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Predicting factors for the need of extracorporeal membrane oxygenation for suicide attempts by cardiac medication:a single-center cohort study

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World Journal of Emergency medicine 2022年第4期13卷 283-289页

作者： David Vandroux Thomas Aujoulat Bernard-Alex gaüzère Bérénice Puech Bertrand Guihard Olivier Martinet Intensive Care Unit Félix Guyon HospitalUniversity Teaching Hospital of La Réunion97400 Saint DenisReunion IslandFrance Cardiosurgical Intensive Care Unit Dupuytren II HospitalUniversity Teaching Hospital of Limoges87042 LimogesFrance UMR 1094 Neuro-épidémiologie Tropicale University of Limoges87042 LimogesFrance Cardiovascular Anesthesia department Félix Guyon HospitalUniversity Teaching Hospital of La Réunion97400 Saint DenisReunion IslandFrance Service d’Aide Médicale d’Urgence Félix Guyon HospitalUniversity Teaching Hospital of La Réunion97400 Saint DenisReunion IslandFrance

BACKGROUND:Severe poisoning due to the overdosing of cardiac drugs can lead to cardiovascular *** order to decrease the mortality rate,the most severe patients should be transferred as quickly as possible to an extracorporeal membrane oxygenation(ECMO)***,the predictive factors showing the need for venous-arterial ECMO(VA-ECMO)had never been ***:A retrospective,descriptive,and single-center cohort *** consecutive patients admitted in the largest ICU of reunion Island(Indian Ocean)between January 2013 and September 2018 for beta-blockers(BB),calcium channel blockers(CCB),renin-angiotensin-aldosterone system blockers,digoxin or anti-arrythmic intentional poisonings were *** implementation was the primary ***:A total of 49 consecutive admissions were *** patients had ECMO,39 patients did not have *** patients in ECMO group died,while no patients in the conventional group *** most relevant ECMO-associated factors were pulse pressure and heart rate at first medical contact and pulse pressure,heart rate,arterial lactate concentration,liver enzymes and left ventricular ejection fraction(lVEF)at *** pulse pressure at first medical contact and lVEF were significant after logistic ***:A transfer to an ECMO center should be considered for a pulse pressuremedical contact or lVEF<20%on admission to ICU.

关键词： Extracorporeal membrane oxygenation Implementation Cardiac medication Overdose Predicting factor

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On the reliability of predictions on Covid-19 dynamics: A systematic and critical review of modelling techniques

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Infectious Disease Modelling 2021年第1期6卷 258-272页

作者： Janyce Eunice Gnanvi KolawoléValère Salako gaëtan Brezesky Kotanmi Romain GlèlèKakaïPhD laboratoire de Biomathématiques et d’Estimations Forestières Universitéd’Abomey-Calavi04 BP 1525CotonouBenin

Since the emergence of the novel 2019 coronavirus pandemic in december 2019(COVID-19),numerous modellers have used diverse techniques to assess the dynamics of transmission of the disease,predict its future course and determine the impact of different control *** this study,we conducted a global systematic literature review to summarize trends in the modelling techniques used for Covid-19 from January 1st,2020 to November 30th,*** further examined the accuracy and precision of predictions by comparing predicted and observed values for cumulative cases and deaths as well as uncertainties of these *** an initial 4311 peer-reviewed articles and preprints found with our defined keywords,242 were fully *** studies were done on Asian(78.93%)and European(59.09%)*** of them used compartmental models(namely SIR and SEIR)(46.1%)and statistical models(growth models and time series)(31.8%)while few used artificial intelligence(6.7%),Bayesian approach(4.7%),Network models(2.3%)and Agent-based models(1.3%).For the number of cumulative cases,the ratio of the predicted over the observed values and the ratio of the amplitude of confidence interval(CI)or credibility interval(CrI)of predictions and the central value were on average larger than 1 indicating cases of inaccurate and imprecise predictions,and large variation across *** was no clear difference among models used for these two *** 75%of predictions that provided CI or CrI,observed values fall within the 95%CI or CrI of the cumulative cases *** 3.7%of the studies predicted the cumulative number of *** 70%of the predictions,the ratio of predicted over observed cumulative deaths was less or close to ***,the Bayesian model made predictions closer to reality than classical statistical models,although these differences are only suggestive due to the small number of predictions within our dataset(9 in total).In addition,we found a significant neg

关键词： Predictions Accuracy Precision SARS-CoV-2 Pandemic Ratio

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large-scale mapping of the Ebola NP and GP proteins reveals multiple immunoprevalent and conserved CD4 T-cell epitopes

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Cellular & Molecular Immunology 2021年第5期18卷 1323-1325页

作者： Yann gallais Raphaël Sierocki gautier lhomme Coline Sivelle Divor Kiseljak Florian Wurm Sami Djoulah Ahmed Bouzidi Jérôme Kerzerho Bernard Maillère Département Médicament et Technologie pour la Santé SIMoSUniversitéParis-SaclayCEA-Saclay91191Gif surYvetteFrance Excellgene MontheySwitzerland Wiratech Europe Genopole91000EvryFrance Vaxeal holding SA VeveySwitzerland

Humankind faces regular outbreaks from emerging viruses,such as Ebola and the current SARS-CoV-2,or from viruses circulating at low levels in the wild animal *** to the suddenness of virus expansion,the lack of knowledge of immune determinants and correlates of protection severely limit the ability to address the *** in 1976,Ebola virus is part of the Filoviridae family and causes severe hemorrhagic fever with a mortality rate between 50%and 90%.From 2013 to 2020,more than 30,000 infections and 15,000 deaths have been reported *** antibody titers against Ebola virus GP are found in patients recovering from Ebola virus infection and correlate with protection in vaccination models.1 Both CD8 and CD4 T-cell responses also seem to participate in the control of Ebola virus infection in animals,and CD4 T cells are necessary to induce resistance to Ebola virus challenge.

关键词： Ebola mortality hemorrhagic

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Artificial neural network approach for multiphase segmentation of battery electrode nano-CT images

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npj Computational Materials 2022年第1期8卷 255-265页

作者： Zeliang Su Etienne decencière Tuan-Tu Nguyen Kaoutar El-Amiry Vincent de Andrade Alejandro A.Franco Arnaud demortière laboratoire de Réactivitéet Chimie des Solides(lRCS) CNRS UMR 7314Universitéde Picardie Jules VerneHub de l’EnergieRue Baudelocque80039Amiens CedexFrance Réseau sur le Stockage Electrochimique de l’Energie(RS2E) CNRS FR 3459Hub de l’EnergieRue Baudelocque80039Amiens CedexFrance MINES ParisTech–PSl research University CMMCenter for Mathematical Morphology35 rue Saint HonoréFontainebleauFrance renault Technocentre 78084GuyancourtFrance Advanced Photon Source Argonne National LaboratoryLemontUSA Institut Universitaire de France 101 Boulevard Saint Michel75005ParisFrance AlISTOre-European research Institute CNRS FR 3104Hub de l’EnergieRue Baudelocque80039Amiens CedexFrance

The segmentation of tomographic images of the battery electrode is a crucial processing step,which will have an additional impact on the results of material characterization and electrochemical ***,manually labeling X-ray CT images(XCT)is time-consuming,and these XCT images are generally difficult to segment with histographical *** propose a deep learning approach with an asymmetrical depth encode-decoder convolutional neural network(CNN)for real-world battery material *** network achieves high accuracy while requiring small amounts of labeled data and predicts a volume of billions voxel within few *** applying supervised machine learning for segmenting real-world data,the ground truth is often *** results of segmentation are usually qualitatively justified by visual *** try to unravel this fuzzy definition of segmentation quality by identifying the uncertainty due to the human bias diluted in the training *** CNN trainings using synthetic data show quantitative impact of such uncertainty on the determination of material’s ***-XCT datasets of various battery materials have been successfully segmented by training this neural network from *** will also show that applying the transfer learning,which consists of reusing a well-trained network,can improve the accuracy of a similar dataset.

关键词： neural network battery

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A multi-agent system for itinerary suggestion in smart environments

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CAAI Transactions on Intelligence Technology 2021年第4期6卷 377-393页

作者： Alessandra de Paola Salvatore gaglio Andrea Giammanco Giuseppe lo re Marco Morana Universita degzi studi di Palermo PalermoItaly Srart Cities and Comtnunitics Natioral Jab CINI-Consorzio Interuniversitario Nazionale per l'Infortnatica PalerinoItaly

Modem smart environments pose several challenges,among which the design of intelligent algorithms aimed to assist the *** a variety of points of interest are available,for instance,trajectory recommendations are needed to suggest users the most suitable itineraries based on their interests and contextual *** in many cases,these interests must be explicitly requested and their lack causes the so-called cold-start ***,lengthy travelling distances and excessive crowdedness of specific points of interest make itinerary planning more *** address these aspects,a multi-agent itinerary suggestion system that aims at assisting the users in an online and collaborative way is proposed.A profiling agent is responsible for the detection of groups of users whose movements are characterised by similar semantic,spatial and temporal features;then,a recommendation agent leverages contextual information and dynamically associates the current user with the trajectory clusters according to a Multi-Armed Bandit policy;Framing the trajectory recommendation as a reinforcement learning problem permits to provide high-quality suggestions while avoiding both cold-start and preference elicitation *** effectiveness of the approach is demonstrated by some deployments in real-life scenarios,such as smart campuses and theme parks.

关键词： artificial intelligence pattern recognition

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Adaptive Bayesian Inference for Discontinuous Inverse Problems,Application to Hyperbolic Conservation laws

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Communications in Computational Physics 2014年第6期16卷 1-34页

作者： Alexandre Birolleau gaël Poëtte Didier lucor CEA DAMDIFF-91297 ArpajonFrance. UPMC Univ Paris 06 UMR 7190Institut Jean Le Rond d’AlembertF-75005 ParisFrance. CNRS UMR 7190Institut Jean Le Rond d’AlembertF-75005 ParisFrance.

Various works from the literature aimed at accelerating Bayesian inference in inverse *** spectral methods have been recently proposed as surrogate approximations of the forward uncertainty propagation model over the support of the prior *** representations are efficient because they allow affordable simulation of a large number of samples from the posterior ***,they do not perform well when the forward model exhibits strong nonlinear behavior with respect to its *** this work,we first relate the fast(exponential)l2-convergence of the forward approximation to the fast(exponential)convergence(in terms of Kullback-leibler divergence)of the approximate *** particular,we prove that in case the prior distribution is uniform,the posterior is at least twice as fast as the convergence rate of the forward model in those *** Bayesian inference strategy is developed in the framework of a stochastic spectral projection *** predicted convergence rates are then demonstrated for simple nonlinear inverse problems of varying *** then propose an efficient numerical approach for the Bayesian solution of inverse problems presenting strongly nonlinear or discontinuous system *** comes with the improvement of the forward model that is adaptively approximated by an iterative generalized Polynomial Chaos-based *** numerical approximations and predicted convergence rates of the former approach are compared to the new iterative numerical method for nonlinear time-dependent test cases of varying dimension and complexity,which are relevant regarding our hydrodynamics motivations and therefore regarding hyperbolic conservation laws and the apparition of discontinuities in finite time.

关键词： Stochastic inverse problems Bayesian inference iterative generalized Polynomial Chaos compressible gas dynamics.

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Elevated atmospheric CO_(2) impact on carbon and nitrogen transformations and microbial community in replicated wetland

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Ecological Processes 2020年第1期9卷 677-688页

作者： Dawei Jiang lifei Chen Nan Xia Eyram Norgbey desmond ato Koomson Williams Kweku Darkwah College of Horticulture Jilin Agricultural UniversityChangchun 130118China Jilin Tiandiren landscape Architecture design Engineering Co.ltd. Changchun 130117China Key laboratory of Integrated regulation and resource development on Shallow lakes Ministry of EducationEnvironmental Engi neering DepartmentCollege of EnvironmentHohai University1 Xikang RoadGulou210098 NanjingChina

Background:Elevated atmospheric CO_(2) has direct and indirect influences on ecosystem *** impact of elevated atmospheric CO_(2) concentration on carbon and nitrogen transformations,together with the microbial community,was evaluated with water hyacinth(Eichhornia crassipes)in an open-top chamber replicated *** responses of nitrogen and carbon pools in water and wetland soil,and microbial community abundance were studied under ambient CO_(2) and elevated CO_(2)(ambient+200μl l^(−1)).results:Total biomass for the whole plant under elevated CO_(2) increased by an average of 8%(p=0.022).Wetlands,with water hyacinth,showed a significant increase in total carbon and total organic carbon in water by 7%(p=0.001)and 21%(p=0.001),respectively,under elevated CO_(2) compared to that of ambient CO_(2).Increase in dissolved carbon in water correlates with the presence of wetland plants since the water hyacinth can directly exchange CO_(2) from the atmosphere to water by the upper epidermis of ***,the enrichment CO_(2) showed an increase in total carbon and total organic carbon concentration in wetland soil by 3%(p=0.344)and 6%(p=0.008),*** total nitrogen content in water increased by 26%(p=0.0001),while total nitrogen in wetland soil pool under CO_(2) enrichment decreased by 9%(p=0.011)due to increased soil microbial community abundance,extracted by phospholipid fatty acids,which was 25%larger in amount than that of the ambient ***:The study revealed that the elevated CO_(2) would affect the carbon and nitrogen transformations in wetland plant,water,and soil pool and increase soil microbial community abundance.

关键词： Elevated CO_(2) Carbon transformation Nitrogen transformation Microbial community abundance Phospholipid fatty acids Open-top chamber

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Unveiling the lamellar structure of the human cornea over its full thickness using polarization-resolved SHG microscopy

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light(Science & Applications) 2023年第9期12卷 1782-1794页

作者： Clothilde Raoux Anatole Chessel Pierre Mahou gaël latour Marie-Claire Schanne-Klein laboratory for Optics and Biosciences Ecole PolytechniqueCNRSINSERMInstitut Polytechnique de Paris91128 PalaiseauFrance UniversitéParis-Saclay 91190 Gif-sur-YvetteFrance

A key property of the human cornea is to maintain its curvature and consequently its refraction capability despite daily changes in intraocular *** is closely related to the multiscale structure of the corneal stroma,which consists of 1-3µm-thick stacked lamellae made of thin collagen ***,the distribution,size,and orientation of these lamellae along the depth of the cornea are poorly characterized up to *** this study,we use second harmonic generation(SHG)microscopy to visualize the collagen distribution over the full depth of 10 intact and unstained human corneas(500-600µm thick).We take advantage of the small coherence length in epi-detection to axially resolve the lamellae while maintaining the corneal physiological ***,as raw epi-detected SHG images are spatially homogenous because of the sub-wavelength size of stromal collagen fibrils,we use a polarimetric approach to measure the collagen orientation in every *** a careful validation of this approach,we show that the collagen lamellae(i)are mostly oriented along the inferior-superior axis in the anterior stroma and along the nasal-temporal axis in the posterior stroma,with a gradual shift in between and(ii)exhibit more disorder in the anterior *** results represent the first quantitative characterization of the lamellar structure of the human cornea continuously along its entire thickness with micrometric *** also shows the unique potential of P-SHG microscopy for imaging of collagen distribution in thick dense tissues.

关键词： structure curvature resolved

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Supply and quality of colonoscopy according to the characteristics of gastroenterologists in the French population-based colorectalcancer screening program

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World Journal of gastroenterology 2023年第9期29卷 1492-1508页

作者： AkoïKoïvogui Catherine Vincelet gaëlle Abihsera Hamou Ait-Hadad Hélène delattre Tu le Trung Agnès Bernoux Rachel Carroll Jérôme Nicolet Site de Seine-Saint-denis Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Bondy 93146France Site des Yvelines Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Le Chesnay Cedex 78153France Site du Val-de-Marne Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Joinville-le-Pont 94340France Site de Seine-et-Marne Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Lieusaint 77763France Site des Hauts-de-Seine Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Nanterre 92000France site du Val-d’Oise Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Cergy Saint-Christophe 95800France Site de l’Essonne Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Fontenay-Les-Briis 91640France Siège Paris Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Paris 75015France

BACKGROUND Since its complete roll-out in 2009,the French colorectal cancer screening program(CRCSP)experienced 3 major constraints[use of a less efficient Guaiac-test(gFOBT),stopping the supply of Fecal-Immunochemical-Test kits(FIT),and suspension of the program due to the coronavirus disease 2019(COVID-19)]affecting its *** To describe the impact of the constraints in terms of changes in the quality of screeningcolonoscopy(Quali-Colo).meTHODS This retrospective cohort study included screening-colonoscopies performed by gastroenterologists between Jan-2010 and dec-2020 in people aged 50-74 living in Ile-de-France(France).The changes in Quali-colo(Proportion of colonoscopies performed beyond 7 mo(Colo_7 mo),Frequency of serious adverse events(SAE)and Colonoscopy detection rate)were described in a cohort of gastroenterologists who performed at least one colonoscopy over each of the four periods defined according to the chronology of the constraints[gFOBT:Normal progress of the CRCSP using gFOBT(2010-2014);FIT:Normal progress of the CRCSP using FIT(2015-2018);STOP-FIT:Year(2019)during which the CRCSP experienced the cessation of the supply of test kits;COVID:Program suspension due to the COVID-19 health crisis(2020)].The link between each dependent variable(Colo_7 mo;SAE occurrence,neoplasm detection rate)and the predictive factors was analyzed in a two-level multivariate hierarchical *** The 533 gastroenterologists(cohort)achieved 21509 screening colonoscopies over gFOBT period,38352 over FIT,7342 over STOP-FIT and 7995 over COVID *** frequency of SAE did not change between periods(gFOBT:0.3%;FIT:0.3%;STOP-FIT:0.3%;and COVID:0.2%;P=0.10).The risk of Colo_7 mo doubled between FIT[adjusted odds ratio(aOR):1.2(1.1;1.2)]and STOPFIT[aOR:2.4(2.1;2.6)];then,decreased by 40%between STOP-FIT and COVID[aOR:2.0(1.8;2.2)].regardless of the period,this Colo_7 mo’s risk was twice as high for screening colonoscopy performed in a public hospital[aOR:2.

关键词： Colorectal cancer screening Screening colonoscopy Faecal immunochemical test Guaiac faecal occult blood test Quality of colonoscopy Severity of tumor lesions

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Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural regeneration research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik Biverstål Nicolas GBazan Shuai Tan Nailin li Makiko Ohshima Marianne Schultzberg Xiaofei li department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA department of medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

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