检索结果-南通市图书馆

Association of physical activity with risk of chronic kidney disease in China:A population-based cohort study

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and health Science 2024年第2期13卷 204-211页

作者： Kexiang Shi Yunqing Zhu Jun Lv Dianjianyi Sun Pei Pei huaidong Du Yiping Chen Ling Yang Bing han rebecca Stevens Junshi Chen Zhengming Chen Liming Li Canqing Yu China Kadoorie Biobank collaborative group Department of Epidemiology&Biostatistics School of Public HealthPeking University Health Science CenterBeijing 100191China Peking University Center for Public health and Epidemic Preparedness&Response Beijing 100191China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijing 100191China Clinical Trial Service Unit&Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK Medical Research Council Population health Research Unit at the University of Oxford Oxford OX37LFUK NCDs Prevention and Control Department Henan Center for Disease Control and PreventionZhengzhou 450016China China National Center for Food Safety Risk Assessment Beijing 100022China 不详

Background:Information on the association between physical activity(PA)and the risk of chronic kidney disease(CKD)is *** aimed to explore the associations of total,domain-specific,and intensity-specific PA with CKD and its subtypes in ***:The study included 475,376 adults from the China Kadoorie Biobank aged 30-79 years during 2004-2008 at *** interviewer-administered questionnaire was used to collect the information about PA,which was quantified as metabolic equivalent of task hours per day(MET-h/day)and categorized into 4 groups based on *** regression was used to analyze the association between PA and CKD ***:During a median follow-up of 12.1 years,5415 incident CKD cases were documented,including 1159 incident diabetic kidney disease(DKD)cases and 362 incident hypertensive nephropathy(hTN)*** PA was inversely associated with CKD risk,with an adjusted hazard ratio(hR,95%confidence interval(95%CI))of 0.83(0.75-0.92)for incident CKD in the highest quartile of total PA as compared with participants in the lowest *** results were observed for risk of DKD and hTN,and the corresponding hRs(95%CIs)were 0.75(0.58-0.97)for DKD risk and 0.56(0.37-0.85)for hTN *** nonoccupational PA,low-intensity PA,and moderate-to-vigorous-intensity PA were significantly associated with a decreased risk of CKD,with hRs(95%CIs)of 0.80(0.73-0.88),0.85(0.77-0.94),and 0.85(0.76-0.95)in the highest quartile,***:PA,including nonoccupational PA,low-intensity PA,and moderate-to-vigorous-intensity PA,was inversely associated with the risk of CKD,including DKD,hTN,and other CKD,and such associations were dose dependent.

关键词： Chronic kidney disease Domain Intensity Physical activity

Intracranial pressure is elevated at 24h post-stroke inmice

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neuroprotection 2024年第1期2卷 60-64页

作者： Kirby E.Warren rebecca J.hood Fredrick R.Walker Neil J.Spratt School of Biomedical Sciences and Pharmacy University of NewcastleCallaghanAustralia hunter Medical Research Institute NewLambton HeightsAustralia School of Biomedicine Discipline of Anatomy and PathologyFaculty of Health and Medical SciencesThe University of AdelaideAdelaideAustralia Department of Neurology John Hunter HospitalNewLambton HeightsAustralia

Background:It has long been assumed that post-stroke intracranial pressure(ICP)elevation occurs because of large infarct and edema ***,we have repeatedly shown IcP elevation at 24 h post-stroke in the presence of little to no edema in *** processes are often conserved across species and types of ***,we aimed to determine if an ICP rise occurs at 24 h post-stroke in the presence of small infarct and edema volumes in ***:Mice were randomized by random number table to either photothrombotic stroke or sham surgery(n=15).Epidural ICP was recorded using a fiber optic catheter at 1 h post-stroke(baseline)and between 23 and ***:ICP was significantly higher at 24 h compared to baseline in stroke animals(n=6;10.71±6.45mmhg vs.3.74±2.20mmhg,respec-tively;p=0.03).ICP at 24 h was also significantly higher in stroke mice compared to sham(n=6;3.45±1.43mmhg;p=0.02).There was no change in ICP in sham mice(p=0.9).Edema volumes in stroke animals were small(0.04±0.04 mm3)and unlikely to have caused significant ICP ***:This study provides evidence of an edema-independent ICP elevation following small ischemic stroke in *** occurrence of this rise supports our findings in other species and suggests it is caused by a previously undescribed mechanism.

关键词： cerebraledema intracranial pressure ischemic stroke

Rhythms of chloroplast magnesium import contribute to daily metabolic feedback

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2022年第11期15卷 1659-1661页

作者： Xiang Li Christopher R.buckley Michael J.haydon School of BioSciences University of MelbourneParkvilleVIC 3010Australia

Organisms have evolved stable yet dynamic circadian systems to coordinate biological rhythms that contribute to *** oscillators generate rhythms via transcriptional and post-transcriptional control of key cellular processes such as metabolism and nutrient transport that fluctuate across the course of the *** addition,intracellular ions and metabolites can act as signaling molecules and protein cofactors that provide feedback to fine-tune biological timekeeping(haydon et al.,2013).

关键词： magnesium metabolism coordinate

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

表面分析工具在磨损基础研究中的应用(上)

润滑与密封 1980年第1期 57-66页

作者： Donaed h.buckley ,杨明安武汉材料保护研究所

本文评述了研究材料磨损的原子级特性的各种技术和表面分析工具。包括化学浸蚀、X射线衍射、电子衍射、扫描电子显微镜,低能电子衍射、俄歇发射能谱分析、化学电子能谱分析、场离子显微镜和原子探针。讨论了表面能、晶体结构、晶相取向... 详细信息

本文评述了研究材料磨损的原子级特性的各种技术和表面分析工具。包括化学浸蚀、X射线衍射、电子衍射、扫描电子显微镜,低能电子衍射、俄歇发射能谱分析、化学电子能谱分析、场离子显微镜和原子探针。讨论了表面能、晶体结构、晶相取向、位错行为模式和内聚键之类对磨损表面的影响和磨损表面区的性能。用前述的工具鉴定了产生磨屑的许多机理。

关键词：扫描电子显微镜六角形表面层 ESCA 衍射图样 LEED 流体层表面分析能谱仪原子层低能电子衍射

Observation of a single protein by ultrafast X-ray diffraction

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第1期13卷 80-90页

作者： Tomas Ekeberg Dameli Assalauova Johan Bielecki rebecca Boll Benedikt J.Daurer Lutz A.Eichacker Linda E.Franken Davide E.Galli Luca Gelisio Lars Gumprecht Laura h.Gunn Janos hajdu Robert hartmann Dirk hasse Alexandr Ignatenko Jayanath Koliyadu Olena Kulyk Ruslan Kurta Markus Kuster Wolfgang Lugmayr Jannik Lübke Adrian P.Mancuso Tommaso Mazza Carl Nettelblad Yevheniy Ovcharenko Daniel E.Rivas Max Rose Amit K.Samanta Philipp Schmidt Egor Sobolev Nicusor Timneanu Sergey Usenko Daniel Westphal Tamme Wollweber Lena Worbs Paul Lourdu Xavier hazem Yousef Kartik Ayyer henry N.Chapman Jonas A.Sellberg Carolin Seuring Ivan A.Vartanyants Jochen Küpper Michael Meyer Filipe R.N.C.Maia Laboratory of Molecular Biophysics Department of Cell and Molecular BiologyUppsala UniversityHusargatan 3(Box 596)SE-75124 UppsalaSweden Deutsches Electronen-Synchrotron DESY Notkestrasse 8522607 HamburgGermany European XFEL Holzkoppel 422869 SchenefeldGermany Diamond Light Source Harwell Science&Innovation CampusDidcot OX110DEUK University of Stavanger Centre Organelle ResearchRichard-Johnsensgate 44021 StavangerNorway Leibniz Institute for Experimental Virology(hPI) Centre for Structural Systems BiologyNotkestraße 8522607 HamburgGermany Dipartimento di Fisica“Aldo Pontremoli” Universitàdegli Studi di Milanovia Celoria 1620133 MilanoItaly Center for Free-Electron Laser Science DESY22607 HamburgGermany Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA PNSensor Gmbh Otto-Hahn-Ring 6D-81739 MünchenGermany Biomedical and X-Ray Physics Department of Applied PhysicsAlbaNova University CenterKTH Royal Institute of TechnologySE-10691 StockholmSweden ELI Beamlines/IoP Institute of Physics AS CR v.v.i.Na Slovance 218221 Prague 8Czech Republic Multi-User CryoEM Facility Centre for Structural Systems BiologyNotkestr.8522607 HamburgGermany University Medical Center hamburg-Eppendorf(UKE) Martinistrasse 5220246 HamburgGermany The hamburg Center for Ultrafast Imaging Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Physics Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Chemistry and Physics La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVIC 3086Australia Division of Scientific Computing Science for Life LaboratoryDepartment of Information TechnologyUppsala UniversityBox 337SE-75105 UppsalaSweden European Molecular Biology Laboratory c/o DESYNotkestrasse 8522607 HamburgGermany Department of Physics and Astronomy Uppsala UniversityBox 516SE-75120 UppsalaSweden Max Planck Institute for the Structure and Dynamics of Matter Luruper Chaussee 14922761 HamburgGe

The idea of using ultrashort X-ray pulses to obtain images of single proteins frozen in time has fascinated and inspired *** was one of the arguments for building X-ray free-electron *** to theory,the extremely intense pulses provide sufficient signal to dispense with using crystals as an amplifier,and the ultrashort pulse duration permits capturing the diffraction data before the sample inevitably *** was first demonstrated on biological samples a decade ago on the giant *** then,a large collaboration has been pushing the limit of the smallest sample that can be *** ability to capture snapshots on the timescale of atomic vibrations,while keeping the sample at room temperature,may allow probing the entire conformational phase space of *** we show the first observation of an X-ray diffraction pattern from a single protein,that of Escherichia coli GroEL which at 14 nm in diameter is the smallest biological sample ever imaged by X-rays,and demonstrate that the concept of diffraction before destruction extends to single *** the pattern,it is possible to determine the approximate orientation of the *** experiment demonstrates the feasibility of ultrafast imaging of single proteins,opening the way to single-molecule time-resolved studies on the femtosecond timescale.

关键词： smallest intense ultrafast

Identification of Persister Drug Combination Clinafloxacin+Cefuroxime+Gentamicin That Eradicates Persistent Pseudomonas aeruginosa Infection in a Murine Cystic Fibrosis Model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Microbes & Diseases 2023年第1期5卷 21-28页

作者： Yuting Yuan rebecca Yee Naina Gour Xinzhong Dong Jie Feng Wanliang Shi Ying Zhang Department of Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public HealthBaltimoreMarylandUSA The Solomon h.Snyder Department of Neuroscience and the Center for Sensory Biology Johns Hopkins University School of MedicineBaltimoreMarylandUSA State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Research Units of Infectious Disease and Microecology Chinese Academy of Medical SciencesHangzhouZhejiangChina Jinan Microecological Biomedicine Shandong Laboratory JinanShandongChina

Pseudomonas aeruginosa can cause persistent infections,such as biofilm infections,in cystic fibrosis patients,which are difficult to cure due to non-growing persister bacteria that are not effectively killed by the current *** antibiotic activity against growing *** is well documented,their activity against non-growing stationary phase cultures is less ***,we evaluated six major classes of antibiotics,including cell wall and cell membrane inhibitors,protein synthesis inhibitors,DNA synthesis inhibitors,RNA synthesis inhibitors,sulfa drugs and nitrofurantoin,for their activity against growing and non-growing *** foundthat cell wall and cell membrane inhibitors(cefuroxime and colistin),DNA synthesis inhibitors(clinafloxacin)and sulfa drugs(sulfamethoxazole)had good activity against stationary-phase bacteria,while protein synthesis inhibitors(gentamicin),RNA synthesis inhibitor(rifampin)and nitrofurantoin showed relatively poor *** was the only drug able to completely eradicate stationary-phase bacteria within four *** cefuroxime+gentamicin+clinafloxacin combination was able to kill all bacteria from a biofilm within two days,whereas the clinically used drug combination cefuroxime+gentamicin/colistin only partially killed the *** amurine persistent cystic fibrosis lung infectionmodel,only the cefuroxime+gentamicin+clinafloxacin drug combination eradicated all bacteria from the lungs,whereas clinafloxacin alone,cefuroxime+clinafloxacin or the currently recommended drug combination cefuroxime+gentamicin failed to do *** complete eradication is a property of the clinafloxacin combination,as the otherwise identical levofloxacin combination did not clear the bacterial loads from the *** findings offer new therapeutic options for more effective treatment of persistent *** infections,with possible implications for treating other persistent infections.

关键词： Pseudomonas aeruginosa persisters stationary-phase bacteria biofilm clinafloxacin cystic fibrosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

David Copperfield

Effects of cucumber mosaic virus-infected chilli plants on non-vector Bemisia tabaci (hemiptera Aleyrodidae)

作者： Charles Dickens edited by Jerome h. buckley.

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Insect Science 2019年第1期26卷 76-85页

作者： Khalid A.Saad M.N.Mohamad Roff rebecca h.hallett Idris B.Abd-Ghani Faculty of Science and Technology School of Environmental and Natural Resource SciencesNational University MalaysiaBangi SelangorMalaysia horticulture Research Centre HeadquartersMARDI-UPMSerdang SelangorMalaysia School of Environmental Sciences University of GuelphGuelphOntarioCanada

Plant virus infections are known to alter host plant attractiveness and suitability for insect *** study was conducted to determine how cucumber mosaic virus (CMV)-infected chilli plants affect the fitness and settling preferences ofnonvector whitefly,Bemisia tabaci adults under dual-choice conditions with volatile organic compounds analyzed using solid phase microextraction coupled with gas chromatography-mass spectrometry (GC-MS).Results showed that the presence of CIVIV in chilli plants substantially affects the settling preferences of the ***,which preferred to settle on noninfected *** of the egg stage and the longevity and fecundity of adult *** on CMV-infected chilli plants were not markedly different from those on noninfected chilli *** contrast,the developmental time from egg to adult was significantly reduced in CMV-infected chilli plants compared to the noninfected *** results also showed that CMV-infected chilli plants released significantly more linalool and phenylacetaldehyde than noninfected ***,it was suggested that the behavioral response of *** might be modified by CMV-infected plants,which alter the release of specific headspace *** on these results,the modification of plant volatile profiles may help in enhancing the effectiveness of biological control and the protection of crop plants against ***.

关键词： Bromoviridae Capsicum anmium cucumovirus in sect-pathogen interactions whitefly

Building Power： Conspicuous Consumption, Projection of Identity, and Female Power in the Late Seventh and Early Eighth Centuries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2012年第4期6卷 472-489页

作者： rebecca Doran Department of East Asian Studies McGill University Montreal Quebec H3A 0E2 Canada

This article explores propaganda and self-portrayals among women rulers in seventh and eighth century Tang China, a unique era in which court politics were dominated by female leaders. I analyze the way in which these leaders themselves wished to be rhetorically constructed, the images and allusions with which they desired to be figured, and the way in which they were rhetorically reconstructed by later writers after their deaths. I focus on the theme of auspiciousness--in particular, the definition of the ＂natural＂ in relation to gender identity and power. Female imagery is deployed in late seventh- and early eighth-century works to create the image of a particular brand of far-reaching, generative power possessed and/or desired by the leaders of the time. Beyond revealing the images and allusions with which the female power-holders wished to hear themselves be described and exalted, and what occasions were deemed worthy of exalting, these works offer a fascinating counterpoint to materials which retroactively defame this image. The rhetorical strategies and images later used to delegitimize and denigrate the power of these women often represent opposite treatments of themes present in the court literature from the Zhou-Jinglong era. This paper argues that reconstructions of these women＇s identities as female power-holders indicate the prerogative of later writers to reshape their images in accordance with their own judgments, conceptualizations, and fears of female power.

关键词： Tang women Tang culture Empress Wu court literature genderroles