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Beyond cardiomyocytes:Cellular diversity in the heart's response to exercise

Journal of Sport and Health Science 2023年第4期12卷 423-437,F0003页

作者： Lena E.Trager Margaret Lyons Alexandra Kuznetsov Cedric Sheffield Kangsan Roh rebecca freeman James Rhee J.Sawalla Guseh Haobo Li Anthony Rosenzweig Corrigan Minehan Heart Center Division of CardiologyCardiovascular Research CenterDepartment of MedicineMassachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA University of Minnesota Medical School MinneapolisMI 55455USA Department of Anesthesiology and Critical Care Massachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Institute for Heart and Brain Health University of Michigan Medical CenterAnn ArborMI 48109USA

Cardiomyocytes comprise~70%to 85%of the total volume of the adult mammalian heart but only about 25%to 35%of its total number of *** in single cell and single nuclei RNA sequencing have greatly facilitated investigation into and increased appreciation of the potential functions of non-cardiomyocytes in the *** much of this work has focused on the relationship between non-cardiomyocytes,disease,and the heart's response to pathological stress,it will also be important to understand the roles that these cells play in the healthy heart,cardiac homeostasis,and the response to physiological stress such as *** present review summarizes recent research highlighting dynamic changes in non-cardiomyocytes in response to the physiological stress of *** particular interest are changes in fibrotic pathways,the cardiac vasculature,and immune or inflammatory *** many instances,limited data are available about how specific lineages change in response to exercise or whether the changes observed are functionally important,underscoring the need for further research.

关键词： Angiogenesis Cardiac fibrosis Cardioprotection Hypertrophy Non-cardiomyocytes Proliferation

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Viral hepatitis in 2021:The challenges remaining and how we should tackle them

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World Journal of Gastroenterology 2022年第1期28卷 76-95页

作者： rebecca Dunn Aaron Wetten Stuart McPherson Mhairi C Donnelly Gastroenterology University Hospital of North TeesStockton on Tees TS198PEUnited Kingdom Liver Unit Freeman HospitalNewcastle NE77DNUnited Kingdom Translational and Clinical Research Institute Newcastle UniversityNewcastle NE17RUUnited Kingdom

Viral hepatitis results in 1.4 million deaths *** World Health Organization(WHO)set an ambitious target to eliminate viral hepatitis by 2030,but significant challenges *** include inequalities in access to healthcare,reaching at risk populations and providing access to screening and effective *** around viral hepatitis persists and must be *** WHO goal of global elimination by 2030 is a worthy aim,but remains ambitious and the coronavirus 2019 pandemic undoubtedly has set back *** review article will focus on hepatitis A to E,highlighting problems that have been resolved in the field over the past decade,those that remain to be resolved and suggest directions for future problem solving and research.

关键词： Hepatitis A Hepatitis B Hepatitis C Hepatitis D Hepatitis E COVID-19

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Storylines of family medicine Ⅻ:family medicine and the healthcare system

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Family Medicine and Community Health 2024年第S3期12卷 109-118页

作者： William B Ventres Leslie A Stone Jeannette E South-Paul Kendall M Campbell Aerial R Petty Hima Ekanadham Kurt C Stange rebecca S Etz William L Miller Robert L Ferrer Marianna Kong Thomas Bodenheimer Roger Strasser Sharon C M Reece Joshua freeman John M Westfall Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Meharry Medical College NashvilleTennesseeUSA Family Medicine University of Texas Medical Branch at Galveston School of MedicineGalvestonTexasUSA Family Medicine Residency Program New York-Presbyterian Columbia University Medical CenterNew YorkNew YorkUSA Center for Family and Community Medicine Columbia University Vagelos College of Physicians and SurgeonsNew YorkNew YorkUSA Center for Community Health Integration Case Western Reserve University School of MedicineClevelandOhioUSA Family Medicine and Population Health Virginia Commonwealth University School of MedicineRichmondVirginiaUSA Family Medicine Lehigh Valley Health NetworkAllentownPennsylvaniaUSA University of South Florida Morsani College of Medicine TampaFloridaUSA Family and Community Medicine UT Health San Antonio Long School of MedicineSan AntonioTexasUSA Family and Community Medicine University of California San Francisco School of MedicineSan FranciscoCaliforniaUSA Northern Ontario School of Medicine University SudburyOntarioCanada Family Medicine Baylor Scott and White HealthTempleTexasUSA Family Medicine University of Kansas School of MedicineKansas CityKansasUSA DARTNet Insitute AuroraColoradoUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅻ:Family medicine and the future of the healthcare system’,authors address the following themes:‘Leadership in family medicine’,‘Becoming an academic family physician’,‘Advocare—our call to act’,‘The paradox of primary care and three simple rules’,‘The quadruple aim—melding the patient and the health system’,‘Fit-for-purpose medical workforce’,‘Universal healthcare—coverage for all’,‘The futures of family medicine’and‘The 100th essay.’May readers of these essays feel empowered to be part of family medicine’s exciting future.

关键词： system illustration family

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