检索结果-南通市图书馆

On the apparent line-of-sight alignment of the peak X-ray intensity of the magnetosheath and the tangent to the magnetopause,as viewed by SMILE-SXI

引用

Earth and Planetary Physics 2024年第1期8卷 155-172页

作者： Andrew read Department of Physics&Astronomy University of LeicesterLeicesterLE17RHUK

The Soft X-ray Imager(SXI)on board the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)spacecraft will be able to view the Earth’s magnetosheath in soft *** images of the X-ray emission visible from the position of SMILE are created for a range of solar wind densities by using 3 years of the SMILE mission orbit,together with models of the expected X-ray emissivity from the Earth’s *** from global magnetohydrodynamic simulations and a simple model for exospheric neutral densities are used to compare the locations of the lines of sight along which integrated soft X-ray intensities peak with the lines of sight lying tangent to surfaces(defined here to be the magnetopause)along which local soft X-ray intensities peak or exhibit their strongest gradients,or both,for strongly southward interplanetary magnetic field conditions when no depletion or low-latitude boundary layers are ***,in the parameter space of the various times and seasons,orbital phases,solar wind conditions,and magnetopause models,the alignment of the X-ray emission peak with the magnetopause tangent is good,or is not,is *** main results are as *** spacecraft needs to be positioned well outside the magnetopause;low-altitude times near perigee are not *** addition,there are seasonal aspects:dayside-apogee orbits are generally very good because the spacecraft travels out sunward at high altitude,but nightside-apogee orbits,behind the Earth,are bad because the spacecraft only rarely leaves the ***-apogee and dawnapogee orbits are ***-apogee orbits worsen slightly over the first three mission years,whereas nightside-apogee orbits improve ***,many more times of good agreement with the peak-to-tangent hypothesis occur when the solar wind is in a high-density state,as opposed to a low-density *** a high-density state,the magnetopause is compressed,and the spacecraft is more often a good d

关键词： X-rays magnetosphere magnetosheath magnetopause Solar wind Magnetosphere Ionosphere Link Explorer(SMILE) Earth solar wind charge exchange

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mshpy23:a user-friendly,parameterized model of magnetosheath conditions

引用

Earth and Planetary Physics 2024年第1期8卷 89-104页

作者： Jaewoong Jung Hyunju Connor Andrew Dimmock Steve Sembay Andrew read Jan Soucek NASA Goddard Space Flight Center GreenbeltMDUSA Department of Astronomy University of MarylandCollege ParkMDUSA Swedish Institude of Space Physics UppsalaSweden University of Leicester LeicesterUK Institute of Atmospheric Physics Academy of Sciences of the Czech Republic

Lunar Environment heliospheric X-ray Imager(LEXI)and Solar wind−Magnetosphere−Ionosphere Link Explorer(SMILE)will observe magnetosheath and its boundary motion in soft X-rays for understanding magnetopause reconnection modes under various solar wind conditions after their respective launches in 2024 and *** conditions,namely,plasma density,velocity,and temperature,are key parameters for predicting and analyzing soft X-ray images from the LEXI and SMILE *** developed a userfriendly model of magnetosheath that parameterizes number density,velocity,temperature,and magnetic field by utilizing the global Magnetohydrodynamics(MHD)model as well as the pre-existing gas-dynamic and analytic *** this parameterized magnetosheath model,scientists can easily reconstruct expected soft X-ray images and utilize them for analysis of observed images of LEXI and SMILE without simulating the complicated global magnetosphere ***,we created an MHD-based magnetosheath model by running a total of 14 OpenGGCM global MHD simulations under 7 solar wind densities(1,5,10,15,20,25,and 30 cm)and 2 interplanetary magnetic field Bz components(±4 nT),and then parameterizing the results in new magnetosheath *** compared the magnetosheath model result with THEMIS statistical data and it showed good agreement with a weighted Pearson correlation coefficient greater than 0.77,especially for plasma density and plasma ***,we compiled a suite of magnetosheath models incorporating previous magnetosheath models(gas-dynamic,analytic),and did two case studies to test the *** MHD-based model was comparable to or better than the previous models while providing self-consistency among the magnetosheath ***,we constructed a tool to calculate a soft X-ray image from any given vantage point,which can support the planning and data analysis of the aforementioned LEXI and SMILE missions.A release of the code has been uploaded to a Git

关键词： magnetosheath python modeling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simulation of the SMILE Soft X-ray Imager response to a southward interplanetary magnetic field turning

引用

Earth and Planetary Physics 2024年第1期8卷 39-46页

作者： Andrey Samsonov Graziella Branduardi-Raymont Steven Sembay Andrew read David Sibeck Lutz Rastaetter Mullard Space Science Laboratory University College LondonDorking RH56NTUK Leicester University Leicester LE17RHUK Goddard Space Flight Center National Aeronautics and Space AdministrationGreenbeltMD 20771USA

The Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)Soft X-ray Imager(SXI)will shine a spotlight on magnetopause dynamics during magnetic *** simulate an event with a southward interplanetary magnetic field turning and produce SXI count maps with a 5-minute integration *** making assumptions about the magnetopause shape,we find the magnetopause standoff distance from the count maps and compare it with the one obtained directly from the magnetohydrodynamic(MHD)*** root mean square deviations between the reconstructed and MHD standoff distances do not exceed 0.2 RE(Earth radius)and the maximal difference equals 0.24 RE during the 25-minute interval around the southward turning.

关键词： magnetopause magnetic reconnection solar wind charge exchange southward interplanetary magnetic field numerical modeling Solar wind Magnetosphere Ionosphere Link Explorer(SMILE) Soft X-ray Imager

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Diagnostic challenges and individualized treatment of cervical adenocarcinoma metastases to the breast:A case report

引用

World Journal of Clinical Cases 2024年第2期12卷 412-417页

作者： Allison Akers Susan read John Feldman Casey Gooden Diana P English Department of Obstetrics and Gynecology University of South FloridaTampaFL 33606United States Department of Gynecologic Oncology Sky Ridge Medical CenterLone TreeCO 80124United States Department of Radiology University of South FloridaTampaFL 33606United States Department of Pathology University of South FloridaTampaFL 33606United States

BACKGROUND Cervical cancer is a rare primary tumor resulting in metastases to the breast with few cases reported in *** metastases are associated with poor *** following case highlights the diagnostic challenges associated with metastatic cervical cancer to the breast along with individualized *** SumMARY A 44-year-old G7P5025 with no significant past medical or surgical history presented with heavy vaginal to an outside emergency department where an exam and a pelvic magnetic resonance imaging showed a 4.5 cm heterogenous lobulated cervical mass involving upper two thirds of vagina,parametria and lymph node *** biopsies confirmed high grade adenocarcinoma with mucinous features.A positron emission tomography/computed tomography(PET/CT)did not show evidence of metastatic *** received concurrent cisplatin with external beam radiation *** up PET/CT scan three months later showed no suspicious fluorodeoxyglucose uptake in the cervix and no evidence of metastatic *** was lost to follow up for six *** was re-imaged on re-presentation and found to have widely metastatic disease including breast *** biopsy confirmed programmed death-ligand 1 positive metastatic cervical *** patient received six cycles of carboplatin and paclitaxel with *** imaging demonstrated *** continued on pembrolizumab with disease *** Metastatic cervical cancer to the breast is uncommon with nonspecific clinical findings that can make diagnosis *** history and immunohistochemical evaluation of breast lesion,and comparison to primary tumor can support diagnosis of metastatic cervical cancer to the ***,the prognosis is poor,but immunotherapy can be considered in select patients and may result in good disease response.

关键词： Cervical adenocarcinoma Breast metastases Immunotherapy Pembrolizumab Carboplatin Paclitaxel Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

儿童期因素及种族间差异对成年后脉搏波传导速度的影响

引用

中华高血压杂志 2016年第6期24卷 574-574页

作者：刘莉叶鹏 Cruickshank JK Silva MJ Molaodi OR Enayat ZE Cassidy A Karamanos A read um Faconti L Dall P Stansfield B Harding S

目前对于脉搏波传导速度（主动脉僵硬度评估指标）的早期决定因素知之甚少。该研究探索多种族队列研究中童年时期曾测量2次的指标,尤其是体质量指数、血压和客观评估的体力活动对成年后主动脉僵硬度的作用。

关键词：脉搏波传导速度动脉僵硬度体力活动童期队列研究体质量动脉造影客观评估亚组设备检测

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Investigation of Nanoscale Scratching on Copper with Conical Tools Using Particle-Based Simulation

引用

Nanomanufacturing and Metrology 2023年第1期6卷 49-60页

作者： Anuj Sharma Sivakumar Kulasegaram Emmanuel Brousseau Kane Esien Dan read School of Engineering Cardiff UniversityCardiff CF243AAUK School of Physics and Astronomy Cardiff UniversityCardiff CF243AAUK Department of Electrical and Computer Engineering University of California Santa BarbaraSanta BarbaraCA 93106USA

In this study,a modeling approach based on smooth particle hydrodynamics(SPH)was implemented to simulate the nanoscale scratching process using conical tools with different negative rake *** implemented model enables the study of the topography of groove profiles,scratching forces,and the residual plastic strain beneath the *** elastoplastic material model was employed for the workpiece,and the tool–workpiece interaction was defined by a contact model adopted from the Hertz *** in-house Lagrangian SPH code was implemented to perform nano-scratching *** SPH simulation results were compared with nanoscale scratching experimental data available in the *** simulation results revealed that the normal force was more dominant compared to the cutting force,in agreement with experimental results reported for a conical tip tool with a 60°negative rake *** addition,the simulated groove profile was in good agreement with the groove profile produced in the aforementioned *** numerical simulations also showed that the normal and cutting forces increased with the increase in the scratching depth and rake *** the cutting and ploughing mechanisms were noticed in nano-scratching,the ploughing mechanism was more dominant for increased negative rake *** was also observed that residual plastic strain exists below the groove surface,and that the plastically deformed layer thickness beneath a scratched groove is larger for more negative values of the tool rake angle and higher scratching depths.

关键词： Nanoscale scratching SPH modeling Ploughing Cutting Groove profiles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficient Orbit Propagation of Orbital Elements Using Modified Chebyshev Picard Iteration Method

引用

Computer Modeling in Engineering & Sciences 2016年第1期111卷 65-81页

作者： J.L.read A.Bani Younes J.L.Junkins Graduate Research Assistant Texas A&M UniversityCollege StationTXUSA. Assistant Professor Khalifa UniversityAbu DhabiUAE. Distinguished Professor Texas A&M UniversityCollege StationTXUSA.

This paper focuses on propagating perturbed two-body motion using orbital elements combined with a novel integration *** previous studies show that Modified Chebyshev Picard Iteration(MCPI)is a powerful tool used to propagate position and velocity,the present results show that using orbital elements to propagate the state vector reduces the number of MCPI iterations and nodes required,which is especially useful for reducing the computation time when including computationally-intensive calculations such as Spherical Harmonic gravity,and it also converges for>5.5x as many revolutions using a single segment when compared with cartesian *** for the Classical Orbital Elements and the Modified Equinoctial Orbital Elements(the latter provides singularity-free solutions)show that state propagation using these variables is inherently well-suited to the propagation method *** benefits are achieved using a segmentation scheme,while future expansion to the two-point boundary value problem is expected to increase the domain of convergence compared with the cartesian *** is an iterative numerical method used to solve linear and nonlinear,ordinary differential equations(ODEs).It is a fusion of orthogonal Chebyshev function approximation with Picard iteration that approximates a long-arc trajectory at every *** studies have shown that it outperforms the state of the practice numerical integrators of ODEs in a serial computing environment;since MCPI is inherently massively parallelizable,this capability is expected to increase the computational efficiency of the method presented.

关键词： Propagation Integration Orbital Mechanics Classical Elements Modified Equinoctial Chebyshev Picard Iteration MCPI Polynomials Initial Value Problem IVP.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor

引用

Signal Transduction and Targeted Therapy 2023年第6期8卷 2463-2466页

作者： Fabian Zech Stefanie Weber Hanna Dietenberger Linyun Zhang Sabrina Noettger Meta Volcic Tim Bergner Clarissa read Konstantin M.J.Sparrer Thomas F.E.Barth Frank Kirchhoff Institute of Molecular Virology Ulm University Medical CenterUlmGermany Institute of Pathology Ulm UniversityUlmGermany Central Facility for Electron Microscopy Ulm UniversityUlmGermany

Dear Editor Effective vaccines and some antiviral agents against SARS-CoV-2,the causative agent of coronavirus disease 2019(COVID-19),have been ***,additional therapeutics are needed since emerging SARS-CoV-2 variants evade immunity induced by vaccination or previous infection and are resistant to therapeutic antibodies and fusion inhibitors.^(1)In addition,many patients experience prolonged post-acute sequelae of SARS-CoV-2.

关键词： ACE2 immunity acute

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Real time monitoring of bioreactor mAb IgG3 cell culture process dynamics via Fourier transform infrared spectroscopy： Implications for enabling cell culture process analytical technology

引用

Frontiers of Chemical Science and Engineering 2015年第3期9卷 386-406页

作者： Huiquan Wu Erik read Maury White Brittany Chavez Kurt Brorson Cyrus Agarabi Mansoor Khan Division of Product Quality Research (DPQR HFD-940) Office of Testing and Research (OTR) Office of Pharmaceutical Quality (OPQ) Center for Drug Evaluation and Research (CDER) US Food and Drug Administration (FDA) Federal Research Center at White Oak 10903 New Hampshire Ave Silver Spring MD 20993 USA Process Assessment Branch II Division of Process Assessment 1 (DPA 1) Office of Process and Facilities (OPF) Office of Pharmaceutical Quality (OPQ) Center for Drug Evaluation and Research (CDER) US Food and Drug Administration (FDA) Federal Research Center at White Oak 10903 New Hampshire Ave Silver Spring MD 20993 USA Division of Biotechnology Review and Research II (DBRRII) Office of Biotechnology Products (OBP) Office of Pharmaceutical Quality (OPQ) Center for' Drug Evaluation and Research (CDER) US Food and Drug Administration (FDA) Federal Research Center at White Oak 10903 New Hampshire Ave Silver Spring MD 20993 USA

Compared to small molecule process analytical technology （PAT） applications, biotechnology product PAT applications have certain unique challenges and opportunities. Understanding process dynamics of bioreactor cell culture process is essential to establish an appropriate process control strategy for biotechnology product PAT applications. Inline spectroscopic techniques for real time monitoring of bioreactor cell culture process have the distinct potential to develop PAT approaches in manufac- turing biotechnology drug products. However, the use of inline Fourier transform infrared （FTIR） spectroscopic techniques for bioreactor cell culture process monitoring has not been reported. In this work, real time inline FTIR Spectroscopy was applied to a lab scale bioreactor mAb IgG3 cell culture fluid biomolecular dynamic model. The technical feasibility of using FTIR Spectroscopy for real time tracking and monitoring four key cell culture metabolites （including glucose, glutamine, lactate, and ammonia） and protein yield at increasing levels of complexity （simple binary system, fully formulated media, actual bioreactor cell culture process） was evaluated via a stepwise approach. The FTIR fingerprints of the key metabolites were identified. The multivariate partial least squares （PLS） calibration models were established to correlate the process FTIR spectra with the concentrations of key metabolites and protein yield of in-process samples, either individually for each metabolite and protein or globally for all four metabolites simultaneously. Applying the 2＇ld derivative pre-processing algorithm to the FTIR spectra helps to reduce the number of PLS latent variables needed significantly and thus simplify the interpretation of the PLS models. The validated PLS models show promise in predicting the concentration profiles of glucose, glutamine, lactate, and ammonia and protein yield over the course of the bioreactor cell culture process. Therefore, this work demonstrated the t

关键词： process analytical technology (PAT) Fouriertransform infrared (FTIR) spectroscopy partial least squares (PLS) regression mouse IgG3 bioreactor cell culture process real time process monitoring

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

NEA''s read Across America

引用

2003年

作者： NEA''s read Across America

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：