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Association of physical activity with risk of chronic kidney disease in China:A population-based cohort study

Journal of Sport and Health Science 2024年第2期13卷 204-211页

作者： Kexiang Shi Yunqing Zhu Jun Lv Dianjianyi Sun Pei Pei Huaidong Du Yiping Chen Ling Yang Bing Han rebecca stevens Junshi Chen Zhengming Chen Liming Li Canqing Yu China Kadoorie Biobank collaborative group Department of Epidemiology&Biostatistics School of Public HealthPeking University Health Science CenterBeijing 100191China Peking University Center for Public Health and Epidemic Preparedness&Response Beijing 100191China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijing 100191China Clinical Trial Service Unit&Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK Medical Research Council Population Health Research Unit at the University of Oxford Oxford OX37LFUK NCDs Prevention and Control Department Henan Center for Disease Control and PreventionZhengzhou 450016China China National Center for Food Safety Risk Assessment Beijing 100022China 不详

Background:Information on the association between physical activity(PA)and the risk of chronic kidney disease(CKD)is limited.We aimed to explore the associations of total,domain-specific,and intensity-specific PA with CKD and its subtypes in China.Methods:The study included 475,376 adults from the China Kadoorie Biobank aged 30-79 years during 2004-2008 at baseline.An interviewer-administered questionnaire was used to collect the information about PA,which was quantified as metabolic equivalent of task hours per day(MET-h/day)and categorized into 4 groups based on quartiles.Cox regression was used to analyze the association between PA and CKD risk.Results:During a median follow-up of 12.1 years,5415 incident CKD cases were documented,including 1159 incident diabetic kidney disease(DKD)cases and 362 incident hypertensive nephropathy(HTN)cases.Total PA was inversely associated with CKD risk,with an adjusted hazard ratio(HR,95%confidence interval(95%CI))of 0.83(0.75-0.92)for incident CKD in the highest quartile of total PA as compared with participants in the lowest quartile.Similar results were observed for risk of DKD and HTN,and the corresponding HRs(95%CIs)were 0.75(0.58-0.97)for DKD risk and 0.56(0.37-0.85)for HTN risk.Increased nonoccupational PA,low-intensity PA,and moderate-to-vigorous-intensity PA were significantly associated with a decreased risk of CKD,with HRs(95%CIs)of 0.80(0.73-0.88),0.85(0.77-0.94),and 0.85(0.76-0.95)in the highest quartile,respectively.Conclusion:PA,including nonoccupational PA,low-intensity PA,and moderate-to-vigorous-intensity PA,was inversely associated with the risk of CKD,including DKD,HTN,and other CKD,and such associations were dose dependent.

关键词： Chronic kidney disease Domain Intensity Physical activity

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Association between fresh fruit consumption and the risk of chronic obstructive pulmonary disease-related hospitalization and death in Chinese adults: A prospective cohort study

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中华医学杂志（英文版） 2023年第19期136卷 2316-2323页

作者： Xin Huang Jiachen Li Weihua Cao Jun Lyu Yu Guo Pei Pei Qingmei Xia Huaidong Du Yiping Chen Yang Ling Rene Kerosi rebecca stevens Xujun Yang Junshi Chen Canqing Yu Zhengming Chen Liming Li on behalf of China Kadoorie Biobank China 100191 China Peking University Center for Public Health and Epidemic Preparedness and Response Beijing 100191 China Key Laboratory of Molecular Cardiovascular Sciences (Peking University) Ministry of Education Beijing 100191 China100191 China 100037 China 100730 Nuffield Department of Population Health Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU) University of Oxford Oxford OX3 7LF UK Medical Research Council Population Health Research Unit at the University of Oxford Oxford OX3 7LF UK China 741020 China 100022 China Peking University Center for Public Health and Epidemic Preparedness and Response Beijing 100191 China100191 Nuffield Department of Population Health Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU) University of Oxford Oxford OX3 7LF UK

Background: Existing evidence suggests that fruit consumption is a significant influencing factor for chronic obstructive pulmonary disease (COPD), but this is unclear in the Chinese population. We examined the association of fresh fruit consumption with the risk of COPD-related hospitalization and death in a nationwide, population-based prospective cohort from China. Methods: Between 2004 and 2008, the China Kadoorie Biobank recruited >0.5 million adults aged 30 to 79 years from ten diverse regions across China. After excluding individuals diagnosed with major chronic diseases and prevalent COPD, the prospective analysis included 421,428 participants. Cox regression was used to calculate the hazard ratios (HRs) for the association between fresh fruit consumption and risk of COPD-related hospitalization and death, with adjustment for established and potential confounders. Results: During a mean follow-up of 10.9 years, 11,292 COPD hospitalization events and deaths were documented, with an overall incidence rate of 2.47/1000 person-years. Participants who consumed fresh fruit daily had a 22% lower risk of COPD-related hospitalization and death compared with non-consumers (HR= 0.78, 95% confidence interval [CI]: 0.71–0.87). The inverse association between fresh fruit consumption and COPD-related hospitalization and death was stronger among non-current smokers and participants with normal body mass index (BMI) (18.5 kg/m 2 ≤ BMI < 24.0 kg/m 2 ); the corresponding HRs for daily fresh fruit consumption were 0.78 (95% CI: 0.68–0.89) and 0.69 (95% CI: 0.59–0.79) compared with their counterparts, respectively. Conclusions: High-frequency fruit consumption was associated with a lower risk of COPD in Chinese adults. Increasing fruit consumption, together with cigarette cessation and weight control, should be considered in the prevention and management of COPD.

关键词： Fresh fruit Chronic obstructive pulmonary disease Smoking Body mass index

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Minimal improvement in coronary artery disease risk prediction in Chinese population using polygenic risk scores:evidence from the China Kadoorie Biobank

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Chinese Medical Journal 2023年第20期136卷 2476-2483页

作者： Songchun Yang Dong Sun Zhijia Sun Canqing Yu Yu Guo Jiahui Si Dianjianyi Sun Yuanjie Pang Pei Pei Ling Yang Iona YMillwood Robin GWalters Yiping Chen Huaidong Du Zengchang Pang Dan Schmidt rebecca stevens Robert Clarke Junshi Chen Zhengming Chen Jun Lv Liming Li On Behalf of the China Kadoorie Biobank Collaborative Group Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Peking University Center for Public Health and Epidemic Preparedness&Response Beijing 100191China Fuwai Hospital Chinese Academy of Medical Sciences Beijing 100730China Medical Research Council Population Health Research Unit at the University of Oxford Oxford OX37LFUK Clinical Trial Service Unit and Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK Qingdao Center of Disease Control and Prevention QingdaoShandong 266033China China National Center for Food Safety Risk Assessment Beijing 100738China 不详

Background:Several studies have reported that polygenic risk scores(PRSs)can enhance risk prediction of coronary artery disease(CAD)in European populations.However,research on this topic is far from sufficient in non-European countries,including China.We aimed to evaluate the potential of PRS for predicting CAD for primary prevention in the Chinese population.Methods:Participants with genome-wide genotypic data from the China Kadoorie Biobank were divided into training(n=28,490)and testing sets(n=72,150).Ten previously developed PRSs were evaluated,and new ones were developed using clumping and thresholding or LDpred method.The PRS showing the strongest association with CAD in the training set was selected to further evaluate its effects on improving the traditional CAD risk-prediction model in the testing set.Genetic risk was computed by summing the product of the weights and allele dosages across genome-wide single-nucleotide polymorphisms.Prediction of the 10-year first CAD events was assessed using hazard ratios(HRs)and measures of model discrimination,calibration,and net reclassification improvement(NRI).Hard CAD(nonfatal I21-I23 and fatal I20-I25)and soft CAD(all fatal or nonfatal I20-I25)were analyzed separately.Results:In the testing set,1214 hard and 7201 soft CAD cases were documented during a mean follow-up of 11.2 years.The HR per standard deviation of the optimal PRS was 1.26(95%CI:1.19-1.33)for hard CAD.Based on a traditional CAD risk prediction model containing only non-laboratory-based information,the addition of PRS for hard CAD increased Harrell’s C index by 0.001(-0.001 to 0.003)in women and 0.003(0.001 to 0.005)in men.Among the different high-risk thresholds ranging from 1%to 10%,the highest categorical NRI was 3.2%(95%CI:0.4-6.0%)at a high-risk threshold of 10.0%in women.The association of the PRS with soft CAD was much weaker than with hard CAD,leading to minimal or no improvement in the soft CAD model.Conclusions:In this Chinese population sample,the current PRSs minimally changed risk disc

关键词： Coronary artery disease Polygenic risk score Risk prediction model Chinese population

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Individual variation in ballooning dispersal by black widow spiderlings： The effects of family and social rearing

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Current Zoology 2015年第3期61卷 520-528页

作者： J. Chadwick JOHNSON rebecca HALPIN Dale stevens II Annika VANNAN Jesse LAM Katie BRATSCH School of Mathematical and Natural Sciences (2352) Arizona State University at the West Campus Glendale AZ 85306 USA

Individual behavioral variation is ubiquitous across taxa and important to understand if we wish to fully use behavioral data to understand the ecology and evolution of organisms. Only recently have studies of individual variation in dispersal behavior become a focus of research. A better understanding of individual variation in dispersal behavior is likely to improve our understanding of population dynamics. In particular, the dynamics of critically small populations (endangered species) and large populations (pest species) may be driven by unique dispersal variants. Here we documented individual variation in the ballooning dispersal behavior of Western black widow spiderlingsLatrodectus hesperus, an urban pest species found in superabundant infestations throughout cities of the desert Southwest USA. We found a great deal of family-level variation in ballooning dispersal, and this variation was highly consistent (repeatable) across time. Maternal egg investment was a poor predictor of this ballooning dispersal. Instead, we show that spiderlings reared in isolation are significantly slower to disperse than spiderlings raised in a more natural setting surrounded by full siblings. Thus, our study examines a widespread but poorly understood dispersal behavior (ballooning), and suggests urban pest population dynamics are likely driven by the interaction of variation in individuals, families and social environments.

关键词：个体差异社会环境家庭环境分散蜘蛛气球扩散行为教养

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Analyzing Virtual World Region Fidelity on Scalability and Simulation Performance

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Open Journal of Modelling and Simulation 2015年第3期3卷 126-135页

作者： Sean C. Mondesire Jonathan stevens rebecca Leis Douglas B. Maxwell US Army Research Laboratory Orlando FL USA Institute for Simulation and Training University of Central Florida Orlando FL USA

Virtual world simulation offers tremendous potential opportunities to improve, and optimize, individual and collective echelon training for the military. The US Army Research Laboratory (ARL) Military Open Simulator Enterprise Strategy (MOSES) project’s charter is to investigate simulation-based training technology for use in military specific training domains. Of particular interest are attributes of virtual worlds such as geographically distributed large-scale trainee support. We have initiated a series of experiments to determine appropriate benchmarks for simulator performance and to determine appropriate independent variables in order to create a robust predictive model that will enable virtual world training scenario designers to calculate, a priori, the number of trainees that may synchronously operate in a virtual world. The present paper’s purposes were to determine the effect that virtual world region fidelity had on server performance and determine whether this independent variable would be appropriate for inclusion into our predictive model. We found that region fidelity had a statistically significant effect on the simulator’s processor memory usage but had no significant effect on the simulator’s vertical scalability, CPU usage nor network performance. In this paper, we discourse on the purpose of this research, our experimental methodology and results, and discuss the significance of our findings.

关键词： Region Fidelity Vertical Scaling Virtual World Simulation Performance Analysis Distributed Simulation

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在教育科学、技术、工程和数学方面的劳动力大军中数学家的主导作用

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数学译林 2019年第1期38卷 53-54页

作者： Eric M.Friedlander Tara S.Holm John Rwing rebecca Goldin William H.Jaco T.Christine stevens David A.Vogan Jr 叶其孝(译) 吴庆宝(校) 美国数学会美国数学会教育委员会 “数学服务美国” 不详

在奥巴马总统的科学技术顾问委员会(Council of Advisors on Science and Technology,缩写为PCAST)最近的报告“参与超越(Engage to Excel)”1),2)中指出数学是大学本科的科学、技术、工程和数学(Science, Technology, Engineering, and...

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