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H2O2-Activated Up-regulation of Glutathione in Arabidopsis Involves Induction of Genes Encoding Enzymes Involved in Cysteine Synthesis in the Chloroplast

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Molecular Plant 2009年第2期2卷 344-356页

作者： Guillaume Queval Dorothée Thominet Hélène Vanacker Myroslawa Miginiac-Maslow Bertrand gakière Graham Noctor Institut de Biotechnologie des Plantes UMR CNRS 8618 Universite de Paris Sud 91405 Orsay cedex France

Glutathione is a key player in cellular redox homeostasis and, therefore, in the response to H2O2, but the factors regulating oxidation-activated glutathione synthesis are still unclear. We investigated H2O2-induced glutathione synthesis in a conditional Arabidopsis catalase-deficient mutant （cat2）. Plants were grown from seed at elevated CO2 for 5 weeks, then transferred to air in either short-day or long-day conditions. Compared to cat2 at elevated CO2 or wild-type plants in any condition, transfer of cat2 to air in both photoperiods caused measurable oxidation of the leaf glutathione pool within hours. Oxidation continued on subsequent days and was accompanied by accumulation of glutathione. This effect was stronger in cat2 transferred to air in short days, and was not linked to appreciable increases in the extractable activities of or transcripts encoding enzymes involved in the committed pathway of glutathione synthesis. In contrast, it was accompanied by increases in serine, O-acetylserine, and cysteine. These changes in metabolites were accompanied by induction of genes encoding adenosine phosphosulfate reductase （APR）, particularly APR3, as well as a specific serine acetyltransferase gene （SAT2.1） encoding a chloroplastic SAT. Marked induction of these genes was only observed in cat2 transferred to air in short-day conditions, where cysteine and glutathione accumulation was most dramatic. Unlike other SAT genes, which showed negligible induction in cat2, the relative abundance of APR and SAT2.1 transcripts was closely correlated with marker transcripts for H2O2 signaling. Together, the data underline the importance of cysteine synthesis in oxidant-induced up-regulation of glutathione synthesis and suggest that the chloroplast makes an important contribution to cysteine production under these circumstances.

关键词： Oxidative stress catalase photoperiod 3,-glutamylcysteine synthetases (γ-ECS) adenosine phosphosulfate reductase (APR) serine acetyltransferase (SAT).

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土地使用对交通出行的影响

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城市规划学刊 2011年第5期 63-72页

作者：任晋锋吕斌北京大学城市与环境学院北京市规划委员会西城分局北京大学城市与区域规划学系

世界范围内关于土地使用对出行影响的研究越来越多,但是由于土地使用和出行关系的复杂性,以及研究者采用的方法、数据等的差异,土地使用是否影响出行、土地使用要素如何影响出行目前没有明确的结论。现对近年来土地使用对出行影响研究... 详细信息

世界范围内关于土地使用对出行影响的研究越来越多,但是由于土地使用和出行关系的复杂性,以及研究者采用的方法、数据等的差异,土地使用是否影响出行、土地使用要素如何影响出行目前没有明确的结论。现对近年来土地使用对出行影响研究的分类、关键要素、分析框架、理论分析模型等进行梳理和归纳,旨在明确各种方法的优势和不足,进而提出了目前研究中存在的问题和面临的挑战,为今后的研究提供借鉴。

关键词：土地使用出行综述

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SUR lE CYClE de MONTEl-MIRANDA DANS lA THEORIE deS FAMIllES NORMAlES

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Science in China,Ser.A 1958年第10期 987-1000页

作者：熊庆来 Institut de Mathématiques Académia Sinica Pékin Mémoire dédié en hommage au Parti Communiste Chinois à l’occasion de son 37 ième anniversaire.

*** 1934 Paul Montel a signaléun critère dont il avait pressentil’exactitude longtemps avant et qui,sous la forme la plus simple,peut s’énoncerainsiThérème *** famille de fonctions f(z)holomorphes dans le cercleunité,qui ne s’y annulent pas et dont les dérivées d’un ordre quelconque kn’y prennent pas la valeur 1 est normale dans ce cercle.

关键词： SUR lE CYClE de MONTEl-MIRANDA DANS lA THEORIE deS FAMIllES NORMAlES

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Jules Verne, cent ans après

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法语学习 2005年第4期 4-8页

作者： Daniel Compère

Jules Verne est né  une époque où la lecture se développe et où de nombreuses revues sont destinées  être lues en famille. Mais, au début du XIXe siècle, en France, le roman est encore considéré comme un genre mineur, surtout destiné  un public féminin. l’écrivain qui veut acquérir une gloire littéraire doit passer par la poésie ou le thétre. lorsqu’il est étudiant en droit  Paris en 1848—1850, Verne pense déj  cette voie littéraire, mais il tente aussi de publier quelques nouvelles.

关键词：法语阅读欣赏读物文化交流

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Modeling the Impact of desert Aerosols on the Solar Radiation of a Mini Solar Central Photovoltaic (PV)

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Energy and Power Engineering 2021年第7期13卷 261-271页

作者： Wend Dolean Arsène Ilboudo Issaka Ouedraogo Windé Nongué Daniel Koumbem Pèlèga Florent Kieno Département Energie Institut de Recherche en Sciences Appliquées et Technologies (IRSAT) Ouagadougou Burkina Faso Unité de Formation et de recherche en Sciences Exactes et Appliquées Université Joseph KI-ZERBO Ouagadougou Burkina Faso

This work focuses on modeling the impact of desert aerosols on a mini central solar photovoltaic (PV). Our studied physical model is comparable to a multilayer. We have described and discretized the mathematical equations which govern the physical model. Also, we analyzed the influence of the parameters τa and X on the solar radiation received at the surface of solar PV modules. The results of the study taken from Figures 6(a)-(d) representing the variations of the global solar radiation on the solstices and equinoxes as well as the 21 of the months of the year days understood show that: if τa = 0 and X = 0, IC = 67.87%;if τa = 0.5 and X le="font-family:

关键词： Modeling Solar Radiation desert Aerosol Photovoltaic Field

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链柔性与相互作用对高分子溶液的介电性质和热力学性质的影响

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高分子学报 1965年第2期 127-148页

作者： l.deBrouckère 比利时布鲁塞尔大学教授

溶液中高分子的行为在很大程度上受着下列三种相互作用的影响,即近程相互作用、远程相互作用、高分子与溶剂分子间的相互作用. 近程相互作用是高分子链上相隔二、三个键的原子或基因间的相互作用;远程相互作

关键词：高分子溶液极性介电性聚合物溶液甲基丙烯酸马丁烯酸介电色散溶剂聚合度偶极矩柔性

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Progressive multi-organ expression of immunoglobulin G4-related disease: A case report

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World Journal of Hepatology 2013年第6期5卷 336-339页

作者： Marcello Maida Fabio Salvatore Macaluso Giuseppe Cabibbo Giuseppe lo re Nicola Alessi Section of gastroenterology DIBIMIS University of Palermo department of Radiology DIBIMEF University of Palermo

A 63-year-old Caucasian man presented with a cholestatic syndrome, renal failure and arthralgias. A laboratory examination revealed high immunoglobulin G (IgG) and IgG4 levels (5.95 g/l; normal range: 0.08-1.4 g/l), pointing to a diagnosis of systemic IgG4-related disease, with definite radiological evidence of biliary and pancreatic expression, and plausible renal, articular, salivary and lacrimal glands involvement. Due to the rarity of the condition, there are currently no random control trials to point to the optimal therapeutic approach. The patient has been on steroid therapy with the subsequent introduction of azathioprine, with a complete resolution of all symptoms, a rapid reduction to normalization of all blood tests, and a complete regression of the radiological picture. Our experience underlines the complexity of IgG4-related disease and its variable and sometimes progressive presentation, while pointing out the need for a careful and complete assessment for possible multi-organ involvement.

关键词： Immunoglobulin G4 related-disease Autoimmune cholangitis Autoimmune pancreatitis renal failure

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Morphological Diversity within <i>Pterocarpus erinaceus</i>Poir. (Fabaceae), an Overexploited Species in the Savannahs of Côte d’Ivoire

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American Journal of Plant Sciences 2019年第9期10卷 1675-1688页

作者： Koudougnon Alice Estère Goba léonie Clémence Kouonon Kouamé Guillaume Koffi Béket Sévérin Bony Issoumaila Diomandé Raoul Sylvère Sié laboratoire de Biologie et Amélioration des Plantes UFR Sciences of Nature Université Nangui Abrogoua Abidjan Cote d’Ivoire

Pterocarpus erinaceus is a high socio-economic tree of African savannahs. It is overexploited due to technological qualities of its wood, forage value and medicinal uses. The main objective of this study is the assessment of the morphological variability within this species in Cote d’Ivoire, in sight of rational management. Fourteen morphological traits were used to appraise the variability within 144 trees in production from six sites (Yalo, Moyenne Marahoué, Kahanso, Kouassi-Ndawa, Ouarigué and Téguirdouo). The results indicate that the variability reaches 6.60 for the height of the fruit and 45.99 for the weight of the fruit. The results reveal also that there are three morphological groups of P. erinaceus in Cote d’Ivoire. Of the four traits that revealed a distinction among the three morphotypes, only the width of leaves and the number of leaflets enabled their complete distinction. Trees of group 1 have long leaves with a high number of leaflets and large fruits. Trees of group 2 have small leaves with a reduced number of leaflets and large fruits. Then trees of group 3 have intermediate value of width of leaves and number of leaflet and small fruits. The three morphological groups could be useful for varietal selection of P. erinaceus in Cote d’Ivoire.

关键词： Morphological Traits Pterocarpus erinaceus Rational Management Varietal Selection

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laparoscopic gastrojejunostomy for gastric outlet obstruction in patients with unresectable hepatopancreatobiliary cancers: A personal series and systematic review of the literature

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World Journal of gastroenterology 2018年第18期24卷 1978-1988页

作者： Alba Manuel-Vázquez Raquel latorre-Fragua Carmen Ramiro-Pérez Aylhin lópez-Marcano Roberto de la Plaza-llamas José Manuel Ramia department of General and Digestive Surgery University Hospital of Guadalajara

The major symptoms of advanced hepatopancreaticbiliary cancer are biliary obstruction, pain and gastric outlet obstruction(GOO). For obstructive jaundice, surgical treatment should de consider in recurrent stent complications. The role of surgery for pain relief is marginal nowadays. On the last, there is no consensus for treatment of malignant GOO. Endoscopic duodenal stents are associated with shorter length of stay and faster relief to oral intake with more recurrent symptoms. Surgical gastrojejunostomy shows better long-term results and lower re-intervention rates, but there are limited data about laparoscopic approach. We performed a systematic review of the literature, according PRISMA guidelines, to search for articles on laparoscopic gastrojejunostomy for malignant GOO treatment. We also report our personal series, from 2009 to 2017. A review of the literature suggests that there is no standardized surgical technique either standardized outcomes to report. Most of the studies are case series, so level of evidence is low. decisionmaking must consider medical condition, nutritional status, quality of life and life expectancy. Evaluation ofthe patient and multidisciplinary expertise are required to select appropriate approach. Given the limited studies and the difficulty to perform prospective controlled trials, no study can answer all the complexities of malignant GOO and more outcome data is needed.

关键词： Duodenal obstruction gastrojejunostomy gastroenterosmy gastric outlet obstruction gastric bypass laparoscopy laparoscopic surgery Sytematic review

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development of a standardized in vitro approach to evaluate microphysical,chemical,and toxicological properties of combustion-derived fine and ultrafine particles

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Journal of Environmental Sciences 2022年第3期34卷 104-117页

作者： Ana Teresa Juarez-Facio Clement Castilla Cecile Corbiere Helene lavanant Carlos Afonso Christophe Morin Nadine merlet-Machour laurence Chevalier Jean-Marie Vaugeois Jerome Yon Christelle Monteil Normandie Univ UNIROUENUNICAEN ABTE76000 RouenFrance Normandie Univ UNIROUENINSA RouenCNRSCOBRA76000 RouenFrance Normandie Univ UNIROUENINSA RouenCNRSGPM-UMR663476000 RouenFrance Normandie Univ UNIROUENINSA RouenCNRSCORIA76000 RouenFrance

Ultrafine particles represent a growing concern in the public health community but their precise role in many illnesses is still unknown. This lack of knowledge is related to the experimental difficulty in linking their biological effects to their multiple properties, which are important determinants of toxicity. Our aim is to propose an interdisciplinary approach to study fine(FP) and ultrafine(UFP) particles, generated in a controlled manner using a mini CAST(Combustion Aerosol Standard) soot generator used with two different operating conditions(CAST1 and CAST3). The chemical characterization was performed by an untargeted analysis using ultra-high resolution mass spectrometry. In conjunction with this approach, subsequent analysis by gas chromatography–mass spectrometry(GC–MS) was performed to identify polycyclic aromatic hydrocarbons(PAH). CAST1 enabled the generation of FP with a predominance of small PAH molecules, and CAST3 enabled the generation of UFP, which presented higher numbers of carbon atoms corresponding to larger PAH molecules. Healthy normal human bronchial epithelial(NHBE) cells differentiated at the air-liquid interface(AlI) were directly exposed to these freshly emitted FP and UFP. Expression of MUC5AC, FOXJ1, OClN and ZOI as well as microscopic observation confirmed the ciliated pseudostratified epithelial phenotype. Study of the mass deposition efficiency revealed a difference between the two operating conditions, probably due to the morphological differences between the two categories of particles. We demonstrated that only NHBE cells exposed to CAST3 particles induced upregulation in the gene expression of Il-8 and NQO1. This approach offers new perspectives to study FP and UFP with stable and controlled properties.

关键词： In vitro Air-liquid interface MiniCAST Fine and ultrafine particles Organic compounds OC/TC

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