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Vitamin and Osidic Composition of Table Sugars from the Inflorescences Sap of 03 Coconut Cultivars (<i>Cocos nucifera</i>L.) in Ivory Coast

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Food and Nutrition Sciences 2020年第12期11卷 1117-1126页

作者： D. Muriel j. Okoma K. jean Louis Konan rebecca R. Assa Marc Delorme Research Station for Coconut National Centre of Agronomic Research (CNRA) Abidjan C&#244 te d’Ivoire Laboratory of Biochemistry and Food Sciences UFR Biosciences University Felix Houphou&#235 t Boigny Abidjan C&#244 te d’Ivoire

In order to revalorize the nucicultural sector in Ivory Coast, initiatives have been taken to diversify the uses of coconut through the production of sugar from its inflorescences. Four water-soluble vitamins have been determined in the crystalline sugar of coconuts. These are vitamins C, B1, B2 and B6. On the other hand, no vitamin was identified in cane sugars. Vitamin C is the most abundant in coconut sugar. The oses contained in coconut sugar are saccharose, glucose and fructose. Sucrose is the main constituent of coconut crystal sugar. Thanks to their sweetening power close to saccharose, the coconut sugars produced can be used as sweetening ingredients in pastries, confectionery, drinks and culinary preparations. Their richness in vitamin C makes them a food that can stimulate the body’s natural and immune defences.

关键词： Coconut Sugar Vitamins Oses

Transjugular Intrahepatic Portosystemic Shunt Linked to Increased Risk of Hepatocellular Carcinoma:A VA Matched Cohort Study

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journal of Clinical and Translational Hepatology 2024年第5期12卷 534-538页

作者： Shalini Bansal Tamar Taddei rebecca Wells Marina Serper Theresa Bittermann Nadim Mahmud David E.Kaplan Sidney Kimmel Medical College at Thomas jefferson University PhiladelphiaPAUSA Division of Gastroenterology and Hepatology Perelman School of Medicine University of PennsylvaniaPhiladelphiaPAUSA Corporal Michael j.Crescenz VA Medical Center PhiladelphiaPAUSA Division of Gastroenterology and Hepatology Yale University School of MedicineNew HavenCTUSA VA Connecticut Healthcare System West HavenCTUSA

Hepatocellular carcinoma(HCC)is the most common primary tumor of the liver and often evolves from regenerating nodules in liver *** there have been significant advances in the treatment of HCC,the overall prognosis in patients with a large tumor burden,vascular invasion,or extrahepatic spread remains poor.1 The magnitude of liver stiffness in cirrhosis has been consistently associated with an increased risk of development of HCC.

关键词： Carcinoma invasion cirrhosis

Changing the paradigm：the potential for targeted therapy in laryngeal squamous cell carcinoma

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Cancer Biology & Medicine 2016年第1期13卷 87-100页

作者： Megan L.Ludwig Andrew C.Birkeland rebecca Hoesli Paul Swiecicki Matthew E.Spector j.Chad Brenner Department of Otolaryngology Head and Neck SurgeryUniversity of Michigan Medical SchoolAnn ArborMI 48109USA Cellular and Molecular Biology Program University of MichiqanAnn ArborMI 48109USA Department of Hematology Oncology University of Michigan Medical SchoolAnn ArborMI 48109USA Comprehensive Cancer Center University of Michigan Medical SchoolAnn ArborMI 48109USA

Laryngeal squamous cell carcinoma(LSCC) remains a highly morbid and fatal disease. Historically, it has been a model example for organ preservation and treatment stratification paradigms. Unfortunately, survival for LSCC has stagnated over the past few decades. As the era of next-generation sequencing and personalized treatment for cancer approaches, LSCC may be an ideal disease for consideration of further treatment stratification and personalization. Here, we will discuss the important history of LSCC as a model system for organ preservation, unique and potentially targetable genetic signatures of LSCC, and methods for bringing stratified, personalized treatment strategies to the 21^(st) century.

关键词： Head and neck cancer laryngeal squamous cell carcinoma genetics targeted therapy personalized medicine

Intracranial pressure is elevated at 24h post-stroke inmice

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Neuroprotection 2024年第1期2卷 60-64页

作者： Kirby E.Warren rebecca j.Hood Fredrick R.Walker Neil j.Spratt School of Biomedical Sciences and Pharmacy University of NewcastleCallaghanAustralia Hunter Medical Research Institute NewLambton HeightsAustralia School of Biomedicine Discipline of Anatomy and PathologyFaculty of Health and Medical SciencesThe University of AdelaideAdelaideAustralia Department of Neurology John Hunter HospitalNewLambton HeightsAustralia

Background:It has long been assumed that post-stroke intracranial pressure(ICP)elevation occurs because of large infarct and edema ***,we have repeatedly shown IcP elevation at 24 h post-stroke in the presence of little to no edema in *** processes are often conserved across species and types of ***,we aimed to determine if an ICP rise occurs at 24 h post-stroke in the presence of small infarct and edema volumes in ***:Mice were randomized by random number table to either photothrombotic stroke or sham surgery(n=15).Epidural ICP was recorded using a fiber optic catheter at 1 h post-stroke(baseline)and between 23 and ***:ICP was significantly higher at 24 h compared to baseline in stroke animals(n=6;10.71±6.45mmHg vs.3.74±2.20mmHg,respec-tively;p=0.03).ICP at 24 h was also significantly higher in stroke mice compared to sham(n=6;3.45±1.43mmHg;p=0.02).There was no change in ICP in sham mice(p=0.9).Edema volumes in stroke animals were small(0.04±0.04 mm3)and unlikely to have caused significant ICP ***:This study provides evidence of an edema-independent ICP elevation following small ischemic stroke in *** occurrence of this rise supports our findings in other species and suggests it is caused by a previously undescribed mechanism.

关键词： cerebraledema intracranial pressure ischemic stroke

Optimization of high throughput spectral flow cytometry for immune cell profiling in mouse liver

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Liver Research 2023年第3期7卷 263-271页

作者： Grayson W.Way Hongkun Lu Xuan Wang Derrick Zhao Carmen Camarena Devanand Sarkar rebecca K.Martin Huiping Zhou C.Kenneth and Dianne Wright Center for Clinical and Translational Research Virginia Commonwealth UniversityRichmondVAUSA Department of Microbiology and Immunology Virginia Commonwealth University School of MedicineRichmondVAUSA Department of Human and Molecular Genetics Massey Cancer CenterVCU Institute of Molecular Medicine(VIMM)Virginia Commonwealth UniversityRichmondVAUSA Massey Cancer Center Virginia Commonwealth UniversityRichmondVAUSA VCU Institute of Molecular Medicine Virginia Commonwealth UniversityRichmondVAUSA Central Virginia Veterans Healthcare System RichmondVAUSA

The liver plays an important role in both metabolism and *** of the hepatic immune microenvironment is closely associated with various liver *** gain a better understanding of how different types of immune cells contribute to the progression of liver diseases,it is crucial to thoroughly characterize hepatic immune *** direct digestion of liver tissue is a relatively simple method for isolating immune cells,it often induces excessive hepatocyte death,which causes a release of intracellular components that leads to the activation of stress responses and injury in the surrounding *** injury can lead to excessive death in the hepatic immune cells,making isolation and accurate characterization of the immune profile challenging,especially in diseased *** method described here addresses these challenges by utilizing Phosphate buffered saline(PBS)and digestion buffer perfusions to eliminate contaminating blood cells,ensure a pure hepatic immune population,and minimize hepatic immune cell *** ex vivo digestion of the liver enables the isolation of the immune cells from the hepatic tissues and the generation of a single-cell suspension that can be stained for spectral flow *** enhance intracellular cytokine detection and maintain signaling under different physiological and pathological conditions,this protocol uses an in vivo administration of Brefeldin A,a less toxic inhibitor of cytokine *** in vivo administration of Brefeldin A allows for a more accurate representation of the immune cell function and cytokine expression compared to the traditionally used ex vivo Brefeldin A administration.A comprehensive spectral flow cytometry panel,comprising extracellular and intracellular staining,is used for deep immunophenotyping and immune cell effector function *** this protocol is specifically designed for liver digestion of Mdr2 knockout mice(a model for primary sclerosing cholangitis)and f

关键词： metabolism flow utilizing

Maintenance therapy in advanced non-small cell lung cancer： a prime-time for change？

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Chinese Medical journal 2013年第12期126卷 2390-2398页

作者： Oscar Siu Hong Chan rebecca Mei WanYeung Anne Wing Mui Lee Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital Hong Kong China

Lung cancer is the leading cancer in terms of incidence and mortality in China and its incidence in China is predicted to increase in the next 20 years.1 The majority of the lung cancer patients are diagnosed with advanced stage disease,for which chemotherapy or targeted therapies are the mainstay palliative *** the identification of single-driver mutations,like the epidermal growth factor receptor （EGFR） mutation,platinum-based doublet was the standard first line treatment for advanced stage nonsmall cell lung cancer （NSCLC） patients with a good performance status （PS）.However,patient prognosis remains poor and the modest treatment efficacy seems to have reached a plateau despite newer generation of platinum doublets.2 The recommendation for the duration of first line platinum doublet treatment is 4-6 cycles.3 The paradigm was based on the fact that a protracted course of chemotherapy did not prolong survival but introduced cumulative toxicities.4,5 The use of maintenance therapy （MT）,defined by Grossi et al6 as the prolongation of chemotherapy with the administration of additional drugs at the end of a defined number of initial chemotherapy cycles after achieving maximum tumor response,was not considered as a standard option in the past.

关键词： non-small cell lung cancer chemotherapy maintenance therapy

Manipulation of photosensory and circadian signaling restricts phenotypic plasticity in response to changing environmental conditions in Arabidopsis

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Molecular Plant 2024年第9期17卷 1458-1471页

作者： Martin William Battle Scott Fraser Ewing Cathryn Dickson joseph Obaje Kristen N.Edgeworth rebecca Bindbeutel Rea LAntoniou-Kourounioti Dmitri A.Nusinow Matthew Alan jones Plant Science Group School of Molecular BiosciencesUniversity of GlasgowGlasgow G128QQUK Danforth Plant Science Center St.LouisMO 63132USA Department of Biological and Biomedical Sciences Washington University in St.LouisSt.LouisMO 63130USA Present address:School of Biological and Environmental Sciences Liverpool John Moores UniversityLiverpool L22QPUK

Plants exploit phenotypic plasticity to adapt their growth and development to prevailing environmental *** of light and temperature signals is aided by the circadian system,which provides a temporal *** plasticity provides a selective and competitive advantage in nature but is obstructive during large-scale,intensive agricultural practices since economically important traits(including vegetative growth and flowering time)can vary widely depending on local environmental *** prevents accurate prediction of harvesting times and produces a variable *** this study,we sought to restrict phenotypic plasticity and circadian regulation by manipulating signaling systems that govern plants'responses to environmental *** modeling of plant growth and develop-ment predicted reduced plant responses to changing environments when circadian and light signaling pathways were *** tested this prediction by utilizing a constitutively active allele of the plant photoreceptor phytochrome B,along with disruption of the circadian systemvia mutation of *** found that these manipulations produced plants that are less responsive to light and temper-ature cues and thus fail to anticipate *** engineered plants have uniform vegetative growth and flowering time,demonstrating how phenotypic plasticity can be limited while maintaining plant *** has significant implications for future agriculture in both open fields and controlled environments.

关键词： circadian developmental plasticity phenotypic plasticity external coincidence light temperature

The Cellulolytic Bacteria <i>R. albus</i>for Improving the Efficiency of Microbial Fuel Cell

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journal of Sustainable Bioenergy Systems 2018年第2期8卷 36-46页

作者： rebecca Chung Diane j. Moon Yoo Na Chang David S. Chung Taekwon Kong justin Kim Centreville High School Clifton VA USA The Gwinnett School of Mathematics Science and Technology Lawrenceville GA USA Korean Minjok Leadership Academy Gangwon-do Korea School of Arts and Sciences Brown University Providence RI USA Department of Chemistry College of Arts & Sciences Washington University St. Louis MO USA School of Art & Sciences University of Pennsylvania Philadelphia PA USA

The current study has been undertaken to examine the beneficial effect in the power output of a microbial fuel cell (MFC) by adding cellulolytic bacteria Ruminococcus albus (R. albus) into the anodic chamber. Mediator-less H-type MFCs were set up where the anode chamber contained anaerobic digester microorganisms as inocula on finely ground pine tree (Avicel) at 2% (w/v) and the cathode chamber of 10mM phosphate buffered saline conductive solution, both separated by a cation exchange membrane. The functioning of the MFCs for generation of electrical power and the amounts of gaseous byproducts was monitored over a 9-day period. The addition of cellulolytic bacteria caused an increase of average power density from 7.9 m W/m2 to19.5 m W/m2, about 245% increase over a 9-day period. For both groups of MFCs;with R. albus and the control, the head space gases collected were methane and CO2. While the methane: CO2 ratios were found unchanged at 1.7:1 throughout the 9 days of operation, the total gas production increased from 248 mL to 319 mL due to the presence of R. albus addition. This study confirms that whereas the biocatalytic activity of anode microbial population determines the energy production, the addition of external cellulolytic bacteria into anode microbial population can improve and extend the biomass utilization.

关键词： Microbial Fuel Cell (MFC) Cellulolytic Bacteria Microorganism R. albus

Treatment of a mouse model of collagen antibody-induced arthritis with human adipose-derived secretions

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Open journal of Regenerative Medicine 2013年第3期2卷 80-91页

作者： Sinead P. Blaber rebecca A. Webster Edmond j. Breen Graham Vesey Benjamin R. Herbert Australian Proteome Analysis Facility Macquarie University North Ryde Australia Department of Chemistry and Biomolecular Sciences Macquarie University North Ryde Australia&Regeneus Ltd. Gordon Australia Department of Chemistry and Biomolecular Sciences Macquarie University North Ryde Australia &Regeneus Ltd. Gordon Australia Regeneus Ltd. Gordon Australia

The use of adipose-derived cells as a treatment for a variety of diseases is becoming increasingly common. These therapies include the use of cultured mesenchymal stem cells (MSCs) and freshly isolated stromal vascular fraction (SVF) alone, or in conjunction with other cells such as adipocytes. There is a substantial amount of literature published on the therapeutic properties of MSCs and their secretions as the main driver of their therapeutic effect. However, there is little data available on the therapeutic potential of secretions from SVF, either with or without adipocytes. We investigated the ability of secretions from human adipose SVF alone and the SVF co-cultured with adipocytes as a proxy for cell therapy, to ameliorate an inflammatory disorder. This ethics approved study involved the treatment of collagen antibody-induced arthritis (CAIA) in mice with secretions from SVF, SVF co-cultured with adipocytes, or a vehicle control via both intravenous (IV) and intramuscular (IM) routes. Treatment outcome was assessed by paw volume, ankle size and clinical arthritis score measurements. Serum samples were obtained following euthanasia and analysed for a panel of 32 mouse cytokines and growth factors. The dose and timing regime used for the IM administration of both human secretion mixtures did not significantly ameliorate arthritis in this model. The IV administration of SVF adipocyte co-culture secretions reduced the paw volume, and significantly reduced the ankle size and clinical arthritis score when compared to the IV vehicle control mice. This was a superior therapeutic effect than treatment with SVF secretions. Furthermore, treatment with SVF adipocyte coculture secretions resulted in a significant reduction in serum levels of key cytokines, IL-2 and VEGF, involved in the pathogenesis of rheumatoid arthritis. Therefore, the SVF cocultured with adipocytes is an attractive therapeutic for inflammatory conditions.

关键词： Collagen Antibody-Induced Arthritis (CAIA) Stromal Vascular Fraction (SVF) Adipocytes Co-Culture Secretions Cytokines Growth Factors Bio-Plex Rheumatoid Arthritis