚酮类化合物)和IDT-NC (引达醒-腈基苯并茚酮类化合物)分别作为第三组分,制备了三元共混有机太阳能电池,研究了第三组分端基对器件性能的影响。IDT-IC和IDT-NC具有相似的化学结构,仅端基不同;IDT-IC端基是苯环,而IDT-NC端基是萘环。与IDT-IC相比,IDT-NC吸收光谱红移40nm,LUMO能级下移0.11 eV,电子迁移率提高50%。基于FTAZ:FOIC,FTAZ:IDT-IC,FTAZ:IDT-NC二元共混体系的有机太阳能电池效率分别为9.73%,7.48%,7.68%。FTAZ:FOIC:IDT-IC和FTAZ:FOIC:IDT-NC三元共混器件的效率分别提升到11.2%和10.4%。对于FTAZ:FOIC:IDT-IC三元共混器件,由于IDT-IC比FOIC具有更高的LUMO能级,开路电压(V_(OC))随着IDT-IC含量的增多而增加。由于IDT-IC与FOIC吸收光谱高度互补,短路电流(j.(SC))也显著提高。第三组份IDT-IC的加入改善了薄膜形貌和载流子传输,填充因子(FF)有所提高。对于FTAZ:FOIC:IDT-NC三元共混器件,由于IDT-NC比FOIC具有更高的LUMO能级,V_(OC)随着IDT-NC含量的增多而增加;但由于IDT-NC的LUMO能级比IDT-IC的LUMO能级低,其V_(OC)比FTAZ:FOIC:IDT-IC体系低。由于FOIC和IDT-NC吸收光谱高度重叠,j.(SC)降低。第三组份IDT-NC的加入改善了薄膜形貌和载流子传输,FF提高,甚至比FTAZ:FOIC:IDT-IC体系有更好的载流子传输和FF。

关键词：稠环电子受体非富勒烯受体有机太阳能电池端基效应三元共混

Cotonou(Benin)大学医院下肢慢性阻塞性动脉疾病与糖尿病患者的流行病学资料(法国)

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（心脏病学分册） 2005年第6期1卷 40-41页

作者： Houénassi M. Sacca-Véhounkpe j. Tchabi Y. 王永兴 Dr.U.Soins Enseignement rech./Cardiol. Faculte des Sciences de la Sante BP 188 Cotonou Bénin France

The aims of this study were to determine the prevalence of chronic obstructive arterial disease of the lower limbs and to identify the factors which contribute to its occurrence in a population of adult African francophone diabetics. This was a prospective study which included all consenting diabetics systematically over a 6 month period at the out patient clinic or during hospital admission. Patients with incomplete data were excluded. An ankle systolic pressure index of less than 0.9 was required for the diagnosis of obstructive arterial disease. Demographic parameters, the characteristics of the diabetes, the quality of blood sugar control, the presence of classical cardiovascular risk factors and the results of their treatment, the nature and distribution of the arterial lesions on ultrasonography were all studied. A univariate analysis and a multivariate analysis of their correspondences were undertaken to determine the correlation coefficients. The prevalence of arterial disease of the lower limbs in the 102 diabetics retained for the study(average age 53 years)was 33.3%. The arterial disease was distal in 47%of cases and diffuse in 26.5%of cases. The arterial wall was calcified in 19.6%of cases. In univariate analysis only age was correlated with arterial disease(p=0.04), the duration of diabetes tended to be related(p=0.07). In multi-factorial analysis of correspondences with other factors, hypertension, hyperlipidaemia and multiple cardiovascular risk factors seemed to be correlated with arterial disease of the lower limbs. Therefore, arterial disease of the lower limbs is very common and an early complication of diabetic patients in Benin. Predisposing factors were age and, probably, duration of diabetes, hypertension, hyperlipidaemia and multiple cardiovascular risk factors.

关键词： Benin Cotonou 动脉疾病大学医院动脉病多因素相关分析血管危险因素踝部收缩压动脉壁脂血症

在线全文

学校读者我要写书评

暂无评论

我何诊断Rosai-Dorfman病

诊断病理学杂志 2024年第3期31卷 263-263页

作者：吴罗燕(译) 刘谦(校) 江西省人民医院(南昌医学院第一附属医院)病理科南昌330006

过去认为,Rosai-Dorfman病(RDD)是一种良性自限性疾病。最近,越来越多研究发现在30%-50%RDD病例中出现MAPK/ERK通路突变,第五版《WHO淋巴造血系统肿瘤分类》和国际共识分类将其归入组织细胞肿瘤中。作者选取两个病例,从临床特征、形态... 详细信息

过去认为,Rosai-Dorfman病(RDD)是一种良性自限性疾病。最近,越来越多研究发现在30%-50%RDD病例中出现MAPK/ERK通路突变,第五版《WHO淋巴造血系统肿瘤分类》和国际共识分类将其归入组织细胞肿瘤中。作者选取两个病例,从临床特征、形态学、免疫组化、分子遗传学和鉴别诊断几个方面进行综合分析,最终给出RDD的病理诊断并总结如下:1、RDD可以发生在淋巴结内和结外部位;2、可以与其它肿瘤(淋巴瘤或组织细胞病变)以及自身免疫系统疾病共存;3、形态学上,RDD组织细胞核大、且呈圆形或卵圆形,核仁明显,胞浆丰富并吞噬炎症细胞(伸入现象);4、RDD细胞表达CD68、CD163(大部分病例)、S100、OCT2和cyclin D1,另外,涉及到鉴别诊断再加上CD1a、Langerin和ALK作为一组套餐使用。

关键词：炎症细胞细胞病变 CD1a 分子遗传学 CD163 病理诊断 CD68 免疫组化

肝细胞癌与胎儿肝脏中对表达抑制的基因的全面研究,dudulin-2mRNA的表达抑制可作为肝硬化发展至肿瘤过程中的一种可能标记

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（胃肠病学分册） 2005年第9期1卷 58-58页

作者： Coulouarn C. Derambure C. Lefebvre G. j.-P. Salier 陈云茹 Inserm Unité519 Inst. Federatif Rech. M. Fac. de Médecine-Pharmacie 22 Bvd Gambetta 76183 Rouen Cedex France

Background/Aims: Whether the transcriptional reprogramming process induced by hepatocellular carcinoma recapitulates that of the developing liver is at present unclear. Methods: With a complete coverage of the liver transcriptome by microarray using adult livers as controls, we searched for similarities and differences in mRNA abundances between hepatocellular carcinoma nodules and fetal livers taken before (early) or after (late) the 22-24th week of gestation. Changes in some mRNA levels were studied in further liver samples by quantitative RT-PCR. Results: Altered gene expression in hepatocellular carcinoma mostly results in down-regulated mRNAs which largely overlap with those repressed in the late fetal liver. Different frequencies of transcription factor binding sites in the down-regulated genes vs control genes as well as changes in abundance of mRNAs for relevant transcription factors point to a transcriptional repression. The down-regulated mRNAs code for proteins involved in (i) transcription and translation, (ii) specific functions of the differentiated hepatocyte or (iii) activation of proliferation and apoptosis. Conclusions: Apoptosis limitation is likely to predominate over active proliferation during liver development and hepatocellular carcinoma. Repression of the apoptosis-associated dudulin-2 mRNA points to a potential marker for the transition from a carcinoma-free to carcinoma-associated cirrhosis.

关键词：肝细胞癌 dudulin-2mRNA 基因表达抑制人肝细胞下调基因癌性基因转录本癌结节用成微阵列技术