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一项关于“视锥细胞营养不良疾病中视杆细胞eRG超常反应”的表型研究

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世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 44-45页

作者： Michaelides M. Holder G.e. Webster A.R. A.t. moore 王海燕 Institute of Ophthalmology University College London 11-43 Bath Street London EC1V 9EL United Kingdom Prof.

Aims: to characterise the detailed phenotype of “cone dystrophy with supernor mal rod eRG”in a case series of 10 patients. Methods: 10 affected patients were examined clinically and underwent colour fundus photography, with nine undergoi ng detailed electrophysiological testing. Five patients were assessed further wi th fundus autofluorescence (AF)imaging, automated photopic and dark adapted peri metry, and dark adaptometry. Detailed colour vision assessment was performed in six subjects. Blood samples were taken from four patients for DNA extraction and mutation screening of NR2e3was undertaken. Results: the onset of symptoms was i n the first and second decades of life. Subjects presented with reduced central vision and marked photophobia. All individuals were myopic and colour vision tes ting revealed severely reduced colour discrimination predominantly along the red -green axes; tritan colour vision was relatively well preserved. Nyctalopia is a later feature of the disorder. Funduscopy and AF imaging revealed a range of m acular appearances. there was electrophysiological evidence of marked macular dy sfunction, reduced and delayed cone responses, and supernormal and delayed rod r esponses. Photopic and dark adapted perimetry revealed central scotomata with wi despread peripheral sensitivity loss. No disease causing sequence variants in NR 2e3 were identified. Conclusions: the largest case series to date has been descr ibed of the clinical, psychophysical and electrophysiological characteristics of this unusual cone dystrophy with supernormal rod responses. electrophysiologica l data were consistent with a post-phototransduction, but pre-inner nuclear la yer, site of dysfunction. While the definitive diagnosis can only be made with e lectrophysiological testing, several characteristics that may increase suspicion of this diagnosis are presented.

关键词：视杆细胞 eRG 中心视力自发荧光色觉检查暗适应计黄斑部内核层眼底照相视野计

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 29-30页

作者： Michaelides M. Holder G.e. Hunt D.M. A.t. moore 王海燕 Institute of Ophthalmology University College London 11- 43 Bath Street London EC1V 9EL United Kingdom

Aim: to characterise the phenotype of an autosomal dominant cone-rod dystrophy (CORD7) associated with the Arg844His mutation in RIM1. Methods: eight members of a four generation, non-consanguineous British family were examined clinically and underwent electrophysiological testing, automated dark adapted perimetry, dark adaptometry, colour vision assessment, colour fundus photography, fundus fluorescein angiography (FFA), and fundus autofluorescence (AF) imaging. Results: the majority of affected individuals described a progressive deterioration of central vision, night vision, and peripheral visual field usually between the third and fourth decades. the visual acuity ranged from 6/6 to3/60. Colour vision testing showed mild to moderate dyschromatopsia in the majority of individuals. Fundus changes comprised a range of macular appearances varying from mild retinal pigment epithelial (RPe) disturbance to extensive atrophy and pigmentation. In some individuals retinal vessels were attenuated and in two subjects peripheral areas of retinal atrophy were present. An absent or severely reduced PeRG was detected in all subjects, indicative of marked macular dysfunction. Full field eRG showed abnormal rod and cone responses. AF imaging revealed decreased macular AF centrally surrounded by a ring of increased AF in the majority of individuals. “ Bull’ s eye” lesions were present in two individuals, comprising of a ring of decreased perifoveal AF bordered peripherally and centrally by increased AF. Photopic sensitivity testing demonstrated elevated central visual field thresholds with additional superior greater than inferior peripheral field loss. there were rod and cone sensitivity reductions in the central and peripheral visual fields, with the inferior retina being more affected than the superior. Conclusions: the detailed phenotype is described of the autosomal dominant cone-red dystrophy, CORD7, which is associated with a point mutation in RIM1, a gene encoding a photor

关键词：视杆细胞 CORD7 RIM1 基因突变表现型视锥视网膜色素上皮中心视力视野缩小视野损害

Comparison ofalternative oxidaseactivitiesbetween trypanosoma brucei,Sauromatumguttatum and Arabidopsis thaliana

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Comparison ofalternative oxidaseactivitiesbetween Trypanosom...

2018全国植物生物学大会

作者： Fei Xu Anthony L.moore Applied Biotechnology Center Wuhan Institute of Bioengineering School of Life Sciences University of Sussex

the alternative oxidase(AOX) is a non-protonmotiveubiquinol oxidase which mediates the cyanide-resistant respiration and catalyzes the reduction of O to H O(moore et al.,2013).AOX does not contribute to energy conservation and therefore has caused much debate about its function inliving ***,a broad distribution of the AOX has been found in protists,fungi,microsporidian parasites and animals(Williams et al.,2010).Interestingly,it should be noted that the respiratory activity of the blood parasite trypanosoma brucei relies solely on the AOX(also named as tAO),while in thermogenic plants(e.g.,Sauromatumguttatum),SgAOX is responsible for heat *** non-thermogenic species(e.g.,Arabidopsis thaliana),AtAOXs play important roles in energy homeostasis and protection against oxidative ***,the activities of AOXs are varied,although the amino acids surrounding the quinol binding site are extremely well ***,it is important to understand what factors affect the activities of AOXs?Recently,the tAO,SgAOX and AtAOX1 a were expressed in the ***(FN102 heme-deficient strain) and the activities were compared with different *** showed that tAO has the highest affinity forubquinol,followed by the AtAOXlaand the *** kinetics of ubiquinol-1 oxidation by purified tAO,SgAOX and AtAOXla showed that Vof these proteins were 340,21 and 64 μmol QH minmg protein,***,SgAOX and AtAOX1 a exhibited 1.5-fold and 6-fold increase in the activity following the addition of 10 mM *** activity of AtAOXla was also improved by 5 mMglyoxylate(6-fold) and 10 mM oxaloacetate(3.5-fold).Additionally,the inhibitory efficacy by different compounds(AF,AC,CB,CD,n-OG and SHAM) showed that AF was the best inhibitor for tAO,whereas CB was the most effective inhibitor against SgAOX and *** exhibited lowest inhibitory efficacy against tAO,SgAOX and *** findings indicate that the metabolic flexibility that t

关键词： alternative oxidase enzyme kinetics protein purification

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拉萨世居藏族青年的最大氧摄取和氧转运功能

中国应用生理学杂志 1993年第2期9卷 116-120页

作者：孙新甫庄建国扎西卓玛黄肇荣 R.G.McCullough R.e.McCullough C.S.Reeves J.t.Reeves L.G.moore. 西藏医学科学研究所拉萨850000 中国科学院上海生理研究所美国科罗拉多大学医学院心血管肺研究室

对拉萨市(海拔3658m)16名世居藏族和20名已习服的移居汉族健康青年男性的最大氧摄取、最大运动负荷及其影响因素进行了对此研究。结果发现在最大努力作功时,藏族的最大氧摄取量、最大运动负荷量、潮气量、肺通气量以及氧脉搏等均大于移... 详细信息

对拉萨市(海拔3658m)16名世居藏族和20名已习服的移居汉族健康青年男性的最大氧摄取、最大运动负荷及其影响因素进行了对此研究。结果发现在最大努力作功时,藏族的最大氧摄取量、最大运动负荷量、潮气量、肺通气量以及氧脉搏等均大于移居汉族。说明西藏高原世居藏族具有更佳的氧转运功能,对高原低氧已获得了良好的生理适应。

关键词：低氧氧摄取运动试验藏族

羊膜移植治疗继发于LOC综合征的眼表瘢痕患者的随访研究

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世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 20-21页

作者： moore J.e. Shah S. KumarV. 桑延智 Department of Ophthalmology Roy al Victoria Hospital Grosvenor Road Belfast BT12 6BA United Kingdom

Aims: to document and discuss the long term outcome of a new ophthalm ic treatment for laryngo-onycho-cutaneous (LOC)-syndrome. Methods: two children were treated by excision of ocular gran ulation tissue and ocular surface rehabilitation with frozen amniotic membrane ( AM). the clinical course of both patients was followed and documented at 2 years and 4 years following the surgery. Results: Patient 1 demonstrated limited recu rrence of granulation tissue at 10 months. After 36 months, re-growth of granul ation and scar tissue required a further three subsequent operations to the righ t eye in an attempt to keep the optical axis clear. 4 years postoperatively, nei ther eye has a clear visual axis. In contrast similar surgery for the right eye of patient 2 has been highly successful, with only very limited nonprogressive r ecurrence after 2 years of followup. the operation to the left eye has been simi larly effective although the followup is only 6 months. Conclusions: Ocular surf ace rehabilitation with AM is the first partially effective treatment for the ey e complications of LOC syndrome. the surprising benefit from AM may stem from th e primary pathology of the condition. LOC syndrome is caused by a genetic defect resulting in an unusual N-terminal deletion of the α3a chain of the basement membrane protein laminin 5. One mechanism through which AM transplantation may a ct to reduce ocular scarring in this disease is to supplement the abnormal secre ted laminin 5 with healthy transplanted laminin. Despite its initial efficacy on e episode of AM treatment does not guarantee long term control of the scarring p rocess and variations in AM graft efficacy may be related to other complicating factors such as limbal stem cell deficiency or severity of the initial scarring process.

关键词：羊膜移植治疗 LOC 随访研究眼表重建瘢痕化角膜缘干细胞眼科治疗视轴非进行性层黏连蛋白

温度压力孔隙压力对断层泥强度及滑动性质的影响

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地震地质 1985年第1期 15-24页

作者：马瑾,D.e.moore,R.Summers,J.D.Byerlee 国家地震局地质研究所美国内务部地质调查所美国内务部地质调查所美国内务部地质调查所

在不同的压力、温度和孔隙压力下进行了含四种不同断层泥标本的强度试验。碎屑型断层泥对压力很敏感,对温度无反应,对孔隙压力的反应符合有效应力律。粘土类断层泥则对温度和孔隙压力有明显响应。这些力学性质的差别反映了具体变形机制... 详细信息

在不同的压力、温度和孔隙压力下进行了含四种不同断层泥标本的强度试验。碎屑型断层泥对压力很敏感,对温度无反应,对孔隙压力的反应符合有效应力律。粘土类断层泥则对温度和孔隙压力有明显响应。这些力学性质的差别反映了具体变形机制的差别。

关键词：断层泥粘土类围压蛇纹石层状硅酸盐矿物孔隙压力

Sodium Diffuses from Glass Substrates through P1 Lines and Passivates Defects in Perovskite Solar Modules

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energy & environmental Materials 2023年第6期6卷 393-401页

作者： Felix Utama Kosasih Francesco Di Giacomo Jordi Ferrer Orri Kexue Li elizabeth M.tennyson Weiwei Li Fabio Matteocci Gunnar Kusch Narges Yaghoobi Nia Rachel A.Oliver Judith L.MacManus-Driscoll Katie L.moore Samuel D.Stranks Aldo Di Carlo Giorgio Divitini Caterina Ducati Department of Materials Science and Metallurgy University of Cambridge27 Charles Babbage RoadCambridge CB30FSUK Centre for Hybrid and Organic Solar energy(CHOSe) Department of Electronic EngineeringUniversity of Rome Tor VergataRome 00133Italy Cavendish Laboratory University of CambridgeJJ Thomson AvenueCambridge CB30HEUK Department of Materials and Photon Science Institute University of ManchesterOxford RoadManchester M139PLUK Department of Chemical engineering and Biotechnology University of CambridgePhilippa Fawcett DriveCambridge CB30ASUK Laboratory for Advanced Solar energy(LASe) National University of Science and Technology MISiSLeninskiy Prospekt 4Moscow 119049Russia energy Research Institute@NtU Nanyang Technological University50 Nanyang DriveSingapore 637553Singapore MIIt Key Laboratory of Aerospace Information Materials and Physics College of PhysicsNanjing University of Aeronautics and AstronauticsNanjing 211106China Istituto di Struttura della Materia-CNR(ISM-CNR) Via del Fosso del Cavaliere 100Rome 00133Italy electron Spectroscopy and Nanoscopy Istituto Italiano di TecnologiaVia Morego 30Genova 16163Italy

Most thin-film photovoltaic modules are constructed on soda-lime glass(SLG)substrates containing alkali oxides,such as Na_(2)*** may diffuse from SLG into a module's active layers through P1 lines,an area between a module's constituent cells where the substrate-side charge transport layer(CtL)is in direct contact with *** diffusion from SLG is known to cause several important effects inⅡ-Ⅵand chalcogenide solar modules,but it has not been studied in perovskite solar modules(PSMs).In this work,we use complementary microscopy and spectroscopy techniques to show that Na diffusion occurs in the fabrication process of *** diffuses vertically inside P1 lines and then laterally from P1 lines into the active area for up to 360 *** propose that this process is driven by the high temperatures the devices are exposed to during CtL and perovskite *** diffused Na preferentially binds with Br,forming Br-poor,l-rich perovskite and a species rich in Na and Br(Na-Br)close to P1 ***-Br passivates defect sites,reducing non-radiative recombination in the perovskite and boosting its luminescence by up to 5×.Na-Br is observed to be stable after 12 weeks of device storage,suggesting long-lasting effects of Na *** results not only point to a potential avenue to increase PSM performance but also highlight the possibility of unabated Na diffusion throughout a module's lifetime,especially if accelerated by the electric field and elevated temperatures achievable during device operation.

关键词： defect passivation monolithic interconnection perovskite solar modules soda-lime glass sodium diffusion solar cells thin-film photovoltaics

重度非典型增生患者环形电刀锥形活检阴性的临床意义

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世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 34-35页

作者： Livasy C.A. moore D.t. Van Le L. 张丽娟 Dept. of Pathol. and Lab. M edicine University of North Carolina Brinkhous-Bullitt Building Chapel Hill NC 27599-7525 United States Dr.

OBJeCtIVe: We sought to estimate the incidence and clinical significance of a negative therapeutic loop electrosurgical excision procedure (LeeP) and to evalu ate patient specimens for limiting histologic features associated with a negativ e LeeP. MetHODS: We identified 674 patients with biopsy-confirmed high-grade c ervical dysplasia who were treated with LeeP from 1991 through 2001. the results of these LeeP procedures were reviewed for the absence of dysplasia or the pres ence of cervical intraepithelial neoplasia stages 1-3. Computerized pathology f iles of patients were then reviewed through July 2002 to determine whether dyspl asia recurred. Slides of negative LeeP specimens were reviewed to confirm the ab sence of dysplasia and to search for histologic features that may have limited o ur interpretation of the specimen. ReSULtS: Ninety-three (14%)of LeeP specimen s reviewed were completely negative for dysplasia. Clinical follow-up was avail able on 75 of the 93 patients, with a median follow-up time of 2 years. eightee n (24%) patients had subsequent positive follow-up, including carcinoma (n = 2 ), high-grade squamous intraepithelial lesions (n = 8), low-grade squamous int raepithelial lesion (n = 6), and atypical squamous cells of undetermined signifi cance (n = 2). Patients with negative LeePs had a recurrence rate similar to pat ients with positive LeePs (24%versus 27%). Limiting histologic features were m ore commonly identified in negative LeePs as compared with LeePs containing dysplasia (16% versus 5%, P egative LeeP is not an uncommon finding, o ccurring in 14%(95%confidence interval 11-17%) of specimens at our instituti on. Negative LeePs are more likely to contain histologic features that limit pat hology interpretation. A negative LeeP is not a reassuring finding and was assoc iated with a recurrence rate similar to those of a positive LeeP. Both negative and positive populations should be carefully followed.

关键词：非典型增生锥形活检鳞状上皮内病变病理学资料组织学特征临床随访资料复发率评估治疗

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亚临床右室功能异常与肥胖的相关性研究

世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 60-61页

作者： Wong C.Y. O'moore- Sullivan t. Leano R. t.H. Marwick 张宪伟 University of Queensland Department of Medicine Princess Alexandra Hospital Ipswich Road Brisbane QLD 4102 Australia Dr.

OBJeCtIVeS: the purpose of this research was to identify the determinants of right ventricular(RV) dysfunction in overweight and obese subjects. BACKGROUND: Right ventricular dysfunction in obese subjects is usually ascribed to comorbid diseases, especially obstructive sleep apnea. We used tissue Doppler imaging to identify the determinants of RV dysfunction in overweight and obese subjects. MetHODS: Standard and tissue Doppler echocardiography was performed in 112 overweight(body mass index [BMI] 25 to 29.9 kg/m2) or obese(BMI >30 kg/m2) subjects and 36 referents(BMIth obstructive sleep apnea but no obesity. tissue Doppler was used to measure RV systolic(sm) and diastolic(em) velocities and strain indexes. ReSULtS: Obese subjects with BMI >35 kg/m2 had reduced RV function compared with referent subjects, evidenced by reduced sm(6.5± 2.4 cm/s vs. 10.2± 1.5 cm/s, peak strain(- 21± 4% vs.- 28± 4% , peak strain rate(- 1.4± 0.4 s- 1 vs.- 2.0± 0.5 s- 1, pem(- 6.8± 2.4 cm/s vs.- 10.3± 2.5 cm/s, pespective of the presence of sleep apnea. Similar but lesser degrees of reduced systolic function(pere present in overweight(BMI 25 to 29.9 kg/m2) and mildly obese(BMI 30 to 35 kg/m2) groups. Differences in RV em, sm, and strain indexes were demonstrated between the severely versus overweight and mildly obese groups(pex remained independently related to RV changes after adjusting for age, log insulin, and mean arterial pressures. In obese patients, these changes were associated with reduced exercise capacity but not the duration of obesity and presence of sleep apnea or its severity. CONCLUSIONS: Increasing BMI is associated with increasing severity of RV dysfunction in overweight and obese subjects without overt heart disease, independent of sleep apnea.

关键词：功能异常肥胖者阻塞性睡眠呼吸暂停右室亚临床组织多普勒超声心动图检查体重指数受试者应变率