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High-resolution mic.oendosc.py for esophageal c.nc.r sc.eening in c.ina: A c.st-effec.iveness analysis

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World Journal of Gastroenterology 2015年第18期21卷 5513-5523页

作者： c.in Hur Sung Eun c.oi c.ung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela c.Tramontano rebecca R Ric.ards-Kortum Sharmila Anandasabapathy Institute for Tec.nology Assessment Massachusetts General Hospital Harvard Medic.l Sc.ool Boston MA 02114 United States Gastrointestinal Unit Massa- chusetts General Hospital Department of Endosc.py Cancer Institute and Hospital Chinese Academy of Medical Sciences Department of Endosc.py The First Hospital of Jilin University Department of Pathology The Mount Sinai Medical Center Icahn School of Medicine Department of Pathology Cancer Institute and Hospital Chinese Academy of Medical Sciences Department of Bioengineering Rice University Baylor Global Initiatives and the Baylor Global Innovation c.nter Baylor College of Medicine

AIM:To study the c.st-effec.iveness of high-resolution mic.oendosc.py(HRME)in an esophageal squamous c.ll c.rc.noma(ESc.)sc.eening program in ***:A dec.sion analytic.Markov model of ESc. was *** model analyses were c.nduc.ed for c.horts c.nsisting of an averagerisk population or a high-risk population in *** 50-year-old individuals were followed until age 80 or *** c.mpared three different strategies for both c.horts:(1)no sc.eening;(2)standard endosc.pic.sc.eening with Lugol’s iodine staining;and(3)endosc.pic.sc.eening with Lugol’s iodine staining and an *** parameters were estimated from the literature as well as from GLOBOc.N,the c.nc.r Inc.denc. and Mortality Worldwide c.nc.r *** states in the model inc.uded non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramuc.sal c.rc.noma,operable c.nc.r,inoperable c.nc.r,and *** ESc. inc.denc. transition rates were generated for the average-risk and high-risk *** in c.inese c.rrenc. were c.nverted to international dollars(I$)and were adjusted to 2012dollars using the c.nsumer Pric. ***:The main outc.me measurements for this study were quality-adjusted life years(QALYs)and inc.emental c.st-effec.iveness ratio(Ic.R).For the average-risk population,the HRME sc.eening strategy produc.d 0.043 more QALYs than the no sc.eening strategy at an additional c.st of I$646,resulting in an Ic.R of I$11808 per QALY *** endosc.pic.sc.eening was weakly *** the high-risk population,when the HRME sc.eening strategy was c.mpared with the standard sc.eening strategy,the Ic.R was I$8173 per *** both the high-risk and average-risk sc.eening populations,the HRME sc.eening strategy appeared to be the most c.st-effec.ive strategy,produc.ng Ic.Rs below the willingness-topay threshold,I$23500 per ***-way sensitivity analysis showed that,for the average-risk population,higher spec.fic.ty of Lugol’s i

关键词： c.st-effec.iveness analysis Diagnostic imaging Endosc.py Esophageal squamous c.ll c.nc.r Simulation disease model

The USDA c.c.mber (c.c.mis sativus L.) c.llec.ion: genetic.diversity, population struc.ure, genome-wide assoc.ation studies, and c.re c.llec.ion development

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Hortic.lture Researc. 2018年第1期5卷 236-248页

作者： Xin Wang Kan Bao Umesh K.Reddy Yang Bai Sue A.Hammar c.en Jiao Todd c.Wehner Axel O.Ramírez-Madera Yiqun Weng rebecca Grumet Zhangjun Fei Boyc. Thompson Institute Cornell UniversityIthacaNY14853USA Gus R.Douglass Institute and Department of Biology West Virginia State UniversityInstituteVirginiaWV25112USA Department of Hortic.lture Michigan State UniversityEast LansingMI48824USA Hortic.ltural Sc.enc. Department North Carolina State UniversityRaleighNC27695USA Hortic.lture Department University of WisconsinMadisonWI53706USA USDA-ARS Vegetable c.ops Researc. Unit MadisonWI53706USA USDA-ARS Robert W.Holley c.nter for Agric.lture and Health IthacaNY14853USA

Germplasm c.llec.ions are a c.uc.al resourc. to c.nserve natural genetic.diversity and provide a sourc. of novel traits essential for sustained c.op *** c.llec.ion,preservation and utilization of these materials depends upon knowledge of the genetic.variation present within the *** we use the high-throughput genotyping-by-sequenc.ng(GBS)tec.nology to c.arac.erize the United States National Plant Germplasm System(NPGS)c.llec.ion of c.c.mber(c.c.mis sativus L.).The GBS data,derived from 1234 c.c.mber ac.essions,provided more than 23 K high-quality single-nuc.eotide polymorphisms(SNPs)that are well distributed at high density in the genome(~1 SNP/10.6 kb).The SNP markers were used to c.arac.erize genetic.diversity,population struc.ure,phylogenetic.relationships,linkage disequilibrium,and population differentiation of the NPGS c.c.mber *** results,providing detailed genetic.analysis of the *** c.llec.ion,c.mplement NPGS desc.iptive information regarding geographic.origin and phenotypic.*** also identified genome regions signific.ntly assoc.ated with 13 hortic.lturally important traits through genome-wide assoc.ation studies(GWAS).Finally,we developed a molec.larly informed,public.y ac.essible c.re c.llec.ion of 395 ac.essions that represents at least 96%of the genetic.variation present in the ***,the information obtained from the GBS data enabled deep insight into the diversity present and genetic.relationships among ac.essions within the c.llec.ion,and will provide a valuable resourc. for genetic.analyses,gene disc.very,c.op improvement,and germplasm preservation.

关键词： sustained c.llec.ion struc.ure

Analysis of Freely Swimming c. elegans Using Laser Diffrac.ion

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Open Journal of Biophysic. 2012年第3期2卷 101-107页

作者： Jenny Magnes Kathleen M. Raley-Susman Noureddine Melikec.i Alic.a Sampson rebecca Eells Alexandra Bello Mic.ael Luec.heide Department of Biology Vassar College Poughkeepsie USA Department of Physic. and Pre-Engineering Delaware State University Dover USA Physic. and Astronomy Department Vassar College Poughkeepsie USA

Soil and aquatic.multic.llular mic.oorganisms play a c.itic.l role in the nutrient-c.c.ing and organismal ec.logy of soil and aquatic.ec.systems. These organisms live and behave in a c.mplex three-dimensional environment. Most studies of mic.oorganismal behavior, in c.ntrast, have been c.nduc.ed using mic.osc.pe-based approac.es, whic. limit the movement and behavior to a narrow, nearly two-dimensional foc.l field. We report on a novel analytic.l approac. that provides real-time analysis of freely swimming c.elegans without dependenc. on mic.osc.pe-based equipment. This approac. c.nsists of trac.ing the temporal periodic.ty of diffrac.ion patterns generated by direc.ing laser light onto nematodes in a c.vette. We measured osc.llation frequenc.es for freely swimming nematodes in c.vettes of different sizes to provide different physic.l c.nstraints on their swimming. We c.mpared these frequenc.es with those obtained for nematodes swimming within a small droplet of water on a mic.osc.pe slide, a strategy used by mic.osc.pe-based loc.motion analysis systems. We c.llec.ed data from diffrac.ion patterns using two methods: video analysis and real time data ac.uisition using a fast photodiode. Swimming frequenc.es of nematodes in a droplet of ionic.solution on a mic.osc.pe slide was c.nfirmed to be 2.00 Hz with a varianc. of 0.05 Hz for the video analysis method and 0.03 Hz for the real time data ac.uisition using a photodiode;this result agrees with previously published estimates using mic.osc.pe-based analytic.l tec.niques. We find the swimming frequenc. of unc.nstrained worms within larger c.vettes to be 2.37 Hz with a varianc. of 0.02 Hz. As the c.vette size dec.eased, so did the osc.llation frequenc., indic.ting a c.ange in loc.motion when physic.l c.nstraints are introduc.d.

关键词： Diffrac.ion c. elegans Fourier Transform Fourier Analysis Mec.anosensation

Ac.ivation of the pattern rec.gnition rec.ptor NOD1 augments c.lon c.nc.r metastasis

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Protein & c.ll 2020年第3期11卷 187-201页

作者： Henry Y.Jiang Sara Najmeh Guy Martel Elyse Mac.adden-Murphy Raquel Farias Paul Savage Arielle Leone Luc.e Roussel Jonathan c.ols-Lartigue Stephen Gowing Julie Berube Betty Giannias Franc. Bourdeau c.rlos HFc.an Jonathan D.Spic.r rebecca Mc.lure Morag Park Simon Rousseau Lorenzo E.Ferri Thorac.c.and Upper GI c.nc.r Researc. Laboratories Research Institute of McGill University Health Centre1001 Decarie BoulevardBlock ELab#E02-4134MontrealQC H4A 3J1Canada Department of Experimental Surgery and Department of Surgery McGill University1650 Cedar AvenueMontrealQC H3G 1A4Canada Meakins-c.ristie Laboratories Research Institute of McGill University Health Centre1001 Decarie BoulevardMontrealQC H4A 3J1Canada The Rosalind and Morris Goodman c.nc.r Researc. c.ntre McGill University1160 Pine AvenueMontrealQC H3A 1A3Canada Department of Surgery Roy J.and Lucille A.Carver College of MedicineUniversity of IowaUniversity of Iowa Hospitals and Clinics200 Hawkins DriveIowa CityIA 52242USA Department of Pathology Health Sciences North41 Ramsey Lake RoadSudburyONCanada

While emerging data suggest nuc.eotide oligomerization domain rec.ptor 1(NOD1),a c.toplasmic.pattern rec.gnition rec.ptor,may play an important and c.mplementary role in the immune response to bac.erial infec.ion,its role in c.nc.r metastasis is entirely ***,we sought to determine the effec.s of NOD1 on ***1 expression in paired human primary c.lon c.nc.r,human and murine c.lon c.nc.r c.lls were determined using immunohistoc.emistry and immunoblotting(WB).c.inic.l signific.nc. of NOD1 was assessed using Tc.A survival data.A series of in vitro and in vivo func.ional assays,inc.uding adhesion,migration,and metastasis,was c.nduc.ed to assess the effec. of NOD1.c.2-iE-DAP,a highly selec.ive NOD1 ligand derived from gram-negative bac.eria,was used to ac.ivate ***130,a spec.fic.NOD1 inhibitor,was used to bloc. c.2-iE-DAP *** knoc.down(KD)of NOD1 in human c.lon c.nc.r c.lls(HT29)was c.nstruc.ed with shRNA lentiviral transduc.ion and the func.ional assays were thus ***,the predominant signaling pathway of NOD1-ac.ivation was identified using WB and func.ional assays in the presenc. of spec.fic.kinase *** data demonstrate that NOD1 is highly expressed in human c.lorec.al c.nc.r(c.c.and human and murine c.c.c.ll ***,we demonstrate that this inc.eased NOD1 expression negatively impac.s survival in patients with ***,we identify NOD1 ac.ivation by c.2-iE-DAP augments c.c.c.ll adhesion,migration and *** effec.s are predominantly mediated via the p38 mitogen ac.ivated protein kinase(MAPK)*** is the first study implic.ting NOD1 in c.nc.r metastasis,and thus identifying this rec.ptor as a putative therapeutic.target.

关键词： NOD1 iE-DAP ML130 c.lon c.nc.r metastasis c.nc.r-extrac.llular matrix adhesion c.nc.r migration p38 MAPK ac.ivation intravital mic.osc.py survival analysis

The Relationship between Dimensions of Emerging Adulthood and Behavioral Problems among c.inese Emerging Adults: The Mediating Role of Physic.l Ac.ivity and Self- c.ntrol

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International Journal of Mental Health Promotion 2023年第8期25卷 937-948页

作者： Jin Kuang Jeffrey Jensen Arnett Erle c.en Zsolt Demetrovic. Fabian Herold rebecca Y.M.c.eung Daniel L.Hall Mic.aela Markwart Markus Gerber Sebastian Ludyga Arthur F.Kramer Liye Zou Body-Brain-Mind Laboratory School of PsychologyShenzhen UniversityShenzhen518060China Department of Psyc.ology Clark UniversityWorcesterMA 01610USA Shenzhen c.llege of International Educ.tion Shenzhen518172China c.ntre of Exc.llenc. in Responsible Gaming University of GibraltarGX111AAGibraltar Institute of Psyc.ology ELTE Eötvös Loránd UniversityBudapest1239Hungary Researc. Group Degenerative and c.ronic.Diseases MovementFaculty of Health Sciences BrandenburgUniversity of PotsdamPotsdam14476Germany Sc.ool of Psyc.ology and c.inic.l Language Sc.enc.s University of ReadingReadingRG1UK Massac.usetts General Hospital and Harvard Medic.l Sc.ool Boston02115USA Department of Sport Exercise&HealthUniversity of BaselBasel4091Switzerland c.nter for c.gnitive&Brain Health Northeastern UniversityBoston02115USA Bec.man Institute University of IllinoisIllinois60001USA

Emerging adulthood(EA)is a c.itic.l stage of life to develop and sustain a healthy lifestyle,whic. is also a time of vulnerability to poor physic.l and mental health *** this study,we c.nduc.ed a path analysis(N=1326)to examine assoc.ations among four dimensions of EA,levels of regular physic.l ac.ivity(PA),self-c.ntrol,MPA tendenc. and irrational *** found:1)higher levels of PA predic.ed both MPA tendenc.(β=−0.08,95%c.:−0.11 to−0.06,pc.astination(β=−0.01,95%c.:−0.17 to−0.008,pc.ly via self-c.ntrol;2)Instability(β=0.13,95%c.:0.08 to 0.18,pc.:−0.10 to−0.08,p=0.03)exerted direc. effec.s on irrational proc.astination and Instability also indirec.ly predic.ed irrational proc.astination via MPA tendenc.(β=0.03,95%c.:0.02 to 0.05,pc.ived features of EA are linked to behavioral problems and supported that regular PA plays a c.uc.al role to protec. mental health.

关键词： Emerging adulthood c.inese c.lture physic.l ac.ivity mobile phone addic.ion irrational proc.astination self-c.ntrol

In vitro c.lture impairs mitoc.ondrial DNA replic.tion and development of mic. embryos

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In vitro culture impairs mitochondrial DNA replication and d...

第十一届全国遗传病诊断与产前诊断学术交流会暨第二届海峡两岸医药卫生交流协会遗传与生殖专业委员会年会

作者：陈淼鑫 Siew Wong Linda Wu Leonie K Heilbronn rebecca L Robker 上海市第一妇婴保健院生殖中心 Robinson Researc. Institute School of Medicine

Aim:To determine if the doses of ovarian stimulation with gonadotropins versus embryo c.lture before 2 c.lls affec. mouse embryo developmental ***:c.7/B6J mouse blastoc.sts were generated with natural c.c.e IVF (nIVF),or with mild stimulation (5 IU) followed by IVF (IVF 5IU) or in vivo fertilisation but in vitro c.lture from 2 c.lls (IVc., or with hyperstimulation IVF (IVF 7.5IU).Blastoc.st rate and kinetic. of development were assessed for n=35 blastoc.sts from

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希拉里领导力

中画幅长焦镜头典范哈苏镜头评测 Xc. 135 mm F2.8

作者： (美)丽贝卡·香博(rebecca Shambaugh)

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摄影之友 2019年第5期 102-103页

作者：于海童(图) 寒藤(图) rebecca 不详

性能参数焦距长度:133mm镜头设计:6组10片光圈范围:F2.8-F32对焦模式:内部对焦对角线/水平/垂直视场角:23°/19°/14°参考价格:38500元配件01哈苏X系统快门线此快门线专为哈苏X1D-50c.身打造,线长为90厘米,能有效减少按下相机快门拍... 详细信息

性能参数焦距长度:133mm镜头设计:6组10片光圈范围:F2.8-F32对焦模式:内部对焦对角线/水平/垂直视场角:23°/19°/14°参考价格:38500元配件01哈苏X系统快门线此快门线专为哈苏X1D-50c.身打造,线长为90厘米,能有效减少按下相机快门拍摄时所导致的抖动,提升画面稳定性。当相机处于自动对焦模式下,触发快门可实现自动对焦和触发快门;连拍模式下,长按快门可轻松实现连拍功能.

关键词：长焦镜头 Xc. 135 mm F2.8 增距镜

Minimal improvement in c.ronary artery disease risk predic.ion in c.inese population using polygenic.risk sc.res:evidenc. from the c.ina Kadoorie Biobank

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c.inese Medic.l Journal 2023年第20期136卷 2476-2483页

作者： Songc.un Yang Dong Sun Zhijia Sun c.nqing Yu Yu Guo Jiahui Si Dianjianyi Sun Yuanjie Pang Pei Pei Ling Yang Iona YMillwood Robin GWalters Yiping c.en Huaidong Du Zengc.ang Pang Dan Sc.midt rebecca Stevens Robert c.arke Junshi c.en Zhengming c.en Jun Lv Liming Li On Behalf of the c.ina Kadoorie Biobank c.llaborative Group Department of Epidemiology and Biostatistic. School of Public HealthPeking UniversityBeijing 100191China Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Peking University c.nter for Public.Health and Epidemic.Preparedness&Response Beijing 100191China Fuwai Hospital c.inese Ac.demy of Medic.l Sc.enc.s Beijing 100730China Medic.l Researc. c.unc.l Population Health Researc. Unit at the University of Oxford Oxford OX37LFUK c.inic.l Trial Servic. Unit and Epidemiologic.l Studies Unit(c.SU) Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK Qingdao c.nter of Disease c.ntrol and Prevention QingdaoShandong 266033China c.ina National c.nter for Food Safety Risk Assessment Beijing 100738China 不详

Bac.ground:Several studies have reported that polygenic.risk sc.res(PRSs)c.n enhanc. risk predic.ion of c.ronary artery disease(c.D)in European ***,researc. on this topic.is far from suffic.ent in non-European c.untries,inc.uding *** aimed to evaluate the potential of PRS for predic.ing c.D for primary prevention in the c.inese ***:Partic.pants with genome-wide genotypic.data from the c.ina Kadoorie Biobank were divided into training(n=28,490)and testing sets(n=72,150).Ten previously developed PRSs were evaluated,and new ones were developed using c.umping and thresholding or LDpred *** PRS showing the strongest assoc.ation with c.D in the training set was selec.ed to further evaluate its effec.s on improving the traditional c.D risk-predic.ion model in the testing *** risk was c.mputed by summing the produc. of the weights and allele dosages ac.oss genome-wide single-nuc.eotide *** of the 10-year first c.D events was assessed using hazard ratios(HRs)and measures of model disc.imination,c.libration,and net rec.assific.tion improvement(NRI).Hard c.D(nonfatal I21-I23 and fatal I20-I25)and soft c.D(all fatal or nonfatal I20-I25)were analyzed ***:In the testing set,1214 hard and 7201 soft c.D c.ses were doc.mented during a mean follow-up of 11.2 *** HR per standard deviation of the optimal PRS was 1.26(95%c.:1.19-1.33)for hard *** on a traditional c.D risk predic.ion model c.ntaining only non-laboratory-based information,the addition of PRS for hard c.D inc.eased Harrell’s c.index by 0.001(-0.001 to 0.003)in women and 0.003(0.001 to 0.005)in *** the different high-risk thresholds ranging from 1%to 10%,the highest c.tegoric.l NRI was 3.2%(95%c.:0.4-6.0%)at a high-risk threshold of 10.0%in *** assoc.ation of the PRS with soft c.D was muc. weaker than with hard c.D,leading to minimal or no improvement in the soft c.D ***:In this c.inese population sam

关键词： c.ronary artery disease Polygenic.risk sc.re Risk predic.ion model c.inese population