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Analysis of the impact of immunotherapy efficacy and safety in patients with gastric cancer and liver metastasis

World Journal of Gastrointestinal surgery 2024年第3期16卷 700-709页

作者： Kai liu chun-Xiao Wu Hui Liang Tao Wang ji-Yuan Zhang Xiao-Tao Wang Department of Radiation and Oncology Traditional Chinese Hospital of Lu’an affiliated to Anhui University of Traditional Chinese MedicineLu’an 237000Anhui ProvinceChina Department of Gastroenterology Ehu branch of Xishan People’s Hospital of Wuxi CityWuxi 214116Jiangsu ProvinceChina Department of Gastrointestinal surgery The First Affiliated Hospital of Guangzhou University of Traditional Chinese MedicineGuangzhou 510400Guangdong ProvinceChina Department of Gastrointestinal surgery Hunan Provincial People’s HospitalChangsha 410002Hunan ProvinceChina Department of Traditional Chinese medicine Ehu branch of Xishan People’s Hospital of Wuxi CityWuxi 214116Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is the fifth most common type of cancer and has the fourth highest death rate among all cancers.There is a lack of studies examining the impact of liver metastases on the effectiveness of immunotherapy in individuals diagnosed with GC.AIm To investigate the influence of liver metastases on the effectiveness and safety of immunotherapy in patients with advanced GC.mETHODs This retrospective investigation collected clinical data of patients with advanced stomach cancer who had immunotherapy at our hospital from February 2021 to January 2023.The baseline attributes were compared using either the Chi-square test or the Fisher exact probability method.The chi-square test and Kaplan-meier survival analysis were employed to assess the therapeutic efficacy and survival duration in GC patients with and without liver metastases.REsULTs The analysis comprised 48 patients diagnosed with advanced GC,who were categorized into two groups:A liver metastasis cohort(n=20)and a non-liver metastatic cohort(n=28).Patients with liver metastasis exhibited a more deteriorated physical condition compared to those without liver metastasis.The objective response rates in the cohort with metastasis and the cohort without metastasis were 15.0%and 35.7%(P>0.05),respectively.similarly,the disease control rates in these two cohorts were 65.0%and 82.1%(P>0.05),respectively.The median progression-free survival was 5.0 months in one group and 11.2 months in the other group,with a hazard ratio of 0.40 and a significance level(P)less than 0.05.The median overall survival was 12.0 months in one group and 19.0 months in the other group,with a significance level(P)greater than 0.05.CONCLUsION Immunotherapy is less effective in GC patients with liver metastases compared to those without liver metastasis.

关键词： Gastric cancer spread of cancer to the liver Treatment with immunotherapy Effectiveness of treatment

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Exploration of pathogenic microorganism within the small intestine of necrotizing enterocolitis

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World Journal of Pediatrics 2024年第2期20卷 165-172页

作者： Yan Wang Kun jiang Qiao Xia Xia Kang shan Wang ji-Hong Yu Wen-Feng Ni Xiao-Qin Qi Ying-Na Zhang jin-Bao Han Gang liu Lei Hou Zhi-chun Feng liu-ming Huang Clinical Biobank Center Medical Innovation Research Division of ChinesePLA General HospitalBeijingChina Institute of Basic medical sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina senior Department of Pediatrics The Seventh Medical Center of PLA General HospitalBeijing 100700China Department of Neurology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Emergency Center National Center for Children's HealthBeijing Children's HospitalCapital Medical UniversityBeijing 100045China

Background Necrotizing enterocolitis(NEC)is the most common severe gastrointestinal emergency in neonates.We designed this study to identify the pathogenic microorganisms of NEC in the microbiota of the small intestine of neonates.methods Using the 16s ribosomal DNA(rDNA)sequencing method,we compared and analyzed the structure and diversity of microbiotas in the intestinal feces of different groups of neonates:patients undergoing jejunostomy to treat NEC(NP group),neonates undergoing jejunostomy to treat other conditions(NN group),and neonates with NEC undergoing conservative treatment(NC group).We took intestinal feces and saliva samples from patients at different time points.Results The beta diversities of the NP,NN,and NC groups were all similar.When comparing the beta diversities between different time points in the NP group,we found similar beta diversities at time points El to E3 but significant differences between the E2-E3 and E4 time points:the abundances of Klebsiella and Enterococcus(Proteobacteria)were higher at the E1-E3 time points;the abundance of Escherichia-shigella(Proteobacteria)increased at the E2 time point,and the abundance of Klebsiella decreased significantly,whereas that of streptococcus increased significantly at the E4 time point.Conclusions Our results suggest that the pathological changes of intestinal necrosis in the small intestine of infants with NEC are not directly caused by excessive proliferation of pathogenic bacteria in the small intestine.The sources of microbiota in the small intestine of neonates,especially in premature infants,may be affected by multiple factors.

关键词： microbiota Necrotizing enterocolitis-small intestine 16s rDNA

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Gene cloning,protein expression,and enzymatic characterization of a double-stranded RNA degrading enzyme in Apolygus lucorum

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Insect science 2024年第1期31卷 119-133页

作者： jie-Yu Zhang jing Zhao Keyan Zhu-salzman Qin-Qin ji Yi-Ping jiang liu-Bin Xiao De-jin Xu Guang-chun Xu Lin-Quan Ge Yong-An Tan College of Plant Protection Yangzhou UniversityYangzhouJiangsu ProvinceChina Institute of Plant Protection Jiangsu Academy of Agricultural SciencesNanjingJiangsu ProvinceChina Department of Entomology Texas A&M UniversityCollege StationTXUSA Taizhou Customs of the People's Republic of China TaizhouJiangsu ProvinceChina

RNA interference(RNAi)is a powerful tool that post-transcriptionally silences target genes in eukaryotic cells.However,silencing efficacy varies greatly among different insect species.Recently,we met with little success when attempting to knock down genes in the mirid bug Apolygus lucorum via dsRNA injection.The disappearance of double-stranded RNA(dsRNA)could be a potential factor that restricts RNAi efficiency.Here,we found that dsRNA can be degraded in midgut fluids,and a dsRNase of A.lucorum(AldsRNase)was identified and characterized.sequence alignment indicated that its 6 key amino acid residues and the mg2+-binding site were similar to those of other insects’dsRNases.The signal peptide and endonuclease non-specific domain shared high sequence identity with the brown-winged green stinkbug Plautia stali dsRNase.AldsRNase showed high salivary gland and midgut expression and was continuously expressed through the whole life cycle,with peaks at the 4th instar ecdysis in the whole body.The purified AldsRNase protein obtained by heterologously expressed can rapidly degrade dsRNA.When comparing the substrate specificity of AldsRNase,3 specific substrates(dsRNA,small interfering RNA,and dsDNA)were all degraded,and the most efficient degradation is dsRNA.subsequently,immunofluorescence revealed that AldsRNase was expressed in the cytoplasm of midgut cells.Through cloning and functional study of AldsRNase,the enzyme activity and substrate specificity of the recombinant protein,as well as the subcellular localization of nuclease,the reason for the disappearance of dsRNA was explained,which was useful in improving RNAi efficiency in A.lucorum and related species.

关键词： Apolygus lucorum cloning dsRNase enzymatic activity protein expression

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Remote sensing of air pollution incorporating integrated-path differential-absorption and coherent-Doppler lidar

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Defence Technology（防务技术） 2024年第1期31卷 594-601页

作者： Ze-hou Yang Yong Chen chun-li Chen Yong-ke Zhang ji-hui Dong Tao Peng Xiao-feng Li Ding-fu Zhou school of Physics Beijing Institute of TechnologyBeijing 100081China southwest Institute of Technical Physics Chengdu 610041SichuanChina school of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China

An innovative complex lidar system deployed on an airborne rotorcraft platform for remote sensing of atmospheric pollution is proposed and demonstrated.The system incorporates integrated-path differential absorption lidar(DIAL) and coherent-doppler lidar(CDL) techniques using a dual tunable TEA CO_(2)laser in the 9—11 μm band and a 1.55 μm fiber laser.By combining the principles of differential absorption detection and pulsed coherent detection,the system enables agile and remote sensing of atmospheric pollution.Extensive static tests validate the system’s real-time detection capabilities,including the measurement of concentration-path-length product(CL),front distance,and path wind speed of air pollution plumes over long distances exceeding 4 km.Flight experiments is conducted with the helicopter.scanning of the pollutant concentration and the wind field is carried out in an approximately 1 km slant range over scanning angle ranges from 45°to 65°,with a radial resolution of 30 m and10 s.The test results demonstrate the system’s ability to spatially map atmospheric pollution plumes and predict their motion and dispersion patterns,thereby ensuring the protection of public safety.

关键词： Differential absorption LIDAR Coherent Doppler lidar Remoting sensing Atmospheric pollution

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The sARs-CoV-2 spike protein induces lung cancer migration and invasion in a TLR2-dependent manner

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Cancer Communications 2024年第2期44卷 273-277页

作者： mi-Jeong Kim ji Young Kim ji Hye shin Juhee son Yeeun Kang soo-Kyung Jeong Duk-Hwan Kim Kyun-Hwan Kim Eunyoung chun Ki-Young Lee Department of Immunology Samsung Biomedical Research InstituteSungkyunkwan University School of MedicineSuwonRepublic of Korea Research and Development Center CHA Vaccine InstituteSeongnam-siRepublic of Korea Department of molecular Cell Biology Sungkyunkwan University School of MedicineSuwonRepublic of Korea Department of Precision medicine Sungkyunkwan University School of MedicineSuwonRepublic of Korea Department of Health sciences and Technology Samsung Advanced Institute for Health Sciences&TechnologySamsung Medical CenterSungkyunkwan UniversitySeoulRepublic of Korea

Dear editor,severe acute respiratory syndrome coronavirus2(sARs-CoV-2)infection can lead to severe outcomes in patients with cancer[1].It has been reported that patients with lung cancers disproportionately manifest severe COVID-19 with a high rate of hospitalization and death[2].Notably,the sARs-CoV-2 spike(s)protein can induce hyper-inflammation in both epithelial cells and macrophages through toll-like receptor(TLR)1/TLR2 or TLR2/6-dependent nuclear factor-kappaB(NF-κB)path-way[3].However,molecular and cellular evidence on whether the sARs-CoV-2 virus affects the severity of lung cancer patients through TLR1/2 or TLR2/6 signaling remains unclear.

关键词： lung TLR2 invasion

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Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain

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science China(Life sciences) 2024年第1期67卷 67-82页

作者： chun-Kui Zhang Pan Wang Yuan-Yuan ji jian-shuai Zhao Jun-Xiang Gu Xian-Xia Yan Hong-Wei Fan ming-ming Zhang Yu Qiao Xiao-Die liu Bao-Juan Li ming-Hui Wang Hai-Long Dong Hao-Hong Li Peng-Cheng Huang Yun-Qing Li Wu-Gang Hou jin-Lian Li Tao Chen Department of Anatomy and K.K.Leung Brain Research Centre Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Basic medical sciences Beijing 100850China Key Laboratory of ministry of Public Health for Forensic science Xi’an Jiaotong UniversityXi’an 710061China Department of Anesthesiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Neurosurgery the Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China school of Biomedical Engineering Fourth Military Medical UniversityXi’an 710032China Affiliated mental Health Centre and Hangzhou seventh People’s Hospital Zhejiang University School of MedicineHangzhou 310013China The mOE Frontier Research Center of Brain&Brain-machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou 310058China Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Anatomy School of MedicineNorthwest UniversityXi’an 710069China

Chronic pain often develops severe mood changes such as depression.However,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely unexplored.Here we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression resilience.We determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA circuit.Furthermore,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic manner.Regulation of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic pain.Our study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.

关键词： chronic pain depression lateral habenula ventral tegmental area dopamine susceptibility

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The Nano Research Young Innovators Awards in bio-inspired nanomaterials

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Nano Research 2024年第2期17卷 417-425页

作者： Jun Chen shuotao Wang Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Key Laboratory of Bio-inspired materials and Interfacial science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Nano Research Young Innovators(NR45)Awards are designed to acknowledge and celebrate the achievements of young researchers under 45 years of age.These individuals have made significant contributions to the field of nanoscience and nanotechnology.since the inaugural NR45 Awards in 2018,the journal's editorial board has recognized over a hundred innovators specializing in nanobiotechnology,nano energy,two-dimensional materials,and nanocatalysis.The focus of the 2023 NR45 Awards is on bioinspired nanomaterials,acknowledging thirty-three outstanding young innovators for their extraordinary contributions in developing these materials with applications spanning clean energy,human healthcare,monitoring,and disease treatments,as shown in Fig.1.We extend our heartfelt congratulations to all the 33 NR45 Awardees in 2023!

关键词： journal materials contributions

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Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

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World Journal of Hepatology 2024年第5期16卷 809-821页

作者： Yuan-Yao Zhang sen Luo Hai Li shu-Ning sun Xian-Bo Wang Xin Zheng Yan Huang Bei-Ling Li Yan-Hang Gao Zhi-Ping Qian Feng liu Xiao-Bo Lu Jun-Ping liu Hao-Tang Ren Yu-Bao Zheng Hua-Dong Yan Guo-Hong Deng Liang Qiao Yan Zhang Wen-Yi Gu Xiao-mei Xiang Yi Zhou Yi-Xin Hou Qun Zhang Yan Xiong Cong-Cong Zou Jun Chen Ze-Bing Huang Xiu-Hua jiang Ting-Ting Qi Yuan-Yuan Chen Na Gao chun-Yan liu Wei Yuan Xue mei jing Li Tao Li Rong-jiong Zheng Xin-Yi Zhou Jun Zhao Zhong-ji meng Department of Infectious Disease Institute of Biomedical ResearchRegulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key LaboratoryHubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400000China Center of Integrative medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina state Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Infectious Diseases The Thir

BACKGROUND Acute-on-chronic liver disease(AoCLD)accounts for the majority of patients hospitalized in the Department of Hepatology or Infectious Diseases.AIm To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of AoCLD.mETHODs Patients with AoCLD from the Chinese Acute-on-Chronic Liver Failure(ACLF)study cohort were included in this study.The clinical characteristics and outcomes,and the 90-d survival rate associated with each clinical type of AoCLD were analyzed,using the Kaplan-meier method and the log-rank test.REsULTs A total of 3375 patients with AoCLD were enrolled,including 1679(49.7%)patients with liver cirrhosis acute decompensation(LC-AD),850(25.2%)patients with ACLF,577(17.1%)patients with chronic hepatitis acute exacer-bation(CHAE),and 269(8.0%)patients with liver cirrhosis active phase(LC-A).The most common cause of chronic liver disease(CLD)was HBV infection(71.4%).The most common precipitants of AoCLD was bacterial infection(22.8%).The 90-d mortality rates of each clinical subtype of AoCLD were 43.4%(232/535)for type-C ACLF,36.0%(36/100)for type-B ACLF,27.0%(58/215)for type-A ACLF,9.0%(151/1679)for LC-AD,3.0%(8/269)for LC-A,and 1.2%(7/577)for CHAE.CONCLUsION HBV infection is the main cause of CLD,and bacterial infection is the main precipitant of AoCLD.The most common clinical type of AoCLD is LC-AD.Early diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure Liver cirrhosis Clinical features Prognosis

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六通道高温超导导体载流性能和交流损耗特性的仿真研究

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核聚变与等离子体物理 2024年第1期44卷 43-50页

作者：穆永春张莉莉刘继伟羊新胜蒋婧西南交通大学电气工程学院磁浮技术与磁浮列车教育部重点实验室成都610031 西南交通大学物理科学与技术学院成都610031

为了满足未来聚变装置磁体系统大电流、强磁场以及优良机械特性的要求,提出一种六通道TsTC-CICC高温超导导体,并采用自洽模型和T-A法,对三种结构的六通道高温超导导体的载流性能和交流损耗特性进行了二维有限元仿真研究,其中结构1中带... 详细信息

为了满足未来聚变装置磁体系统大电流、强磁场以及优良机械特性的要求,提出一种六通道TsTC-CICC高温超导导体,并采用自洽模型和T-A法,对三种结构的六通道高温超导导体的载流性能和交流损耗特性进行了二维有限元仿真研究,其中结构1中带材堆叠方向垂直于径向方向,结构2中带材堆叠方向平行于径向方向,结构3中带材堆叠方式既有垂直于径向又有平行于径向两种方式。由研究结果可知,结构1导体的临界电流最大,结构2导体的最小,结构3导体的介于两者之间。结构1和结构3导体在低磁场下具有较好的临界电流各向同性特性。三种结构导体的临界电流随外磁场角度及磁场强度的变化各不相同。结构1导体的传输交流(AC)损耗最小,结构2导体的传输AC损耗最大,结构3导体的AC传输损耗介于两者之间。在不同角度的外磁场中,三种结构的导体表现出的AC损耗各不相同。

关键词：自洽模型 T-A法六通道TsTC-CICC 高温超导导体载流性能交流损耗仿真研究

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O、s、Ce含量对U71mnG钢中Ce_(2)O_(3)和Ce_(2)O_(2)s夹杂物的影响

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稀有金属与硬质合金 2024年第2期52卷 45-49页

作者：王敏刘香军杨昌桥杨吉春内蒙古科技大学材料与冶金学院内蒙古包头014010

我国稀土钢未实现大规模的生产,其主要原因是对稀土与钢中O、s等杂质元素的相互作用规律认识不足。考虑到Ce、O、s含量对钢中稀土夹杂物的影响缺少定量分析,使用Factsage 7.1软件计算U71mnG钢中不同含量O、s、Ce之间的相互作用关系及其... 详细信息

我国稀土钢未实现大规模的生产,其主要原因是对稀土与钢中O、s等杂质元素的相互作用规律认识不足。考虑到Ce、O、s含量对钢中稀土夹杂物的影响缺少定量分析,使用Factsage 7.1软件计算U71mnG钢中不同含量O、s、Ce之间的相互作用关系及其对Ce_(2)O_(2)s、Ce_(2)O_(3)夹杂物析出量的影响。热力学计算结果表明,在U71mnG钢的成分体系下,随着Ce含量的增多,Ce_(2)O_(3)的析出量呈先增多后减少的趋势,m_(O)/m_(Ce)约为1/7.4时,Ce_(2)O_(3)的析出量最大;Ce_(2)O_(2)s的生成需要O、s、Ce共同作用,m_(O+s)/m_(Ce)约为1/3.7时,Ce_(2)O_(2)s析出量最大。试验钢夹杂物的sEm图像以及夹杂物颗粒数量统计结果显示,Ce含量为0.024%的试验钢中Ce_(2)O_(3)、Ce_(2)O_(2)s的个数大于Ce含量为0.016%的试验钢,钢中夹杂物析出规律与热力学计算结果一致。

关键词：稀土夹杂物热力学钢 Ce_(2)O_(2)s Ce_(2)O_(3)

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