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Evaluation of febrile neutropenic patients hospitalized in a hematology clinic

Asian Pacific Journal of Tropical Biomedicine 2015年第12期5卷 1051-1054页

作者： Mucahit Goruk Mehmet Sinan Dal Tuba Dal Abdullah Karakus recep tekin Nida Ozcan Orhan Ayyildiz Department of Internal Medicine Dicle University School of Medicine Department of Medical Microbiology Yildirim Beyazit University School of Medicine Department of Clinical Microbiology and Infectious Diseases Dicle University School of Medicine Department of Medical Microbiology Dicle University School of Medicine

Objective:To evaluate the febrile neutropenic patients with hematological malignancies hospitalized in hematology clinic with poor hygiene ***:A total of 124 patients with hematological malignancies(69 male,55 female)hospitalized in hematology clinic with poor hygiene conditions depending on hospital conditions,between January 2007 and December 2010,were evaluated,***:In this study,250 febrile neutropenia episodes developing in 124 hospitalized patients were *** the patients,69 were men(56%)and 55 women(44%).A total of 40 patients(32%)had acute myeloid leukemia,25(20%)acute lymphoblastic leukemia,19(15%)non-Hodgkin's lymphoma,10(8%)multiple myeloma,and 8(8%)chronic myeloid *** our study,56 patients(22%)were diagnosed as pneumonia,38(15%)invasive aspergillosis,38(15%)sepsis,16(6%)typhlitis,9(4%)mucormycosis,and 4(2%)urinary tract ***-positive cocci were isolated from 52%(n=20),while Gram-negative bacilli 42%(n=16)and yeasts from 6%(n=2)of the sepsis patients,*** most frequently isolated Gram-positive bacteria were methicillin-resistant coagulase-negative staphylococci(n=18),while the most frequently isolated Gram-negative bacteria was Escherichia coli(n=10).Conclusions:Febrile neutropenia is still a problem in patients with hematological *** documentation of the flora and detection of causative agents of infections in each unit would help to decide appropriate empirical *** control procedures should be applied for preventing infections and transmissions.

关键词： Febrile neutropenia Hematological malignancy Leuke Multiple myeloma Infections

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Molecular epidemiology of HIV-1 strains in the south-east and east of Turkey

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Asian Pacific Journal of Tropical Biomedicine 2015年第9期5卷 743-747页

作者： Mustafa Kemal elen Murat Sayan Tuba Dal Celal Ayaz Alicem tekin Tuncer zekinci Suda tekin Koruk Tunga Barcin recep tekin Mehmet Sinan Dal Sevgi Kalkanl Dicle University Clinical Laboratory Kocaeli University Research Center of Experimental Health Sciences Near East University Yildirim Beyazit University Harran University Kiziltepe State Hospital Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

Objective:To detect the subtype characterization and drug-resistant mutations in HIV-1 strains after the refugee movement from Syria to Turkey between 2011 and 2014 in south east border lines. Methods: A total of 65 patients were included in this study, of which 57(88%) patients were antiretroviral therapy-naive patients. HIV-1 RNA was detected and quantii ed by realtime PCR assay. HIV-1 subtypes and circulating recombinant forms(CRFs) were identii ed by phylogenetic analysis(neighbor-joining method), and drug-resistant mutations were ***: Three major HIV groups were indicated. Two of these groups were located in subtype B. The other group showed heterogeneity. Subtype B(48/65, 73.8%), followed by CRFs(12/65, 18.5%) was the most common strain. Subtype of CRFs consisted of CRF01_AE(9/65, 13.8%) and CRF02_AG(3/65, 4.6%). Subtype C(1/65, 1.5%), sub-subtypes A1(2/65, 3.1%) and F1(2/65, 3.1%) were also detected with low prevalence. The rate of overall primary antiretroviral resistance was 4.9%(3/61). Drug-resistant rate for non-nucleoside reverse transcriptase inhibitors was 4.9%. The thymidine analogue mutation rate was 13.1%(8/61).Conclusions: HIV molecular epidemiology studies are necessary to determine transmission patterns and spread. Subtype B and CRF01_AE, CRF02_AG are the most prevalent strains in the south-east of Turkey. However, subtype C, sub-subtypes A1 and F1 are of low prevalence but persist in the south-east of Turkey. In the near future, changing of HIV epidemiology will be possible in Turkey due to migration movement in border lines and resistance testing will play an important role in HIV management.

关键词： HIV-1 Turkey Molecular epidemiology Refugee

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