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Transcriptional cofactors Ski and SnoN are major regulatorsof the TGF-β/Smad signaling pathway in health and disease

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Signal Transduction and Targeted Therapy 2018年第1期3卷 184-198页

作者： Angeles C.Tecalco-Cruz diana G.Rios-Lopez Genaro Vazquez-Victorio reyna e.Rosales-Alvarez Marina Macias-Silva Instituto de Investigaciones Biomedicas at Universidad Nacional Autonoma de Mexico Mexico city 04510Mexico Instituto de Fisiologia Celular at Universidad Nacional Autonoma de Mexico Mexico city 04510Mexico Facultad de Ciencias at Universidad Nacional Autonoma de Mexico Mexico city 04510Mexico

The transforming growth factor-β(TGF-β)family plays major pleiotropic roles by regulating many physiological processes in development and tissue *** TGF-βsignaling pathway outcome relies on the control of the spatial and temporal expression of>500 genes,which depend on the functions of the Smad protein along with those of diverse modulators of this signaling pathway,such as transcriptional factors and ***(Sloan-Kettering Institute)and SnoN(Ski novel)are Smadinteracting proteins that negatively regulate the TGF-βsignaling pathway by disrupting the formation of R-Smad/Smad4 complexes,as well as by inhibiting Smad association with the p300/CBP *** Ski and SnoN transcriptional cofactors recruit diverse corepressors and histone deacetylases to repress gene *** TGF-β/Smad pathway and coregulators Ski and SnoN clearly regulate each other through several positive and negative feedback ***,these cross-regulatory processes finely modify the TGF-βsignaling outcome as they control the magnitude and duration of the TGF-β*** a result,any alteration in these regulatory mechanisms may lead to disease ***,the design of targeted therapies to exert tight control of the levels of negative modulators of the TGF-βpathway,such as Ski and SnoN,is critical to restore cell homeostasis under the specific pathological conditions in which these cofactors are deregulated,such as fibrosis and cancer.

关键词： SnoN homeostasis Smad

New observations and transit solutions of the inflated exoplanets HAT-P-40b and HAT-P-51b

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re.e.rch in Astronomy and Astrophysics 2021年第2期21卷 157-160页

作者： diana P.Kjurkchieva Nikola I.Petrov Velimir A.Popov Department of Physics and Astronomy Shumen University115 Universitetska str.9700 ShumenBulgaria Institute of Astronomy and NAO Bulgarian Academy of SciencesTsarigradsko shossee 721784 SofiaBulgaria

We pre.e.t high-precision photometric observations of the transiting exoplanets HAT-P-40 b and HAT-P-51 b by the Rozhen 2-m *** newly-observed transit of HAT-P-40 b is the first one with a complete *** orbital periods of the two targets were *** modeled the observed transits and found bigger stellar radii than those derived from the stellar *** planet radii of HATP-40 b and HAT-P-51 b obtained from our transit solutions are bigger than the values calculated by the empirical relations for Jupiter-mass and Saturn-mass planets *** values re.e.l the highlyinflated nature of the two targets,especially that of HAT-P-51 *** established that the best transit solutions correspond to a quadratic limb-darkening *** fitted limb-darkening coefficients of HAT-P-40 are close to the theoretical ones while those of HAT-P-51 are a little *** precise astrometric Gaia distances of the two targets are smaller by 6%–7%than the calculated values from the stellar *** propose the Gaia distances to be used for improvement of the stellar models as well as for more reliable calculation of the parameters of the known exoplanets.

关键词： (Stars )planetary systems-techniques photometric-Stars individual(HAT-P-40 and HAT-P-51)

Seismic imaging of the double seismic zone in the subducting slab in Northern Chile

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earthquake re.e.rch Advances 2021年第1期1卷 25-33页

作者： Pan Lu Haijiang Zhang Lei Gao diana Comte Laboratory of Seismology and Physics of earth's Interior School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefeiAnhui230026China Departamento de Geofísica Advanced Mining Technology CenterFacultad de Ciencias Físicas y MatematicasUniversidad de ChileBlanco Encalada2002SantiagoChile

Double seismic zones are commonly observed in the subducting slabs in a global scale,serving as ideal examples for studying the seismogenetic mechanism of the intermediate-depth *** this study,we relocate earthquakes and determine seismic velocity models using the double-difference seismic tomography method in the northern Chile subduction zone where a double seismic zone *** results suggest that the double seismic zone in northern Chile is located at about 50-140 km depth,with an interval of approximately 20 km between the two *** upper seismic zone is characterized by relatively low Vp(~7.8-8.0 km/s),low Vs(~4.4-4.5 km/s)and high Vp/Vs(~1.85)above the depth of~90 km,while the region below~90 km is distinguished by relatively high Vp(~8.2 km/s),high Vs(~4.8 km/s)and slightly high Vp/Vs(~1.75),which may be related to a series of dehydration reactions of hydrous minerals in the subducted oceanic *** comparison,the lower seismic zone is featured by the anomaly of low Vp/Vs(~1.7),although some local areas may consist of relatively high Vp/Vs values(~1.8),possibly due to the dehydration reaction of *** on the Vp,Vs,Vp/Vs anomalies combined with previous petrological experiments and thermodynamic models,it can be derived that intermediate-depth earthquakes are mainly related to the dehydration of various hydrous minerals in the subducting *** dehydration process of hydrous minerals re.e.ses water into the subducting slab and subsequently leads to the increase of pore fluid pressure and the decrease of effective normal stress,thus causing the occurrence of brittle failure and intermediate-depth earthquakes in subduction *** imaging results of the northern Chile subduction zone further indicate that the existence of the double seismic zone is related to the dehydration process of different hydrous minerals.

关键词： Chile subduction Zone Double difference seismic tomography Double seismic zone Dehydration embrittlement

Temperature.e.fect on the sensitivity of the copepod eucyclops serrulatus （Crustacea, Copepoda, Cyclopoida） to agricultural pollutants in the hyporheic zone

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Current Zoology 2015年第4期61卷 629-640页

作者： Tiziana DI LOreNZO Walter D. DI MARZIO Marco CIFONI Barbara FIASCA M. BARATTI Maria e. SAeNZ diana M.P. GALASSI Institute of ecosystem Study - CNR - National re.e.rch Council of Italy Via Madonna del Piano 10 50019 Sesto Fiorentino Florence Italy Programa de Investigacion en ecotoxicologia Departamento de Ciencias Basicas Universidad Nacional de Lujan - Comision National de Investigaciones Cientificas y Tecnicas CONICET Argentina Department of Life Health and Environmental Sciences University of L'Aquila Via Vetoio 1 Coppito 67100 L'Aquila Italy

The sensitivity of freshwater invertebrates to agricultural pollutants is supposed to increase with rising temperature due to global warming. The aim of this study was to measure the effect of temperature on the lethal toxicity of ammonia-N, the herbicide Imazamox and the mixture of the two chemicals, in the adults and the juveniles of a population of the copepod eucyc- lops serrulatus. This is a widely distributed species found in surface waters, in transitional habitats between surface water and groundwater, and in genuine groundwater environments. We tested the sensitivity by short-term bioassays （96 h） at 15℃ and 18℃, respectively. Our results highlighted the following：（1） increasing temperature affected the sensitivity of the adults to am- monia-N and of the juveniles to the mixture, all of which were more sensitive to its detrimental effects at 18~C; （2） the juvenile stages were more sensitive than the adults to all toxicants, and （3） for all combinations of chemicals and temperatures, the effects were synergistic and approximately one order of magnitude greater than those expected according to a concentration addition model when comparing the LC50 for each chemical in the mixture with the LC50s of chemicals individually assayed. Overall, in a context of global change, ammonia-N and mixtures of agricultural pollutants may affect the survival rate of species that spend a part or the whole life-cycle in the hyporheic habitat, with detrimental effects to biodiversity and ecosystem services provided by the hyporheic biota [Current Zoology 61 （4）： 629~540, 2015].

关键词： Hyporheie Global wanning Copepods Ammonia Herbicide Mixtures

Spectrum of neuropsychiatric symptoms in chronic post-stroke aphasia

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World Journal of Psychiatry 2022年第3期12卷 450-469页

作者： Lisa edelkraut diana López-Barroso María JoséTorres-Prioris Sergio e Starkstein Ricardo e Jorge Jessica Aloisi Marcelo L Berthier Guadalupe Dávila Department of Psychobiology and Methodology of Behavioral Science Faculty of Psychology and Speech TherapyUniversity of MalagaMalaga 29071Spain Cognitive Neurology and Aphasia Unit Centro de Investigaciones Médico-SanitariasUniversity of MalagaMalaga 29010Spain Instituto de Investigación Biomédica de Málaga University of MalagaMalaga 29010Spain School of Psychiatry and Neurosciences The University of Western AustraliaPerth 6009Australia Department of Psychiatry and Behavioral Sciences Baylor College of MedicineHoustonTX 77030United States

BACKGROUND Neuropsychiatric symptoms(NPS)have been insufficiently examined in persons with aphasia(PWA)because most previous studies exclude participants with language and communication *** To report a two-part study consisting of a literature review and an observational study on NPS in post-stroke *** Study 1 reviewed articles obtained from PubMed,PsycINFO,Google Scholar and Cochrane databases after cross-re.e.encing key words of post-stroke aphasia to NPS and *** 2 examined language deficits and activities of daily living in 20 PWA(median age:58,range:28-65 years;13 men)with the Western Aphasia Battery-revised and the Barthel Index,*** of these 20 PWA were proxy-evaluated with the Neuropsychiatric Inventory and domain-specific scales,including the Stroke Aphasia Depression Questionnaire-10 item version and the Starkstein Apathy *** addition,an adapted version of the Hospital Anxiety and Depression Scale was directly administered to the PWA *** observational study is based on the baseline assessment of an intervention clinical trial(eudraCT:2017-002858-36;*** identifier:NCT04134416).reSULTS The literature review re.e.led a broad spectrum of NPS in PWA,including depression,anxiety,apathy,agitation/aggression,eating and sleep disorders,psychosis,and hypomania/*** findings alert to the need for improving assessment and treatment approaches of NPS taking into consideration their frequent occurrence in *** 2 showed that the 20 participants had mild-to-moderate aphasia severity and were functionally independent.A wide range of comorbid NPS was found in the post-stroke aphasic population(median number of NPS:5,range:1-8).The majority of PWA(75%)had depressive symptoms,followed by agitation/aggression(70%),irritability(70%),anxiety(65%)and appetite/eating symptoms(65%).Half of them also pre.e.ted symptoms of apathy,whereas euphoria and psychotic symptoms were rare(5%).Domain

关键词： Aphasia Stroke Neuropsychiatric symptoms Anxiety Apathy Depression

Boosting Interfacial Polarization Through Heterointerface engineering in MXene/Graphene Intercalated-Based Microspheres for electromagnetic Wave Absorption

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Nano-Micro Letters 2023年第9期15卷 436-460页

作者： Ge Wang Changfeng Li diana estevez Peng Xu Mengyue Peng Huijie Wei Faxiang Qin Institute for Composites Science Innovation(InCSI) School of Materials Science and EngineeringZhejiang University38 Zheda RoadHangzhou 310027People’s Republic of China Ningbo Institute of Technology Zhejiang University1 Qianhu South RdNingbo 315100People’s Republic of China Foshan(Southern China)Institute for New Materials FoshanPeople’s Republic of China

Multi-layer 2D material assemblies provide a great number of interfaces beneficial for electromagnetic wave ***,avoiding agglomeration and achieving layer-by-layer ordered intercalation remain ***,3D reduced graphene oxide(rGO)/MXene/TiO_(2)/Fe_(2)C lightweight porous microspheres with periodical intercalated structures and pronounced inter-facial effects were constructed by spray-freeze-drying and microwave irradiation based on the Maxwell–Wagner *** approach reinforced interfacial effects via defects introduction,porous skeleton,multi-layer assembly and multi-compo-nent system,leading to synergistic loss *** abundant 2D/2D/0D/0D intercalated heterojunctions in the microspheres provide a high density of polari-zation charges while generating abundant polarization sites,resulting in boosted interfacial polarization,which is verified by CST Microwave Studio *** precisely tuning the 2D nanosheets intercalation in the heterostructures,both the polarization loss and impedance matching improve *** a low filler loading of 5 wt%,the polarization loss rate exceeds 70%,and a minimum reflection loss(RLmin)of-67.4 dB can be ***,radar cross-section simulations further confirm the attenuation ability of the optimized porous *** results not only provide novel insights into understanding and enhancing interfacial effects,but also constitute an attractive platform for implementing heterointerface engineering based on customized 2D hierarchical architectures.

关键词： MXene Hierarchical microspheres Interfacial polarization Spray-freeze-drying Microwave absorption

exosomes from adipose tissue-derived stem/stromal cells:A key to future re.e.erative medicine

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BIOCeLL 2022年第12期46卷 2701-2704页

作者： JÉRÔMe LALOZe ALeXIS DeSMOULIÈre University of Limoges Neuropathies and Therapeutic Innovations(UR 20218)Faculties of Medicine and PharmacyLimogesF-87000France Department of Maxillo-Facial and reconstructive Surgery and Stomatology University Hospital DupuytrenLimogesF-87000France

Advances in re.e.erative medicine correlate strongly with progress in the use of adipose tissue-derived mesenchymal stem/stromal *** range of therapeutic indications has also expanded over re.e.t *** re.e.t studies have highlighted the primary importance of paracrine secretion by these *** it is interesting to compare the different types of such secretions,we believe that exosomes(extra-cellular vesicles possessing the same properties as their source cells)will likely be the main key in tomorrow’s cell *** also have many advantages compared to the direct use of cells,making these particles amajor target in fundamental and translational re.e.rch.

关键词： Adipose-derived mesenchymal stem/stromal cell exosome re.e.erative medicine Secretome

Novel Mycelium-Based Biocomposites (MBB) as Building Materials

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Journal of re.e.able Materials 2020年第9期8卷 1067-1076页

作者： Zinta Zimele Ilze Irbe Juris Grinins Oskars Bikovens Anrijs Verovkins diana Bajare Riga Technical University RigaLV-1658Latvia Latvian State Institute of Wood Chemistry RigaLV-1006Latvia

Novel mycelium-based biocomposites(MBB)were obtained from local agricultural(hemp shives)and forestry(wood chips)by-products which were bounded together with natural growth of fungal *** a result,hemp mycocomposites(HMC)and wood mycocomposites(WMC)were ***,water absorption and biodegradation properties of MBB were *** were characterized also by ash content and elemental *** results of MBB were compared with the re.e.ence materials such as the commercial MBB material manufactured by ecovative®Design(eV),hemp magnesium oxychloride concre.e.HC)and cemented wood wool panel(CW),manufactured by CeWOOD®.The mechanical properties of HMC and WMC showed that the bending strength difference was about 30%,with a better result for *** strength was better for WMC by about 60%compared to that of *** mechanical strength of HMC and HC materials was equal;both materials contained hemp shives but differed by the binding *** absorption and volumetric swelling tests showed that HMC and WMC could be considered as potential *** content and elemental analysis showed that re.e.ence materials(CW,HC)contained significant amounts of inorganic compounds that decreased the biodegradation rate,compared to the case of HMC and WMC *** biodegradation results of HMC and WMC,after 12 weeks,re.e.led a mass loss(ML)above 70%,while in the case of eV,HC and CW,it was about 60%,17%and only 6%,*** were completely biodegradable.

关键词： Mycelium-based biocomposites(MBB) mechanical properties water absorption biodegradation

Corrosion rate determination of rare.e.rth Mg alloys in a Na_(2)SO_(4)solution by electrochemical measure.e.ts and inductive coupled plasma-optical emission spectroscopy

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Journal of Magnesium and Alloys 2019年第1期7卷 47-57页

作者： Samuel Leleu Bertrand Rives Nicolas Causse Nadine Pébère CIRIMAT Universitéde ToulouseCNRSINPTUPSENSIACET4 allée Emile Monso BP4436231030 Toulouse cedex 4 France IRT Saint exupéry 118 route de Narbonne-CS 4424831432 ToulouseFrance

The corrosion resistance of three Mg alloys containing rare.e.rth elements(We43,eV31 and Ze41)was studied and compared to that of two Mg-Al alloys(AZ31 and AZ91)and of pure Mg(99.95 wt.%).Current-voltage curves and electrochemical impedance measure.e.ts were performed with rotating disk electrodes in an aerated 0.1 M Na_(2)SO_(4)*** all the alloys,it was confirmed that the intermetallic particles acted as local cathodes and that more protective films were formed on the alloys surface by comparison with the pure *** rates were determined from inductive coupled plasma-optical emission spectroscopy measure.e.ts and from the electrochemical *** corrosion rates were observed for the rare.e.rth Mg alloys compared to the AZ series *** data allowed the corrosion mechanisms to be discussed.

关键词： Magnesium alloys Rare.e.rth elements eIS ICP-OeS Interface