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Temporal variability and sources of PFAS in the Rio Grande,New Mexico through an arid urban area using multiple tracers and highfrequency sampling

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Emerging Contaminants 2024年第3期10卷 205-220页

作者： Kimberly R.Beisner rebecca E.Travis David A.Alvarez Larry B.Barber Jacob A.Fleck Jeramy R.Jasmann U.S.Geological Survey 6700 Edith Blvd NEAlbuquerqueNM87113USA U.S.Geological Survey 4200 New Haven RoadColumbiaMO65201USA U.S.Geological Survey 3215 Marine St.BoulderCO80303USA U.S.Geological Survey 6000 J St.Placer Hall.SacramentoCA95819USA

Per-and polyfluoroalkyl substances(PFAS)are ubiquitous in the environment but sources are not well defined for temporal and spatial aspects within an urban environment,and especially for an arid urban environment subject to seasonal short term high-intensity precipitation events.A focused diel sampling was conducted in the summer of 2021 to assess the temporal and spatial variability of PFAS in the Rio Grande near Albuquerque,New Mexico and showed an order of magnitude increase of PFAS as it flows through the Albuquerque urban *** samples were collected at two different locations on the Rio Grande in addition to wastewater treatment plant(WWTP)effluent that discharges directly to the Rio Grande between the sampling ***-term high-intensity precipitation events occurred during the study period and mobilized PFAS from urban *** organic mat.er composed of tryptophan-like organic substances and refined fuel and fuel byproducts,characteristic of an urban signature,were also related to the precipitation *** PFAS in discharge from the WWTP was consistent over a 24-h period with slight differences in some *** presence on the Rio Grande downstream of the WWTP was evidenced by a gadolinium anomaly as well as increases in several other trace elements,total dissolved nitrogen,and fluorescence indicators,in addition to *** varied depending on source contribution,where urban runoff was associated with PFOA,PFOS,and PFBA,whereas PFHxA and PFPeA were associated with wastewater *** addition,passive polar organic chemical integrative samplers(POCIS)using hydrophilic-lipid balance(HLB)sorption media were deployed for a month at two locations on the Rio Grande to assess longer term PFAS *** POCIS results show some compounds(PFPeA and PFHpA)were greater than the average concentration from discrete samples,whereas other compounds(PFHxA,PFOA,PFDA,and PFNA)were lower in the POCIS,and PFOS was very simila

关键词： wastewater Rio runoff

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Bat-derived oligopeptide LE6 inhibits the contact-kinin pathway and harbors anti-thromboinflammation and stroke potential

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Zoological Research 2024年第5期45卷 1001-1012页

作者： Li-Na Cha Juan Yang Jin-Ai Gao Xin Lu Xiao-Long Chang rebecca Caroline Thuku Qi Liu Qiu-Min Lu Dong-Sheng Li Ren Lai Ming-Qian Fang Engineering Laboratory of Peptides of Chinese Academy of Sciences Key Laboratory of Bioactive Peptides of Yunnan ProvinceKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Center for Non-Human PrimatesNational Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Key Laboratory of Genetic Evolution&Animal ModelsSino-African Joint Research Centerand New Cornerstone Science LaboratoryKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China School of Molecular Medicine Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China First Affiliated Hospital of Kunming Medical University KunmingYunnan 650032China

Thrombosis and inflammation are primary contributors to the onset and progression of ischemic *** contact-kinin pathway,initiated by plasma kallikrein(PK)and activated factor XII(FXIIa),functions bidirectionally with the coagulation and inflammation cascades,providing a novel target for therapeutic drug development in ischemic *** this study,we identified a bat-derived oligopeptide from Myotis myotis(Borkhausen,1797),designated LE6(Leu-Ser-Glu-Glu-Pro-Glu,702 Da),with considerable potential in stroke therapy due to its effects on the contact kinin ***,LE6 demonstrated significant inhibitory effects on PK and FXIIa,with inhibition constants of 43.97μmol/L and 6.37μmol/L,*** vitro analyses revealed that LE6 prolonged plasma recalcification time and activated partial thromboplastin *** murine models,LE6 effectively inhibited carrageenan-induced mouse tail thrombosis,FeCl3-induced carotid artery thrombosis,and photochemically induced intracerebral ***,LE6 significantly decreased inflammation and stroke injury in transient middle cerebral artery occlusion ***,the low toxicity,hemolytic activity,and bleeding risk of LE6,along with its synthetic simplicity,underscore its clinical *** conclusion,as an inhibitor of FXIIa and PK,LE6 offers potential therapeutic benefits in stroke treatment by mitigating inflammation and preventing thrombus formation.

关键词： PK FXIIa Anti-thromboinflammation Ischemic stroke therapies Oligopeptide

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Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

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Neural Regeneration Research 2025年第1期20卷 82-92页

作者： Stiven Roytman rebecca Paalanen Giulia Carli Uros Marusic Prabesh Kanel Teus van Laar Nico I.Bohnen Department of Radiology University of MichiganAnn ArborMIUSA Department of Neurology University of MichiganAnn ArborMIUSA Morris K.Udall Center of Excellence for Parkinson’s Disease Research University of MichiganAnn ArborMIUSA Institute for Kinesiology Research Science and Research Centre KoperKoperSlovenia Department of Health Sciences Alma Mater Europaea–ECMMariborSlovenia Parkinson’s Foundation Research Center of Excellence University of MichiganAnn ArborMIUSA Department of Neurology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Neurology Service and GRECC VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging *** and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous *** effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory *** mechanisms which underpin the integration of these multisensory signals are the principal topic of the present *** multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older *** emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and *** the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s *** also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older ***,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

关键词： aging balance encephalography functional magnetic resonance imaging gait multisensory integration Parkinson’s disease positron emission tomography somatosensory vestibular visual

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Assessing Barriers to Mental Healthcare Interventions for Deaf People in Ghana

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Journal of Biosciences and Medicines 2024年第1期12卷 29-51页

作者： Wisdom Kwadwo Mprah Juventus Duorinaah Lyla Adwan-Kamara rebecca Tawiah Department of Health Promotion and Disability Studies Kwame Nkrumah University of Science and Technology Kumasi Ghana Ghana National Association of the Deaf Accra Ghana Ghana Somubi Dwumadie (Ghana Participation programme) Accra Ghana

While mental health issues are increasingly gaining attention in Ghana, little is known about the situation among deaf people. This study assessed the mental health care needs of deaf people in Ghana. A descriptive design, consisting of interviews and focus group discussions, was used to collect data from 97 participants. Findings indicated that participants had limited knowledge on mental health issues. Mental health stigma, inaccessible mental health information and exclusion from mental health programmes were the major barriers hindering access to mental health care services. This study bridges the knowledge gap and provides evidence for the implementation of deaf-friendly services.

关键词： Access Barriers Deaf People Mental Health Caregivers Civil Society Organizations

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Association of physical activity with risk of chronic kidney disease in China:A population-based cohort study

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Journal of Sport and Health Science 2024年第2期13卷 204-211页

作者： Kexiang Shi Yunqing Zhu Jun Lv Dianjianyi Sun Pei Pei Huaidong Du Yiping Chen Ling Yang Bing Han rebecca Stevens Junshi Chen Zhengming Chen Liming Li Canqing Yu China Kadoorie Biobank collaborative group Department of Epidemiology&Biostatistics School of Public HealthPeking University Health Science CenterBeijing 100191China Peking University Center for Public Health and Epidemic Preparedness&Response Beijing 100191China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijing 100191China Clinical Trial Service Unit&Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK Medical Research Council Population Health Research Unit at the University of Oxford Oxford OX37LFUK NCDs Prevention and Control Department Henan Center for Disease Control and PreventionZhengzhou 450016China China National Center for Food Safety Risk Assessment Beijing 100022China 不详

Background:Information on the association between physical activity(PA)and the risk of chronic kidney disease(CKD)is *** aimed to explore the associations of total,domain-specific,and intensity-specific PA with CKD and its subtypes in ***:The study included 475,376 adults from the China Kadoorie Biobank aged 30-79 years during 2004-2008 at *** interviewer-administered questionnaire was used to collect the information about PA,which was quantified as metabolic equivalent of task hours per day(MET-h/day)and categorized into 4 groups based on *** regression was used to analyze the association between PA and CKD ***:During a median follow-up of 12.1 years,5415 incident CKD cases were documented,including 1159 incident diabetic kidney disease(DKD)cases and 362 incident hypertensive nephropathy(HTN)*** PA was inversely associated with CKD risk,with an adjusted hazard ratio(HR,95%confidence interval(95%CI))of 0.83(0.75-0.92)for incident CKD in the highest quartile of total PA as compared with participants in the lowest *** results were observed for risk of DKD and HTN,and the corresponding HRs(95%CIs)were 0.75(0.58-0.97)for DKD risk and 0.56(0.37-0.85)for HTN *** nonoccupational PA,low-intensity PA,and moderate-to-vigorous-intensity PA were significantly associated with a decreased risk of CKD,with HRs(95%CIs)of 0.80(0.73-0.88),0.85(0.77-0.94),and 0.85(0.76-0.95)in the highest quartile,***:PA,including nonoccupational PA,low-intensity PA,and moderate-to-vigorous-intensity PA,was inversely associated with the risk of CKD,including DKD,HTN,and other CKD,and such associations were dose dependent.

关键词： Chronic kidney disease Domain Intensity Physical activity

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Enhancing the clinical relevance of haemorrhage prediction models in trauma

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Military Medical Research 2024年第3期11卷 467-468页

作者： Sankalp Tandle Jared M.Wohlgemut Max E.R.Marsden erhan Pisirir Evangelia Kyrimi rebecca S.Stoner William Marsh Zane B.Perkins Nigel R.M.Tai Centre for Trauma Sciences Blizard InstituteQueen Mary University of LondonLondon E12ATUK The Royal London Hospital Barts Health NHS TrustLondon E11FRUK Academic Department of Military Surgery and Trauma Research and Clinical InnovationThe Royal Centre for Defence MedicineBirmingham B152WBUK Department of Electronic Engineering and Computer Science Queen Mary University of LondonLondon E14NSUK

We read with interest the recent systematic reviewaArtificial intelligence and machine learning for hemorrhagic trauma careoby Peng et al.[1],which evaluated literature on machine learning(ML)in the management of trau... 详细信息

关键词： Trauma Injury Blood transfusion Massive transfusion Prediction Artificial intelligence Machine learning

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理想主义全场景镜头尼克尔Z28-400mm F4-8VR镜头体验

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摄影之友 2024年第6期 118-119页

作者： rebecca CRY(图) 不详

是否存在一支理想中的镜头,能满足多种拍摄需求,从而实现一镜走天下的终极目标呢?本期我们从实际拍摄中体验这支尼克尔Z28-400mm F4-8VR镜头,看看它是否可以成为这样一支理想主义镜头。

关键词：尼克尔镜头 VR 理想主义体验拍摄终极目标

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“米尔顿”发威

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财新周刊 2024年第40期 14-15页

作者： rebecca Blackwell(图) 视觉中国

当地时间2024年10月10日,美国佛罗里达州帕尔梅托,一位居民正在检查她被飓风摧毁的家。9日晚间,飓风“米尔顿”在美国佛州西斯塔岛登陆,强度3级,造成至少10人死亡、超过340万户断电,并带来数十起龙卷风。佛州当局向15个县(总人口约720万... 详细信息

当地时间2024年10月10日,美国佛罗里达州帕尔梅托,一位居民正在检查她被飓风摧毁的家。9日晚间,飓风“米尔顿”在美国佛州西斯塔岛登陆,强度3级,造成至少10人死亡、超过340万户断电,并带来数十起龙卷风。佛州当局向15个县(总人口约720万)发布强制疏散令,约有8万人在避难所过夜,数千人撤离。

关键词：龙卷风飓风米尔顿避难所

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不同连接节点的重型管道支吊架承载性能研究

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建筑结构 2024年第20期54卷 76-83页

作者：侯和涛 rebecca Fikre EDO 程天顺胡杰王道永赵靖山东大学土建与水利学院济南250061 中建八局第二建设有限公司济南250014

随着装配式建筑的快速发展,装配式管道支吊架的应用范围越来越广,与传统焊接支吊架相比,装配式支吊架具有施工效率高、环境污染小等优势。目前针对装配式重型支吊架的设计规范及相关研究较为缺乏,因此针对不同连接方式的装配式重型支吊... 详细信息

随着装配式建筑的快速发展,装配式管道支吊架的应用范围越来越广,与传统焊接支吊架相比,装配式支吊架具有施工效率高、环境污染小等优势。目前针对装配式重型支吊架的设计规范及相关研究较为缺乏,因此针对不同连接方式的装配式重型支吊架展开足尺试验研究,结合数值仿真与理论分析,探究不同连接节点支吊架的破坏形态与承载能力。研究结果表明:不同节点的支吊架破坏形式均表现为横梁弯扭破坏,且符合极值点失稳特征;使用槽钢横梁及半槽型连接件的支吊架承载力明显低于采用端板连接的H型钢横梁支吊架,外伸竖向端板连接结构的承载力优于平齐竖向端板连接,也优于水平端板连接节点;在进行理论计算时,半槽型连接节点和外伸端板连接节点可采用半刚接模型计算,平齐端板连接节点可采用铰接模型计算,4种节点形式的支吊架整体稳定系数均高于规范计算数值,能够满足整体稳定性的要求。

关键词：装配式管道支吊架节点连接钢梁半槽型连接件足尺试验承载力稳定性

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Frequency of the C677T Polymorphism of MTHFR, G20210A of Prothrombin and R506Q of Factor V Leiden in Type 2 Diabetics in Abidjan

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Open Journal of Genetics 2024年第1期14卷 13-25页

作者： N’Guessan-Blao rebecca Yapo Vincent Yayo-Ayé Mireille Adjambri Eusèbe Koné-Koné Fatoumata Sawadogo Duni Hematology and General Biology Unit Faculty of Pharmaceutical and Biological Sciences Department of Biological Sciences Felix Houphouet-Boigny University Abidjan Ivory Coast Laboratory of Biology and Medical Research National Institute of Public Health (INSP) Abidjan Ivory Coast Molecular Biology Unit Center for Diagnosis and Research on AIDS and Other Infectious Diseases (CeDReS) Treichville University Hospital (CHU) Abidjan Ivory Coast

In Africa, the prevalence of diabetes is escalating and remains a concern due to the numerous complications it causes. Vascular damage associated with diabetes leads to a prothrombotic state observed in diabetic individuals. Diabetes is a complex and multifactorial disease involving genetic components. With the aim of preventing complications and contributing to an efficient management of diabetes, we investigated genes likely to lead to a risk of thrombosis, in particular the C677T of MTHFR, G20210A of prothrombin, and R506Q of factor V Leiden in type 2 diabetics in Abidjan receiving ambulatory care. A descriptive cross-sectional study was carried out on consenting type 2 diabetic patients. Mutation detection was carried out using the PCR-RFLP method employing restriction enzymes. Hemostasis tests (fibrinogen, D-dimers, fibrin monomers, and von Willebrand factor) were performed using citrate tubes on the Stage? Star Max automated system. Plasminogen activator inhibitor was assayed by ELISA method, and biochemical parameters were determined using the COBAS C311. The study population consisted of 45 diabetic patients, 51.1% of whom presented vascular complications, mainly neuropathy. Disturbances in hemostasis parameters were observed, with 15.5% of patients showing an increase in fibrin monomers. Mutation analysis revealed an absence of factor V mutation (factor V Leiden) and of G20210A mutation of the prothrombin gene. However, 15.6% of subjects had a heterozygous C677T mutation of MTHFR, with 57% of them being anemic. The exploration of biological and genetic factors associated with thrombotic risk is of significant interest in the optimal management of African type 2 diabetics.

关键词： Type 2 Diabetes C677T of MTHFR G20210A Factor V Leiden Thrombosis

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