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Manipulation of photosensory and circadian signaling restricts phenotypic plasticity in response to changing environmental conditions in Arabidopsis

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Molecular Plant 2024年第9期17卷 1458-1471页

作者： Martin William Battle Scott Fraser Ewing Cathryn Dickson Joseph Obaje Kristen N.Edgeworth Rebecca Bindbeutel rea lantoniou-kourounioti Dmitri A.Nusinow Matthew Alan Jones Plant Science Group School of Molecular BiosciencesUniversity of GlasgowGlasgow G128QQUK Danforth Plant Science Center St.LouisMO 63132USA Department of Biological and Biomedical Sciences Washington University in St.LouisSt.LouisMO 63130USA Present address:School of Biological and Environmental Sciences Liverpool John Moores UniversityLiverpool L22QPUK

Plants exploit phenotypic plasticity to adapt their growth and development to prevailing environmental *** of light and temperature signals is aided by the circadian system,which provides a temporal *** plasticity provides a selective and competitive advantage in nature but is obstructive during large-scale,intensive agricultural practices since economically important traits(including vegetative growth and flowering time)can vary widely depending on local environmental *** prevents accurate prediction of harvesting times and produces a variable *** this study,we sought to restrict phenotypic plasticity and circadian regulation by manipulating signaling systems that govern plants'responses to environmental *** modeling of plant growth and develop-ment predicted reduced plant responses to changing environments when circadian and light signaling pathways were *** tested this prediction by utilizing a constitutively active allele of the plant photoreceptor phytochrome B,along with disruption of the circadian systemvia mutation of *** found that these manipulations produced plants that are less responsive to light and temper-ature cues and thus fail to anticipate *** engineered plants have uniform vegetative growth and flowering time,demonstrating how phenotypic plasticity can be limited while maintaining plant *** has significant implications for future agriculture in both open fields and controlled environments.

关键词： circadian developmental plasticity phenotypic plasticity external coincidence light temperature

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Functional Design for Customizing Sit-To-Stand Assisting Devices

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Journal of Bionic Engineering 2018年第1期15卷 83-93页

作者： Pierluigi rea Erika Ottaviano DICeM-Department of Civil and Mechanical Engineering University of Cassino and Southern Lazio via Di Biasio 43 03043 Cassino (FR) Italy

Standing up refers to the transition from the seating to the standing postures to perform a movement that involves several body segments and requires both voluntary action and equilibrium control during an important displacement of the body Centre of Gravity （COG）. This task can be considered very important for people with reduced mobility to achieve minimal independence in Activity of Daily Living （ADL）. In this paper, we propose solutions for the homecare of persons with reduced mobility, describing a functional design to customize assisting devices for the Sit-to-Stand （STS）. In particular, the support mechanism that generates the requested motion and sustains the body of a person can be synthesized ad-hoc according to the experimental data of the subject. Experimental tests carried out during the Sit-To-Stand are used to track and record point trajectories and the orientation of the trunk of an individual, and they are used to design a 1-DOF mechanism able to reproduce the assigned rigid-body motion. A four-bar linkage has been synthesized according to the desired features. Simulation results are reported to illustrate the engineering soundness of the proposed mechatronic solution.

关键词： assisting device Sit-to-Stand bionic design kinematic synthesis experimental evaluation simulation

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A Procedure for the Design of Novel Assisting Devices for the Sit-to-Stand

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Journal of Bionic Engineering 2013年第4期10卷 488-496页

作者： Pierluigi rea Erika Ottaviano Gianni Castelli Department of Civil and Mechanical Engineering University of Cassino and Southern Lazio via G. Di Biasio 43 03043 Cassino (FR) Italy

The Sit-to-Stand （STS） is an activity most people perform numerous times daily. Standing up deals with the transition from two stabilized postures, namely seated to standing, with movement of all body segments except the feet. During the STS the body＇s Center of Gravity （COG） is moved upward from a sitting position to a standing position without losing balance and requiring a good coordination of many muscles. Three main phases of the STS movement can be recognized. One begins to stand up by inclining the upper body forward, which moves body mass toward the feet in order to maintain balance after lift-off. Prior to leaving the chair, hip and knee extensor muscles are activated to provide antigravity support for these joints, this action is commonly referred to as ＂weight shift＂. Finally; after leaving the chair, the leg and trunk joints are straightened to achieve upright stance. The STS task can be considered of major importance for impaired and elderly people to achieve minimal mo- bility and independence. In this paper we detail a procedure for the design of assisting devices to be used for the STS. In par- ticular, an experimental procedure is described firstly to track and record point trajectories and the orientation of the trunk during the STS. This analysis is then used to get information for the design of assisting devices. A proposal and simulation results are presented for a novel mechatronic system. In particular, for the case under study experimental tests are used to drive the actua- tion system for the reported simulation. A functional mechatronic scheme is then proposed to control the device during its operation.

关键词： Sit-to-Stand assisting devices mechatronic design experimental evaluation simulation

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The role of sequestosome 1/p62 protein in amyotrophic lateral sclerosis and frontotemporal dementia pathogenesis

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Neural Regeneration Research 2020年第12期15卷 2186-2194页

作者： Adriana Delice Foster Sarah Lyn rea Harry Perkins Institute of Medical Research University of Western Australia Perron Institute for Neurological and Translational Science Centre for Neuromuscular and Neurological DisordersThe University of Western AustraliaNedlandsWestern AustraliaAustralia Centre for Molecular Medicine and Innovative Therapeutics Murdoch University Murdoch Western Australia Australia

Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are multifaceted diseases with genotypic,pathological and clinical *** such overlap is the presence of SQSTM1/p62 *** traditionally mutations manifesting in the ubiquitin-associated domain of p62 were associated with Paget’s disease of bone,mutations affecting all functional domains of p62 have now been identified in amyotrophic lateral sclerosis and frontotemporal lobar degeneration patients.p62 is a multifunctional protein that facilitates protein degradation through autophagy and the ubiquitin-proteasome system,and also regulates cell survival via the Nrf2 antioxidant response pathway,the nuclear factor-kappa B signaling pathway and *** in these signaling and protein degradation pathways have been observed in amyotrophic lateral sclerosis and frontotemporal lobar degeneration,and mutations that affect the role of p62 in these pathways may contribute to disease *** this review we discuss the role of p62 in these pathways,the effects of p62 mutations and the effect of mutations in the p62 modulator TANK-binding kinase 1,in relation to amyotrophic lateral sclerosis-frontotemporal lobar degeneration pathogenesis.

关键词： aggregate/inclusion body formation amyotrophic lateral sclerosis-frontotemporal lobar degeneration autophagy cell signaling mitophagy p62/SQSTM1 protein degradation

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Activated P13Kδ disrupts germinal center GC T(fh)/GC B cell cross talk and B cell antibody coding

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Cellular & Molecular Immunology 2019年第11期16卷 848-850页

作者： I.Maeve rea School of Medicine Dentistry and Biomedical SciencesQueens University Belfast97 Lisburn RoadBelfast BT71NNUK

In a study by Priete and research groups from the USA and Italy,1 a mouse model with a mutation in the P13K gene that causes the activation of the P13K pathway was used to demonstrate the cellular and molecular mechanisms underlying the main biological and clinical features of the rare human immunodeficiency disease known as APDS or activated P13kδ*** humans,the overactivation of the P13Kδpathway causes recurrent respiratory infections with secondary bronchiectasis,lymphopenia,lymphoproliferation,and poor vaccination responses.2 The P13Kδmouse model has a gain-of-function(GOF)mutation in the P13Kδgene and shows lymphopenia,lymphoproliferation,and poor responses to vaccination,similar to the findings in human *** findings suggested that the P13Kδ-GOF mouse could be a useful tool to dissect the cellular and molecular mechanisms and pathways that contribute to the similar human *** authors then probed the immune response/s in the P13KδGOF mouse model using a variety of challenges and methods to identify where and how the P13Kδ-GOF-activated gene disturbs the cellular and molecular pathways of competent antibody formation and used comparisons with wild-type(WT)mice and normal human donors to help define the APDS phenotype and the P13Kδ-GOF mutant mouse model(MM).

关键词： P13K vaccination respiratory

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Bioactive lipids in cancer stem cells

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World Journal of Stem Cells 2019年第9期11卷 693-704页

作者： Romana-rea Begicevic Frank Arfuso Marco Falasca Metabolic Signalling Group School of Pharmacy and Biomedical SciencesCurtin Health Innovation Research InstituteCurtin UniversityPerthWA 6102Australia Stem Cell and Cancer Biology Laboratory School of Pharmacy and Biomedical SciencesCurtin Health Innovation Research InstituteCurtin UniversityPerthWA 6102Australia

Tumours are known to be a heterogeneous group of cells,which is why they are difficult to *** possible cause for this is the existence of slow-cycling cancer stem cells(CSCs)endowed with stem cell-like properties of self-renewal,which are responsible for resistance to chemotherapy and *** recent years,the role of lipid metabolism has garnered increasing attention in ***,the key roles of enzymes such as stearoyl-CoA desaturase-1 and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase in CSCs,have gained particular ***,despite accumulating evidence on the role of proteins in controlling lipid metabolism,very little is known about the specific role played by lipid products in *** review highlights recent findings on the role of lipid metabolism in CSCs,focusing on the specific mechanism by which bioactive lipids regulate the fate of CSCs and their involvement in signal transduction pathways.

关键词： Cancer stem cells Lipid metabolism Bioactive lipids ABC transporters

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Risk factors and strategies for prevention of depression, anxiety and eating disorders among adolescents during the coronavirus disease 2019 (COVID-19) pandemic: a review

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Global Health Journal 2023年第2期7卷 78-86页

作者： rea Pillai Isha Patel Rajesh Balkrishnan Department of Public Health Sciences University of Virginia School of MedicineP.0.Box 800717 CharlottesvilleVirginiaVA 22908USA

The purpose of this review is to identify prevalent trends and risk factors in depression,anxiety,and eating disorders in the adolescent population in the post coronavirus disease 2019(COvID-19)*** examined the literature published on adolescent mental health since the COVID-19 *** chose to summarize studies published from 2019 to 2022,using bibliographic search *** developed criteria for selecting articles for our review using diagnostic indicators and *** health conditions such as depression,anxiety and eating disorders are commonly prevalent in this population and have shown increasing rates in the past three *** risk factors associated with these diagnoses include reduction in social interaction,increased workloads,routine shifts,sleep quality,social media usage and parental ***,sleep cycles,physical activity,and social media should all be considered as a part of prevention in this *** that seem to be successful include maintaining social ties and avoiding negative social media usage with harmful *** global public awareness,as well as parental awareness,through media campaigns,is critical to slowing the spread of mental health challenges in adolescents and teenagers in the post-COvID-19 era.

关键词： Coronavirus disease 2019(COVID-19) Mental health Teenagers Impact of mental health

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Personalizing medicine for metastatic colorectal cancer:Current developments

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World Journal of Gastroenterology 2014年第30期20卷 10425-10431页

作者： rea Marin Marques Alice Turner Ramon rade de Mello Centro Hospitalar do Médio Ave Unidade de Santo Tirso4780-371 Santo Tirso4200-072 PortoPortugal School of Medicine University of Otago2 Riccarton AveChristchurch Central8011 ChristchurchNew Zealand Department of Medical Oncology Portuguese Oncology Institute (IPO PORTO)4200-072 PortoPortugal Department of Biomedical Sciences and Medicine School of MedicineUniversity of Algarve8005-139 FaroPortugal

Metastatic colorectal cancer(mCRC)is still one of the tumor types with the highest incidence and *** 2012,colorectal cancer was the second most prevalence cancer among males(9%)and the third among females(8%).In this disease,early diagnosis is important to improve treatment ***,at the time of diagnosis,about one quarter of patients already have metastases,and overall survival of these patients at 5-years survival is very *** of these poor statistics,the development of new drugs against specific targets,including the pathway of angiogenesis,has witnessed a remarkable ***,targets therapies through epidermal growth factor and its receptor and also KRAS pathways modulation acquired a main role whether in association with standard chemotherapy and *** the current knowledge in the field of molecular biology,including genetic mutations and polymorphisms,we know better why patients respond so differently to the same ***,in the future we can develop increasingly personalized treatments to the patient and not the *** review aims to summarize some molecular pathways and their relation to tumor growth,as well as novel targeted developing drugs and recently approved for mCRC.

关键词： Metastatic colorectal cancer Angiogenesis Vascular endothelial growth factor Epidermal growth factor Target therapy

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Acute fractures of the pediatric foot and ankle

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World Journal of Pediatrics 2015年第1期11卷 14-20页

作者： Mansur Halai Bilal Jamal Paul rea Mobeen Qureshi Anand Pillai Department of Trauma and Orthopedics University Hospitials of South ManchesterManchester M239LTUK

Background:Injuries around the foot and ankle are *** is a paucity of literature,outside that of specialist orthopedic journals,that focuses on this subject in the pediatric *** sources:In this review,we outline pediatric foot and ankle fractures in an anatomically oriented manner from the current *** aim is to aid the emergency department doctor to manage these challenging injuries more efectively in the acute ***:These injuries require a detailed history and examination to aid the ***,plain radiographs are suficient,but more complex injuries require the use of magnetic resonance *** is dependent on the proximity to skeletal maturity and the degree of displacement of *** have a marked ability to remodel after fractures and therefore mainstay treatment is immobilization by a cast or *** fxation,although uncommon in this population,may be necessary with adolescents,certain unstable injuries or in cases with displaced articular *** the setting of severe foot trauma,skin compromise and compartment syndrome of the foot must be ***:The integrity of the physis,articular surface and soft tissues are all equally important in treating these injuries.

关键词： ankle foot fractures

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Fluoroquinolone-based protocols for eradication of Helicobacter pylori

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World Journal of Gastroenterology 2014年第27期20卷 8947-8956页

作者： Antonio Rispo Pietro Capone fabiana Castiglione Luigi Pasquale Matilde rea Nicola Caporaso Division of Gastroenterology Department of Clinical Medicine and Surgery-University "Federico Ⅱ" of Naples 80131 Napoli Italy Division of Gastroenterology P.O. "Sant’ Ottone Frangipane" Ariano Irpino 80131 Napoli Italy

Helicobacter pylori (H. pylori) is a widespread pathogen infecting about 40% of people living in urban areas and over 90% of people living in the developing regions of the world. H. pylori is well-documented as the main factor in the pathogenesis of peptic ulcer disease, chronic gastritis, and gastric malignancies such as cancer and mucosa-associated lymphoid tissue-lymphoma; hence, its eradication is strongly recommended. The Maastricht IV consensus, which focused on the management of H. pylori infection, set important new strategies in terms of treatment approaches, particularly with regards to first- and second-line treatment protocols and led to improved knowledge and understanding of H. pylori resistance to antibiotics. In recent years, various fluoroquinolone-based protocols, mainly including levofloxacin, have been proposed and effectively tested at all therapeutic lines for H. pylori eradication. The aim of the present paper is to review the scientific literature focused on the use of fluoroquinolones in eradicating H. pylori.

关键词： Helicobacter pylori eradication fluoroquinolone therapy

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